Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7Y9_LEIMA

TriTrypDb:

LmjF.28.2730 , LMJLV39_280035700 , LMJSD75_280035400

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Y9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008233	peptidase activity	3	1
GO:0008236	serine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0017171	serine hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.636
CLV_NRD_NRD_1	208	210	PF00675	0.422
CLV_NRD_NRD_1	458	460	PF00675	0.579
CLV_PCSK_FUR_1	436	440	PF00082	0.520
CLV_PCSK_KEX2_1	148	150	PF00082	0.634
CLV_PCSK_KEX2_1	208	210	PF00082	0.422
CLV_PCSK_KEX2_1	24	26	PF00082	0.710
CLV_PCSK_KEX2_1	438	440	PF00082	0.543
CLV_PCSK_KEX2_1	457	459	PF00082	0.485
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.747
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.655
CLV_PCSK_SKI1_1	101	105	PF00082	0.491
CLV_PCSK_SKI1_1	150	154	PF00082	0.617
CLV_PCSK_SKI1_1	178	182	PF00082	0.568
CLV_PCSK_SKI1_1	25	29	PF00082	0.717
CLV_PCSK_SKI1_1	61	65	PF00082	0.500
CLV_PCSK_SKI1_1	9	13	PF00082	0.687
CLV_PCSK_SKI1_1	93	97	PF00082	0.482
DEG_APCC_DBOX_1	122	130	PF00400	0.384
DEG_APCC_DBOX_1	3	11	PF00400	0.724
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DEG_SPOP_SBC_1	10	14	PF00917	0.724
DEG_SPOP_SBC_1	302	306	PF00917	0.669
DEG_SPOP_SBC_1	313	317	PF00917	0.554
DOC_MAPK_FxFP_2	230	233	PF00069	0.483
DOC_MAPK_gen_1	101	109	PF00069	0.584
DOC_MAPK_gen_1	182	190	PF00069	0.622
DOC_MAPK_gen_1	53	62	PF00069	0.543
DOC_MAPK_MEF2A_6	101	109	PF00069	0.537
DOC_MAPK_MEF2A_6	53	62	PF00069	0.518
DOC_PP1_RVXF_1	373	379	PF00149	0.421
DOC_PP1_RVXF_1	59	65	PF00149	0.537
DOC_PP2B_LxvP_1	80	83	PF13499	0.501
DOC_PP4_FxxP_1	230	233	PF00568	0.483
DOC_PP4_FxxP_1	260	263	PF00568	0.534
DOC_PP4_FxxP_1	332	335	PF00568	0.503
DOC_USP7_MATH_1	11	15	PF00917	0.708
DOC_USP7_MATH_1	184	188	PF00917	0.571
DOC_USP7_MATH_1	200	204	PF00917	0.424
DOC_USP7_MATH_1	281	285	PF00917	0.670
DOC_USP7_MATH_1	303	307	PF00917	0.717
DOC_USP7_MATH_1	308	312	PF00917	0.718
DOC_USP7_MATH_1	314	318	PF00917	0.703
DOC_USP7_MATH_1	370	374	PF00917	0.457
DOC_USP7_MATH_1	527	531	PF00917	0.787
DOC_USP7_MATH_1	582	586	PF00917	0.749
DOC_USP7_MATH_1	588	592	PF00917	0.758
DOC_USP7_UBL2_3	16	20	PF12436	0.776
DOC_WW_Pin1_4	158	163	PF00397	0.627
DOC_WW_Pin1_4	214	219	PF00397	0.547
DOC_WW_Pin1_4	283	288	PF00397	0.631
DOC_WW_Pin1_4	319	324	PF00397	0.657
DOC_WW_Pin1_4	33	38	PF00397	0.567
DOC_WW_Pin1_4	400	405	PF00397	0.404
DOC_WW_Pin1_4	442	447	PF00397	0.656
DOC_WW_Pin1_4	484	489	PF00397	0.656
DOC_WW_Pin1_4	498	503	PF00397	0.666
DOC_WW_Pin1_4	556	561	PF00397	0.710
LIG_14-3-3_CanoR_1	135	141	PF00244	0.507
LIG_14-3-3_CanoR_1	148	153	PF00244	0.626
LIG_14-3-3_CanoR_1	185	189	PF00244	0.563
LIG_14-3-3_CanoR_1	236	241	PF00244	0.588
LIG_14-3-3_CanoR_1	25	33	PF00244	0.593
LIG_14-3-3_CanoR_1	371	375	PF00244	0.440
LIG_14-3-3_CanoR_1	382	392	PF00244	0.435
LIG_14-3-3_CanoR_1	489	494	PF00244	0.722
LIG_14-3-3_CanoR_1	87	95	PF00244	0.589
LIG_14-3-3_CanoR_1	9	17	PF00244	0.674
