Putative membrane-bound acid phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q7Z7_LEIMA

TriTrypDb:

LmjF.28.2650 , LMJLV39_280034900 , LMJSD75_280034400

Length:

548

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 60

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 31, no: 3
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	27

Expansion

Sequence features

Q4Q7Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Z7

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016311	dephosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0003993	acid phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	393	395	PF00675	0.549
CLV_PCSK_KEX2_1	393	395	PF00082	0.516
CLV_PCSK_SKI1_1	6	10	PF00082	0.682
DEG_Kelch_Keap1_1	337	342	PF01344	0.235
DOC_CKS1_1	31	36	PF01111	0.404
DOC_CYCLIN_RxL_1	3	12	PF00134	0.606
DOC_MAPK_MEF2A_6	14	22	PF00069	0.509
DOC_PP1_RVXF_1	392	399	PF00149	0.357
DOC_PP4_FxxP_1	162	165	PF00568	0.182
DOC_PP4_FxxP_1	74	77	PF00568	0.173
DOC_PP4_MxPP_1	322	325	PF00568	0.321
DOC_USP7_MATH_1	139	143	PF00917	0.242
DOC_USP7_MATH_1	176	180	PF00917	0.328
DOC_USP7_MATH_1	262	266	PF00917	0.308
DOC_USP7_MATH_1	32	36	PF00917	0.693
DOC_USP7_MATH_1	457	461	PF00917	0.348
DOC_USP7_MATH_1	519	523	PF00917	0.628
DOC_WW_Pin1_4	30	35	PF00397	0.581
DOC_WW_Pin1_4	67	72	PF00397	0.398
LIG_14-3-3_CanoR_1	125	134	PF00244	0.258
LIG_14-3-3_CanoR_1	292	296	PF00244	0.238
LIG_14-3-3_CanoR_1	93	101	PF00244	0.319
LIG_APCC_Cbox_2	187	193	PF00515	0.173
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BRCT_BRCA1_1	262	266	PF00533	0.378
LIG_EH1_1	2	10	PF00400	0.355
LIG_FHA_1	21	27	PF00498	0.528
LIG_FHA_1	211	217	PF00498	0.377
LIG_FHA_1	225	231	PF00498	0.312
LIG_FHA_1	292	298	PF00498	0.277
LIG_FHA_1	327	333	PF00498	0.308
LIG_FHA_1	365	371	PF00498	0.337
LIG_FHA_1	381	387	PF00498	0.364
LIG_FHA_1	412	418	PF00498	0.391
LIG_FHA_1	426	432	PF00498	0.289
LIG_FHA_1	500	506	PF00498	0.297
LIG_FHA_1	61	67	PF00498	0.382
LIG_FHA_2	112	118	PF00498	0.303
LIG_FHA_2	151	157	PF00498	0.309
LIG_FHA_2	311	317	PF00498	0.296
LIG_FHA_2	420	426	PF00498	0.422
LIG_FHA_2	97	103	PF00498	0.383
LIG_HP1_1	165	169	PF01393	0.182
LIG_LIR_Apic_2	161	165	PF02991	0.310
LIG_LIR_Gen_1	163	174	PF02991	0.293
LIG_LIR_Gen_1	192	201	PF02991	0.300
LIG_LIR_Nem_3	163	169	PF02991	0.267
LIG_LIR_Nem_3	192	196	PF02991	0.294
LIG_LIR_Nem_3	252	257	PF02991	0.292
LIG_LIR_Nem_3	390	395	PF02991	0.294
LIG_PCNA_PIPBox_1	83	92	PF02747	0.290
LIG_PCNA_yPIPBox_3	181	190	PF02747	0.246
LIG_PCNA_yPIPBox_3	328	336	PF02747	0.320
LIG_Pex14_1	166	170	PF04695	0.316
LIG_Pex14_1	204	208	PF04695	0.355
LIG_Pex14_2	162	166	PF04695	0.310
