Putative molybdenum cofactor biosynthesis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

molybdenum cofactor biosynthesis protein, putative

Species:

Leishmania major

UniProt:

Q4Q7Z8_LEIMA

TriTrypDb:

LmjF.28.2640 , LMJLV39_280034800 , LMJSD75_280034300

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Z8

Function

Biological processes
Term	Name	Level	Count
GO:0006777	Mo-molybdopterin cofactor biosynthetic process	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009987	cellular process	1	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019637	organophosphate metabolic process	3	6
GO:0019720	Mo-molybdopterin cofactor metabolic process	4	6
GO:0032324	molybdopterin cofactor biosynthetic process	4	6
GO:0043545	molybdopterin cofactor metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0051189	prosthetic group metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:0090407	organophosphate biosynthetic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016829	lyase activity	2	2
GO:0016830	carbon-carbon lyase activity	3	2
GO:0016849	phosphorus-oxygen lyase activity	3	2
GO:0061798	GTP 3',8'-cyclase activity	4	2
GO:0061799	cyclic pyranopterin monophosphate synthase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.796
CLV_C14_Caspase3-7	556	560	PF00656	0.624
CLV_C14_Caspase3-7	588	592	PF00656	0.623
CLV_C14_Caspase3-7	651	655	PF00656	0.657
CLV_C14_Caspase3-7	703	707	PF00656	0.765
CLV_NRD_NRD_1	277	279	PF00675	0.684
CLV_NRD_NRD_1	318	320	PF00675	0.820
CLV_NRD_NRD_1	404	406	PF00675	0.840
CLV_NRD_NRD_1	428	430	PF00675	0.786
CLV_NRD_NRD_1	499	501	PF00675	0.840
CLV_NRD_NRD_1	574	576	PF00675	0.850
CLV_NRD_NRD_1	586	588	PF00675	0.661
CLV_NRD_NRD_1	604	606	PF00675	0.647
CLV_NRD_NRD_1	614	616	PF00675	0.682
CLV_NRD_NRD_1	664	666	PF00675	0.847
CLV_NRD_NRD_1	746	748	PF00675	0.847
CLV_NRD_NRD_1	76	78	PF00675	0.529
CLV_NRD_NRD_1	96	98	PF00675	0.199
CLV_PCSK_KEX2_1	167	169	PF00082	0.529
CLV_PCSK_KEX2_1	273	275	PF00082	0.700
CLV_PCSK_KEX2_1	277	279	PF00082	0.665
CLV_PCSK_KEX2_1	310	312	PF00082	0.661
CLV_PCSK_KEX2_1	318	320	PF00082	0.801
CLV_PCSK_KEX2_1	404	406	PF00082	0.834
CLV_PCSK_KEX2_1	428	430	PF00082	0.786
CLV_PCSK_KEX2_1	498	500	PF00082	0.854
CLV_PCSK_KEX2_1	525	527	PF00082	0.853
CLV_PCSK_KEX2_1	532	534	PF00082	0.726
CLV_PCSK_KEX2_1	586	588	PF00082	0.822
CLV_PCSK_KEX2_1	663	665	PF00082	0.849
CLV_PCSK_KEX2_1	679	681	PF00082	0.601
CLV_PCSK_KEX2_1	75	77	PF00082	0.529
CLV_PCSK_KEX2_1	755	757	PF00082	0.827
CLV_PCSK_KEX2_1	760	762	PF00082	0.736
CLV_PCSK_KEX2_1	95	97	PF00082	0.199
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.529
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.840
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.762
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.854
