MRP protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MRP protein-like protein

Species:

Leishmania major

UniProt:

Q4Q816_LEIMA

TriTrypDb:

LmjF.28.2470 , LMJLV39_280032900 , LMJSD75_280032500

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q816

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q816

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0010257	NADH dehydrogenase complex assembly	6	2
GO:0016043	cellular component organization	3	11
GO:0016226	iron-sulfur cluster assembly	4	11
GO:0022607	cellular component assembly	4	11
GO:0031163	metallo-sulfur cluster assembly	5	11
GO:0032981	mitochondrial respiratory chain complex I assembly	7	2
GO:0033108	mitochondrial respiratory chain complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	11
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016530	metallochaperone activity	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051539	4 iron, 4 sulfur cluster binding	4	2
GO:0051540	metal cluster binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140104	molecular carrier activity	1	11
GO:0140657	ATP-dependent activity	1	11
GO:0140663	ATP-dependent FeS chaperone activity	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.256
CLV_PCSK_KEX2_1	12	14	PF00082	0.392
CLV_PCSK_KEX2_1	166	168	PF00082	0.256
CLV_PCSK_KEX2_1	196	198	PF00082	0.340
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.388
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.340
CLV_PCSK_SKI1_1	113	117	PF00082	0.256
CLV_PCSK_SKI1_1	13	17	PF00082	0.335
CLV_PCSK_SKI1_1	159	163	PF00082	0.275
DEG_MDM2_SWIB_1	117	124	PF02201	0.256
DEG_Nend_UBRbox_1	1	4	PF02207	0.494
DOC_ANK_TNKS_1	4	11	PF00023	0.480
DOC_CKS1_1	154	159	PF01111	0.256
DOC_CYCLIN_RxL_1	110	120	PF00134	0.256
DOC_MAPK_MEF2A_6	208	217	PF00069	0.277
DOC_MAPK_MEF2A_6	26	35	PF00069	0.275
DOC_MAPK_MEF2A_6	87	95	PF00069	0.256
DOC_MAPK_RevD_3	152	167	PF00069	0.256
DOC_PP1_RVXF_1	111	118	PF00149	0.256
DOC_PP2B_LxvP_1	213	216	PF13499	0.256
DOC_PP2B_LxvP_1	93	96	PF13499	0.256
DOC_PP4_FxxP_1	78	81	PF00568	0.275
DOC_USP7_MATH_1	222	226	PF00917	0.363
DOC_WW_Pin1_4	153	158	PF00397	0.256
LIG_14-3-3_CanoR_1	257	263	PF00244	0.472
LIG_14-3-3_CanoR_1	5	9	PF00244	0.498
LIG_APCC_ABBA_1	94	99	PF00400	0.256
LIG_BRCT_BRCA1_1	74	78	PF00533	0.275
LIG_eIF4E_1	111	117	PF01652	0.256
LIG_EVH1_2	80	84	PF00568	0.275
LIG_FHA_1	133	139	PF00498	0.256
LIG_FHA_1	141	147	PF00498	0.256
LIG_FHA_1	26	32	PF00498	0.313
LIG_FHA_1	67	73	PF00498	0.277
LIG_FHA_2	117	123	PF00498	0.256
LIG_FHA_2	259	265	PF00498	0.392
LIG_GBD_Chelix_1	254	262	PF00786	0.335
LIG_Integrin_RGD_1	240	242	PF01839	0.256
LIG_LIR_Apic_2	75	81	PF02991	0.275
LIG_LIR_Gen_1	119	129	PF02991	0.256
LIG_LIR_Gen_1	170	180	PF02991	0.256
LIG_LIR_Nem_3	119	124	PF02991	0.256
LIG_LIR_Nem_3	125	129	PF02991	0.256
LIG_LIR_Nem_3	170	175	PF02991	0.256
LIG_NRBOX	123	129	PF00104	0.388
LIG_PCNA_yPIPBox_3	176	190	PF02747	0.369
LIG_Pex14_2	117	121	PF04695	0.256
LIG_PTB_Apo_2	182	189	PF02174	0.256
LIG_PTB_Phospho_1	182	188	PF10480	0.256
LIG_SH2_NCK_1	252	256	PF00017	0.300
LIG_SH2_SRC	97	100	PF00017	0.300
LIG_SH2_STAP1	97	101	PF00017	0.300
