G2 M phase-specific E3 ubiquitin- ligase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q814_LEIMA

TriTrypDb:

LmjF.28.2490 , LMJLV39_280033100 , LMJSD75_280032700

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q814

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q814

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.577
CLV_C14_Caspase3-7	64	68	PF00656	0.610
CLV_NRD_NRD_1	196	198	PF00675	0.544
CLV_NRD_NRD_1	20	22	PF00675	0.666
CLV_NRD_NRD_1	209	211	PF00675	0.545
CLV_NRD_NRD_1	485	487	PF00675	0.376
CLV_NRD_NRD_1	52	54	PF00675	0.537
CLV_NRD_NRD_1	75	77	PF00675	0.636
CLV_PCSK_FUR_1	209	213	PF00082	0.548
CLV_PCSK_KEX2_1	196	198	PF00082	0.544
CLV_PCSK_KEX2_1	20	22	PF00082	0.666
CLV_PCSK_KEX2_1	209	211	PF00082	0.545
CLV_PCSK_KEX2_1	485	487	PF00082	0.376
CLV_PCSK_KEX2_1	52	54	PF00082	0.537
CLV_PCSK_KEX2_1	75	77	PF00082	0.636
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.552
CLV_PCSK_SKI1_1	156	160	PF00082	0.581
CLV_PCSK_SKI1_1	316	320	PF00082	0.532
CLV_PCSK_SKI1_1	460	464	PF00082	0.429
CLV_PCSK_SKI1_1	55	59	PF00082	0.551
CLV_PCSK_SKI1_1	75	79	PF00082	0.485
DEG_Nend_UBRbox_2	1	3	PF02207	0.559
DEG_SPOP_SBC_1	171	175	PF00917	0.581
DEG_SPOP_SBC_1	256	260	PF00917	0.619
DEG_SPOP_SBC_1	368	372	PF00917	0.608
DOC_CYCLIN_RxL_1	454	467	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.485
DOC_MAPK_gen_1	304	313	PF00069	0.537
DOC_MAPK_gen_1	496	504	PF00069	0.460
DOC_MAPK_gen_1	52	59	PF00069	0.527
DOC_PP2B_PxIxI_1	445	451	PF00149	0.427
DOC_USP7_MATH_1	119	123	PF00917	0.638
DOC_USP7_MATH_1	143	147	PF00917	0.563
DOC_USP7_MATH_1	170	174	PF00917	0.612
DOC_USP7_MATH_1	183	187	PF00917	0.662
DOC_USP7_MATH_1	237	241	PF00917	0.722
DOC_USP7_MATH_1	242	246	PF00917	0.787
DOC_USP7_MATH_1	248	252	PF00917	0.732
DOC_USP7_MATH_1	256	260	PF00917	0.614
DOC_WW_Pin1_4	224	229	PF00397	0.597
DOC_WW_Pin1_4	469	474	PF00397	0.464
DOC_WW_Pin1_4	497	502	PF00397	0.472
LIG_14-3-3_CanoR_1	75	84	PF00244	0.615
LIG_APCC_ABBA_1	57	62	PF00400	0.539
LIG_BIR_III_2	340	344	PF00653	0.627
LIG_BRCT_BRCA1_1	30	34	PF00533	0.523
LIG_CaM_IQ_9	474	490	PF13499	0.379
LIG_deltaCOP1_diTrp_1	404	412	PF00928	0.565
LIG_FHA_1	119	125	PF00498	0.615
LIG_FHA_1	465	471	PF00498	0.507
LIG_FHA_1	52	58	PF00498	0.542
LIG_FHA_2	30	36	PF00498	0.608
LIG_FHA_2	310	316	PF00498	0.510
LIG_FXI_DFP_1	409	413	PF00024	0.627
LIG_Integrin_isoDGR_2	296	298	PF01839	0.495
LIG_LIR_Nem_3	288	293	PF02991	0.517
LIG_LIR_Nem_3	404	409	PF02991	0.560
LIG_PDZ_Class_1	506	511	PF00595	0.528
LIG_SH2_CRK	491	495	PF00017	0.404
LIG_SH2_STAP1	309	313	PF00017	0.549
LIG_SH2_STAP1	364	368	PF00017	0.539
LIG_SH3_2	47	52	PF14604	0.476
LIG_SH3_3	155	161	PF00018	0.556
LIG_SH3_3	250	256	PF00018	0.703
LIG_SH3_3	261	267	PF00018	0.593
LIG_SH3_3	41	47	PF00018	0.607
LIG_SH3_3	467	473	PF00018	0.472
