Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7X9_LEIMA

TriTrypDb:

LmjF.28.2830 , LMJLV39_280036800 , LMJSD75_280036400

Length:

945

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.557
CLV_C14_Caspase3-7	890	894	PF00656	0.651
CLV_NRD_NRD_1	122	124	PF00675	0.652
CLV_NRD_NRD_1	238	240	PF00675	0.607
CLV_NRD_NRD_1	308	310	PF00675	0.666
CLV_NRD_NRD_1	368	370	PF00675	0.660
CLV_NRD_NRD_1	493	495	PF00675	0.610
CLV_NRD_NRD_1	711	713	PF00675	0.640
CLV_NRD_NRD_1	847	849	PF00675	0.560
CLV_PCSK_FUR_1	306	310	PF00082	0.645
CLV_PCSK_KEX2_1	122	124	PF00082	0.652
CLV_PCSK_KEX2_1	238	240	PF00082	0.607
CLV_PCSK_KEX2_1	308	310	PF00082	0.647
CLV_PCSK_KEX2_1	368	370	PF00082	0.660
CLV_PCSK_KEX2_1	493	495	PF00082	0.644
CLV_PCSK_KEX2_1	539	541	PF00082	0.666
CLV_PCSK_KEX2_1	711	713	PF00082	0.640
CLV_PCSK_KEX2_1	847	849	PF00082	0.560
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.738
CLV_PCSK_SKI1_1	238	242	PF00082	0.577
CLV_PCSK_SKI1_1	249	253	PF00082	0.516
CLV_PCSK_SKI1_1	309	313	PF00082	0.661
CLV_PCSK_SKI1_1	386	390	PF00082	0.712
CLV_PCSK_SKI1_1	427	431	PF00082	0.685
CLV_PCSK_SKI1_1	468	472	PF00082	0.684
CLV_PCSK_SKI1_1	536	540	PF00082	0.676
CLV_PCSK_SKI1_1	67	71	PF00082	0.599
CLV_PCSK_SKI1_1	712	716	PF00082	0.627
CLV_PCSK_SKI1_1	859	863	PF00082	0.695
DEG_APCC_DBOX_1	328	336	PF00400	0.627
DEG_APCC_DBOX_1	472	480	PF00400	0.687
DEG_APCC_DBOX_1	935	943	PF00400	0.627
DEG_Nend_UBRbox_4	1	3	PF02207	0.639
DEG_SPOP_SBC_1	363	367	PF00917	0.604
DEG_SPOP_SBC_1	571	575	PF00917	0.708
DOC_AGCK_PIF_1	273	278	PF00069	0.629
DOC_CYCLIN_RxL_1	246	253	PF00134	0.703
DOC_CYCLIN_RxL_1	35	46	PF00134	0.611
DOC_MAPK_gen_1	167	176	PF00069	0.660
DOC_MAPK_gen_1	368	376	PF00069	0.662
DOC_MAPK_gen_1	493	499	PF00069	0.639
DOC_MAPK_gen_1	756	765	PF00069	0.738
DOC_MAPK_MEF2A_6	167	176	PF00069	0.677
DOC_MAPK_MEF2A_6	756	765	PF00069	0.738
DOC_MAPK_MEF2A_6	903	911	PF00069	0.693
DOC_MAPK_NFAT4_5	756	764	PF00069	0.674
DOC_PP1_RVXF_1	148	155	PF00149	0.643
DOC_PP1_RVXF_1	931	938	PF00149	0.687
DOC_PP2B_LxvP_1	761	764	PF13499	0.738
DOC_USP7_MATH_1	177	181	PF00917	0.557
DOC_USP7_MATH_1	216	220	PF00917	0.800
DOC_USP7_MATH_1	269	273	PF00917	0.621
DOC_USP7_MATH_1	363	367	PF00917	0.652
DOC_USP7_MATH_1	388	392	PF00917	0.710
DOC_USP7_MATH_1	419	423	PF00917	0.726
DOC_USP7_MATH_1	445	449	PF00917	0.652
DOC_USP7_MATH_1	547	551	PF00917	0.656
DOC_USP7_MATH_1	554	558	PF00917	0.669
DOC_USP7_MATH_1	570	574	PF00917	0.703
DOC_USP7_MATH_1	607	611	PF00917	0.707
DOC_USP7_MATH_1	764	768	PF00917	0.655
DOC_USP7_MATH_1	822	826	PF00917	0.655
DOC_WW_Pin1_4	214	219	PF00397	0.710
DOC_WW_Pin1_4	279	284	PF00397	0.604
DOC_WW_Pin1_4	766	771	PF00397	0.728
DOC_WW_Pin1_4	8	13	PF00397	0.720
LIG_14-3-3_CanoR_1	287	293	PF00244	0.601
LIG_14-3-3_CanoR_1	368	377	PF00244	0.686
LIG_14-3-3_CanoR_1	408	418	PF00244	0.605
LIG_14-3-3_CanoR_1	493	499	PF00244	0.621
LIG_14-3-3_CanoR_1	511	515	PF00244	0.433
LIG_14-3-3_CanoR_1	758	764	PF00244	0.668
LIG_Actin_RPEL_3	896	915	PF02755	0.573
