ADP-ribosylglycohydrolase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylglycohydrolase, putative

Species:

Leishmania major

UniProt:

Q4Q802_LEIMA

TriTrypDb:

LmjF.28.2590 , LMJLV39_280034400 , LMJSD75_280033900

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q802

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q802

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.498
CLV_C14_Caspase3-7	260	264	PF00656	0.512
CLV_C14_Caspase3-7	332	336	PF00656	0.482
CLV_PCSK_SKI1_1	369	373	PF00082	0.319
CLV_PCSK_SKI1_1	93	97	PF00082	0.516
CLV_Separin_Metazoa	136	140	PF03568	0.459
DEG_APCC_DBOX_1	298	306	PF00400	0.687
DEG_SPOP_SBC_1	111	115	PF00917	0.648
DOC_CKS1_1	185	190	PF01111	0.449
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.376
DOC_MAPK_gen_1	156	166	PF00069	0.306
DOC_MAPK_MEF2A_6	30	38	PF00069	0.438
DOC_MAPK_MEF2A_6	398	407	PF00069	0.514
DOC_USP7_MATH_1	102	106	PF00917	0.694
DOC_USP7_MATH_1	111	115	PF00917	0.646
DOC_USP7_MATH_1	140	144	PF00917	0.465
DOC_USP7_MATH_1	192	196	PF00917	0.468
DOC_USP7_MATH_1	198	202	PF00917	0.403
DOC_USP7_MATH_1	292	296	PF00917	0.643
DOC_USP7_MATH_1	97	101	PF00917	0.633
DOC_USP7_MATH_2	387	393	PF00917	0.583
DOC_WW_Pin1_4	184	189	PF00397	0.407
DOC_WW_Pin1_4	210	215	PF00397	0.490
DOC_WW_Pin1_4	228	233	PF00397	0.671
DOC_WW_Pin1_4	258	263	PF00397	0.349
DOC_WW_Pin1_4	6	11	PF00397	0.600
DOC_WW_Pin1_4	70	75	PF00397	0.596
DOC_WW_Pin1_4	88	93	PF00397	0.410
LIG_14-3-3_CanoR_1	108	116	PF00244	0.522
LIG_14-3-3_CanoR_1	139	148	PF00244	0.411
LIG_14-3-3_CanoR_1	256	262	PF00244	0.386
LIG_14-3-3_CanoR_1	312	317	PF00244	0.673
LIG_14-3-3_CanoR_1	330	339	PF00244	0.433
LIG_14-3-3_CanoR_1	98	102	PF00244	0.545
LIG_AP2alpha_2	204	206	PF02296	0.479
LIG_BIR_III_4	221	225	PF00653	0.624
LIG_eIF4E_1	152	158	PF01652	0.499
LIG_FHA_1	128	134	PF00498	0.369
LIG_FHA_1	185	191	PF00498	0.420
LIG_FHA_1	205	211	PF00498	0.449
LIG_FHA_1	274	280	PF00498	0.405
LIG_FHA_1	400	406	PF00498	0.403
LIG_FHA_2	218	224	PF00498	0.650
LIG_FHA_2	292	298	PF00498	0.670
LIG_FHA_2	330	336	PF00498	0.501
LIG_FHA_2	76	82	PF00498	0.519
LIG_LIR_Apic_2	201	205	PF02991	0.432
LIG_LIR_Apic_2	411	415	PF02991	0.431
LIG_LIR_Gen_1	204	214	PF02991	0.398
LIG_LIR_Gen_1	81	92	PF02991	0.495
LIG_LIR_Nem_3	118	124	PF02991	0.510
LIG_LIR_Nem_3	128	134	PF02991	0.313
LIG_LIR_Nem_3	20	24	PF02991	0.432
LIG_LIR_Nem_3	204	209	PF02991	0.378
LIG_LIR_Nem_3	81	87	PF02991	0.480
LIG_PCNA_PIPBox_1	53	62	PF02747	0.433
LIG_PCNA_yPIPBox_3	46	60	PF02747	0.505
LIG_SH2_CRK	121	125	PF00017	0.477
LIG_SH2_GRB2like	17	20	PF00017	0.397
LIG_SH2_SRC	17	20	PF00017	0.409
LIG_SH2_SRC	202	205	PF00017	0.487
LIG_SH2_STAP1	193	197	PF00017	0.502
LIG_SH2_STAP1	246	250	PF00017	0.362
LIG_SH2_STAT5	134	137	PF00017	0.356
LIG_SH2_STAT5	152	155	PF00017	0.245
