2OG-FeII_Oxy_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7Z1_LEIMA

TriTrypDb:

LmjF.28.2710 , LMJLV39_280035500 , LMJSD75_280035200

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q7Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Z1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0006996	organelle organization	4	11
GO:0007005	mitochondrion organization	5	11
GO:0007006	mitochondrial membrane organization	5	11
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0033554	cellular response to stress	3	11
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0046902	regulation of mitochondrial membrane permeability	4	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0061024	membrane organization	4	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090559	regulation of membrane permeability	3	11
GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	5	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.599
CLV_C14_Caspase3-7	81	85	PF00656	0.553
CLV_NRD_NRD_1	237	239	PF00675	0.539
CLV_NRD_NRD_1	260	262	PF00675	0.495
CLV_NRD_NRD_1	280	282	PF00675	0.275
CLV_NRD_NRD_1	6	8	PF00675	0.645
CLV_PCSK_KEX2_1	237	239	PF00082	0.539
CLV_PCSK_KEX2_1	260	262	PF00082	0.465
CLV_PCSK_KEX2_1	280	282	PF00082	0.275
CLV_PCSK_KEX2_1	6	8	PF00082	0.620
CLV_PCSK_PC7_1	2	8	PF00082	0.667
CLV_PCSK_SKI1_1	188	192	PF00082	0.385
CLV_PCSK_SKI1_1	2	6	PF00082	0.671
CLV_PCSK_SKI1_1	67	71	PF00082	0.426
DEG_Nend_UBRbox_1	1	4	PF02207	0.660
DOC_CYCLIN_RxL_1	2	13	PF00134	0.658
DOC_CYCLIN_yClb5_NLxxxL_5	118	127	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.343
DOC_MAPK_gen_1	237	245	PF00069	0.558
DOC_MAPK_gen_1	260	269	PF00069	0.393
DOC_MAPK_HePTP_8	267	279	PF00069	0.336
DOC_MAPK_MEF2A_6	270	279	PF00069	0.344
DOC_PP1_RVXF_1	151	157	PF00149	0.372
DOC_PP2B_LxvP_1	116	119	PF13499	0.570
DOC_PP4_FxxP_1	31	34	PF00568	0.427
DOC_PP4_FxxP_1	72	75	PF00568	0.435
DOC_USP7_MATH_1	128	132	PF00917	0.436
DOC_WW_Pin1_4	245	250	PF00397	0.442
DOC_WW_Pin1_4	254	259	PF00397	0.454
DOC_WW_Pin1_4	270	275	PF00397	0.258
DOC_WW_Pin1_4	44	49	PF00397	0.494
LIG_14-3-3_CanoR_1	173	179	PF00244	0.417
LIG_14-3-3_CanoR_1	188	193	PF00244	0.375
LIG_14-3-3_CanoR_1	238	244	PF00244	0.551
LIG_14-3-3_CanoR_1	260	268	PF00244	0.432
LIG_14-3-3_CanoR_1	79	83	PF00244	0.547
LIG_deltaCOP1_diTrp_1	221	228	PF00928	0.378
LIG_FHA_1	11	17	PF00498	0.585
LIG_FHA_1	174	180	PF00498	0.488
LIG_FHA_1	263	269	PF00498	0.378
LIG_FHA_1	274	280	PF00498	0.418
LIG_FHA_1	51	57	PF00498	0.488
LIG_FHA_2	108	114	PF00498	0.564
LIG_FHA_2	60	66	PF00498	0.474
LIG_LIR_Apic_2	30	34	PF02991	0.456
LIG_LIR_Apic_2	53	58	PF02991	0.465
LIG_LIR_Apic_2	71	75	PF02991	0.512
LIG_LIR_Gen_1	100	108	PF02991	0.519
LIG_LIR_Gen_1	74	82	PF02991	0.393
LIG_LIR_Nem_3	74	80	PF02991	0.412
