Putative splicing factor 3B subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

splicing factor 3B subunit 1, putative

Species:

Leishmania major

UniProt:

Q4Q804_LEIMA

TriTrypDb:

LmjF.28.2570 , LMJLV39_280034200 , LMJSD75_280033700

Length:

1026

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	12
GO:0005684	U2-type spliceosomal complex	4	2
GO:0005686	U2 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	12
GO:0071004	U2-type prespliceosome	5	2
GO:0071010	prespliceosome	4	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0097525	spliceosomal snRNP complex	4	2

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Expansion

Sequence features

Q4Q804

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q804

Function

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Biological processes
Term	Name	Level	Count
GO:0000245	spliceosomal complex assembly	7	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003729	mRNA binding	5	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.637
CLV_C14_Caspase3-7	163	167	PF00656	0.542
CLV_C14_Caspase3-7	418	422	PF00656	0.446
CLV_C14_Caspase3-7	582	586	PF00656	0.468
CLV_C14_Caspase3-7	687	691	PF00656	0.491
CLV_C14_Caspase3-7	752	756	PF00656	0.440
CLV_C14_Caspase3-7	769	773	PF00656	0.335
CLV_C14_Caspase3-7	801	805	PF00656	0.321
CLV_C14_Caspase3-7	94	98	PF00656	0.267
CLV_NRD_NRD_1	216	218	PF00675	0.362

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M6	Leptomonas seymouri	88%	91%
A0A0S4JZE5	Bodo saltans	47%	93%
A0A1X0NQN8	Trypanosomatidae	64%	92%
A0A3Q8IB75	Leishmania donovani	99%	100%
A0A422NKG9	Trypanosoma rangeli	63%	94%
A4HGW1	Leishmania braziliensis	96%	97%
A4I3Z1	Leishmania infantum	99%	100%
D0A961	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	93%
E9B081	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O57683	Xenopus laevis	32%	79%

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