R3H domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

R3H domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q811_LEIMA

TriTrypDb:

LmjF.28.2520 , LMJLV39_280033400 , LMJSD75_280033100

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q811

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q811

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.737
CLV_C14_Caspase3-7	72	76	PF00656	0.691
CLV_MEL_PAP_1	173	179	PF00089	0.536
CLV_NRD_NRD_1	381	383	PF00675	0.699
CLV_NRD_NRD_1	398	400	PF00675	0.467
CLV_NRD_NRD_1	491	493	PF00675	0.634
CLV_NRD_NRD_1	630	632	PF00675	0.614
CLV_PCSK_FUR_1	396	400	PF00082	0.667
CLV_PCSK_KEX2_1	379	381	PF00082	0.673
CLV_PCSK_KEX2_1	396	398	PF00082	0.671
CLV_PCSK_KEX2_1	491	493	PF00082	0.634
CLV_PCSK_KEX2_1	630	632	PF00082	0.614
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.673
CLV_PCSK_SKI1_1	101	105	PF00082	0.329
CLV_PCSK_SKI1_1	154	158	PF00082	0.460
CLV_PCSK_SKI1_1	225	229	PF00082	0.611
CLV_PCSK_SKI1_1	28	32	PF00082	0.763
CLV_PCSK_SKI1_1	524	528	PF00082	0.498
CLV_PCSK_SKI1_1	617	621	PF00082	0.510
CLV_PCSK_SKI1_1	8	12	PF00082	0.620
DEG_APCC_DBOX_1	100	108	PF00400	0.562
DEG_APCC_KENBOX_2	88	92	PF00400	0.574
DEG_Nend_UBRbox_2	1	3	PF02207	0.648
DEG_SPOP_SBC_1	270	274	PF00917	0.690
DEG_SPOP_SBC_1	293	297	PF00917	0.688
DOC_CKS1_1	52	57	PF01111	0.803
DOC_CYCLIN_RxL_1	521	529	PF00134	0.516
DOC_CYCLIN_RxL_1	97	108	PF00134	0.563
DOC_MAPK_DCC_7	593	602	PF00069	0.595
DOC_MAPK_gen_1	110	117	PF00069	0.441
DOC_MAPK_gen_1	153	159	PF00069	0.653
DOC_MAPK_gen_1	510	519	PF00069	0.473
DOC_MAPK_gen_1	94	104	PF00069	0.372
DOC_MAPK_HePTP_8	507	519	PF00069	0.524
DOC_MAPK_HePTP_8	560	572	PF00069	0.328
DOC_MAPK_MEF2A_6	510	519	PF00069	0.537
DOC_MAPK_MEF2A_6	563	572	PF00069	0.458
DOC_MAPK_MEF2A_6	593	602	PF00069	0.595
DOC_MAPK_MEF2A_6	97	106	PF00069	0.581
DOC_PP1_RVXF_1	152	159	PF00149	0.646
DOC_PP1_RVXF_1	174	180	PF00149	0.604
DOC_PP2B_LxvP_1	115	118	PF13499	0.476
DOC_PP4_FxxP_1	159	162	PF00568	0.608
DOC_PP4_FxxP_1	531	534	PF00568	0.563
DOC_USP7_MATH_1	14	18	PF00917	0.521
DOC_USP7_MATH_1	270	274	PF00917	0.701
DOC_USP7_MATH_1	285	289	PF00917	0.594
DOC_USP7_MATH_1	293	297	PF00917	0.675
DOC_USP7_MATH_1	3	7	PF00917	0.544
DOC_USP7_MATH_1	41	45	PF00917	0.765
DOC_USP7_MATH_1	437	441	PF00917	0.607
DOC_USP7_MATH_1	497	501	PF00917	0.684
DOC_USP7_MATH_1	53	57	PF00917	0.794
DOC_USP7_MATH_1	621	625	PF00917	0.535
DOC_USP7_MATH_1	632	636	PF00917	0.570
DOC_WW_Pin1_4	272	277	PF00397	0.700
DOC_WW_Pin1_4	286	291	PF00397	0.609
DOC_WW_Pin1_4	341	346	PF00397	0.626
DOC_WW_Pin1_4	39	44	PF00397	0.798
DOC_WW_Pin1_4	51	56	PF00397	0.813
LIG_14-3-3_CanoR_1	176	180	PF00244	0.634
LIG_14-3-3_CanoR_1	187	197	PF00244	0.631
