MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q808_LEIMA

TriTrypDb:

LmjF.28.2550 , LMJLV39_280033700 , LMJSD75_280033400

Length:

1009

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q808

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q808

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.662
CLV_C14_Caspase3-7	205	209	PF00656	0.675
CLV_C14_Caspase3-7	273	277	PF00656	0.777
CLV_NRD_NRD_1	126	128	PF00675	0.646
CLV_NRD_NRD_1	130	132	PF00675	0.654
CLV_NRD_NRD_1	494	496	PF00675	0.604
CLV_NRD_NRD_1	563	565	PF00675	0.599
CLV_NRD_NRD_1	827	829	PF00675	0.527
CLV_NRD_NRD_1	881	883	PF00675	0.716
CLV_NRD_NRD_1	893	895	PF00675	0.749
CLV_NRD_NRD_1	917	919	PF00675	0.798
CLV_PCSK_KEX2_1	126	128	PF00082	0.587
CLV_PCSK_KEX2_1	130	132	PF00082	0.595
CLV_PCSK_KEX2_1	494	496	PF00082	0.604
CLV_PCSK_KEX2_1	563	565	PF00082	0.599
CLV_PCSK_KEX2_1	827	829	PF00082	0.527
CLV_PCSK_KEX2_1	880	882	PF00082	0.710
CLV_PCSK_KEX2_1	892	894	PF00082	0.755
CLV_PCSK_KEX2_1	917	919	PF00082	0.798
CLV_PCSK_PC7_1	126	132	PF00082	0.649
CLV_PCSK_PC7_1	559	565	PF00082	0.674
CLV_PCSK_SKI1_1	152	156	PF00082	0.516
CLV_PCSK_SKI1_1	339	343	PF00082	0.542
CLV_PCSK_SKI1_1	378	382	PF00082	0.599
CLV_PCSK_SKI1_1	489	493	PF00082	0.481
CLV_PCSK_SKI1_1	566	570	PF00082	0.693
CLV_PCSK_SKI1_1	651	655	PF00082	0.553
CLV_PCSK_SKI1_1	669	673	PF00082	0.460
CLV_PCSK_SKI1_1	687	691	PF00082	0.488
CLV_PCSK_SKI1_1	746	750	PF00082	0.736
CLV_PCSK_SKI1_1	75	79	PF00082	0.566
CLV_PCSK_SKI1_1	814	818	PF00082	0.644
CLV_PCSK_SKI1_1	828	832	PF00082	0.495
DEG_APCC_DBOX_1	129	137	PF00400	0.616
DEG_SPOP_SBC_1	287	291	PF00917	0.785
DEG_SPOP_SBC_1	410	414	PF00917	0.660
DEG_SPOP_SBC_1	591	595	PF00917	0.653
DOC_ANK_TNKS_1	188	195	PF00023	0.665
DOC_ANK_TNKS_1	543	550	PF00023	0.557
DOC_CKS1_1	508	513	PF01111	0.593
DOC_CKS1_1	927	932	PF01111	0.840
DOC_CKS1_1	976	981	PF01111	0.733
DOC_CYCLIN_RxL_1	334	347	PF00134	0.625
DOC_CYCLIN_RxL_1	4	12	PF00134	0.612
DOC_CYCLIN_RxL_1	666	675	PF00134	0.477
DOC_MAPK_gen_1	126	136	PF00069	0.638
DOC_MAPK_gen_1	480	490	PF00069	0.587
DOC_MAPK_gen_1	72	80	PF00069	0.655
DOC_MAPK_gen_1	827	833	PF00069	0.531
DOC_MAPK_MEF2A_6	483	492	PF00069	0.588
DOC_MAPK_MEF2A_6	531	539	PF00069	0.440
DOC_PP2B_LxvP_1	357	360	PF13499	0.590
DOC_PP2B_LxvP_1	379	382	PF13499	0.716
DOC_PP2B_LxvP_1	588	591	PF13499	0.509
DOC_PP4_FxxP_1	779	782	PF00568	0.570
DOC_USP7_MATH_1	119	123	PF00917	0.718
DOC_USP7_MATH_1	231	235	PF00917	0.671
DOC_USP7_MATH_1	281	285	PF00917	0.822
DOC_USP7_MATH_1	287	291	PF00917	0.700
DOC_USP7_MATH_1	344	348	PF00917	0.531
DOC_USP7_MATH_1	380	384	PF00917	0.697
DOC_USP7_MATH_1	410	414	PF00917	0.700
DOC_USP7_MATH_1	601	605	PF00917	0.732
DOC_USP7_MATH_1	847	851	PF00917	0.610