LIG_LIR_Nem_3	96	101	PF02991	0.387
LIG_PALB2_WD40_1	72	80	PF16756	0.404
LIG_PCNA_PIPBox_1	87	96	PF02747	0.448
LIG_Pex14_1	51	55	PF04695	0.480
LIG_Pex14_2	72	76	PF04695	0.432
LIG_SH2_CRK	101	105	PF00017	0.460
LIG_SH2_NCK_1	101	105	PF00017	0.466
LIG_SH2_PTP2	212	215	PF00017	0.453
LIG_SH2_PTP2	55	58	PF00017	0.476
LIG_SH2_STAT5	144	147	PF00017	0.418
LIG_SH2_STAT5	212	215	PF00017	0.358
LIG_SH2_STAT5	55	58	PF00017	0.476
LIG_SH3_3	122	128	PF00018	0.557
LIG_SH3_3	13	19	PF00018	0.647
LIG_SH3_3	143	149	PF00018	0.444
LIG_SH3_3	192	198	PF00018	0.475
LIG_SH3_3	29	35	PF00018	0.476
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.445
LIG_TRAF2_1	35	38	PF00917	0.563
LIG_TRAF2_1	62	65	PF00917	0.474
MOD_CDK_SPxK_1	245	251	PF00069	0.574
MOD_CDK_SPxK_1	254	260	PF00069	0.437
MOD_CDK_SPxxK_3	254	261	PF00069	0.581
MOD_CK1_1	172	178	PF00069	0.421
MOD_CK1_1	21	27	PF00069	0.458
MOD_CK1_1	262	268	PF00069	0.429
MOD_CK1_1	273	279	PF00069	0.469
MOD_CK2_1	59	65	PF00069	0.452
MOD_GlcNHglycan	161	164	PF01048	0.418
MOD_GSK3_1	169	176	PF00069	0.415
MOD_N-GLC_1	173	178	PF02516	0.386
MOD_NEK2_1	140	145	PF00069	0.441
MOD_NEK2_1	159	164	PF00069	0.441
MOD_NEK2_1	190	195	PF00069	0.398
MOD_NEK2_1	97	102	PF00069	0.408
MOD_PIKK_1	102	108	PF00454	0.439
MOD_PKA_2	172	178	PF00069	0.445
MOD_PKA_2	259	265	PF00069	0.468
MOD_PKA_2	78	84	PF00069	0.552
MOD_Plk_1	262	268	PF00069	0.436
MOD_Plk_1	65	71	PF00069	0.530
MOD_Plk_2-3	59	65	PF00069	0.554
MOD_Plk_2-3	78	84	PF00069	0.539
MOD_Plk_4	140	146	PF00069	0.452
MOD_Plk_4	18	24	PF00069	0.498
MOD_Plk_4	27	33	PF00069	0.492
MOD_Plk_4	273	279	PF00069	0.507
MOD_Plk_4	65	71	PF00069	0.525
MOD_ProDKin_1	245	251	PF00069	0.449
MOD_ProDKin_1	254	260	PF00069	0.455
MOD_ProDKin_1	270	276	PF00069	0.262
MOD_ProDKin_1	44	50	PF00069	0.490
MOD_SUMO_rev_2	59	69	PF00179	0.514
TRG_DiLeu_BaEn_1	200	205	PF01217	0.418
TRG_DiLeu_BaEn_1	65	70	PF01217	0.391
TRG_DiLeu_BaEn_4	65	71	PF01217	0.417
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.684
TRG_ENDOCYTIC_2	101	104	PF00928	0.372
TRG_ENDOCYTIC_2	212	215	PF00928	0.358
TRG_ENDOCYTIC_2	94	97	PF00928	0.370
TRG_ER_diArg_1	217	220	PF00400	0.473
TRG_ER_diArg_1	236	238	PF00400	0.326
TRG_ER_diArg_1	259	261	PF00400	0.495
TRG_ER_diArg_1	279	281	PF00400	0.265
TRG_ER_diArg_1	282	285	PF00400	0.601
TRG_ER_diArg_1	5	7	PF00400	0.648
TRG_NES_CRM1_1	234	246	PF08389	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYL5	Leptomonas seymouri	76%	98%
A0A0S4JCJ0	Bodo saltans	47%	89%
A0A1X0NR19	Trypanosomatidae	60%	100%
A0A3Q8IE10	Leishmania donovani	96%	100%
A4HGX4	Leishmania braziliensis	84%	99%
A4I404	Leishmania infantum	95%	100%
D0A901	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B094	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B945	Trypanosoma cruzi	58%	100%