Beta-lactamase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-lactamase, putative

Species:

Leishmania major

UniProt:

Q4Q7Y2_LEIMA

TriTrypDb:

LmjF.28.2800 , LMJLV39_280036500 , LMJSD75_280036100

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Y2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.627
CLV_C14_Caspase3-7	357	361	PF00656	0.410
CLV_NRD_NRD_1	496	498	PF00675	0.562
CLV_PCSK_KEX2_1	318	320	PF00082	0.355
CLV_PCSK_KEX2_1	496	498	PF00082	0.445
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.355
CLV_PCSK_SKI1_1	135	139	PF00082	0.322
CLV_PCSK_SKI1_1	162	166	PF00082	0.297
CLV_PCSK_SKI1_1	240	244	PF00082	0.384
CLV_PCSK_SKI1_1	277	281	PF00082	0.389
CLV_PCSK_SKI1_1	349	353	PF00082	0.294
CLV_PCSK_SKI1_1	362	366	PF00082	0.470
CLV_PCSK_SKI1_1	394	398	PF00082	0.522
CLV_PCSK_SKI1_1	447	451	PF00082	0.523
CLV_PCSK_SKI1_1	478	482	PF00082	0.607
CLV_PCSK_SKI1_1	53	57	PF00082	0.395
DEG_APCC_DBOX_1	161	169	PF00400	0.447
DOC_CDC14_PxL_1	145	153	PF14671	0.355
DOC_CKS1_1	140	145	PF01111	0.341
DOC_CYCLIN_RxL_1	346	357	PF00134	0.279
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.279
DOC_CYCLIN_yCln2_LP_2	120	126	PF00134	0.279
DOC_MAPK_gen_1	11	18	PF00069	0.491
DOC_MAPK_MEF2A_6	11	18	PF00069	0.578
DOC_PP1_RVXF_1	13	19	PF00149	0.557
DOC_PP1_RVXF_1	275	282	PF00149	0.378
DOC_PP2B_LxvP_1	120	123	PF13499	0.279
DOC_PP2B_LxvP_1	340	343	PF13499	0.279
DOC_PP4_FxxP_1	280	283	PF00568	0.355
DOC_PP4_FxxP_1	304	307	PF00568	0.279
DOC_PP4_FxxP_1	317	320	PF00568	0.279
DOC_SPAK_OSR1_1	431	435	PF12202	0.408
DOC_USP7_MATH_1	283	287	PF00917	0.297
DOC_USP7_MATH_1	405	409	PF00917	0.321
DOC_WW_Pin1_4	139	144	PF00397	0.341
DOC_WW_Pin1_4	187	192	PF00397	0.462
DOC_WW_Pin1_4	211	216	PF00397	0.383
DOC_WW_Pin1_4	232	237	PF00397	0.357
DOC_WW_Pin1_4	327	332	PF00397	0.379
LIG_14-3-3_CanoR_1	162	168	PF00244	0.366
LIG_14-3-3_CanoR_1	248	258	PF00244	0.317
LIG_14-3-3_CanoR_1	410	417	PF00244	0.389
LIG_Actin_WH2_2	164	180	PF00022	0.278
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_BIR_III_2	401	405	PF00653	0.443
LIG_Clathr_ClatBox_1	352	356	PF01394	0.297
LIG_eIF4E_1	347	353	PF01652	0.297
LIG_FHA_1	117	123	PF00498	0.308
LIG_FHA_1	140	146	PF00498	0.260
LIG_FHA_1	241	247	PF00498	0.440
LIG_FHA_1	391	397	PF00498	0.424
LIG_FHA_2	355	361	PF00498	0.435
LIG_FHA_2	488	494	PF00498	0.682
LIG_LIR_Apic_2	278	283	PF02991	0.453
LIG_LIR_Apic_2	289	294	PF02991	0.273
LIG_LIR_Apic_2	295	300	PF02991	0.190
LIG_LIR_Apic_2	302	307	PF02991	0.231
LIG_LIR_Apic_2	315	320	PF02991	0.150
LIG_LIR_Nem_3	17	21	PF02991	0.501
LIG_LIR_Nem_3	345	350	PF02991	0.278
LIG_LIR_Nem_3	486	492	PF02991	0.560
LIG_Pex14_2	485	489	PF04695	0.627
LIG_SH2_CRK	117	121	PF00017	0.279
LIG_SH2_CRK	291	295	PF00017	0.279
LIG_SH2_CRK	347	351	PF00017	0.297
LIG_SH2_NCK_1	202	206	PF00017	0.357
LIG_SH2_NCK_1	341	345	PF00017	0.410
LIG_SH2_SRC	202	205	PF00017	0.402
LIG_SH2_SRC	341	344	PF00017	0.357
LIG_SH2_SRC	383	386	PF00017	0.490
LIG_SH2_STAT5	128	131	PF00017	0.297
LIG_SH2_STAT5	147	150	PF00017	0.297