DOC_USP7_MATH_1	899	903	PF00917	0.838
DOC_USP7_MATH_2	219	225	PF00917	0.691
DOC_WW_Pin1_4	111	116	PF00397	0.663
DOC_WW_Pin1_4	274	279	PF00397	0.838
DOC_WW_Pin1_4	371	376	PF00397	0.702
DOC_WW_Pin1_4	431	436	PF00397	0.689
DOC_WW_Pin1_4	507	512	PF00397	0.754
DOC_WW_Pin1_4	623	628	PF00397	0.688
DOC_WW_Pin1_4	766	771	PF00397	0.713
DOC_WW_Pin1_4	789	794	PF00397	0.572
DOC_WW_Pin1_4	911	916	PF00397	0.791
DOC_WW_Pin1_4	919	924	PF00397	0.840
DOC_WW_Pin1_4	926	931	PF00397	0.658
DOC_WW_Pin1_4	975	980	PF00397	0.729
LIG_14-3-3_CanoR_1	174	181	PF00244	0.570
LIG_14-3-3_CanoR_1	21	29	PF00244	0.590
LIG_14-3-3_CanoR_1	339	344	PF00244	0.689
LIG_14-3-3_CanoR_1	40	47	PF00244	0.423
LIG_14-3-3_CanoR_1	544	548	PF00244	0.447
LIG_14-3-3_CanoR_1	651	656	PF00244	0.417
LIG_14-3-3_CanoR_1	661	667	PF00244	0.477
LIG_14-3-3_CanoR_1	673	681	PF00244	0.439
LIG_14-3-3_CanoR_1	687	695	PF00244	0.514
LIG_Actin_WH2_2	530	546	PF00022	0.332
LIG_Actin_WH2_2	550	568	PF00022	0.561
LIG_APCC_ABBA_1	165	170	PF00400	0.702
LIG_APCC_ABBA_1	390	395	PF00400	0.688
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BIR_III_2	208	212	PF00653	0.684
LIG_BIR_III_4	285	289	PF00653	0.852
LIG_BRCT_BRCA1_1	346	350	PF00533	0.541
LIG_BRCT_BRCA1_1	849	853	PF00533	0.503
LIG_CaM_NSCaTE_8	580	587	PF13499	0.580
LIG_EH1_1	646	654	PF00400	0.527
LIG_EH1_1	664	672	PF00400	0.310
LIG_eIF4E_1	666	672	PF01652	0.476
LIG_EVH1_1	357	361	PF00568	0.572
LIG_FHA_1	593	599	PF00498	0.748
LIG_FHA_1	700	706	PF00498	0.498
LIG_FHA_1	757	763	PF00498	0.606
LIG_FHA_1	938	944	PF00498	0.576
LIG_FHA_2	140	146	PF00498	0.574
LIG_FHA_2	289	295	PF00498	0.772
LIG_FHA_2	383	389	PF00498	0.802
LIG_FHA_2	504	510	PF00498	0.711
LIG_FHA_2	71	77	PF00498	0.476
LIG_FHA_2	911	917	PF00498	0.824
LIG_FHA_2	927	933	PF00498	0.625
LIG_LIR_Apic_2	776	782	PF02991	0.583
LIG_LIR_Gen_1	49	57	PF02991	0.486
LIG_LIR_Nem_3	49	53	PF02991	0.498
LIG_LIR_Nem_3	998	1004	PF02991	0.651
LIG_LYPXL_S_1	80	84	PF13949	0.557
LIG_LYPXL_yS_3	81	84	PF13949	0.557
LIG_PCNA_yPIPBox_3	40	51	PF02747	0.432
LIG_PCNA_yPIPBox_3	746	758	PF02747	0.668
LIG_Pex14_2	709	713	PF04695	0.486
LIG_REV1ctd_RIR_1	645	655	PF16727	0.462
LIG_RPA_C_Fungi	490	502	PF08784	0.514
LIG_SH2_CRK	540	544	PF00017	0.461
LIG_SH2_CRK	88	92	PF00017	0.548
LIG_SH2_NCK_1	88	92	PF00017	0.648
LIG_SH2_PTP2	815	818	PF00017	0.521
LIG_SH2_STAT5	132	135	PF00017	0.568
LIG_SH2_STAT5	149	152	PF00017	0.500
LIG_SH2_STAT5	168	171	PF00017	0.601
LIG_SH2_STAT5	318	321	PF00017	0.747
LIG_SH2_STAT5	468	471	PF00017	0.487
LIG_SH2_STAT5	666	669	PF00017	0.504
LIG_SH2_STAT5	815	818	PF00017	0.538
LIG_SH2_STAT5	821	824	PF00017	0.473
LIG_SH3_2	115	120	PF14604	0.686
LIG_SH3_3	112	118	PF00018	0.672
LIG_SH3_3	355	361	PF00018	0.543