LIG_BRCT_BRCA1_1	105	109	PF00533	0.350
LIG_BRCT_BRCA1_1	402	406	PF00533	0.400
LIG_BRCT_BRCA1_1	480	484	PF00533	0.576
LIG_deltaCOP1_diTrp_1	460	468	PF00928	0.558
LIG_DLG_GKlike_1	148	156	PF00625	0.609
LIG_DLG_GKlike_1	489	496	PF00625	0.751
LIG_EH_1	481	485	PF12763	0.478
LIG_EVH1_2	446	450	PF00568	0.684
LIG_FHA_1	17	23	PF00498	0.770
LIG_FHA_1	175	181	PF00498	0.616
LIG_FHA_1	192	198	PF00498	0.315
LIG_FHA_1	215	221	PF00498	0.467
LIG_FHA_1	229	235	PF00498	0.355
LIG_FHA_1	263	269	PF00498	0.480
LIG_FHA_1	348	354	PF00498	0.417
LIG_FHA_1	383	389	PF00498	0.433
LIG_FHA_1	551	557	PF00498	0.799
LIG_FHA_1	87	93	PF00498	0.562
LIG_FHA_2	16	22	PF00498	0.751
LIG_FHA_2	413	419	PF00498	0.635
LIG_FHA_2	566	572	PF00498	0.741
LIG_GBD_Chelix_1	39	47	PF00786	0.481
LIG_LIR_Apic_2	227	233	PF02991	0.448
LIG_LIR_Apic_2	330	335	PF02991	0.484
LIG_LIR_Gen_1	106	117	PF02991	0.590
LIG_LIR_Gen_1	252	263	PF02991	0.523
LIG_LIR_Gen_1	460	470	PF02991	0.414
LIG_LIR_Gen_1	473	478	PF02991	0.425
LIG_LIR_Gen_1	487	498	PF02991	0.619
LIG_LIR_Nem_3	106	112	PF02991	0.528
LIG_LIR_Nem_3	239	244	PF02991	0.558
LIG_LIR_Nem_3	252	258	PF02991	0.420
LIG_LIR_Nem_3	405	410	PF02991	0.463
LIG_LIR_Nem_3	42	47	PF02991	0.427
LIG_LIR_Nem_3	460	466	PF02991	0.416
LIG_LIR_Nem_3	473	477	PF02991	0.427
LIG_LIR_Nem_3	487	493	PF02991	0.596
LIG_PCNA_yPIPBox_3	61	74	PF02747	0.593
LIG_Pex14_2	241	245	PF04695	0.462
LIG_REV1ctd_RIR_1	150	156	PF16727	0.647
LIG_REV1ctd_RIR_1	404	412	PF16727	0.539
LIG_SH2_CRK	119	123	PF00017	0.572
LIG_SH2_CRK	44	48	PF00017	0.427
LIG_SH2_CRK	474	478	PF00017	0.495
LIG_SH2_GRB2like	119	122	PF00017	0.578
LIG_SH2_SRC	119	122	PF00017	0.578
LIG_SH2_STAP1	410	414	PF00017	0.677
LIG_SH2_STAP1	474	478	PF00017	0.534
LIG_SH2_STAP1	88	92	PF00017	0.548
LIG_SH2_STAT5	168	171	PF00017	0.619
LIG_SH2_STAT5	352	355	PF00017	0.419
LIG_SH2_STAT5	361	364	PF00017	0.449
LIG_SH2_STAT5	88	91	PF00017	0.465
LIG_SH3_1	154	160	PF00018	0.637
LIG_SH3_2	173	178	PF14604	0.681
LIG_SH3_3	154	160	PF00018	0.591
LIG_SH3_3	170	176	PF00018	0.631
LIG_SH3_3	446	452	PF00018	0.582
LIG_SH3_3	551	557	PF00018	0.799
LIG_SH3_3	59	65	PF00018	0.528
LIG_SH3_3	73	79	PF00018	0.619
LIG_SH3_4	16	23	PF00018	0.701
LIG_SH3_CIN85_PxpxPR_1	162	167	PF14604	0.719
MOD_CDK_SPK_2	484	489	PF00069	0.656
MOD_CK1_1	139	145	PF00069	0.587
MOD_CK1_1	191	197	PF00069	0.527
MOD_CK1_1	276	282	PF00069	0.691
MOD_CK1_1	292	298	PF00069	0.656
MOD_CK1_1	317	323	PF00069	0.662
MOD_CK1_1	413	419	PF00069	0.706
MOD_CK2_1	351	357	PF00069	0.431
MOD_CK2_1	383	389	PF00069	0.577
MOD_CK2_1	565	571	PF00069	0.743
MOD_CMANNOS	296	299	PF00535	0.557
MOD_DYRK1A_RPxSP_1	283	287	PF00069	0.637
MOD_GlcNHglycan	142	145	PF01048	0.522
MOD_GlcNHglycan	202	205	PF01048	0.632
MOD_GlcNHglycan	221	224	PF01048	0.484
MOD_GlcNHglycan	283	286	PF01048	0.682
MOD_GlcNHglycan	305	308	PF01048	0.762
MOD_GlcNHglycan	316	319	PF01048	0.683
MOD_GlcNHglycan	412	415	PF01048	0.558
MOD_GlcNHglycan	582	585	PF01048	0.746
MOD_GlcNHglycan	591	594	PF01048	0.802