LIG_14-3-3_CanoR_1	4	8	PF00244	0.685
LIG_14-3-3_CanoR_1	545	550	PF00244	0.651
LIG_14-3-3_CanoR_1	593	598	PF00244	0.582
LIG_deltaCOP1_diTrp_1	456	463	PF00928	0.465
LIG_eIF4E_1	232	238	PF01652	0.544
LIG_FHA_1	273	279	PF00498	0.736
LIG_FHA_1	296	302	PF00498	0.739
LIG_FHA_1	455	461	PF00498	0.580
LIG_FHA_1	555	561	PF00498	0.613
LIG_FHA_1	578	584	PF00498	0.517
LIG_FHA_1	620	626	PF00498	0.568
LIG_FHA_2	231	237	PF00498	0.599
LIG_FHA_2	34	40	PF00498	0.802
LIG_FHA_2	437	443	PF00498	0.473
LIG_FHA_2	516	522	PF00498	0.445
LIG_FHA_2	70	76	PF00498	0.756
LIG_LIR_Apic_2	529	534	PF02991	0.544
LIG_LIR_Gen_1	480	489	PF02991	0.404
LIG_LIR_Nem_3	325	331	PF02991	0.549
LIG_LIR_Nem_3	480	484	PF02991	0.449
LIG_Pex14_1	459	463	PF04695	0.442
LIG_Pex14_2	477	481	PF04695	0.454
LIG_PTB_Apo_2	525	532	PF02174	0.531
LIG_Rb_LxCxE_1	358	373	PF01857	0.643
LIG_RPA_C_Fungi	302	314	PF08784	0.732
LIG_SH2_CRK	99	103	PF00017	0.451
LIG_SH2_PTP2	506	509	PF00017	0.486
LIG_SH2_SRC	328	331	PF00017	0.476
LIG_SH2_STAP1	113	117	PF00017	0.449
LIG_SH2_STAT3	232	235	PF00017	0.625
LIG_SH2_STAT5	188	191	PF00017	0.661
LIG_SH2_STAT5	232	235	PF00017	0.607
LIG_SH2_STAT5	353	356	PF00017	0.496
LIG_SH2_STAT5	506	509	PF00017	0.453
LIG_SH3_3	287	293	PF00018	0.687
LIG_SH3_3	52	58	PF00018	0.792
LIG_SH3_3	595	601	PF00018	0.608
LIG_TRAF2_1	233	236	PF00917	0.572
LIG_TRAF2_1	429	432	PF00917	0.771
LIG_TRAF2_1	624	627	PF00917	0.575
LIG_TYR_ITIM	326	331	PF00017	0.542
LIG_UBA3_1	103	112	PF00899	0.432
MOD_CDC14_SPxK_1	42	45	PF00782	0.579
MOD_CDK_SPxK_1	39	45	PF00069	0.578
MOD_CK1_1	138	144	PF00069	0.324
MOD_CK1_1	288	294	PF00069	0.693
MOD_CK1_1	295	301	PF00069	0.659
MOD_CK1_1	308	314	PF00069	0.683
MOD_CK1_1	425	431	PF00069	0.755
MOD_CK1_1	465	471	PF00069	0.563
MOD_CK1_1	548	554	PF00069	0.565
MOD_CK2_1	108	114	PF00069	0.346
MOD_CK2_1	175	181	PF00069	0.586
MOD_CK2_1	230	236	PF00069	0.556
MOD_CK2_1	383	389	PF00069	0.699
MOD_CK2_1	425	431	PF00069	0.739
MOD_CK2_1	621	627	PF00069	0.535
MOD_Cter_Amidation	394	397	PF01082	0.788
MOD_GlcNHglycan	12	15	PF01048	0.656
MOD_GlcNHglycan	190	193	PF01048	0.650
MOD_GlcNHglycan	259	262	PF01048	0.622
MOD_GlcNHglycan	283	286	PF01048	0.684
MOD_GlcNHglycan	38	42	PF01048	0.754
MOD_GlcNHglycan	393	396	PF01048	0.724
MOD_GlcNHglycan	428	431	PF01048	0.796
MOD_GlcNHglycan	451	455	PF01048	0.525
MOD_GlcNHglycan	467	470	PF01048	0.419
MOD_GlcNHglycan	535	538	PF01048	0.686
MOD_GlcNHglycan	547	550	PF01048	0.538
MOD_GSK3_1	10	17	PF00069	0.651
MOD_GSK3_1	135	142	PF00069	0.455
MOD_GSK3_1	175	182	PF00069	0.571
MOD_GSK3_1	265	272	PF00069	0.710
MOD_GSK3_1	277	284	PF00069	0.692
MOD_GSK3_1	288	295	PF00069	0.635
MOD_GSK3_1	33	40	PF00069	0.725
MOD_GSK3_1	418	425	PF00069	0.776
MOD_GSK3_1	446	453	PF00069	0.583
