Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7Z3_LEIMA

TriTrypDb:

LmjF.28.2690 , LMJLV39_280035300 , LMJSD75_280035000

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q7Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Z3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.333
CLV_C14_Caspase3-7	172	176	PF00656	0.352
CLV_NRD_NRD_1	3	5	PF00675	0.662
CLV_NRD_NRD_1	307	309	PF00675	0.408
CLV_NRD_NRD_1	323	325	PF00675	0.434
CLV_NRD_NRD_1	335	337	PF00675	0.404
CLV_PCSK_KEX2_1	3	5	PF00082	0.691
CLV_PCSK_KEX2_1	323	325	PF00082	0.492
CLV_PCSK_KEX2_1	334	336	PF00082	0.405
CLV_PCSK_SKI1_1	189	193	PF00082	0.538
CLV_PCSK_SKI1_1	349	353	PF00082	0.441
CLV_PCSK_SKI1_1	354	358	PF00082	0.467
CLV_PCSK_SKI1_1	6	10	PF00082	0.619
DEG_APCC_DBOX_1	323	331	PF00400	0.690
DEG_SPOP_SBC_1	117	121	PF00917	0.439
DEG_SPOP_SBC_1	229	233	PF00917	0.442
DOC_CYCLIN_RxL_1	3	11	PF00134	0.463
DOC_MAPK_DCC_7	271	279	PF00069	0.358
DOC_MAPK_gen_1	271	279	PF00069	0.358
DOC_MAPK_MEF2A_6	273	281	PF00069	0.405
DOC_PP4_FxxP_1	356	359	PF00568	0.714
DOC_USP7_MATH_1	117	121	PF00917	0.390
DOC_USP7_MATH_1	229	233	PF00917	0.443
DOC_USP7_MATH_1	243	247	PF00917	0.415
DOC_USP7_MATH_1	293	297	PF00917	0.306
DOC_USP7_MATH_1	350	354	PF00917	0.632
DOC_USP7_MATH_1	88	92	PF00917	0.459
DOC_WW_Pin1_4	110	115	PF00397	0.389
DOC_WW_Pin1_4	289	294	PF00397	0.385
DOC_WW_Pin1_4	84	89	PF00397	0.383
LIG_14-3-3_CanoR_1	106	116	PF00244	0.539
LIG_14-3-3_CanoR_1	170	180	PF00244	0.264
LIG_14-3-3_CanoR_1	308	317	PF00244	0.534
LIG_14-3-3_CanoR_1	324	332	PF00244	0.706
LIG_14-3-3_CanoR_1	335	341	PF00244	0.706
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_BRCT_BRCA1_1	295	299	PF00533	0.306
LIG_BRCT_BRCA1_1	352	356	PF00533	0.631
LIG_BRCT_BRCA1_1	64	68	PF00533	0.416
LIG_deltaCOP1_diTrp_1	101	108	PF00928	0.420
LIG_deltaCOP1_diTrp_1	46	52	PF00928	0.351
LIG_FHA_1	185	191	PF00498	0.329
LIG_FHA_1	204	210	PF00498	0.251
LIG_FHA_1	233	239	PF00498	0.399
LIG_FHA_2	170	176	PF00498	0.421
LIG_FHA_2	194	200	PF00498	0.388
LIG_IRF3_LxIS_1	76	82	PF10401	0.251
LIG_LIR_Apic_2	353	359	PF02991	0.712
LIG_LIR_Gen_1	287	295	PF02991	0.281
LIG_LIR_Gen_1	296	307	PF02991	0.283
LIG_LIR_Gen_1	66	77	PF02991	0.355
LIG_LIR_Nem_3	128	134	PF02991	0.362
LIG_LIR_Nem_3	178	184	PF02991	0.392
LIG_LIR_Nem_3	287	291	PF02991	0.281
LIG_LIR_Nem_3	296	302	PF02991	0.283
LIG_LIR_Nem_3	66	72	PF02991	0.347
LIG_Pex14_1	131	135	PF04695	0.317
LIG_Pex14_1	64	68	PF04695	0.335
LIG_SH2_CRK	10	14	PF00017	0.331
LIG_SH2_CRK	181	185	PF00017	0.352
LIG_SH2_SRC	263	266	PF00017	0.373
LIG_SH2_STAP1	10	14	PF00017	0.510
LIG_SH2_STAT5	10	13	PF00017	0.420
LIG_SH2_STAT5	181	184	PF00017	0.338
LIG_SH2_STAT5	205	208	PF00017	0.450
LIG_SH2_STAT5	263	266	PF00017	0.453
LIG_SH2_STAT5	345	348	PF00017	0.606
LIG_SH3_1	344	350	PF00018	0.599
LIG_SH3_2	347	352	PF14604	0.660
LIG_SH3_3	154	160	PF00018	0.418
LIG_SH3_3	344	350	PF00018	0.610
