Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q7Z2_LEIMA

TriTrypDb:

LmjF.28.2700 , LMJLV39_280035400 , LMJSD75_280035100

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Z2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.642
CLV_C14_Caspase3-7	429	433	PF00656	0.627
CLV_NRD_NRD_1	144	146	PF00675	0.653
CLV_NRD_NRD_1	193	195	PF00675	0.700
CLV_NRD_NRD_1	233	235	PF00675	0.724
CLV_NRD_NRD_1	262	264	PF00675	0.693
CLV_NRD_NRD_1	295	297	PF00675	0.682
CLV_NRD_NRD_1	423	425	PF00675	0.654
CLV_NRD_NRD_1	459	461	PF00675	0.611
CLV_PCSK_KEX2_1	144	146	PF00082	0.653
CLV_PCSK_KEX2_1	192	194	PF00082	0.701
CLV_PCSK_KEX2_1	233	235	PF00082	0.701
CLV_PCSK_KEX2_1	262	264	PF00082	0.698
CLV_PCSK_KEX2_1	423	425	PF00082	0.654
CLV_PCSK_KEX2_1	459	461	PF00082	0.611
CLV_PCSK_PC7_1	455	461	PF00082	0.613
CLV_PCSK_SKI1_1	174	178	PF00082	0.674
DEG_APCC_DBOX_1	14	22	PF00400	0.590
DEG_APCC_DBOX_1	192	200	PF00400	0.701
DEG_APCC_DBOX_1	423	431	PF00400	0.632
DEG_SCF_FBW7_2	163	169	PF00400	0.670
DEG_SPOP_SBC_1	205	209	PF00917	0.662
DEG_SPOP_SBC_1	298	302	PF00917	0.652
DEG_SPOP_SBC_1	370	374	PF00917	0.693
DOC_ANK_TNKS_1	289	296	PF00023	0.697
DOC_CKS1_1	163	168	PF01111	0.670
DOC_CKS1_1	175	180	PF01111	0.581
DOC_PP2B_LxvP_1	225	228	PF13499	0.651
DOC_PP2B_LxvP_1	402	405	PF13499	0.650
DOC_PP4_FxxP_1	380	383	PF00568	0.672
DOC_USP7_MATH_1	154	158	PF00917	0.649
DOC_USP7_MATH_1	205	209	PF00917	0.669
DOC_USP7_MATH_1	258	262	PF00917	0.618
DOC_USP7_MATH_1	298	302	PF00917	0.687
DOC_USP7_MATH_1	304	308	PF00917	0.632
DOC_USP7_MATH_1	370	374	PF00917	0.652
DOC_USP7_MATH_1	403	407	PF00917	0.553
DOC_USP7_MATH_1	68	72	PF00917	0.728
DOC_USP7_MATH_2	254	260	PF00917	0.593
DOC_USP7_UBL2_3	121	125	PF12436	0.638
DOC_WW_Pin1_4	114	119	PF00397	0.587
DOC_WW_Pin1_4	125	130	PF00397	0.567
DOC_WW_Pin1_4	162	167	PF00397	0.702
DOC_WW_Pin1_4	174	179	PF00397	0.589
DOC_WW_Pin1_4	250	255	PF00397	0.608
DOC_WW_Pin1_4	274	279	PF00397	0.687
DOC_WW_Pin1_4	418	423	PF00397	0.652
LIG_14-3-3_CanoR_1	144	149	PF00244	0.636
LIG_14-3-3_CanoR_1	156	164	PF00244	0.584
LIG_14-3-3_CanoR_1	192	197	PF00244	0.700
LIG_14-3-3_CanoR_1	206	212	PF00244	0.583
LIG_14-3-3_CanoR_1	262	270	PF00244	0.678
LIG_14-3-3_CanoR_1	296	304	PF00244	0.657
LIG_14-3-3_CanoR_1	455	463	PF00244	0.632
LIG_14-3-3_CanoR_1	84	88	PF00244	0.546
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_deltaCOP1_diTrp_1	413	416	PF00928	0.645
LIG_FHA_1	275	281	PF00498	0.671
LIG_FHA_1	98	104	PF00498	0.502
LIG_FHA_2	251	257	PF00498	0.677
LIG_GBD_Chelix_1	95	103	PF00786	0.535
LIG_LIR_Apic_2	378	383	PF02991	0.669
LIG_PAM2_1	137	149	PF00658	0.534
LIG_SH2_CRK	440	444	PF00017	0.521
LIG_SH2_STAP1	440	444	PF00017	0.521
LIG_SH2_STAT3	439	442	PF00017	0.608
LIG_SH2_STAT5	164	167	PF00017	0.672
LIG_SH2_STAT5	50	53	PF00017	0.563
LIG_SH2_STAT5	55	58	PF00017	0.511
LIG_SH2_STAT5	78	81	PF00017	0.572
LIG_SH3_3	160	166	PF00018	0.691
LIG_SH3_3	172	178	PF00018	0.623
LIG_SH3_3	213	219	PF00018	0.656
LIG_SH3_3	362	368	PF00018	0.595
LIG_SH3_3	380	386	PF00018	0.600
LIG_SH3_3	444	450	PF00018	0.594
LIG_SUMO_SIM_par_1	99	106	PF11976	0.553
LIG_TRAF2_1	11	14	PF00917	0.594
LIG_WW_3	237	241	PF00397	0.580
MOD_CDC14_SPxK_1	421	424	PF00782	0.637