LIG_Pex14_2	360	364	PF04695	0.405
LIG_SH2_NCK_1	223	227	PF00017	0.206
LIG_SH2_NCK_1	447	451	PF00017	0.247
LIG_SH2_SRC	223	226	PF00017	0.299
LIG_SH2_SRC	260	263	PF00017	0.380
LIG_SH2_STAP1	326	330	PF00017	0.245
LIG_SH2_STAT5	170	173	PF00017	0.221
LIG_SH2_STAT5	189	192	PF00017	0.213
LIG_SH2_STAT5	208	211	PF00017	0.262
LIG_SH2_STAT5	395	398	PF00017	0.337
LIG_SH2_STAT5	453	456	PF00017	0.320
LIG_SH3_3	428	434	PF00018	0.422
LIG_SH3_3	98	104	PF00018	0.279
LIG_SH3_5	107	111	PF00018	0.217
LIG_SUMO_SIM_anti_2	514	519	PF11976	0.394
LIG_SUMO_SIM_par_1	18	23	PF11976	0.501
LIG_SUMO_SIM_par_1	218	224	PF11976	0.294
LIG_SUMO_SIM_par_1	328	333	PF11976	0.315
LIG_SUMO_SIM_par_1	516	522	PF11976	0.523
LIG_SxIP_EBH_1	51	64	PF03271	0.303
LIG_TRAF2_1	422	425	PF00917	0.261
LIG_WRC_WIRS_1	159	164	PF05994	0.318
LIG_WRC_WIRS_1	500	505	PF05994	0.320
LIG_WRC_WIRS_1	86	91	PF05994	0.310
MOD_CDK_SPxK_1	30	36	PF00069	0.403
MOD_CK1_1	118	124	PF00069	0.311
MOD_CK1_1	154	160	PF00069	0.345
MOD_CK1_1	210	216	PF00069	0.284
MOD_CK1_1	337	343	PF00069	0.322
MOD_CK1_1	35	41	PF00069	0.427
MOD_CK1_1	375	381	PF00069	0.377
MOD_CK1_1	474	480	PF00069	0.470
MOD_CK1_1	488	494	PF00069	0.462
MOD_CK1_1	499	505	PF00069	0.415
MOD_CK2_1	111	117	PF00069	0.291
MOD_CK2_1	336	342	PF00069	0.243
MOD_CK2_1	419	425	PF00069	0.410
MOD_GlcNHglycan	128	131	PF01048	0.451
MOD_GlcNHglycan	178	181	PF01048	0.583
MOD_GlcNHglycan	300	303	PF01048	0.499
MOD_GlcNHglycan	336	339	PF01048	0.516
MOD_GlcNHglycan	411	417	PF01048	0.552
MOD_GlcNHglycan	441	444	PF01048	0.524
MOD_GlcNHglycan	455	458	PF01048	0.516
MOD_GlcNHglycan	465	468	PF01048	0.523
MOD_GlcNHglycan	487	490	PF01048	0.641
MOD_GlcNHglycan	55	58	PF01048	0.528
MOD_GSK3_1	111	118	PF00069	0.223
MOD_GSK3_1	147	154	PF00069	0.252
MOD_GSK3_1	207	214	PF00069	0.303
MOD_GSK3_1	260	267	PF00069	0.303
MOD_GSK3_1	360	367	PF00069	0.376
MOD_GSK3_1	453	460	PF00069	0.402
MOD_GSK3_1	481	488	PF00069	0.494
MOD_GSK3_1	53	60	PF00069	0.362
MOD_GSK3_1	85	92	PF00069	0.343
MOD_N-GLC_1	111	116	PF02516	0.459
MOD_N-GLC_1	139	144	PF02516	0.464
MOD_N-GLC_1	210	215	PF02516	0.510
MOD_N-GLC_1	375	380	PF02516	0.532
MOD_N-GLC_1	481	486	PF02516	0.575
MOD_N-GLC_1	61	66	PF02516	0.545
MOD_N-GLC_2	385	387	PF02516	0.489
MOD_NEK2_1	158	163	PF00069	0.309
MOD_NEK2_1	169	174	PF00069	0.324
MOD_NEK2_1	298	303	PF00069	0.292
MOD_NEK2_1	334	339	PF00069	0.329
MOD_NEK2_1	439	444	PF00069	0.366
MOD_NEK2_1	89	94	PF00069	0.296
MOD_OFUCOSY	462	469	PF10250	0.637
MOD_OGLYCOS	67	72	PF02709	0.471
MOD_PIKK_1	151	157	PF00454	0.359
MOD_PIKK_1	160	166	PF00454	0.359
MOD_PIKK_1	457	463	PF00454	0.426
MOD_PK_1	534	540	PF00069	0.565
MOD_PKA_2	291	297	PF00069	0.267