LIG_SH2_STAT5	202	205	PF00017	0.497
LIG_SH2_STAT5	246	249	PF00017	0.336
LIG_SH2_STAT5	59	62	PF00017	0.569
LIG_SH3_2	286	291	PF14604	0.461
LIG_SH3_3	283	289	PF00018	0.515
LIG_SUMO_SIM_par_1	122	128	PF11976	0.301
LIG_WRC_WIRS_1	126	131	PF05994	0.344
MOD_CDK_SPK_2	88	93	PF00069	0.461
MOD_CK1_1	110	116	PF00069	0.718
MOD_CK1_1	213	219	PF00069	0.563
MOD_CK1_1	315	321	PF00069	0.750
MOD_CK1_1	6	12	PF00069	0.544
MOD_CK2_1	112	118	PF00069	0.555
MOD_CK2_1	228	234	PF00069	0.641
MOD_CK2_1	291	297	PF00069	0.623
MOD_CK2_1	335	341	PF00069	0.549
MOD_CK2_1	59	65	PF00069	0.411
MOD_CK2_1	75	81	PF00069	0.558
MOD_CK2_1	88	94	PF00069	0.321
MOD_GlcNHglycan	109	112	PF01048	0.654
MOD_GlcNHglycan	142	145	PF01048	0.438
MOD_GlcNHglycan	248	251	PF01048	0.305
MOD_GlcNHglycan	293	297	PF01048	0.644
MOD_GlcNHglycan	318	321	PF01048	0.700
MOD_GlcNHglycan	391	394	PF01048	0.385
MOD_GSK3_1	1	8	PF00069	0.535
MOD_GSK3_1	102	109	PF00069	0.680
MOD_GSK3_1	112	119	PF00069	0.569
MOD_GSK3_1	173	180	PF00069	0.424
MOD_GSK3_1	204	211	PF00069	0.468
MOD_GSK3_1	213	220	PF00069	0.595
MOD_GSK3_1	258	265	PF00069	0.388
MOD_GSK3_1	308	315	PF00069	0.685
MOD_GSK3_1	331	338	PF00069	0.479
MOD_NEK2_1	1	6	PF00069	0.596
MOD_NEK2_1	116	121	PF00069	0.634
MOD_NEK2_1	125	130	PF00069	0.510
MOD_NEK2_1	177	182	PF00069	0.426
MOD_NEK2_1	316	321	PF00069	0.692
MOD_NEK2_2	17	22	PF00069	0.396
MOD_PIKK_1	49	55	PF00454	0.519
MOD_PKA_2	107	113	PF00069	0.529
MOD_PKA_2	311	317	PF00069	0.654
MOD_PKA_2	329	335	PF00069	0.482
MOD_PKA_2	97	103	PF00069	0.510
MOD_Plk_1	117	123	PF00069	0.489
MOD_Plk_1	244	250	PF00069	0.472
MOD_Plk_1	80	86	PF00069	0.458
MOD_Plk_2-3	335	341	PF00069	0.473
MOD_Plk_4	112	118	PF00069	0.619
MOD_Plk_4	173	179	PF00069	0.354
MOD_Plk_4	180	186	PF00069	0.333
MOD_Plk_4	22	28	PF00069	0.494
MOD_ProDKin_1	184	190	PF00069	0.409
MOD_ProDKin_1	210	216	PF00069	0.505
MOD_ProDKin_1	228	234	PF00069	0.667
MOD_ProDKin_1	258	264	PF00069	0.344
MOD_ProDKin_1	6	12	PF00069	0.600
MOD_ProDKin_1	70	76	PF00069	0.585
MOD_ProDKin_1	88	94	PF00069	0.415
MOD_SUMO_rev_2	392	400	PF00179	0.530
MOD_SUMO_rev_2	91	97	PF00179	0.510
TRG_DiLeu_BaEn_1	173	178	PF01217	0.343
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.441
TRG_ENDOCYTIC_2	121	124	PF00928	0.475
TRG_ENDOCYTIC_2	134	137	PF00928	0.328
TRG_ER_diArg_1	298	301	PF00400	0.750
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW3	Leptomonas seymouri	59%	97%
A0A0S4IN38	Bodo saltans	33%	100%
A0A1X0NQK8	Trypanosomatidae	41%	100%
A0A3Q8IF26	Leishmania donovani	92%	100%
A0A3R7KDQ9	Trypanosoma rangeli	45%	100%
A4HGW3	Leishmania braziliensis	81%	100%
A4I3Z3	Leishmania infantum	92%	100%
D0A963	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B083	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BC55	Trypanosoma cruzi	44%	100%