MOD_CDK_SPK_2	162	167	PF00069	0.702
MOD_CDK_SPK_2	250	255	PF00069	0.608
MOD_CDK_SPK_2	418	423	PF00069	0.652
MOD_CDK_SPxK_1	418	424	PF00069	0.652
MOD_CDK_SPxxK_3	114	121	PF00069	0.598
MOD_CDK_SPxxK_3	250	257	PF00069	0.590
MOD_CK1_1	117	123	PF00069	0.579
MOD_CK1_1	147	153	PF00069	0.567
MOD_CK1_1	195	201	PF00069	0.660
MOD_CK1_1	204	210	PF00069	0.600
MOD_CK1_1	261	267	PF00069	0.687
MOD_CK1_1	281	287	PF00069	0.581
MOD_CK1_1	299	305	PF00069	0.544
MOD_CK1_1	307	313	PF00069	0.653
MOD_CK1_1	326	332	PF00069	0.575
MOD_CK1_1	357	363	PF00069	0.709
MOD_CK1_1	369	375	PF00069	0.585
MOD_CK2_1	250	256	PF00069	0.613
MOD_CK2_1	372	378	PF00069	0.655
MOD_CK2_1	68	74	PF00069	0.602
MOD_CMANNOS	411	414	PF00535	0.685
MOD_Cter_Amidation	294	297	PF01082	0.677
MOD_DYRK1A_RPxSP_1	174	178	PF00069	0.650
MOD_GlcNHglycan	1	4	PF01048	0.629
MOD_GlcNHglycan	139	142	PF01048	0.588
MOD_GlcNHglycan	149	152	PF01048	0.574
MOD_GlcNHglycan	188	191	PF01048	0.707
MOD_GlcNHglycan	203	206	PF01048	0.569
MOD_GlcNHglycan	313	316	PF01048	0.673
MOD_GlcNHglycan	323	326	PF01048	0.614
MOD_GlcNHglycan	343	346	PF01048	0.554
MOD_GlcNHglycan	356	359	PF01048	0.681
MOD_GlcNHglycan	368	371	PF01048	0.579
MOD_GlcNHglycan	374	377	PF01048	0.532
MOD_GlcNHglycan	70	73	PF01048	0.735
MOD_GSK3_1	188	195	PF00069	0.685
MOD_GSK3_1	201	208	PF00069	0.585
MOD_GSK3_1	257	264	PF00069	0.689
MOD_GSK3_1	274	281	PF00069	0.552
MOD_GSK3_1	298	305	PF00069	0.702
MOD_GSK3_1	307	314	PF00069	0.628
MOD_GSK3_1	317	324	PF00069	0.568
MOD_GSK3_1	366	373	PF00069	0.673
MOD_GSK3_1	70	77	PF00069	0.619
MOD_GSK3_1	79	86	PF00069	0.544
MOD_N-GLC_1	326	331	PF02516	0.666
MOD_NEK2_1	103	108	PF00069	0.564
MOD_NEK2_1	188	193	PF00069	0.663
MOD_NEK2_1	4	9	PF00069	0.709
MOD_NEK2_1	79	84	PF00069	0.571
MOD_NEK2_2	304	309	PF00069	0.649
MOD_PIKK_1	228	234	PF00454	0.677
MOD_PIKK_1	278	284	PF00454	0.694
MOD_PIKK_1	336	342	PF00454	0.649
MOD_PK_1	58	64	PF00069	0.609
MOD_PKA_1	144	150	PF00069	0.636
MOD_PKA_1	192	198	PF00069	0.659
MOD_PKA_1	262	268	PF00069	0.686
MOD_PKA_1	296	302	PF00069	0.677
MOD_PKA_2	144	150	PF00069	0.636
MOD_PKA_2	155	161	PF00069	0.581
MOD_PKA_2	192	198	PF00069	0.703
MOD_PKA_2	205	211	PF00069	0.588
MOD_PKA_2	256	262	PF00069	0.679
MOD_PKA_2	366	372	PF00069	0.674
MOD_PKA_2	454	460	PF00069	0.635
MOD_PKA_2	79	85	PF00069	0.544
MOD_PKB_1	255	263	PF00069	0.685
MOD_PKB_1	309	317	PF00069	0.715
MOD_Plk_4	74	80	PF00069	0.599
MOD_Plk_4	97	103	PF00069	0.561
MOD_ProDKin_1	114	120	PF00069	0.588
MOD_ProDKin_1	125	131	PF00069	0.566
MOD_ProDKin_1	162	168	PF00069	0.701
MOD_ProDKin_1	174	180	PF00069	0.584
MOD_ProDKin_1	250	256	PF00069	0.607
MOD_ProDKin_1	274	280	PF00069	0.688
MOD_ProDKin_1	418	424	PF00069	0.652
TRG_ENDOCYTIC_2	243	246	PF00928	0.857
TRG_ENDOCYTIC_2	440	443	PF00928	0.523
TRG_ER_diArg_1	144	146	PF00400	0.655
TRG_ER_diArg_1	15	18	PF00400	0.593
TRG_ER_diArg_1	192	194	PF00400	0.660
TRG_ER_diArg_1	308	311	PF00400	0.725
TRG_ER_diArg_1	422	424	PF00400	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IID2	Leishmania donovani	92%	100%
A4HGX3	Leishmania braziliensis	58%	100%
A4I403	Leishmania infantum	92%	100%
E9B093	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%