LIG_SH2_STAT5	111	114	PF00017	0.256
LIG_SH2_STAT5	126	129	PF00017	0.256
LIG_SH2_STAT5	188	191	PF00017	0.266
LIG_SH2_STAT5	199	202	PF00017	0.239
LIG_SH3_3	100	106	PF00018	0.300
LIG_SH3_3	151	157	PF00018	0.388
LIG_SH3_3	172	178	PF00018	0.256
LIG_SH3_3	3	9	PF00018	0.372
LIG_SH3_3	51	57	PF00018	0.290
LIG_SUMO_SIM_par_1	13	19	PF11976	0.275
LIG_TRAF2_1	209	212	PF00917	0.253
LIG_TYR_ITIM	124	129	PF00017	0.256
MOD_CDK_SPxK_1	153	159	PF00069	0.275
MOD_CK1_1	27	33	PF00069	0.256
MOD_CK1_1	4	10	PF00069	0.488
MOD_CK1_1	55	61	PF00069	0.256
MOD_CK2_1	116	122	PF00069	0.287
MOD_CK2_1	258	264	PF00069	0.562
MOD_CK2_1	62	68	PF00069	0.256
MOD_GlcNHglycan	18	21	PF01048	0.267
MOD_GlcNHglycan	272	276	PF01048	0.706
MOD_GSK3_1	258	265	PF00069	0.487
MOD_GSK3_1	62	69	PF00069	0.260
MOD_N-GLC_1	184	189	PF02516	0.256
MOD_NEK2_1	1	6	PF00069	0.436
MOD_NEK2_1	40	45	PF00069	0.369
MOD_PIKK_1	140	146	PF00454	0.256
MOD_PIKK_1	62	68	PF00454	0.256
MOD_PKA_2	1	7	PF00069	0.585
MOD_Plk_1	184	190	PF00069	0.256
MOD_Plk_1	241	247	PF00069	0.275
MOD_Plk_1	62	68	PF00069	0.235
MOD_Plk_4	184	190	PF00069	0.256
MOD_Plk_4	55	61	PF00069	0.256
MOD_ProDKin_1	153	159	PF00069	0.256
TRG_DiLeu_BaEn_1	123	128	PF01217	0.256
TRG_ENDOCYTIC_2	126	129	PF00928	0.256
TRG_ENDOCYTIC_2	251	254	PF00928	0.335
TRG_ER_diArg_1	165	167	PF00400	0.256
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT32	Leptomonas seymouri	86%	100%
A0A0N1I422	Leptomonas seymouri	37%	97%
A0A0N1I939	Leptomonas seymouri	40%	89%
A0A0S4IUN9	Bodo saltans	77%	100%
A0A0S4JE42	Bodo saltans	44%	90%
A0A1X0NQL6	Trypanosomatidae	76%	100%
A0A1X0NSI2	Trypanosomatidae	41%	98%
A0A1X0NZ57	Trypanosomatidae	37%	94%
A0A3Q8IBU2	Leishmania donovani	38%	89%
A0A3Q8IET9	Leishmania donovani	97%	100%
A0A3Q8IFM3	Leishmania donovani	39%	95%
A0A3R7KED8	Trypanosoma rangeli	40%	94%
A0A422NVG5	Trypanosoma rangeli	38%	100%
A1C4X8	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	36%	93%
A1C7T4	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	43%	85%
A4HBR3	Leishmania braziliensis	39%	100%
A4HEP9	Leishmania braziliensis	39%	100%
A4HGU9	Leishmania braziliensis	90%	100%
A4HZ65	Leishmania infantum	38%	89%
A4I1X9	Leishmania infantum	39%	95%
A4I3X9	Leishmania infantum	97%	100%
A4QNM5	Xenopus tropicalis	37%	100%
A7RUD5	Nematostella vectensis	43%	92%
A7SE07	Nematostella vectensis	42%	100%
A8PW87	Brugia malayi	40%	94%
A8WWQ7	Caenorhabditis briggsae	38%	93%
A9V7A1	Monosiga brevicollis	43%	100%
B0X4N8	Culex quinquefasciatus	39%	87%
B0XDJ0	Culex quinquefasciatus	41%	100%
B3M9R3	Drosophila ananassae	42%	100%
B3MU92	Drosophila ananassae	40%	94%
B3NIP2	Drosophila erecta	41%	100%
B3NNJ9	Drosophila erecta	40%	94%
B3RPX4	Trichoplax adhaerens	42%	100%
B4G8R5	Drosophila persimilis	39%	94%
B4H7P4	Drosophila persimilis	41%	100%
B4I540	Drosophila sechellia	39%	94%
B4IAD1	Drosophila sechellia	41%	100%
B4IUH5	Drosophila yakuba	41%	100%
B4IYG8	Drosophila grimshawi	42%	100%
B4JBI7	Drosophila grimshawi	39%	94%
B4KHX1	Drosophila mojavensis	36%	94%
B4KY56	Drosophila mojavensis	43%	100%
B4LGB4	Drosophila virilis	43%	100%
B4LUF5	Drosophila virilis	38%	94%
B4N1C3	Drosophila willistoni	39%	94%
B4N4D9	Drosophila willistoni	40%	100%