LIG_SH3_3	505	511	PF00018	0.625
LIG_SH3_3	79	85	PF00018	0.570
LIG_SH3_3	918	924	PF00018	0.847
LIG_SH3_3	973	979	PF00018	0.769
LIG_SH3_5	314	318	PF00018	0.707
LIG_SUMO_SIM_anti_2	198	205	PF11976	0.816
LIG_TRAF2_1	121	124	PF00917	0.669
LIG_TRAF2_1	262	265	PF00917	0.691
LIG_TRAF2_2	449	454	PF00917	0.668
LIG_WW_3	117	121	PF00397	0.692
LIG_WW_3	974	978	PF00397	0.727
MOD_CDC14_SPxK_1	914	917	PF00782	0.781
MOD_CDK_SPK_2	111	116	PF00069	0.678
MOD_CDK_SPK_2	789	794	PF00069	0.581
MOD_CDK_SPxK_1	911	917	PF00069	0.787
MOD_CDK_SPxxK_3	371	378	PF00069	0.580
MOD_CDK_SPxxK_3	766	773	PF00069	0.704
MOD_CDK_SPxxK_3	789	796	PF00069	0.645
MOD_CDK_SPxxK_3	911	918	PF00069	0.788
MOD_CK1_1	1003	1009	PF00069	0.644
MOD_CK1_1	274	280	PF00069	0.616
MOD_CK1_1	290	296	PF00069	0.817
MOD_CK1_1	298	304	PF00069	0.723
MOD_CK1_1	305	311	PF00069	0.594
MOD_CK1_1	42	48	PF00069	0.611
MOD_CK1_1	660	666	PF00069	0.426
MOD_CK1_1	922	928	PF00069	0.767
MOD_CK1_1	992	998	PF00069	0.694
MOD_CK2_1	118	124	PF00069	0.682
MOD_CK2_1	197	203	PF00069	0.713
MOD_CK2_1	382	388	PF00069	0.801
MOD_CK2_1	503	509	PF00069	0.714
MOD_CK2_1	601	607	PF00069	0.580
MOD_CK2_1	70	76	PF00069	0.477
MOD_CK2_1	910	916	PF00069	0.819
MOD_CK2_1	926	932	PF00069	0.623
MOD_Cter_Amidation	878	881	PF01082	0.698
MOD_GlcNHglycan	181	184	PF01048	0.641
MOD_GlcNHglycan	232	236	PF01048	0.795
MOD_GlcNHglycan	273	276	PF01048	0.612
MOD_GlcNHglycan	294	298	PF01048	0.764
MOD_GlcNHglycan	363	367	PF01048	0.809
MOD_GlcNHglycan	398	401	PF01048	0.749
MOD_GlcNHglycan	419	422	PF01048	0.628
MOD_GlcNHglycan	44	47	PF01048	0.628
MOD_GlcNHglycan	440	443	PF01048	0.532
MOD_GlcNHglycan	540	543	PF01048	0.446
MOD_GlcNHglycan	545	548	PF01048	0.534
MOD_GlcNHglycan	585	588	PF01048	0.551
MOD_GlcNHglycan	599	602	PF01048	0.707
MOD_GlcNHglycan	662	665	PF01048	0.360
MOD_GlcNHglycan	901	904	PF01048	0.776
MOD_GlcNHglycan	937	940	PF01048	0.797
MOD_GlcNHglycan	966	969	PF01048	0.749
MOD_GlcNHglycan	991	994	PF01048	0.678
MOD_GSK3_1	179	186	PF00069	0.644
MOD_GSK3_1	286	293	PF00069	0.770
MOD_GSK3_1	298	305	PF00069	0.674
MOD_GSK3_1	318	325	PF00069	0.442
MOD_GSK3_1	503	510	PF00069	0.725
MOD_GSK3_1	538	545	PF00069	0.562
MOD_GSK3_1	590	597	PF00069	0.702
MOD_GSK3_1	619	626	PF00069	0.728
MOD_GSK3_1	922	929	PF00069	0.732
MOD_GSK3_1	964	971	PF00069	0.763
MOD_GSK3_1	984	991	PF00069	0.774
MOD_LATS_1	891	897	PF00433	0.628
MOD_N-GLC_1	301	306	PF02516	0.812
MOD_N-GLC_2	56	58	PF02516	0.469
MOD_NEK2_1	1000	1005	PF00069	0.652
MOD_NEK2_1	161	166	PF00069	0.556
MOD_NEK2_1	202	207	PF00069	0.712
MOD_NEK2_1	233	238	PF00069	0.692
MOD_NEK2_1	300	305	PF00069	0.817
MOD_NEK2_1	396	401	PF00069	0.598
MOD_NEK2_1	438	443	PF00069	0.563
MOD_NEK2_1	543	548	PF00069	0.504
