Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7X8_LEIMA

TriTrypDb:

LmjF.28.2840 , LMJLV39_280036900 , LMJSD75_280036500

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7X8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	387	391	PF00656	0.758
CLV_C14_Caspase3-7	409	413	PF00656	0.788
CLV_C14_Caspase3-7	414	418	PF00656	0.819
CLV_NRD_NRD_1	155	157	PF00675	0.577
CLV_NRD_NRD_1	176	178	PF00675	0.487
CLV_NRD_NRD_1	264	266	PF00675	0.532
CLV_NRD_NRD_1	273	275	PF00675	0.479
CLV_NRD_NRD_1	291	293	PF00675	0.557
CLV_NRD_NRD_1	306	308	PF00675	0.552
CLV_NRD_NRD_1	325	327	PF00675	0.688
CLV_NRD_NRD_1	360	362	PF00675	0.750
CLV_NRD_NRD_1	479	481	PF00675	0.581
CLV_NRD_NRD_1	53	55	PF00675	0.541
CLV_PCSK_FUR_1	274	278	PF00082	0.545
CLV_PCSK_FUR_1	289	293	PF00082	0.414
CLV_PCSK_KEX2_1	155	157	PF00082	0.577
CLV_PCSK_KEX2_1	175	177	PF00082	0.582
CLV_PCSK_KEX2_1	273	275	PF00082	0.531
CLV_PCSK_KEX2_1	276	278	PF00082	0.569
CLV_PCSK_KEX2_1	291	293	PF00082	0.407
CLV_PCSK_KEX2_1	306	308	PF00082	0.534
CLV_PCSK_KEX2_1	325	327	PF00082	0.638
CLV_PCSK_KEX2_1	362	364	PF00082	0.801
CLV_PCSK_KEX2_1	479	481	PF00082	0.582
CLV_PCSK_KEX2_1	52	54	PF00082	0.539
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.595
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.801
CLV_PCSK_PC7_1	475	481	PF00082	0.625
CLV_PCSK_SKI1_1	162	166	PF00082	0.560
CLV_PCSK_SKI1_1	176	180	PF00082	0.326
CLV_PCSK_SKI1_1	450	454	PF00082	0.668
DEG_COP1_1	131	139	PF00400	0.644
DEG_SCF_FBW7_1	465	470	PF00400	0.565
DEG_SCF_TRCP1_1	393	398	PF00400	0.582
DEG_SPOP_SBC_1	222	226	PF00917	0.588
DEG_SPOP_SBC_1	228	232	PF00917	0.696
DEG_SPOP_SBC_1	343	347	PF00917	0.803
DEG_SPOP_SBC_1	451	455	PF00917	0.683
DOC_CKS1_1	136	141	PF01111	0.635
DOC_CKS1_1	252	257	PF01111	0.569
DOC_MAPK_gen_1	273	283	PF00069	0.499
DOC_MAPK_gen_1	361	372	PF00069	0.739
DOC_MAPK_MEF2A_6	416	424	PF00069	0.716
DOC_MAPK_MEF2A_6	483	491	PF00069	0.702
DOC_PP2B_LxvP_1	35	38	PF13499	0.597
DOC_USP7_MATH_1	11	15	PF00917	0.666
DOC_USP7_MATH_1	137	141	PF00917	0.735
DOC_USP7_MATH_1	227	231	PF00917	0.736
DOC_USP7_MATH_1	313	317	PF00917	0.720
DOC_USP7_MATH_1	318	322	PF00917	0.727
DOC_USP7_MATH_1	357	361	PF00917	0.717
DOC_USP7_MATH_1	391	395	PF00917	0.733
DOC_USP7_MATH_1	434	438	PF00917	0.762
DOC_USP7_MATH_1	452	456	PF00917	0.631
DOC_USP7_MATH_1	87	91	PF00917	0.734
DOC_USP7_MATH_1	95	99	PF00917	0.543
DOC_WW_Pin1_4	135	140	PF00397	0.727
DOC_WW_Pin1_4	232	237	PF00397	0.742
