Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q7Z9_LEIMA

TriTrypDb:

LmjF.28.2630 , LMJLV39_280034700 , LMJSD75_280034200

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.743
CLV_NRD_NRD_1	348	350	PF00675	0.661
CLV_NRD_NRD_1	357	359	PF00675	0.549
CLV_NRD_NRD_1	47	49	PF00675	0.617
CLV_PCSK_KEX2_1	138	140	PF00082	0.744
CLV_PCSK_KEX2_1	163	165	PF00082	0.698
CLV_PCSK_KEX2_1	348	350	PF00082	0.661
CLV_PCSK_KEX2_1	357	359	PF00082	0.549
CLV_PCSK_KEX2_1	47	49	PF00082	0.617
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.744
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.698
CLV_PCSK_PC7_1	344	350	PF00082	0.598
CLV_PCSK_SKI1_1	387	391	PF00082	0.686
CLV_PCSK_SKI1_1	426	430	PF00082	0.661
DEG_APCC_DBOX_1	290	298	PF00400	0.629
DEG_SCF_FBW7_1	232	237	PF00400	0.675
DEG_SCF_FBW7_1	389	394	PF00400	0.684
DEG_SPOP_SBC_1	297	301	PF00917	0.655
DEG_SPOP_SBC_1	34	38	PF00917	0.675
DOC_CKS1_1	231	236	PF01111	0.677
DOC_CKS1_1	306	311	PF01111	0.656
DOC_MAPK_DCC_7	238	247	PF00069	0.687
DOC_MAPK_HePTP_8	235	247	PF00069	0.684
DOC_MAPK_MEF2A_6	238	247	PF00069	0.687
DOC_MAPK_RevD_3	336	349	PF00069	0.590
DOC_PP2B_LxvP_1	101	104	PF13499	0.630
DOC_PP2B_LxvP_1	130	133	PF13499	0.610
DOC_PP2B_LxvP_1	179	182	PF13499	0.678
DOC_PP2B_LxvP_1	240	243	PF13499	0.791
DOC_PP2B_LxvP_1	406	409	PF13499	0.562
DOC_PP4_FxxP_1	231	234	PF00568	0.679
DOC_USP7_MATH_1	133	137	PF00917	0.682
DOC_USP7_MATH_1	155	159	PF00917	0.719
DOC_USP7_MATH_1	298	302	PF00917	0.606
DOC_USP7_MATH_1	34	38	PF00917	0.784
DOC_USP7_MATH_1	383	387	PF00917	0.625
DOC_USP7_MATH_1	391	395	PF00917	0.636
DOC_USP7_MATH_1	413	417	PF00917	0.615
DOC_USP7_MATH_1	96	100	PF00917	0.589
DOC_WW_Pin1_4	128	133	PF00397	0.728
DOC_WW_Pin1_4	148	153	PF00397	0.537
DOC_WW_Pin1_4	230	235	PF00397	0.690
DOC_WW_Pin1_4	245	250	PF00397	0.637
DOC_WW_Pin1_4	305	310	PF00397	0.714
DOC_WW_Pin1_4	324	329	PF00397	0.670
DOC_WW_Pin1_4	332	337	PF00397	0.607
DOC_WW_Pin1_4	379	384	PF00397	0.638
DOC_WW_Pin1_4	387	392	PF00397	0.587
LIG_14-3-3_CanoR_1	112	116	PF00244	0.692
LIG_14-3-3_CanoR_1	262	267	PF00244	0.676
LIG_14-3-3_CanoR_1	296	306	PF00244	0.748
LIG_14-3-3_CanoR_1	426	431	PF00244	0.600
LIG_AP2alpha_2	220	222	PF02296	0.692
LIG_BIR_III_2	24	28	PF00653	0.638
LIG_BRCT_BRCA1_1	415	419	PF00533	0.638
LIG_BRCT_BRCA1_1	98	102	PF00533	0.642
LIG_deltaCOP1_diTrp_1	364	374	PF00928	0.614
LIG_EVH1_2	243	247	PF00568	0.553
LIG_FHA_1	125	131	PF00498	0.605
LIG_FHA_1	13	19	PF00498	0.689
LIG_FHA_1	235	241	PF00498	0.679
LIG_FHA_2	282	288	PF00498	0.712
LIG_FHA_2	328	334	PF00498	0.649
LIG_FHA_2	388	394	PF00498	0.710
LIG_FHA_2	429	435	PF00498	0.733
LIG_Integrin_RGD_1	395	397	PF01839	0.659
LIG_LIR_Gen_1	61	69	PF02991	0.757
LIG_LIR_Nem_3	61	65	PF02991	0.754
LIG_SH2_CRK	326	330	PF00017	0.647
LIG_SH2_STAP1	62	66	PF00017	0.658
LIG_SH2_STAT5	307	310	PF00017	0.653
LIG_SH3_3	129	135	PF00018	0.623
LIG_SH3_3	149	155	PF00018	0.526
LIG_SH3_3	20	26	PF00018	0.742