LIG_APCC_ABBAyCdc20_2	239	245	PF00400	0.640
LIG_APCC_ABBAyCdc20_2	427	433	PF00400	0.684
LIG_CaM_IQ_9	142	158	PF13499	0.628
LIG_Clathr_ClatBox_1	914	918	PF01394	0.687
LIG_deltaCOP1_diTrp_1	421	428	PF00928	0.646
LIG_deltaCOP1_diTrp_1	843	851	PF00928	0.679
LIG_eIF4E_1	236	242	PF01652	0.712
LIG_FHA_1	140	146	PF00498	0.720
LIG_FHA_1	169	175	PF00498	0.449
LIG_FHA_1	26	32	PF00498	0.641
LIG_FHA_1	376	382	PF00498	0.633
LIG_FHA_1	858	864	PF00498	0.687
LIG_FHA_1	930	936	PF00498	0.682
LIG_FHA_2	370	376	PF00498	0.733
LIG_FHA_2	612	618	PF00498	0.718
LIG_GBD_Chelix_1	722	730	PF00786	0.577
LIG_LIR_Apic_2	414	419	PF02991	0.637
LIG_LIR_Gen_1	107	115	PF02991	0.558
LIG_LIR_Gen_1	268	278	PF02991	0.625
LIG_LIR_Gen_1	378	387	PF02991	0.607
LIG_LIR_Gen_1	504	515	PF02991	0.700
LIG_LIR_Gen_1	644	654	PF02991	0.632
LIG_LIR_Gen_1	811	819	PF02991	0.593
LIG_LIR_Gen_1	898	907	PF02991	0.552
LIG_LIR_Nem_3	107	113	PF02991	0.562
LIG_LIR_Nem_3	180	184	PF02991	0.667
LIG_LIR_Nem_3	268	273	PF02991	0.621
LIG_LIR_Nem_3	378	382	PF02991	0.585
LIG_LIR_Nem_3	504	510	PF02991	0.692
LIG_LIR_Nem_3	644	649	PF02991	0.601
LIG_LIR_Nem_3	811	815	PF02991	0.590
LIG_LIR_Nem_3	873	878	PF02991	0.681
LIG_MYND_1	766	770	PF01753	0.730
LIG_PTAP_UEV_1	3	8	PF05743	0.679
LIG_SH2_CRK	137	141	PF00017	0.495
LIG_SH2_CRK	181	185	PF00017	0.619
LIG_SH2_CRK	379	383	PF00017	0.589
LIG_SH2_CRK	507	511	PF00017	0.710
LIG_SH2_CRK	646	650	PF00017	0.583
LIG_SH2_NCK_1	379	383	PF00017	0.693
LIG_SH2_SRC	243	246	PF00017	0.699
LIG_SH2_SRC	263	266	PF00017	0.370
LIG_SH2_SRC	927	930	PF00017	0.688
LIG_SH2_STAP1	236	240	PF00017	0.621
LIG_SH2_STAP1	377	381	PF00017	0.650
LIG_SH2_STAP1	505	509	PF00017	0.636
LIG_SH2_STAP1	927	931	PF00017	0.682
LIG_SH2_STAT3	370	373	PF00017	0.697
LIG_SH2_STAT3	642	645	PF00017	0.590
LIG_SH2_STAT5	263	266	PF00017	0.639
LIG_SH2_STAT5	279	282	PF00017	0.587
LIG_SH2_STAT5	377	380	PF00017	0.597
LIG_SH2_STAT5	411	414	PF00017	0.544
LIG_SH2_STAT5	552	555	PF00017	0.521
LIG_SH2_STAT5	630	633	PF00017	0.643
LIG_SH2_STAT5	646	649	PF00017	0.492
LIG_SH2_STAT5	653	656	PF00017	0.596
LIG_SH2_STAT5	878	881	PF00017	0.677
LIG_SH2_STAT5	899	902	PF00017	0.631
LIG_SH3_1	212	218	PF00018	0.563
LIG_SH3_3	1	7	PF00018	0.747
LIG_SH3_3	205	211	PF00018	0.698
LIG_SH3_3	212	218	PF00018	0.703
LIG_SH3_3	277	283	PF00018	0.586
LIG_SUMO_SIM_par_1	474	480	PF11976	0.524
LIG_SUMO_SIM_par_1	859	864	PF11976	0.693
LIG_TRAF2_1	489	492	PF00917	0.657
LIG_TRAF2_1	500	503	PF00917	0.691
LIG_TRAF2_1	597	600	PF00917	0.673
LIG_UBA3_1	879	884	PF00899	0.693
MOD_CDK_SPxK_1	8	14	PF00069	0.810
MOD_CDK_SPxxK_3	766	773	PF00069	0.726
MOD_CK1_1	566	572	PF00069	0.820
MOD_CK1_1	573	579	PF00069	0.473
MOD_CK1_1	610	616	PF00069	0.728
MOD_CK1_1	8	14	PF00069	0.760
MOD_CK1_1	800	806	PF00069	0.440
MOD_CK1_1	825	831	PF00069	0.609
MOD_CK1_1	887	893	PF00069	0.630
MOD_CK2_1	571	577	PF00069	0.644
MOD_CK2_1	594	600	PF00069	0.653
MOD_CK2_1	611	617	PF00069	0.737
MOD_CK2_1	645	651	PF00069	0.465
MOD_CK2_1	766	772	PF00069	0.650
MOD_CK2_1	800	806	PF00069	0.620