MOD_GlcNHglycan	76	79	PF01048	0.634
MOD_GSK3_1	11	18	PF00069	0.693
MOD_GSK3_1	136	143	PF00069	0.518
MOD_GSK3_1	184	191	PF00069	0.633
MOD_GSK3_1	214	221	PF00069	0.500
MOD_GSK3_1	228	235	PF00069	0.312
MOD_GSK3_1	258	265	PF00069	0.523
MOD_GSK3_1	288	295	PF00069	0.697
MOD_GSK3_1	308	315	PF00069	0.531
MOD_GSK3_1	347	354	PF00069	0.435
MOD_GSK3_1	39	46	PF00069	0.569
MOD_GSK3_1	478	485	PF00069	0.539
MOD_GSK3_1	565	572	PF00069	0.582
MOD_GSK3_1	582	589	PF00069	0.680
MOD_NEK2_1	136	141	PF00069	0.470
MOD_NEK2_1	2	7	PF00069	0.629
MOD_NEK2_1	228	233	PF00069	0.447
MOD_NEK2_1	288	293	PF00069	0.643
MOD_NEK2_1	351	356	PF00069	0.405
MOD_NEK2_1	381	386	PF00069	0.543
MOD_NEK2_1	43	48	PF00069	0.490
MOD_NEK2_1	550	555	PF00069	0.766
MOD_NEK2_1	74	79	PF00069	0.581
MOD_NEK2_2	370	375	PF00069	0.470
MOD_PIKK_1	253	259	PF00454	0.461
MOD_PIKK_1	383	389	PF00454	0.480
MOD_PKA_1	148	154	PF00069	0.615
MOD_PKA_2	140	146	PF00069	0.615
MOD_PKA_2	148	154	PF00069	0.620
MOD_PKA_2	184	190	PF00069	0.562
MOD_PKA_2	276	282	PF00069	0.614
MOD_PKA_2	370	376	PF00069	0.445
MOD_PKA_2	381	387	PF00069	0.435
MOD_PKA_2	488	494	PF00069	0.718
MOD_PKA_2	564	570	PF00069	0.737
MOD_PKA_2	86	92	PF00069	0.594
MOD_Plk_1	289	295	PF00069	0.729
MOD_Plk_1	49	55	PF00069	0.457
MOD_Plk_1	550	556	PF00069	0.800
MOD_Plk_1	97	103	PF00069	0.651
MOD_Plk_2-3	569	575	PF00069	0.580
MOD_Plk_4	148	154	PF00069	0.622
MOD_Plk_4	191	197	PF00069	0.521
MOD_Plk_4	236	242	PF00069	0.587
MOD_Plk_4	289	295	PF00069	0.685
MOD_Plk_4	347	353	PF00069	0.542
MOD_Plk_4	402	408	PF00069	0.436
MOD_Plk_4	550	556	PF00069	0.800
MOD_ProDKin_1	158	164	PF00069	0.628
MOD_ProDKin_1	214	220	PF00069	0.547
MOD_ProDKin_1	283	289	PF00069	0.628
MOD_ProDKin_1	319	325	PF00069	0.643
MOD_ProDKin_1	33	39	PF00069	0.560
MOD_ProDKin_1	400	406	PF00069	0.405
MOD_ProDKin_1	442	448	PF00069	0.662
MOD_ProDKin_1	484	490	PF00069	0.667
MOD_ProDKin_1	498	504	PF00069	0.667
MOD_ProDKin_1	556	562	PF00069	0.711
TRG_DiLeu_BaEn_1	192	197	PF01217	0.402
TRG_DiLeu_BaEn_1	473	478	PF01217	0.445
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.487
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.525
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.417
TRG_ENDOCYTIC_2	119	122	PF00928	0.578
TRG_ENDOCYTIC_2	44	47	PF00928	0.426
TRG_ENDOCYTIC_2	474	477	PF00928	0.496
TRG_ENDOCYTIC_2	48	51	PF00928	0.427
TRG_ENDOCYTIC_2	88	91	PF00928	0.437
TRG_ER_diArg_1	133	136	PF00400	0.569
TRG_ER_diArg_1	208	210	PF00400	0.422
TRG_ER_diArg_1	4	7	PF00400	0.551
TRG_ER_diArg_1	456	459	PF00400	0.586
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	45	50	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F0	Leptomonas seymouri	70%	98%
A0A1X0NQL7	Trypanosomatidae	55%	100%
A0A3Q8IE54	Leishmania donovani	94%	100%
A0A422MYL5	Trypanosoma rangeli	55%	100%
A4HGX6	Leishmania braziliensis	86%	100%
A4I406	Leishmania infantum	94%	100%
D0A900	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B096	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BI69	Trypanosoma cruzi	54%	100%