Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q815_LEIMA

TriTrypDb:

LmjF.28.2480 , LMJLV39_280033000 , LMJSD75_280032600

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q815

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q815

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.696
CLV_NRD_NRD_1	178	180	PF00675	0.803
CLV_NRD_NRD_1	272	274	PF00675	0.553
CLV_NRD_NRD_1	3	5	PF00675	0.457
CLV_NRD_NRD_1	45	47	PF00675	0.768
CLV_PCSK_KEX2_1	272	274	PF00082	0.552
CLV_PCSK_KEX2_1	3	5	PF00082	0.457
CLV_PCSK_KEX2_1	45	47	PF00082	0.768
DOC_MAPK_MEF2A_6	99	108	PF00069	0.480
DOC_USP7_MATH_1	118	122	PF00917	0.560
DOC_USP7_MATH_1	213	217	PF00917	0.604
DOC_USP7_MATH_1	263	267	PF00917	0.439
DOC_USP7_UBL2_3	165	169	PF12436	0.476
DOC_WW_Pin1_4	119	124	PF00397	0.627
DOC_WW_Pin1_4	150	155	PF00397	0.581
DOC_WW_Pin1_4	181	186	PF00397	0.494
DOC_WW_Pin1_4	70	75	PF00397	0.521
LIG_14-3-3_CanoR_1	9	17	PF00244	0.605
LIG_FHA_1	101	107	PF00498	0.604
LIG_FHA_1	128	134	PF00498	0.571
LIG_FHA_1	16	22	PF00498	0.430
LIG_FHA_1	168	174	PF00498	0.478
LIG_FHA_1	26	32	PF00498	0.390
LIG_FHA_2	295	301	PF00498	0.745
LIG_FHA_2	37	43	PF00498	0.587
LIG_Integrin_isoDGR_2	43	45	PF01839	0.767
LIG_LIR_LC3C_4	103	108	PF02991	0.477
LIG_MYND_1	162	166	PF01753	0.479
LIG_PDZ_Class_2	296	301	PF00595	0.784
LIG_Pex14_2	243	247	PF04695	0.335
LIG_SH2_NCK_1	85	89	PF00017	0.510
LIG_SH3_3	28	34	PF00018	0.439
LIG_SH3_3	283	289	PF00018	0.751
LIG_SH3_3	48	54	PF00018	0.412
LIG_SH3_3	76	82	PF00018	0.551
LIG_SH3_4	165	172	PF00018	0.478
LIG_SUMO_SIM_anti_2	170	175	PF11976	0.476
LIG_SUMO_SIM_par_1	103	109	PF11976	0.479
LIG_SUMO_SIM_par_1	254	260	PF11976	0.433
LIG_TRAF2_1	88	91	PF00917	0.579
LIG_UBA3_1	173	180	PF00899	0.481
LIG_WRC_WIRS_1	240	245	PF05994	0.502
MOD_CDK_SPxxK_3	181	188	PF00069	0.493
MOD_CK1_1	217	223	PF00069	0.675
MOD_CK1_1	80	86	PF00069	0.479
MOD_CK2_1	222	228	PF00069	0.587
MOD_CK2_1	36	42	PF00069	0.585
MOD_CK2_1	80	86	PF00069	0.527
MOD_CK2_1	95	101	PF00069	0.502
MOD_Cter_Amidation	43	46	PF01082	0.769
MOD_GlcNHglycan	11	14	PF01048	0.548
MOD_GlcNHglycan	217	220	PF01048	0.802
MOD_GlcNHglycan	236	239	PF01048	0.722
MOD_GlcNHglycan	265	268	PF01048	0.546
MOD_GlcNHglycan	28	31	PF01048	0.340
MOD_GlcNHglycan	79	82	PF01048	0.734
MOD_GlcNHglycan	95	98	PF01048	0.716
MOD_GSK3_1	165	172	PF00069	0.569
MOD_GSK3_1	209	216	PF00069	0.587
MOD_GSK3_1	21	28	PF00069	0.382
MOD_GSK3_1	217	224	PF00069	0.611
MOD_N-GLC_1	213	218	PF02516	0.756
MOD_NEK2_1	167	172	PF00069	0.479
MOD_NEK2_1	25	30	PF00069	0.503
MOD_NEK2_1	294	299	PF00069	0.790
MOD_PKA_2	2	8	PF00069	0.720
MOD_PKA_2	294	300	PF00069	0.790
MOD_Plk_1	100	106	PF00069	0.584
MOD_Plk_4	15	21	PF00069	0.408
MOD_Plk_4	169	175	PF00069	0.546
MOD_ProDKin_1	119	125	PF00069	0.626
MOD_ProDKin_1	150	156	PF00069	0.579
MOD_ProDKin_1	181	187	PF00069	0.496
MOD_ProDKin_1	70	76	PF00069	0.521
MOD_SUMO_rev_2	284	292	PF00179	0.691
TRG_ER_diArg_1	272	275	PF00400	0.793
TRG_ER_diArg_1	45	47	PF00400	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X1W1	Leishmania donovani	82%	100%
A4HGV0	Leishmania braziliensis	51%	100%
A4I3Y0	Leishmania infantum	82%	100%
E9B070	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%