Putative leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania major

UniProt:

Q4Q803_LEIMA

TriTrypDb:

LmjF.28.2580 , LMJLV39_280034300 , LMJSD75_280033800

Length:

885

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

Q4Q803

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q803

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0019900	kinase binding	4	2
GO:0019901	protein kinase binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	820	824	PF00656	0.732
CLV_NRD_NRD_1	319	321	PF00675	0.542
CLV_NRD_NRD_1	344	346	PF00675	0.628
CLV_NRD_NRD_1	354	356	PF00675	0.669
CLV_NRD_NRD_1	462	464	PF00675	0.540
CLV_NRD_NRD_1	511	513	PF00675	0.634
CLV_NRD_NRD_1	531	533	PF00675	0.503
CLV_NRD_NRD_1	657	659	PF00675	0.312
CLV_NRD_NRD_1	683	685	PF00675	0.583
CLV_NRD_NRD_1	706	708	PF00675	0.631
CLV_NRD_NRD_1	747	749	PF00675	0.596
CLV_NRD_NRD_1	835	837	PF00675	0.578
CLV_PCSK_KEX2_1	319	321	PF00082	0.542
CLV_PCSK_KEX2_1	354	356	PF00082	0.700
CLV_PCSK_KEX2_1	462	464	PF00082	0.540
CLV_PCSK_KEX2_1	531	533	PF00082	0.502
CLV_PCSK_KEX2_1	657	659	PF00082	0.314
CLV_PCSK_KEX2_1	683	685	PF00082	0.563
CLV_PCSK_KEX2_1	835	837	PF00082	0.578
CLV_PCSK_SKI1_1	111	115	PF00082	0.523
CLV_PCSK_SKI1_1	237	241	PF00082	0.552
CLV_PCSK_SKI1_1	28	32	PF00082	0.558
CLV_PCSK_SKI1_1	296	300	PF00082	0.467
CLV_PCSK_SKI1_1	544	548	PF00082	0.339
CLV_PCSK_SKI1_1	601	605	PF00082	0.551
CLV_PCSK_SKI1_1	65	69	PF00082	0.481
CLV_PCSK_SKI1_1	678	682	PF00082	0.651
CLV_PCSK_SKI1_1	721	725	PF00082	0.651
CLV_PCSK_SKI1_1	836	840	PF00082	0.577
DEG_APCC_DBOX_1	219	227	PF00400	0.462
DEG_APCC_DBOX_1	27	35	PF00400	0.552
DEG_APCC_DBOX_1	295	303	PF00400	0.396
DEG_APCC_DBOX_1	543	551	PF00400	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DEG_SPOP_SBC_1	152	156	PF00917	0.763
DEG_SPOP_SBC_1	481	485	PF00917	0.477
DOC_CDC14_PxL_1	189	197	PF14671	0.457
DOC_CKS1_1	1	6	PF01111	0.607
DOC_CKS1_1	359	364	PF01111	0.630
DOC_MAPK_gen_1	111	121	PF00069	0.506
DOC_MAPK_gen_1	319	327	PF00069	0.608
DOC_MAPK_gen_1	531	539	PF00069	0.369
DOC_MAPK_gen_1	654	663	PF00069	0.372
DOC_MAPK_JIP1_4	296	302	PF00069	0.429
DOC_MAPK_MEF2A_6	196	203	PF00069	0.473
DOC_MAPK_MEF2A_6	237	245	PF00069	0.457
DOC_PP1_RVXF_1	115	122	PF00149	0.509
DOC_PP1_RVXF_1	162	168	PF00149	0.676
DOC_PP2B_LxvP_1	135	138	PF13499	0.609
DOC_PP2B_LxvP_1	190	193	PF13499	0.354
DOC_PP4_FxxP_1	258	261	PF00568	0.549
DOC_PP4_FxxP_1	359	362	PF00568	0.561
DOC_PP4_FxxP_1	686	689	PF00568	0.580
DOC_USP7_MATH_1	170	174	PF00917	0.664
DOC_USP7_MATH_1	230	234	PF00917	0.442
DOC_USP7_MATH_1	461	465	PF00917	0.685
DOC_USP7_MATH_1	587	591	PF00917	0.721
DOC_USP7_MATH_1	838	842	PF00917	0.657
DOC_USP7_MATH_1	85	89	PF00917	0.490
DOC_WW_Pin1_4	147	152	PF00397	0.702
DOC_WW_Pin1_4	358	363	PF00397	0.620
DOC_WW_Pin1_4	424	429	PF00397	0.694