B4P9A8	Drosophila yakuba	39%	94%
B4PES4	Drosophila yakuba	41%	100%
B4Q7F5	Drosophila simulans	39%	94%
B4QJ46	Drosophila simulans	42%	100%
C9ZS40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A1H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	94%
D0A946	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AV32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	89%
E9AY25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	95%
E9B069	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O24999	Helicobacter pylori (strain ATCC 700392 / 26695)	39%	79%
O49472	Arabidopsis thaliana	44%	93%
O58667	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	42%	99%
O66946	Aquifex aeolicus (strain VF5)	45%	80%
O78436	Guillardia theta	27%	100%
O94442	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	92%
P0AF08	Escherichia coli (strain K12)	45%	79%
P0AF09	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	45%	79%
P0C8Q1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	35%	87%
P0CO88	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	40%	87%
P0CO89	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	40%	87%
P0CO90	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	36%	88%
P0CO91	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	36%	88%
P40558	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P45135	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	44%	79%
P50863	Bacillus subtilis (strain 168)	39%	83%
P52920	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	89%
P53381	Clostridium perfringens (strain 13 / Type A)	42%	100%
P53382	Mycobacterium leprae (strain TN)	34%	76%
P53383	Synechocystis sp. (strain PCC 6803 / Kazusa)	49%	83%
P53384	Homo sapiens	41%	91%
P56346	Chlorella vulgaris	29%	100%
P65442	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	34%	77%
P72190	Pseudomonas fragi	44%	100%
P9WJN6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	34%	77%
P9WJN7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	34%	77%
Q01464	Bacillus subtilis (strain 168)	26%	100%
Q0CE30	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	37%	94%
Q0CVD6	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	43%	84%
Q0UAM9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	34%	98%
Q0UI56	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	43%	86%
Q16H50	Aedes aegypti	40%	100%
Q16T79	Aedes aegypti	41%	92%
Q1DSY6	Coccidioides immitis (strain RS)	34%	85%
Q1EAU8	Coccidioides immitis (strain RS)	42%	85%
Q1RHB0	Rickettsia bellii (strain RML369-C)	42%	92%
Q20EV4	Oltmannsiellopsis viridis	27%	92%
Q24K00	Bos taurus	42%	91%
Q29DB7	Drosophila pseudoobscura pseudoobscura	43%	100%
Q29MT7	Drosophila pseudoobscura pseudoobscura	39%	94%
Q2GWZ4	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	39%	96%
Q2H317	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	44%	85%
Q2UA27	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	36%	93%
Q2UDE2	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	44%	90%
Q3B7Q7	Danio rerio	39%	100%
Q3KQF0	Xenopus laevis	41%	93%
Q3MHY6	Bos taurus	38%	100%
Q4HZ34	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	43%	85%