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.853
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.726
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.638
CLV_PCSK_PC1ET2_1	755	757	PF00082	0.827
CLV_PCSK_PC1ET2_1	760	762	PF00082	0.736
CLV_PCSK_PC7_1	756	762	PF00082	0.821
CLV_PCSK_PC7_1	91	97	PF00082	0.529
CLV_PCSK_SKI1_1	2	6	PF00082	0.699
CLV_PCSK_SKI1_1	234	238	PF00082	0.660
CLV_PCSK_SKI1_1	435	439	PF00082	0.846
CLV_PCSK_SKI1_1	748	752	PF00082	0.846
CLV_PCSK_SKI1_1	77	81	PF00082	0.529
CLV_PCSK_SKI1_1	91	95	PF00082	0.298
DEG_Nend_UBRbox_1	1	4	PF02207	0.720
DEG_SCF_FBW7_1	7	13	PF00400	0.817
DEG_SPOP_SBC_1	473	477	PF00917	0.862
DOC_CKS1_1	334	339	PF01111	0.743
DOC_CKS1_1	4	9	PF01111	0.828
DOC_CKS1_1	63	68	PF01111	0.467
DOC_CYCLIN_yCln2_LP_2	327	330	PF00134	0.785
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.825
DOC_MAPK_DCC_7	19	28	PF00069	0.510
DOC_MAPK_FxFP_2	61	64	PF00069	0.467
DOC_MAPK_MEF2A_6	19	28	PF00069	0.510
DOC_PP2B_LxvP_1	327	330	PF13499	0.785
DOC_PP2B_LxvP_1	80	83	PF13499	0.529
DOC_PP4_FxxP_1	61	64	PF00568	0.467
DOC_USP7_MATH_1	103	107	PF00917	0.492
DOC_USP7_MATH_1	22	26	PF00917	0.688
DOC_USP7_MATH_1	222	226	PF00917	0.787
DOC_USP7_MATH_1	350	354	PF00917	0.771
DOC_USP7_MATH_1	408	412	PF00917	0.728
DOC_USP7_MATH_1	437	441	PF00917	0.784
DOC_USP7_MATH_1	443	447	PF00917	0.688
DOC_USP7_MATH_1	596	600	PF00917	0.706
DOC_USP7_UBL2_3	373	377	PF12436	0.705
DOC_USP7_UBL2_3	667	671	PF12436	0.859
DOC_USP7_UBL2_3	748	752	PF12436	0.859
DOC_WW_Pin1_4	199	204	PF00397	0.640
DOC_WW_Pin1_4	220	225	PF00397	0.735
DOC_WW_Pin1_4	3	8	PF00397	0.833
DOC_WW_Pin1_4	328	333	PF00397	0.833
DOC_WW_Pin1_4	336	341	PF00397	0.722
DOC_WW_Pin1_4	610	615	PF00397	0.791
DOC_WW_Pin1_4	62	67	PF00397	0.526
DOC_WW_Pin1_4	738	743	PF00397	0.666
LIG_14-3-3_CanoR_1	234	239	PF00244	0.742
LIG_14-3-3_CanoR_1	384	393	PF00244	0.699
LIG_14-3-3_CanoR_1	428	436	PF00244	0.677
LIG_14-3-3_CanoR_1	499	509	PF00244	0.748
LIG_14-3-3_CanoR_1	595	601	PF00244	0.660
LIG_14-3-3_CanoR_1	618	626	PF00244	0.789
LIG_14-3-3_CanoR_1	69	75	PF00244	0.529
LIG_14-3-3_CanoR_1	95	101	PF00244	0.529
LIG_BIR_III_4	239	243	PF00653	0.784
LIG_BRCT_BRCA1_1	12	16	PF00533	0.654
LIG_BRCT_BRCA1_1	596	600	PF00533	0.745
LIG_BRCT_BRCA1_1	70	74	PF00533	0.454
LIG_deltaCOP1_diTrp_1	690	696	PF00928	0.855
LIG_Dynein_DLC8_1	523	529	PF01221	0.786
LIG_FHA_1	173	179	PF00498	0.738
LIG_FHA_1	362	368	PF00498	0.594
LIG_FHA_1	394	400	PF00498	0.848
LIG_FHA_1	407	413	PF00498	0.630
LIG_FHA_1	41	47	PF00498	0.389
LIG_FHA_2	139	145	PF00498	0.529
LIG_FHA_2	283	289	PF00498	0.792
LIG_FHA_2	477	483	PF00498	0.763
LIG_FHA_2	586	592	PF00498	0.624
LIG_FHA_2	725	731	PF00498	0.839
LIG_LIR_Gen_1	109	116	PF02991	0.529
LIG_LIR_Gen_1	141	150	PF02991	0.529
LIG_LIR_Gen_1	173	182	PF02991	0.756