MOD_GSK3_1	47	54	PF00069	0.528
MOD_GSK3_1	513	520	PF00069	0.488
MOD_GSK3_1	544	551	PF00069	0.755
MOD_GSK3_1	573	580	PF00069	0.499
MOD_GSK3_1	632	639	PF00069	0.620
MOD_GSK3_1	77	84	PF00069	0.684
MOD_LATS_1	420	426	PF00433	0.680
MOD_N-GLC_1	118	123	PF02516	0.444
MOD_N-GLC_1	135	140	PF02516	0.328
MOD_N-GLC_1	573	578	PF02516	0.496
MOD_NEK2_1	230	235	PF00069	0.664
MOD_NEK2_1	294	299	PF00069	0.728
MOD_NEK2_1	305	310	PF00069	0.738
MOD_NEK2_1	37	42	PF00069	0.809
MOD_NEK2_1	515	520	PF00069	0.525
MOD_NEK2_2	14	19	PF00069	0.585
MOD_NEK2_2	3	8	PF00069	0.702
MOD_NEK2_2	322	327	PF00069	0.454
MOD_NEK2_2	573	578	PF00069	0.480
MOD_PIKK_1	230	236	PF00454	0.556
MOD_PIKK_1	619	625	PF00454	0.537
MOD_PK_1	593	599	PF00069	0.584
MOD_PKA_2	14	20	PF00069	0.451
MOD_PKA_2	175	181	PF00069	0.639
MOD_PKA_2	218	224	PF00069	0.531
MOD_PKA_2	3	9	PF00069	0.700
MOD_PKA_2	348	354	PF00069	0.632
MOD_PKA_2	358	364	PF00069	0.574
MOD_PKA_2	418	424	PF00069	0.784
MOD_PKA_2	425	431	PF00069	0.679
MOD_PKA_2	465	471	PF00069	0.550
MOD_PKA_2	544	550	PF00069	0.740
MOD_PKB_1	424	432	PF00069	0.666
MOD_Plk_1	118	124	PF00069	0.444
MOD_Plk_1	513	519	PF00069	0.561
MOD_Plk_1	573	579	PF00069	0.502
MOD_Plk_1	81	87	PF00069	0.634
MOD_Plk_2-3	175	181	PF00069	0.603
MOD_Plk_2-3	201	207	PF00069	0.657
MOD_Plk_2-3	383	389	PF00069	0.546
MOD_Plk_2-3	71	77	PF00069	0.683
MOD_Plk_4	322	328	PF00069	0.566
MOD_Plk_4	358	364	PF00069	0.488
MOD_Plk_4	573	579	PF00069	0.480
MOD_ProDKin_1	272	278	PF00069	0.701
MOD_ProDKin_1	286	292	PF00069	0.606
MOD_ProDKin_1	341	347	PF00069	0.630
MOD_ProDKin_1	39	45	PF00069	0.801
MOD_ProDKin_1	51	57	PF00069	0.811
MOD_SUMO_for_1	244	247	PF00179	0.688
MOD_SUMO_for_1	370	373	PF00179	0.642
MOD_SUMO_rev_2	175	184	PF00179	0.652
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.449
TRG_ENDOCYTIC_2	328	331	PF00928	0.454
TRG_ENDOCYTIC_2	506	509	PF00928	0.486
TRG_ENDOCYTIC_2	99	102	PF00928	0.449
TRG_ER_diArg_1	18	21	PF00400	0.590
TRG_ER_diArg_1	338	341	PF00400	0.513
TRG_ER_diArg_1	380	382	PF00400	0.795
TRG_ER_diArg_1	396	399	PF00400	0.488
TRG_ER_diArg_1	490	492	PF00400	0.638
TRG_ER_diArg_1	610	613	PF00400	0.552
TRG_ER_diArg_1	629	631	PF00400	0.533
TRG_NES_CRM1_1	360	373	PF08389	0.605
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.813
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I070	Leptomonas seymouri	61%	100%
A0A0S4IU96	Bodo saltans	24%	100%
A0A1X0NQY1	Trypanosomatidae	33%	100%
A0A3Q8IE01	Leishmania donovani	94%	100%
A0A3R7KGE8	Trypanosoma rangeli	32%	100%
A4HGV4	Leishmania braziliensis	81%	100%
A4I3Y4	Leishmania infantum	94%	100%
D0A955	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B074	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BGS0	Trypanosoma cruzi	31%	100%