MOD_NEK2_1	742	747	PF00069	0.680
MOD_NEK2_1	853	858	PF00069	0.617
MOD_NEK2_2	2	7	PF00069	0.657
MOD_NEK2_2	682	687	PF00069	0.619
MOD_PIKK_1	318	324	PF00454	0.697
MOD_PIKK_1	382	388	PF00454	0.809
MOD_PIKK_1	40	46	PF00454	0.460
MOD_PIKK_1	601	607	PF00454	0.580
MOD_PIKK_1	853	859	PF00454	0.592
MOD_PK_1	917	923	PF00069	0.788
MOD_PKA_1	893	899	PF00069	0.735
MOD_PKA_1	917	923	PF00069	0.788
MOD_PKA_2	119	125	PF00069	0.677
MOD_PKA_2	20	26	PF00069	0.597
MOD_PKA_2	221	227	PF00069	0.687
MOD_PKA_2	29	35	PF00069	0.439
MOD_PKA_2	305	311	PF00069	0.821
MOD_PKA_2	344	350	PF00069	0.550
MOD_PKA_2	39	45	PF00069	0.435
MOD_PKA_2	543	549	PF00069	0.436
MOD_PKA_2	660	666	PF00069	0.511
MOD_PKA_2	672	678	PF00069	0.439
MOD_PKA_2	893	899	PF00069	0.735
MOD_PKA_2	917	923	PF00069	0.788
MOD_Plk_1	197	203	PF00069	0.654
MOD_Plk_1	362	368	PF00069	0.702
MOD_Plk_1	699	705	PF00069	0.500
MOD_Plk_2-3	635	641	PF00069	0.465
MOD_Plk_4	1003	1009	PF00069	0.660
MOD_Plk_4	197	203	PF00069	0.767
MOD_Plk_4	295	301	PF00069	0.778
MOD_Plk_4	847	853	PF00069	0.437
MOD_ProDKin_1	111	117	PF00069	0.667
MOD_ProDKin_1	274	280	PF00069	0.836
MOD_ProDKin_1	371	377	PF00069	0.705
MOD_ProDKin_1	431	437	PF00069	0.676
MOD_ProDKin_1	507	513	PF00069	0.754
MOD_ProDKin_1	623	629	PF00069	0.688
MOD_ProDKin_1	766	772	PF00069	0.703
MOD_ProDKin_1	789	795	PF00069	0.567
MOD_ProDKin_1	911	917	PF00069	0.791
MOD_ProDKin_1	919	925	PF00069	0.839
MOD_ProDKin_1	926	932	PF00069	0.659
MOD_ProDKin_1	975	981	PF00069	0.730
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.808
TRG_DiLeu_BaLyEn_6	648	653	PF01217	0.574
TRG_DiLeu_BaLyEn_6	666	671	PF01217	0.303
TRG_DiLeu_BaLyEn_6	867	872	PF01217	0.555
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.683
TRG_DiLeu_BaLyEn_6	980	985	PF01217	0.734
TRG_DiLeu_LyEn_5	433	438	PF01217	0.592
TRG_ENDOCYTIC_2	540	543	PF00928	0.446
TRG_ENDOCYTIC_2	81	84	PF00928	0.557
TRG_ENDOCYTIC_2	88	91	PF00928	0.551
TRG_ER_diArg_1	125	127	PF00400	0.689
TRG_ER_diArg_1	130	132	PF00400	0.603
TRG_ER_diArg_1	324	327	PF00400	0.667
TRG_ER_diArg_1	494	496	PF00400	0.593
TRG_ER_diArg_1	563	566	PF00400	0.572
TRG_ER_diArg_1	793	796	PF00400	0.616
TRG_ER_diArg_1	826	828	PF00400	0.523
TRG_ER_diArg_1	868	871	PF00400	0.557
TRG_ER_diArg_1	880	882	PF00400	0.720
TRG_ER_diArg_1	892	894	PF00400	0.755
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	734	738	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.698
TRG_Pf-PMV_PEXEL_1	994	998	PF00026	0.767

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B1	Leptomonas seymouri	54%	100%
A0A3Q8IE47	Leishmania donovani	91%	100%
A4HGV7	Leishmania braziliensis	75%	100%
A4I3Y7	Leishmania infantum	91%	100%
E9B077	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%