MOD_PKA_2	35	41	PF00069	0.350
MOD_PKB_1	91	99	PF00069	0.349
MOD_Plk_1	111	117	PF00069	0.253
MOD_Plk_1	139	145	PF00069	0.309
MOD_Plk_1	303	309	PF00069	0.275
MOD_Plk_1	412	418	PF00069	0.383
MOD_Plk_1	425	431	PF00069	0.369
MOD_Plk_1	481	487	PF00069	0.363
MOD_Plk_1	534	540	PF00069	0.703
MOD_Plk_1	61	67	PF00069	0.328
MOD_Plk_1	96	102	PF00069	0.281
MOD_Plk_4	111	117	PF00069	0.298
MOD_Plk_4	154	160	PF00069	0.277
MOD_Plk_4	326	332	PF00069	0.296
MOD_Plk_4	511	517	PF00069	0.296
MOD_Plk_4	534	540	PF00069	0.713
MOD_Plk_4	85	91	PF00069	0.263
MOD_Plk_4	96	102	PF00069	0.291
MOD_ProDKin_1	30	36	PF00069	0.579
MOD_ProDKin_1	67	73	PF00069	0.391
TRG_DiLeu_BaEn_1	413	418	PF01217	0.342
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.182
TRG_ENDOCYTIC_2	243	246	PF00928	0.386
TRG_ENDOCYTIC_2	254	257	PF00928	0.299
TRG_ENDOCYTIC_2	295	298	PF00928	0.380
TRG_ER_diArg_1	392	394	PF00400	0.347
TRG_ER_diArg_1	543	546	PF00400	0.731
TRG_ER_diArg_1	90	93	PF00400	0.293
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	46%	96%
A0A0N1I756	Leptomonas seymouri	38%	100%
A0A0N1PEH4	Leptomonas seymouri	31%	100%
A0A0S4IRF5	Bodo saltans	24%	82%
A0A0S4IUV8	Bodo saltans	23%	100%
A0A0S4IV77	Bodo saltans	33%	100%
A0A0S4IXN9	Bodo saltans	22%	100%
A0A0S4JEA9	Bodo saltans	25%	100%
A0A0S4JJK3	Bodo saltans	28%	100%
A0A0S4JW09	Bodo saltans	26%	100%
A0A1X0NNY4	Trypanosomatidae	36%	99%
A0A1X0NQL4	Trypanosomatidae	28%	100%
A0A1X0NY34	Trypanosomatidae	25%	100%
A0A1X0P3J2	Trypanosomatidae	23%	100%
A0A1X0P7V5	Trypanosomatidae	38%	100%
A0A3Q8IR23	Leishmania donovani	47%	96%
A0A3R7KGH3	Trypanosoma rangeli	24%	100%
A0A3R7KSH4	Trypanosoma rangeli	24%	100%
A0A3R7MEN7	Trypanosoma rangeli	38%	100%
A0A3R7MHJ7	Trypanosoma rangeli	28%	100%
A0A3S5H827	Leishmania donovani	34%	100%
A0A3S7WXU0	Leishmania donovani	44%	100%
A0A3S7X1W4	Leishmania donovani	94%	100%
A4HCZ0	Leishmania braziliensis	42%	89%
A4HGW8	Leishmania braziliensis	72%	100%
A4HPC1	Leishmania braziliensis	35%	100%
A4HPC5	Leishmania braziliensis	45%	95%
A4HQG6	Leishmania braziliensis	34%	100%
A4HQG9	Leishmania braziliensis	34%	100%
A4I0H5	Leishmania infantum	44%	100%
A4I3Z8	Leishmania infantum	94%	100%
A4ICA5	Leishmania infantum	34%	82%
A4ICG3	Leishmania infantum	34%	100%
A4ICG5	Leishmania infantum	47%	96%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	96%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q3KQG9	Xenopus laevis	28%	100%
Q4Q1G2	Leishmania major	45%	100%
Q4Q1G4	Leishmania major	33%	100%
Q4QB35	Leishmania major	44%	100%
V5BCI2	Trypanosoma cruzi	24%	100%
V5BIM1	Trypanosoma cruzi	22%	100%
V5BK91	Trypanosoma cruzi	38%	100%
V5BL75	Trypanosoma cruzi	27%	100%