DOC_WW_Pin1_4	52	57	PF00397	0.532
DOC_WW_Pin1_4	771	776	PF00397	0.745
DOC_WW_Pin1_4	840	845	PF00397	0.765
LIG_14-3-3_CanoR_1	164	170	PF00244	0.705
LIG_14-3-3_CanoR_1	237	242	PF00244	0.540
LIG_14-3-3_CanoR_1	354	363	PF00244	0.722
LIG_14-3-3_CanoR_1	411	417	PF00244	0.639
LIG_14-3-3_CanoR_1	426	432	PF00244	0.480
LIG_14-3-3_CanoR_1	462	471	PF00244	0.697
LIG_14-3-3_CanoR_1	65	70	PF00244	0.494
LIG_14-3-3_CanoR_1	683	687	PF00244	0.628
LIG_14-3-3_CanoR_1	698	706	PF00244	0.555
LIG_14-3-3_CanoR_1	835	841	PF00244	0.797
LIG_Actin_RPEL_3	524	543	PF02755	0.408
LIG_Actin_WH2_2	222	239	PF00022	0.531
LIG_Actin_WH2_2	500	517	PF00022	0.581
LIG_Actin_WH2_2	56	73	PF00022	0.499
LIG_Actin_WH2_2	85	102	PF00022	0.495
LIG_APCC_ABBA_1	324	329	PF00400	0.655
LIG_BIR_III_4	103	107	PF00653	0.481
LIG_BIR_III_4	391	395	PF00653	0.671
LIG_BRCT_BRCA1_1	558	562	PF00533	0.553
LIG_CaM_IQ_9	536	551	PF13499	0.508
LIG_CaM_IQ_9	660	675	PF13499	0.490
LIG_Clathr_ClatBox_1	306	310	PF01394	0.480
LIG_deltaCOP1_diTrp_1	290	301	PF00928	0.552
LIG_EH_1	259	263	PF12763	0.501
LIG_eIF4E_1	123	129	PF01652	0.463
LIG_FHA_1	236	242	PF00498	0.486
LIG_FHA_1	502	508	PF00498	0.591
LIG_FHA_1	602	608	PF00498	0.726
LIG_FHA_1	761	767	PF00498	0.688
LIG_FHA_1	861	867	PF00498	0.590
LIG_FHA_2	313	319	PF00498	0.467
LIG_FHA_2	428	434	PF00498	0.768
LIG_LIR_Apic_2	291	297	PF02991	0.521
LIG_LIR_Apic_2	339	343	PF02991	0.648
LIG_LIR_Apic_2	357	362	PF02991	0.430
LIG_LIR_Apic_2	430	434	PF02991	0.734
LIG_LIR_Apic_2	685	689	PF02991	0.575
LIG_LIR_Gen_1	120	131	PF02991	0.414
LIG_LIR_Gen_1	197	206	PF02991	0.359
LIG_LIR_Gen_1	639	650	PF02991	0.657
LIG_LIR_Gen_1	84	94	PF02991	0.426
LIG_LIR_Gen_1	848	858	PF02991	0.578
LIG_LIR_Nem_3	197	203	PF02991	0.366
LIG_LIR_Nem_3	292	298	PF02991	0.498
LIG_LIR_Nem_3	382	386	PF02991	0.644
LIG_LIR_Nem_3	559	565	PF02991	0.532
LIG_LIR_Nem_3	639	645	PF02991	0.656
LIG_LIR_Nem_3	84	89	PF02991	0.469
LIG_MYND_1	612	616	PF01753	0.662
LIG_NRBOX	719	725	PF00104	0.617
LIG_PCNA_TLS_4	346	353	PF02747	0.611
LIG_PCNA_yPIPBox_3	632	642	PF02747	0.597
LIG_Pex14_1	294	298	PF04695	0.477
LIG_Pex14_2	258	262	PF04695	0.545
LIG_SH2_CRK	340	344	PF00017	0.647
LIG_SH2_CRK	383	387	PF00017	0.648
LIG_SH2_GRB2like	340	343	PF00017	0.641
LIG_SH2_GRB2like	736	739	PF00017	0.545
LIG_SH2_NCK_1	736	740	PF00017	0.568
LIG_SH2_PTP2	66	69	PF00017	0.450
LIG_SH2_SRC	736	739	PF00017	0.533
LIG_SH2_STAT3	565	568	PF00017	0.571
LIG_SH2_STAT5	200	203	PF00017	0.551
LIG_SH2_STAT5	352	355	PF00017	0.551
LIG_SH2_STAT5	66	69	PF00017	0.450
LIG_SH3_3	166	172	PF00018	0.599
LIG_SH3_3	238	244	PF00018	0.453
LIG_SH3_3	395	401	PF00018	0.620
LIG_SH3_3	436	442	PF00018	0.746
LIG_SH3_3	469	475	PF00018	0.726
LIG_SH3_3	684	690	PF00018	0.582
LIG_SUMO_SIM_anti_2	518	525	PF11976	0.571
LIG_SUMO_SIM_anti_2	87	93	PF11976	0.476
LIG_SUMO_SIM_par_1	173	180	PF11976	0.555