LIG_SH2_STAT5	231	234	PF00017	0.248
LIG_SH2_STAT5	250	253	PF00017	0.410
LIG_SH2_STAT5	383	386	PF00017	0.490
LIG_SH2_STAT5	488	491	PF00017	0.490
LIG_SH3_3	198	204	PF00018	0.302
LIG_SH3_3	453	459	PF00018	0.652
LIG_SH3_5	343	347	PF00018	0.297
LIG_SUMO_SIM_anti_2	254	260	PF11976	0.282
LIG_SUMO_SIM_par_1	319	325	PF11976	0.355
LIG_SUMO_SIM_par_1	349	354	PF11976	0.297
LIG_SUMO_SIM_par_1	54	59	PF11976	0.468
LIG_TYR_ITIM	115	120	PF00017	0.297
LIG_UBA3_1	440	447	PF00899	0.405
LIG_WRC_WIRS_1	164	169	PF05994	0.357
LIG_WRC_WIRS_1	406	411	PF05994	0.313
MOD_CDK_SPK_2	232	237	PF00069	0.355
MOD_CK1_1	163	169	PF00069	0.333
MOD_CK1_1	252	258	PF00069	0.301
MOD_CK1_1	271	277	PF00069	0.322
MOD_CK1_1	286	292	PF00069	0.297
MOD_CK1_1	354	360	PF00069	0.363
MOD_CK1_1	369	375	PF00069	0.550
MOD_CK1_1	424	430	PF00069	0.379
MOD_CK1_1	487	493	PF00069	0.699
MOD_CK1_1	59	65	PF00069	0.438
MOD_CK2_1	487	493	PF00069	0.567
MOD_CK2_1	51	57	PF00069	0.388
MOD_GlcNHglycan	371	374	PF01048	0.475
MOD_GlcNHglycan	63	66	PF01048	0.437
MOD_GlcNHglycan	90	93	PF01048	0.306
MOD_GSK3_1	118	125	PF00069	0.279
MOD_GSK3_1	153	160	PF00069	0.389
MOD_GSK3_1	210	217	PF00069	0.327
MOD_GSK3_1	232	239	PF00069	0.355
MOD_GSK3_1	271	278	PF00069	0.336
MOD_GSK3_1	405	412	PF00069	0.358
MOD_GSK3_1	483	490	PF00069	0.705
MOD_N-GLC_1	240	245	PF02516	0.336
MOD_N-GLC_1	327	332	PF02516	0.283
MOD_N-GLC_1	334	339	PF02516	0.276
MOD_N-GLC_1	369	374	PF02516	0.438
MOD_N-GLC_1	435	440	PF02516	0.467
MOD_NEK2_1	242	247	PF00069	0.381
MOD_NEK2_1	390	395	PF00069	0.424
MOD_NEK2_1	56	61	PF00069	0.433
MOD_NEK2_2	405	410	PF00069	0.365
MOD_OFUCOSY	419	425	PF10250	0.436
MOD_PIKK_1	262	268	PF00454	0.407
MOD_PIKK_1	64	70	PF00454	0.466
MOD_PKA_2	236	242	PF00069	0.347
MOD_PKA_2	409	415	PF00069	0.391
MOD_PKA_2	93	99	PF00069	0.355
MOD_Plk_1	435	441	PF00069	0.444
MOD_Plk_1	472	478	PF00069	0.682
MOD_Plk_1	56	62	PF00069	0.479
MOD_Plk_4	163	169	PF00069	0.246
MOD_Plk_4	292	298	PF00069	0.386
MOD_Plk_4	354	360	PF00069	0.407
MOD_Plk_4	392	398	PF00069	0.542
MOD_Plk_4	484	490	PF00069	0.537
MOD_ProDKin_1	139	145	PF00069	0.341
MOD_ProDKin_1	187	193	PF00069	0.462
MOD_ProDKin_1	211	217	PF00069	0.383
MOD_ProDKin_1	232	238	PF00069	0.357
MOD_ProDKin_1	327	333	PF00069	0.379
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.330
TRG_ENDOCYTIC_2	117	120	PF00928	0.279
TRG_ENDOCYTIC_2	202	205	PF00928	0.309
TRG_ENDOCYTIC_2	341	344	PF00928	0.319
TRG_ENDOCYTIC_2	347	350	PF00928	0.274
TRG_ENDOCYTIC_2	376	379	PF00928	0.466
TRG_ER_diArg_1	11	14	PF00400	0.558
TRG_ER_diArg_1	496	498	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	98	103	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWQ0	Leptomonas seymouri	71%	96%
A0A0S4J446	Bodo saltans	46%	94%
A0A1X0NQV6	Trypanosomatidae	59%	96%
A0A3Q8IDD8	Leishmania donovani	96%	100%
A4HGY3	Leishmania braziliensis	89%	100%
A4I415	Leishmania infantum	96%	100%
D0A8Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9B0A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5ATN3	Trypanosoma cruzi	57%	100%