LIG_LIR_Nem_3	109	113	PF02991	0.529
LIG_LIR_Nem_3	141	146	PF02991	0.529
LIG_LIR_Nem_3	173	177	PF02991	0.715
LIG_NRP_CendR_1	760	762	PF00754	0.840
LIG_Pex14_1	692	696	PF04695	0.858
LIG_RPA_C_Fungi	660	672	PF08784	0.794
LIG_SH2_CRK	110	114	PF00017	0.529
LIG_SH2_CRK	143	147	PF00017	0.529
LIG_SH2_STAP1	110	114	PF00017	0.529
LIG_SH2_STAT5	114	117	PF00017	0.529
LIG_SH2_STAT5	33	36	PF00017	0.529
LIG_SH2_STAT5	534	537	PF00017	0.833
LIG_SH3_1	326	332	PF00018	0.786
LIG_SH3_2	675	680	PF14604	0.783
LIG_SH3_2	742	747	PF14604	0.824
LIG_SH3_3	179	185	PF00018	0.810
LIG_SH3_3	18	24	PF00018	0.563
LIG_SH3_3	210	216	PF00018	0.778
LIG_SH3_3	326	332	PF00018	0.689
LIG_SH3_3	334	340	PF00018	0.642
LIG_SH3_3	4	10	PF00018	0.825
LIG_SH3_3	672	678	PF00018	0.783
LIG_SH3_3	737	743	PF00018	0.830
LIG_SH3_3	76	82	PF00018	0.529
LIG_SH3_CIN85_PxpxPR_1	742	747	PF14604	0.601
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.758
LIG_TRAF2_1	258	261	PF00917	0.857
LIG_TRAF2_1	263	266	PF00917	0.760
LIG_TRAF2_1	418	421	PF00917	0.794
LIG_TRAF2_1	462	465	PF00917	0.803
LIG_TRAF2_1	469	472	PF00917	0.708
LIG_TRAF2_1	544	547	PF00917	0.784
LIG_TRAF2_1	634	637	PF00917	0.786
LIG_TRAF2_1	716	719	PF00917	0.739
LIG_WW_3	744	748	PF00397	0.790
LIG_WW_3	81	85	PF00397	0.529
MOD_CDK_SPK_2	610	615	PF00069	0.791
MOD_CDK_SPxK_1	610	616	PF00069	0.792
MOD_CDK_SPxxK_3	336	343	PF00069	0.747
MOD_CDK_SPxxK_3	62	69	PF00069	0.467
MOD_CK1_1	202	208	PF00069	0.601
MOD_CK1_1	225	231	PF00069	0.817
MOD_CK1_1	339	345	PF00069	0.826
MOD_CK1_1	351	357	PF00069	0.624
MOD_CK1_1	376	382	PF00069	0.834
MOD_CK1_1	431	437	PF00069	0.621
MOD_CK1_1	520	526	PF00069	0.714
MOD_CK1_1	697	703	PF00069	0.840
MOD_CK2_1	103	109	PF00069	0.467
MOD_CK2_1	155	161	PF00069	0.529
MOD_CK2_1	177	183	PF00069	0.736
MOD_CK2_1	24	30	PF00069	0.759
MOD_CK2_1	303	309	PF00069	0.779
MOD_CK2_1	353	359	PF00069	0.680
MOD_CK2_1	408	414	PF00069	0.669
MOD_CK2_1	443	449	PF00069	0.783
MOD_CK2_1	630	636	PF00069	0.792
MOD_CK2_1	724	730	PF00069	0.839
MOD_Cter_Amidation	523	526	PF01082	0.851
MOD_Cter_Amidation	584	587	PF01082	0.855
MOD_Cter_Amidation	603	606	PF01082	0.539
MOD_GlcNHglycan	12	15	PF01048	0.731
MOD_GlcNHglycan	188	191	PF01048	0.826
MOD_GlcNHglycan	192	195	PF01048	0.792
MOD_GlcNHglycan	204	207	PF01048	0.755
MOD_GlcNHglycan	224	227	PF01048	0.515
MOD_GlcNHglycan	244	247	PF01048	0.548
MOD_GlcNHglycan	269	272	PF01048	0.761
MOD_GlcNHglycan	291	295	PF01048	0.840
MOD_GlcNHglycan	350	353	PF01048	0.804
MOD_GlcNHglycan	355	358	PF01048	0.730
MOD_GlcNHglycan	387	390	PF01048	0.779
MOD_GlcNHglycan	439	442	PF01048	0.842
MOD_GlcNHglycan	445	448	PF01048	0.741
MOD_GlcNHglycan	522	525	PF01048	0.799
MOD_GlcNHglycan	568	571	PF01048	0.730
MOD_GlcNHglycan	602	605	PF01048	0.815
MOD_GlcNHglycan	619	622	PF01048	0.577
MOD_GlcNHglycan	629	635	PF01048	0.689