LIG_SUMO_SIM_par_1	303	308	PF11976	0.500
LIG_SUMO_SIM_par_1	48	55	PF11976	0.462
LIG_SUMO_SIM_par_1	7	12	PF11976	0.368
LIG_SUMO_SIM_par_1	90	95	PF11976	0.358
LIG_TRAF2_1	35	38	PF00917	0.609
LIG_TRAF2_1	379	382	PF00917	0.603
LIG_TRAF2_1	516	519	PF00917	0.600
LIG_TRAF2_1	633	636	PF00917	0.615
LIG_TYR_ITIM	64	69	PF00017	0.496
LIG_UBA3_1	109	114	PF00899	0.509
LIG_UBA3_1	849	856	PF00899	0.580
LIG_WRC_WIRS_1	503	508	PF05994	0.630
LIG_WRPW_2	295	298	PF00400	0.469
MOD_CK1_1	140	146	PF00069	0.703
MOD_CK1_1	427	433	PF00069	0.758
MOD_CK1_1	482	488	PF00069	0.711
MOD_CK1_1	502	508	PF00069	0.578
MOD_CK1_1	51	57	PF00069	0.552
MOD_CK1_1	530	536	PF00069	0.408
MOD_CK1_1	630	636	PF00069	0.620
MOD_CK1_1	701	707	PF00069	0.424
MOD_CK1_1	768	774	PF00069	0.727
MOD_CK1_1	852	858	PF00069	0.768
MOD_CK1_1	860	866	PF00069	0.769
MOD_CK2_1	312	318	PF00069	0.433
MOD_CK2_1	333	339	PF00069	0.639
MOD_CK2_1	376	382	PF00069	0.681
MOD_CK2_1	513	519	PF00069	0.561
MOD_CK2_1	630	636	PF00069	0.594
MOD_CK2_1	777	783	PF00069	0.779
MOD_CK2_1	786	792	PF00069	0.729
MOD_CK2_1	84	90	PF00069	0.454
MOD_GlcNHglycan	142	145	PF01048	0.695
MOD_GlcNHglycan	155	158	PF01048	0.684
MOD_GlcNHglycan	161	164	PF01048	0.636
MOD_GlcNHglycan	196	199	PF01048	0.492
MOD_GlcNHglycan	266	269	PF01048	0.614
MOD_GlcNHglycan	278	281	PF01048	0.732
MOD_GlcNHglycan	382	386	PF01048	0.722
MOD_GlcNHglycan	407	410	PF01048	0.704
MOD_GlcNHglycan	465	468	PF01048	0.701
MOD_GlcNHglycan	485	488	PF01048	0.438
MOD_GlcNHglycan	573	576	PF01048	0.577
MOD_GlcNHglycan	582	585	PF01048	0.579
MOD_GlcNHglycan	589	592	PF01048	0.705
MOD_GlcNHglycan	598	601	PF01048	0.680
MOD_GlcNHglycan	788	791	PF01048	0.787
MOD_GlcNHglycan	826	829	PF01048	0.738
MOD_GlcNHglycan	872	875	PF01048	0.812
MOD_GSK3_1	105	112	PF00069	0.467
MOD_GSK3_1	115	122	PF00069	0.494
MOD_GSK3_1	136	143	PF00069	0.726
MOD_GSK3_1	147	154	PF00069	0.658
MOD_GSK3_1	159	166	PF00069	0.548
MOD_GSK3_1	260	267	PF00069	0.527
MOD_GSK3_1	269	276	PF00069	0.593
MOD_GSK3_1	329	336	PF00069	0.596
MOD_GSK3_1	354	361	PF00069	0.722
MOD_GSK3_1	477	484	PF00069	0.758
MOD_GSK3_1	48	55	PF00069	0.459
MOD_GSK3_1	698	705	PF00069	0.574
MOD_GSK3_1	708	715	PF00069	0.511
MOD_GSK3_1	765	772	PF00069	0.772
MOD_GSK3_1	773	780	PF00069	0.744
MOD_GSK3_1	836	843	PF00069	0.813
MOD_GSK3_1	845	852	PF00069	0.771
MOD_GSK3_1	857	864	PF00069	0.824
MOD_LATS_1	834	840	PF00433	0.582
MOD_N-GLC_1	131	136	PF02516	0.613
MOD_N-GLC_1	182	187	PF02516	0.467
MOD_N-GLC_1	204	209	PF02516	0.445
MOD_N-GLC_1	274	279	PF02516	0.646
MOD_N-GLC_1	329	334	PF02516	0.592
MOD_N-GLC_1	42	47	PF02516	0.463
MOD_N-GLC_1	596	601	PF02516	0.710
MOD_N-GLC_1	768	773	PF02516	0.729
MOD_NEK2_1	109	114	PF00069	0.509
MOD_NEK2_1	131	136	PF00069	0.599
MOD_NEK2_1	153	158	PF00069	0.726
MOD_NEK2_1	165	170	PF00069	0.565
