Putative eukaryotic translation initiation factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E-3

Species:

Leishmania major

UniProt:

Q4Q813_LEIMA

TriTrypDb:

LmjF.28.2500 , LMJLV39_280033200 , LMJSD75_280032800

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0010494	cytoplasmic stress granule	5	2
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q813

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q813

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000339	RNA cap binding	5	2
GO:0000340	RNA 7-methylguanosine cap binding	6	2
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003743	translation initiation factor activity	4	10
GO:0005488	binding	1	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0045182	translation regulator activity	1	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.755
CLV_NRD_NRD_1	208	210	PF00675	0.325
CLV_PCSK_SKI1_1	210	214	PF00082	0.364
CLV_PCSK_SKI1_1	242	246	PF00082	0.376
CLV_PCSK_SKI1_1	279	283	PF00082	0.375
DEG_APCC_DBOX_1	302	310	PF00400	0.524
DEG_MDM2_SWIB_1	186	193	PF02201	0.524
DEG_Nend_UBRbox_3	1	3	PF02207	0.707
DEG_SPOP_SBC_1	19	23	PF00917	0.765
DOC_MAPK_gen_1	220	229	PF00069	0.524
DOC_MAPK_gen_1	274	283	PF00069	0.516
DOC_MAPK_HePTP_8	273	285	PF00069	0.595
DOC_MAPK_JIP1_4	279	285	PF00069	0.564
DOC_MAPK_MEF2A_6	222	231	PF00069	0.541
DOC_MAPK_MEF2A_6	276	285	PF00069	0.578
DOC_PP2B_LxvP_1	193	196	PF13499	0.507
DOC_USP7_MATH_1	10	14	PF00917	0.714
DOC_USP7_MATH_1	136	140	PF00917	0.677
DOC_USP7_MATH_1	161	165	PF00917	0.624
DOC_USP7_MATH_1	19	23	PF00917	0.729
DOC_USP7_MATH_1	194	198	PF00917	0.624
DOC_USP7_MATH_1	329	333	PF00917	0.715
DOC_USP7_MATH_1	81	85	PF00917	0.827
DOC_USP7_UBL2_3	16	20	PF12436	0.791
DOC_USP7_UBL2_3	313	317	PF12436	0.524
DOC_USP7_UBL2_3	338	342	PF12436	0.753
DOC_WW_Pin1_4	162	167	PF00397	0.548
DOC_WW_Pin1_4	341	346	PF00397	0.562
LIG_14-3-3_CanoR_1	236	245	PF00244	0.600
LIG_BIR_III_4	14	18	PF00653	0.762
LIG_deltaCOP1_diTrp_1	184	190	PF00928	0.524
LIG_FHA_1	224	230	PF00498	0.511
LIG_FHA_1	280	286	PF00498	0.556
LIG_FHA_1	328	334	PF00498	0.659
LIG_FHA_1	71	77	PF00498	0.685
LIG_FHA_2	57	63	PF00498	0.780
LIG_FHA_2	64	70	PF00498	0.688
LIG_LIR_Apic_2	215	219	PF02991	0.595
LIG_LIR_Gen_1	204	212	PF02991	0.511
LIG_LIR_Gen_1	246	257	PF02991	0.541
LIG_LIR_Nem_3	146	150	PF02991	0.528
LIG_LIR_Nem_3	169	175	PF02991	0.571
LIG_LIR_Nem_3	184	189	PF02991	0.455
LIG_LIR_Nem_3	204	208	PF02991	0.525
LIG_PAM2_1	37	49	PF00658	0.695
LIG_Pex14_2	172	176	PF04695	0.595
LIG_Pex14_2	186	190	PF04695	0.521
LIG_SH2_SRC	192	195	PF00017	0.525
LIG_SH2_STAP1	203	207	PF00017	0.624
LIG_SH2_STAT3	8	11	PF00017	0.719
LIG_SH2_STAT5	192	195	PF00017	0.541
LIG_SH2_STAT5	203	206	PF00017	0.541
LIG_SH2_STAT5	8	11	PF00017	0.758
LIG_SH3_3	24	30	PF00018	0.804
LIG_SH3_3	42	48	PF00018	0.688
LIG_SUMO_SIM_anti_2	226	231	PF11976	0.564
LIG_SxIP_EBH_1	135	147	PF03271	0.648
LIG_WRC_WIRS_1	183	188	PF05994	0.624
MOD_CK1_1	162	168	PF00069	0.601
MOD_CK1_1	237	243	PF00069	0.583
MOD_CK1_1	55	61	PF00069	0.810
MOD_CK2_1	257	263	PF00069	0.524
MOD_CK2_1	64	70	PF00069	0.673
MOD_CMANNOS	187	190	PF00535	0.324
MOD_GlcNHglycan	138	141	PF01048	0.660
MOD_GlcNHglycan	196	199	PF01048	0.364
MOD_GlcNHglycan	22	25	PF01048	0.791
MOD_GlcNHglycan	235	239	PF01048	0.395
MOD_GlcNHglycan	3	6	PF01048	0.765
MOD_GlcNHglycan	39	42	PF01048	0.714
MOD_GlcNHglycan	54	57	PF01048	0.719
MOD_GlcNHglycan	87	90	PF01048	0.826
MOD_GSK3_1	155	162	PF00069	0.596
MOD_GSK3_1	164	171	PF00069	0.598
MOD_GSK3_1	194	201	PF00069	0.564
MOD_GSK3_1	298	305	PF00069	0.576
MOD_GSK3_1	30	37	PF00069	0.736
MOD_GSK3_1	341	348	PF00069	0.554
MOD_GSK3_1	52	59	PF00069	0.805
MOD_GSK3_1	81	88	PF00069	0.783
MOD_N-GLC_1	162	167	PF02516	0.392
MOD_NEK2_1	298	303	PF00069	0.524
MOD_NEK2_1	54	59	PF00069	0.785
MOD_PIKK_1	102	108	PF00454	0.708
MOD_PIKK_1	30	36	PF00454	0.764
MOD_PKA_2	302	308	PF00069	0.584
MOD_Plk_1	102	108	PF00069	0.681
MOD_Plk_4	182	188	PF00069	0.624
MOD_Plk_4	198	204	PF00069	0.547
MOD_ProDKin_1	162	168	PF00069	0.548
MOD_ProDKin_1	341	347	PF00069	0.557
MOD_SUMO_for_1	212	215	PF00179	0.624
MOD_SUMO_for_1	95	98	PF00179	0.852
MOD_SUMO_rev_2	117	124	PF00179	0.671
MOD_SUMO_rev_2	13	22	PF00179	0.759
MOD_SUMO_rev_2	206	214	PF00179	0.569
MOD_SUMO_rev_2	58	66	PF00179	0.834
MOD_SUMO_rev_2	68	73	PF00179	0.806
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.608
TRG_ENDOCYTIC_2	205	208	PF00928	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S7	Leptomonas seymouri	72%	100%
A0A1X0NR97	Trypanosomatidae	54%	73%
A0A3Q8IDB8	Leishmania donovani	97%	100%
A0A3R7L212	Trypanosoma rangeli	50%	77%
A4HGV2	Leishmania braziliensis	87%	100%
A4I3Y2	Leishmania infantum	97%	100%
D0A951	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	79%
E9B072	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%