Q4I174	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	40%	98%
Q4P8S7	Ustilago maydis (strain 521 / FGSC 9021)	35%	81%
Q4Q9E8	Leishmania major	40%	100%
Q4QCE9	Leishmania major	38%	100%
Q4UKB5	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	41%	92%
Q4WEN1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	37%	92%
Q4WZS2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	43%	85%
Q54F15	Dictyostelium discoideum	46%	90%
Q57731	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	45%	100%
Q59MP1	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	88%
Q59YD9	Candida albicans (strain SC5314 / ATCC MYA-2876)	40%	99%
Q5BBC5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	43%	86%
Q5EB25	Xenopus tropicalis	42%	91%
Q5I050	Xenopus laevis	42%	93%
Q5I0L4	Rattus norvegicus	40%	91%
Q5ZKV4	Gallus gallus	38%	100%
Q68FS1	Rattus norvegicus	37%	100%
Q68XP6	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	39%	92%
Q6BTZ6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	40%	89%
Q6BWQ9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	40%	98%
Q6C5D0	Yarrowia lipolytica (strain CLIB 122 / E 150)	41%	100%
Q6C7A6	Yarrowia lipolytica (strain CLIB 122 / E 150)	43%	86%
Q6CE48	Yarrowia lipolytica (strain CLIB 122 / E 150)	47%	94%
Q6CMN0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	39%	90%
Q6CQV4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	42%	100%
Q6DEE4	Xenopus laevis	38%	100%
Q6FPP7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	41%	100%
Q6LZC5	Methanococcus maripaludis (strain S2 / LL)	41%	100%
Q6P298	Danio rerio	44%	91%
Q754X6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	88%
Q75AC3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	100%
Q76NZ7	Dictyostelium discoideum	38%	100%
Q7PV10	Anopheles gambiae	39%	90%
Q7QGS3	Anopheles gambiae	41%	100%
Q7S8Z0	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	44%	85%
Q874M2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	39%	87%
Q8H1Q2	Arabidopsis thaliana	37%	83%
Q8T2F3	Dictyostelium discoideum	41%	93%
Q8TB37	Homo sapiens	46%	92%
Q8U1R0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	41%	99%
Q8X0F1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	38%	96%
Q8ZNN5	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	45%	79%
Q92JA4	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	40%	92%
Q93459	Caenorhabditis elegans	37%	93%
Q97ZW4	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	39%	99%
Q9CWD8	Mus musculus	43%	92%
Q9MUM5	Mesostigma viride	26%	100%
Q9R060	Mus musculus	40%	91%
Q9R061	Mus musculus	37%	100%
Q9RVM9	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	47%	83%
Q9T3P6	Nephroselmis olivacea	25%	100%
Q9V0D9	Pyrococcus abyssi (strain GE5 / Orsay)	43%	99%
Q9VJI9	Drosophila melanogaster	40%	94%
Q9VPD2	Drosophila melanogaster	42%	100%
Q9X2I3	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	25%	100%
Q9Y5Y2	Homo sapiens	39%	100%
Q9ZE27	Rickettsia prowazekii (strain Madrid E)	39%	92%
Q9ZMM5	Helicobacter pylori (strain J99 / ATCC 700824)	39%	79%
V5BGR5	Trypanosoma cruzi	80%	100%
V5DEP1	Trypanosoma cruzi	37%	94%
V5DR48	Trypanosoma cruzi	42%	100%