MOD_Cter_Amidation	845	848	PF01082	0.543
MOD_GlcNHglycan	205	208	PF01048	0.692
MOD_GlcNHglycan	267	270	PF01048	0.644
MOD_GlcNHglycan	346	350	PF01048	0.665
MOD_GlcNHglycan	351	356	PF01048	0.607
MOD_GlcNHglycan	600	604	PF01048	0.708
MOD_GlcNHglycan	608	612	PF01048	0.715
MOD_GlcNHglycan	693	697	PF01048	0.633
MOD_GlcNHglycan	7	10	PF01048	0.703
MOD_GlcNHglycan	824	827	PF01048	0.615
MOD_GSK3_1	265	272	PF00069	0.619
MOD_GSK3_1	331	338	PF00069	0.648
MOD_GSK3_1	560	567	PF00069	0.734
MOD_GSK3_1	595	602	PF00069	0.649
MOD_GSK3_1	607	614	PF00069	0.633
MOD_GSK3_1	730	737	PF00069	0.625
MOD_GSK3_1	822	829	PF00069	0.575
MOD_GSK3_1	883	890	PF00069	0.705
MOD_LATS_1	882	888	PF00433	0.693
MOD_NEK2_1	23	28	PF00069	0.514
MOD_NEK2_1	312	317	PF00069	0.635
MOD_NEK2_1	335	340	PF00069	0.699
MOD_NEK2_1	403	408	PF00069	0.732
MOD_NEK2_1	510	515	PF00069	0.731
MOD_NEK2_1	664	669	PF00069	0.707
MOD_NEK2_1	730	735	PF00069	0.680
MOD_NEK2_1	759	764	PF00069	0.643
MOD_NEK2_1	797	802	PF00069	0.478
MOD_NEK2_2	547	552	PF00069	0.506
MOD_PIKK_1	17	23	PF00454	0.686
MOD_PIKK_1	369	375	PF00454	0.696
MOD_PIKK_1	492	498	PF00454	0.651
MOD_PIKK_1	519	525	PF00454	0.767
MOD_PIKK_1	595	601	PF00454	0.737
MOD_PKA_2	492	498	PF00069	0.684
MOD_PKA_2	510	516	PF00069	0.503
MOD_PKA_2	664	670	PF00069	0.683
MOD_PKB_1	54	62	PF00069	0.617
MOD_Plk_1	805	811	PF00069	0.550
MOD_Plk_1	887	893	PF00069	0.691
MOD_Plk_4	377	383	PF00069	0.574
MOD_Plk_4	547	553	PF00069	0.509
MOD_Plk_4	625	631	PF00069	0.629
MOD_Plk_4	887	893	PF00069	0.689
MOD_ProDKin_1	214	220	PF00069	0.712
MOD_ProDKin_1	279	285	PF00069	0.599
MOD_ProDKin_1	766	772	PF00069	0.727
MOD_ProDKin_1	8	14	PF00069	0.724
MOD_SUMO_for_1	538	541	PF00179	0.737
MOD_SUMO_rev_2	225	232	PF00179	0.683
TRG_DiLeu_BaEn_4	65	71	PF01217	0.674
TRG_DiLeu_BaEn_4	681	687	PF01217	0.705
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.703
TRG_DiLeu_BaLyEn_6	770	775	PF01217	0.583
TRG_ENDOCYTIC_2	181	184	PF00928	0.666
TRG_ENDOCYTIC_2	379	382	PF00928	0.589
TRG_ENDOCYTIC_2	507	510	PF00928	0.706
TRG_ENDOCYTIC_2	646	649	PF00928	0.564
TRG_ENDOCYTIC_2	727	730	PF00928	0.579
TRG_ENDOCYTIC_2	899	902	PF00928	0.553
TRG_ER_diArg_1	306	309	PF00400	0.655
TRG_ER_diArg_1	368	370	PF00400	0.658
TRG_ER_diArg_1	756	759	PF00400	0.669
TRG_ER_diArg_1	782	785	PF00400	0.586
TRG_ER_diArg_1	922	925	PF00400	0.625
TRG_ER_diArg_1	941	944	PF00400	0.649
TRG_NES_CRM1_1	898	913	PF08389	0.574
TRG_NES_CRM1_1	934	945	PF08389	0.630
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	239	244	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	337	342	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	773	778	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	859	864	PF00026	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC11	Leptomonas seymouri	32%	100%
A0A3Q8IIE5	Leishmania donovani	88%	100%
A4HGY6	Leishmania braziliensis	69%	100%
A4I418	Leishmania infantum	88%	100%
E9B0A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BDP5	Trypanosoma cruzi	24%	95%