LIG_SH3_3	246	252	PF00018	0.753
LIG_SH3_3	322	328	PF00018	0.588
LIG_SH3_3	72	78	PF00018	0.722
LIG_SUMO_SIM_par_1	327	333	PF11976	0.651
LIG_SUMO_SIM_par_1	426	431	PF11976	0.554
LIG_TRAF2_1	183	186	PF00917	0.673
LIG_TRAF2_1	285	288	PF00917	0.716
LIG_TYR_ITIM	324	329	PF00017	0.649
LIG_WRC_WIRS_1	210	215	PF05994	0.596
MOD_CDK_SPxK_1	305	311	PF00069	0.714
MOD_CK1_1	28	34	PF00069	0.653
MOD_CK1_1	281	287	PF00069	0.662
MOD_CK1_1	299	305	PF00069	0.581
MOD_CK1_1	327	333	PF00069	0.656
MOD_CK1_1	36	42	PF00069	0.698
MOD_CK1_1	88	94	PF00069	0.733
MOD_CK2_1	111	117	PF00069	0.718
MOD_CK2_1	281	287	PF00069	0.727
MOD_CK2_1	387	393	PF00069	0.686
MOD_DYRK1A_RPxSP_1	387	391	PF00069	0.686
MOD_GlcNHglycan	135	138	PF01048	0.695
MOD_GlcNHglycan	214	217	PF01048	0.721
MOD_GlcNHglycan	222	225	PF01048	0.649
MOD_GlcNHglycan	280	283	PF01048	0.721
MOD_GlcNHglycan	317	320	PF01048	0.622
MOD_GlcNHglycan	359	362	PF01048	0.666
MOD_GlcNHglycan	398	404	PF01048	0.637
MOD_GlcNHglycan	415	418	PF01048	0.681
MOD_GlcNHglycan	51	54	PF01048	0.597
MOD_GSK3_1	124	131	PF00069	0.834
MOD_GSK3_1	230	237	PF00069	0.678
MOD_GSK3_1	278	285	PF00069	0.609
MOD_GSK3_1	28	35	PF00069	0.655
MOD_GSK3_1	297	304	PF00069	0.709
MOD_GSK3_1	374	381	PF00069	0.752
MOD_GSK3_1	383	390	PF00069	0.655
MOD_GSK3_1	83	90	PF00069	0.827
MOD_N-GLC_1	302	307	PF02516	0.650
MOD_N-GLC_1	91	96	PF02516	0.633
MOD_NEK2_1	374	379	PF00069	0.656
MOD_NEK2_2	194	199	PF00069	0.603
MOD_PIKK_1	250	256	PF00454	0.662
MOD_PIKK_1	407	413	PF00454	0.721
MOD_PKA_1	357	363	PF00069	0.642
MOD_PKA_2	111	117	PF00069	0.673
MOD_PKA_2	206	212	PF00069	0.746
MOD_PKA_2	357	363	PF00069	0.664
MOD_PKA_2	88	94	PF00069	0.714
MOD_Plk_1	168	174	PF00069	0.636
MOD_Plk_1	302	308	PF00069	0.651
MOD_Plk_2-3	143	149	PF00069	0.647
MOD_Plk_4	111	117	PF00069	0.603
MOD_Plk_4	262	268	PF00069	0.664
MOD_Plk_4	28	34	PF00069	0.577
MOD_Plk_4	302	308	PF00069	0.728
MOD_Plk_4	36	42	PF00069	0.789
MOD_Plk_4	61	67	PF00069	0.714
MOD_ProDKin_1	128	134	PF00069	0.726
MOD_ProDKin_1	148	154	PF00069	0.537
MOD_ProDKin_1	230	236	PF00069	0.688
MOD_ProDKin_1	245	251	PF00069	0.637
MOD_ProDKin_1	305	311	PF00069	0.714
MOD_ProDKin_1	324	330	PF00069	0.671
MOD_ProDKin_1	332	338	PF00069	0.606
MOD_ProDKin_1	379	385	PF00069	0.636
MOD_ProDKin_1	387	393	PF00069	0.587
TRG_DiLeu_BaEn_1	423	428	PF01217	0.649
TRG_DiLeu_BaEn_1	435	440	PF01217	0.481
TRG_DiLeu_LyEn_5	423	428	PF01217	0.649
TRG_ENDOCYTIC_2	326	329	PF00928	0.646
TRG_ENDOCYTIC_2	62	65	PF00928	0.767
TRG_ER_diArg_1	139	141	PF00400	0.743
TRG_ER_diArg_1	348	351	PF00400	0.689
TRG_ER_diArg_1	357	359	PF00400	0.555
TRG_ER_diArg_1	47	49	PF00400	0.617
TRG_NLS_MonoExtC_3	137	142	PF00514	0.742
TRG_NLS_MonoExtC_3	162	168	PF00514	0.660
TRG_NLS_MonoExtN_4	135	142	PF00514	0.631
TRG_NLS_MonoExtN_4	160	167	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7K1	Leishmania donovani	88%	95%
A4HGW6	Leishmania braziliensis	55%	93%
E9B086	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%