LIG_SH3_3	356	362	PF00018	0.637
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.445
LIG_SUMO_SIM_par_1	77	82	PF11976	0.373
LIG_TYR_ITIM	179	184	PF00017	0.297
LIG_TYR_ITIM	8	13	PF00017	0.343
LIG_UBA3_1	190	195	PF00899	0.309
LIG_UBA3_1	280	286	PF00899	0.444
LIG_UBA3_1	303	309	PF00899	0.469
LIG_WW_1	367	370	PF00397	0.630
MOD_CK1_1	119	125	PF00069	0.489
MOD_CK1_1	169	175	PF00069	0.439
MOD_CK1_1	230	236	PF00069	0.492
MOD_CK1_1	82	88	PF00069	0.454
MOD_CK1_1	95	101	PF00069	0.517
MOD_CK2_1	95	101	PF00069	0.416
MOD_GlcNHglycan	121	124	PF01048	0.710
MOD_GlcNHglycan	215	219	PF01048	0.538
MOD_GlcNHglycan	232	235	PF01048	0.655
MOD_GlcNHglycan	33	36	PF01048	0.541
MOD_GSK3_1	102	109	PF00069	0.585
MOD_GSK3_1	112	119	PF00069	0.529
MOD_GSK3_1	162	169	PF00069	0.372
MOD_GSK3_1	171	178	PF00069	0.343
MOD_GSK3_1	189	196	PF00069	0.274
MOD_GSK3_1	197	204	PF00069	0.405
MOD_GSK3_1	228	235	PF00069	0.440
MOD_GSK3_1	280	287	PF00069	0.378
MOD_GSK3_1	289	296	PF00069	0.285
MOD_GSK3_1	336	343	PF00069	0.678
MOD_GSK3_1	350	357	PF00069	0.579
MOD_GSK3_1	8	15	PF00069	0.554
MOD_GSK3_1	84	91	PF00069	0.394
MOD_N-GLC_1	153	158	PF02516	0.537
MOD_N-GLC_1	175	180	PF02516	0.519
MOD_N-GLC_1	193	198	PF02516	0.503
MOD_N-GLC_1	243	248	PF02516	0.587
MOD_N-GLC_1	293	298	PF02516	0.306
MOD_N-GLC_1	310	315	PF02516	0.478
MOD_N-GLC_1	325	330	PF02516	0.486
MOD_NEK2_1	116	121	PF00069	0.456
MOD_NEK2_1	134	139	PF00069	0.340
MOD_NEK2_1	162	167	PF00069	0.454
MOD_NEK2_1	179	184	PF00069	0.254
MOD_NEK2_1	280	285	PF00069	0.428
MOD_NEK2_1	31	36	PF00069	0.459
MOD_NEK2_1	317	322	PF00069	0.604
MOD_NEK2_1	340	345	PF00069	0.634
MOD_NEK2_1	79	84	PF00069	0.341
MOD_NEK2_1	8	13	PF00069	0.533
MOD_PIKK_1	107	113	PF00454	0.449
MOD_PIKK_1	162	168	PF00454	0.376
MOD_PKA_2	169	175	PF00069	0.273
MOD_PKA_2	82	88	PF00069	0.470
MOD_PKB_1	334	342	PF00069	0.696
MOD_Plk_1	153	159	PF00069	0.376
MOD_Plk_1	293	299	PF00069	0.355
MOD_Plk_1	325	331	PF00069	0.655
MOD_Plk_4	153	159	PF00069	0.394
MOD_Plk_4	175	181	PF00069	0.394
MOD_Plk_4	293	299	PF00069	0.374
MOD_Plk_4	336	342	PF00069	0.696
MOD_Plk_4	8	14	PF00069	0.437
MOD_ProDKin_1	110	116	PF00069	0.389
MOD_ProDKin_1	289	295	PF00069	0.385
MOD_ProDKin_1	84	90	PF00069	0.390
TRG_ENDOCYTIC_2	10	13	PF00928	0.440
TRG_ENDOCYTIC_2	181	184	PF00928	0.319
TRG_ENDOCYTIC_2	345	348	PF00928	0.695
TRG_ER_diArg_1	3	6	PF00400	0.621
TRG_ER_diArg_1	322	324	PF00400	0.694
TRG_ER_diArg_1	334	336	PF00400	0.661
TRG_ER_diArg_1	362	365	PF00400	0.732

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M3	Leptomonas seymouri	47%	98%
A0A1X0NQJ6	Trypanosomatidae	36%	100%
A0A3S7X1V5	Leishmania donovani	87%	99%
A0A422MSP0	Trypanosoma rangeli	38%	100%
A4HGX2	Leishmania braziliensis	66%	94%
A4I402	Leishmania infantum	88%	99%
D0A972	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B092	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
V5AWR0	Trypanosoma cruzi	35%	100%