LIG_SH3_CIN85_PxpxPR_1	47	52	PF14604	0.476
LIG_SUMO_SIM_par_1	427	433	PF11976	0.379
LIG_SUMO_SIM_par_1	499	505	PF11976	0.524
LIG_TRAF2_1	130	133	PF00917	0.566
LIG_TRAF2_1	3	6	PF00917	0.533
LIG_WW_3	49	53	PF00397	0.596
MOD_CDK_SPK_2	224	229	PF00069	0.616
MOD_CK1_1	146	152	PF00069	0.612
MOD_CK1_1	257	263	PF00069	0.769
MOD_CK1_1	28	34	PF00069	0.646
MOD_CK1_1	97	103	PF00069	0.396
MOD_CK2_1	11	17	PF00069	0.607
MOD_CK2_1	127	133	PF00069	0.571
MOD_CK2_1	255	261	PF00069	0.642
MOD_CK2_1	309	315	PF00069	0.498
MOD_CK2_1	469	475	PF00069	0.465
MOD_CK2_1	97	103	PF00069	0.468
MOD_Cter_Amidation	18	21	PF01082	0.535
MOD_Cter_Amidation	73	76	PF01082	0.629
MOD_GlcNHglycan	136	139	PF01048	0.573
MOD_GlcNHglycan	143	146	PF01048	0.581
MOD_GlcNHglycan	185	188	PF01048	0.622
MOD_GlcNHglycan	218	221	PF01048	0.627
MOD_GlcNHglycan	239	242	PF01048	0.731
MOD_GlcNHglycan	250	253	PF01048	0.575
MOD_GlcNHglycan	27	30	PF01048	0.688
MOD_GlcNHglycan	37	40	PF01048	0.631
MOD_GlcNHglycan	379	382	PF01048	0.671
MOD_GlcNHglycan	79	82	PF01048	0.643
MOD_GlcNHglycan	96	99	PF01048	0.410
MOD_GSK3_1	114	121	PF00069	0.649
MOD_GSK3_1	141	148	PF00069	0.607
MOD_GSK3_1	216	223	PF00069	0.729
MOD_GSK3_1	23	30	PF00069	0.665
MOD_GSK3_1	237	244	PF00069	0.666
MOD_GSK3_1	75	82	PF00069	0.598
MOD_NEK2_1	27	32	PF00069	0.593
MOD_NEK2_1	34	39	PF00069	0.532
MOD_NEK2_2	172	177	PF00069	0.683
MOD_PIKK_1	75	81	PF00454	0.622
MOD_PKA_1	75	81	PF00069	0.622
MOD_PKA_2	51	57	PF00069	0.526
MOD_PKA_2	75	81	PF00069	0.622
MOD_PKB_1	154	162	PF00069	0.579
MOD_Plk_1	109	115	PF00069	0.520
MOD_Plk_1	309	315	PF00069	0.563
MOD_Plk_4	119	125	PF00069	0.639
MOD_Plk_4	490	496	PF00069	0.467
MOD_ProDKin_1	224	230	PF00069	0.599
MOD_ProDKin_1	469	475	PF00069	0.465
MOD_ProDKin_1	497	503	PF00069	0.467
MOD_SUMO_rev_2	351	356	PF00179	0.551
TRG_DiLeu_BaEn_1	190	195	PF01217	0.533
TRG_DiLeu_BaEn_2	450	456	PF01217	0.384
TRG_DiLeu_BaEn_4	418	424	PF01217	0.579
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.577
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.505
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.369
TRG_ENDOCYTIC_2	491	494	PF00928	0.402
TRG_ER_diArg_1	153	156	PF00400	0.623
TRG_ER_diArg_1	195	197	PF00400	0.553
TRG_ER_diArg_1	20	22	PF00400	0.575
TRG_ER_diArg_1	209	212	PF00400	0.542
TRG_ER_diArg_1	303	306	PF00400	0.511
TRG_ER_diArg_1	484	486	PF00400	0.379
TRG_ER_diArg_1	495	498	PF00400	0.446
TRG_ER_diArg_1	51	53	PF00400	0.739
TRG_ER_diArg_1	75	77	PF00400	0.548
TRG_NLS_Bipartite_1	196	214	PF00514	0.527
TRG_NLS_MonoExtC_3	209	214	PF00514	0.555
TRG_NLS_MonoExtN_4	209	214	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA28	Leptomonas seymouri	44%	100%
A0A3S5H7K0	Leishmania donovani	85%	99%
A4HGV1	Leishmania braziliensis	65%	100%
A4I3Y1	Leishmania infantum	85%	99%
E9B071	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%