MOD_NEK2_1	177	182	PF00069	0.427
MOD_NEK2_1	204	209	PF00069	0.445
MOD_NEK2_1	248	253	PF00069	0.392
MOD_NEK2_1	26	31	PF00069	0.621
MOD_NEK2_1	264	269	PF00069	0.529
MOD_NEK2_1	289	294	PF00069	0.614
MOD_NEK2_1	333	338	PF00069	0.657
MOD_NEK2_1	42	47	PF00069	0.405
MOD_NEK2_1	479	484	PF00069	0.579
MOD_NEK2_1	50	55	PF00069	0.425
MOD_NEK2_1	724	729	PF00069	0.528
MOD_NEK2_1	826	831	PF00069	0.744
MOD_NEK2_1	849	854	PF00069	0.605
MOD_NEK2_1	861	866	PF00069	0.648
MOD_NEK2_1	9	14	PF00069	0.451
MOD_NEK2_1	92	97	PF00069	0.351
MOD_NEK2_2	269	274	PF00069	0.618
MOD_PIKK_1	838	844	PF00454	0.807
MOD_PK_1	513	519	PF00069	0.563
MOD_PKA_1	354	360	PF00069	0.715
MOD_PKA_1	462	468	PF00069	0.534
MOD_PKA_2	140	146	PF00069	0.748
MOD_PKA_2	163	169	PF00069	0.708
MOD_PKA_2	273	279	PF00069	0.681
MOD_PKA_2	354	360	PF00069	0.727
MOD_PKA_2	461	467	PF00069	0.730
MOD_PKA_2	530	536	PF00069	0.445
MOD_PKA_2	682	688	PF00069	0.647
MOD_PKA_2	864	870	PF00069	0.640
MOD_Plk_1	119	125	PF00069	0.446
MOD_Plk_1	131	137	PF00069	0.568
MOD_Plk_1	26	32	PF00069	0.549
MOD_Plk_1	289	295	PF00069	0.558
MOD_Plk_1	376	382	PF00069	0.598
MOD_Plk_1	701	707	PF00069	0.565
MOD_Plk_1	9	15	PF00069	0.481
MOD_Plk_2-3	777	783	PF00069	0.685
MOD_Plk_2-3	845	851	PF00069	0.585
MOD_Plk_4	105	111	PF00069	0.427
MOD_Plk_4	237	243	PF00069	0.440
MOD_Plk_4	289	295	PF00069	0.555
MOD_Plk_4	502	508	PF00069	0.564
MOD_Plk_4	65	71	PF00069	0.515
MOD_Plk_4	777	783	PF00069	0.702
MOD_Plk_4	845	851	PF00069	0.616
MOD_Plk_4	872	878	PF00069	0.788
MOD_ProDKin_1	147	153	PF00069	0.704
MOD_ProDKin_1	358	364	PF00069	0.623
MOD_ProDKin_1	424	430	PF00069	0.692
MOD_ProDKin_1	52	58	PF00069	0.527
MOD_ProDKin_1	771	777	PF00069	0.746
MOD_ProDKin_1	840	846	PF00069	0.766
TRG_DiLeu_BaEn_1	719	724	PF01217	0.617
TRG_DiLeu_BaEn_2	557	563	PF01217	0.565
TRG_DiLeu_BaEn_4	37	43	PF01217	0.576
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.467
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.477
TRG_ENDOCYTIC_2	123	126	PF00928	0.454
TRG_ENDOCYTIC_2	200	203	PF00928	0.408
TRG_ENDOCYTIC_2	383	386	PF00928	0.653
TRG_ENDOCYTIC_2	648	651	PF00928	0.604
TRG_ENDOCYTIC_2	66	69	PF00928	0.529
TRG_ER_diArg_1	319	321	PF00400	0.542
TRG_ER_diArg_1	353	355	PF00400	0.580
TRG_ER_diArg_1	531	534	PF00400	0.505
TRG_ER_diArg_1	670	673	PF00400	0.512
TRG_ER_diArg_1	835	837	PF00400	0.578
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	515	519	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	721	725	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0J5	Leptomonas seymouri	52%	100%
A0A0S4IJ40	Bodo saltans	22%	100%
A0A3R7LYV2	Trypanosoma rangeli	30%	100%
A0A3S7X1U4	Leishmania donovani	93%	100%
A4HGW2	Leishmania braziliensis	66%	100%
A4I3Z2	Leishmania infantum	93%	100%
E9B082	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BL83	Trypanosoma cruzi	30%	100%