MOD_GlcNHglycan	657	660	PF01048	0.756
MOD_GlcNHglycan	84	87	PF01048	0.302
MOD_GSK3_1	186	193	PF00069	0.828
MOD_GSK3_1	225	232	PF00069	0.795
MOD_GSK3_1	339	346	PF00069	0.800
MOD_GSK3_1	427	434	PF00069	0.807
MOD_GSK3_1	472	479	PF00069	0.863
MOD_GSK3_1	499	506	PF00069	0.833
MOD_GSK3_1	508	515	PF00069	0.712
MOD_GSK3_1	520	527	PF00069	0.627
MOD_GSK3_1	581	588	PF00069	0.779
MOD_GSK3_1	596	603	PF00069	0.680
MOD_GSK3_1	6	13	PF00069	0.735
MOD_N-GLC_1	431	436	PF02516	0.850
MOD_NEK2_1	136	141	PF00069	0.411
MOD_NEK2_1	186	191	PF00069	0.826
MOD_NEK2_1	40	45	PF00069	0.389
MOD_NEK2_1	600	605	PF00069	0.752
MOD_NEK2_2	138	143	PF00069	0.529
MOD_NEK2_2	408	413	PF00069	0.627
MOD_NEK2_2	70	75	PF00069	0.378
MOD_PIKK_1	524	530	PF00454	0.782
MOD_PIKK_1	694	700	PF00454	0.630
MOD_PKA_1	428	434	PF00069	0.622
MOD_PKA_1	499	505	PF00069	0.849
MOD_PKA_1	95	101	PF00069	0.529
MOD_PKA_2	303	309	PF00069	0.717
MOD_PKA_2	427	433	PF00069	0.665
MOD_PKA_2	499	505	PF00069	0.849
MOD_PKA_2	585	591	PF00069	0.683
MOD_PKA_2	594	600	PF00069	0.578
MOD_PKA_2	617	623	PF00069	0.845
MOD_PKA_2	68	74	PF00069	0.529
MOD_PKA_2	95	101	PF00069	0.529
MOD_PKB_1	343	351	PF00069	0.790
MOD_PKB_1	382	390	PF00069	0.615
MOD_Plk_1	108	114	PF00069	0.529
MOD_Plk_1	431	437	PF00069	0.847
MOD_Plk_2-3	155	161	PF00069	0.529
MOD_Plk_2-3	549	555	PF00069	0.623
MOD_Plk_4	108	114	PF00069	0.529
MOD_Plk_4	138	144	PF00069	0.529
MOD_Plk_4	24	30	PF00069	0.759
MOD_Plk_4	376	382	PF00069	0.834
MOD_Plk_4	517	523	PF00069	0.625
MOD_Plk_4	54	60	PF00069	0.465
MOD_ProDKin_1	199	205	PF00069	0.642
MOD_ProDKin_1	220	226	PF00069	0.734
MOD_ProDKin_1	3	9	PF00069	0.831
MOD_ProDKin_1	328	334	PF00069	0.832
MOD_ProDKin_1	336	342	PF00069	0.725
MOD_ProDKin_1	610	616	PF00069	0.792
MOD_ProDKin_1	62	68	PF00069	0.526
MOD_ProDKin_1	738	744	PF00069	0.664
TRG_ENDOCYTIC_2	110	113	PF00928	0.529
TRG_ENDOCYTIC_2	143	146	PF00928	0.529
TRG_ER_diArg_1	276	278	PF00400	0.698
TRG_ER_diArg_1	317	319	PF00400	0.808
TRG_ER_diArg_1	404	406	PF00400	0.834
TRG_ER_diArg_1	433	436	PF00400	0.838
TRG_ER_diArg_1	663	665	PF00400	0.787
TRG_ER_diArg_1	74	77	PF00400	0.529
TRG_ER_diArg_1	94	97	PF00400	0.199
TRG_NES_CRM1_1	130	144	PF08389	0.529
TRG_NLS_Bipartite_1	605	619	PF00514	0.855
TRG_NLS_MonoCore_2	496	501	PF00514	0.854
TRG_NLS_MonoExtC_3	746	751	PF00514	0.853
TRG_NLS_MonoExtN_4	497	502	PF00514	0.849
TRG_NLS_MonoExtN_4	614	619	PF00514	0.852
TRG_NLS_MonoExtN_4	744	751	PF00514	0.836
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.781
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.764
TRG_Pf-PMV_PEXEL_1	533	537	PF00026	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDC7	Leishmania donovani	90%	100%
A4HGW7	Leishmania braziliensis	67%	100%
A4I3Z7	Leishmania infantum	90%	85%
E9B087	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%