DOC_WW_Pin1_4	251	256	PF00397	0.556
DOC_WW_Pin1_4	3	8	PF00397	0.703
DOC_WW_Pin1_4	314	319	PF00397	0.716
DOC_WW_Pin1_4	374	379	PF00397	0.702
DOC_WW_Pin1_4	393	398	PF00397	0.718
DOC_WW_Pin1_4	463	468	PF00397	0.598
LIG_14-3-3_CanoR_1	167	172	PF00244	0.545
LIG_14-3-3_CanoR_1	314	318	PF00244	0.704
LIG_14-3-3_CanoR_1	450	460	PF00244	0.695
LIG_Actin_WH2_2	106	124	PF00022	0.660
LIG_BIR_II_1	1	5	PF00653	0.743
LIG_BIR_III_3	1	5	PF00653	0.743
LIG_BRCT_BRCA1_1	487	491	PF00533	0.707
LIG_Clathr_ClatBox_1	58	62	PF01394	0.665
LIG_deltaCOP1_diTrp_1	481	491	PF00928	0.696
LIG_eIF4E_1	439	445	PF01652	0.706
LIG_FHA_1	112	118	PF00498	0.600
LIG_FHA_1	131	137	PF00498	0.599
LIG_FHA_1	252	258	PF00498	0.570
LIG_FHA_1	273	279	PF00498	0.619
LIG_FHA_1	464	470	PF00498	0.753
LIG_FHA_2	122	128	PF00498	0.691
LIG_FHA_2	242	248	PF00498	0.514
LIG_FHA_2	258	264	PF00498	0.541
LIG_FHA_2	399	405	PF00498	0.759
LIG_FHA_2	407	413	PF00498	0.778
LIG_FHA_2	430	436	PF00498	0.701
LIG_Integrin_RGD_1	365	367	PF01839	0.786
LIG_LIR_Apic_2	436	442	PF02991	0.716
LIG_LIR_Nem_3	151	157	PF02991	0.600
LIG_LIR_Nem_3	203	209	PF02991	0.617
LIG_MYND_1	442	446	PF01753	0.704
LIG_MYND_1	7	11	PF01753	0.506
LIG_PDZ_Class_2	486	491	PF00595	0.705
LIG_RPA_C_Fungi	151	163	PF08784	0.421
LIG_RPA_C_Fungi	302	314	PF08784	0.565
LIG_SH2_CRK	154	158	PF00017	0.541
LIG_SH2_NCK_1	439	443	PF00017	0.704
LIG_SH2_PTP2	448	451	PF00017	0.756
LIG_SH2_STAT3	249	252	PF00017	0.537
LIG_SH2_STAT5	120	123	PF00017	0.672
LIG_SH2_STAT5	443	446	PF00017	0.670
LIG_SH2_STAT5	448	451	PF00017	0.662
LIG_SH3_3	131	137	PF00018	0.723
LIG_SUMO_SIM_anti_2	379	385	PF11976	0.805
LIG_SUMO_SIM_anti_2	398	404	PF11976	0.750
LIG_SUMO_SIM_par_1	131	138	PF11976	0.557
LIG_SUMO_SIM_par_1	379	385	PF11976	0.740
LIG_SUMO_SIM_par_1	401	407	PF11976	0.771
MOD_CK1_1	132	138	PF00069	0.747
MOD_CK1_1	140	146	PF00069	0.648
MOD_CK1_1	3	9	PF00069	0.727
MOD_CK1_1	411	417	PF00069	0.691
MOD_CK1_1	455	461	PF00069	0.728
MOD_CK1_1	74	80	PF00069	0.720
MOD_CK1_1	90	96	PF00069	0.593
MOD_CK2_1	241	247	PF00069	0.526
MOD_CK2_1	257	263	PF00069	0.538
MOD_CK2_1	284	290	PF00069	0.450
MOD_CK2_1	434	440	PF00069	0.724
MOD_GlcNHglycan	13	16	PF01048	0.514
MOD_GlcNHglycan	146	149	PF01048	0.610
MOD_GlcNHglycan	2	5	PF01048	0.744
MOD_GlcNHglycan	211	214	PF01048	0.640
MOD_GlcNHglycan	225	228	PF01048	0.650
MOD_GlcNHglycan	346	349	PF01048	0.650
MOD_GlcNHglycan	350	353	PF01048	0.654
MOD_GlcNHglycan	384	387	PF01048	0.781
MOD_GlcNHglycan	392	396	PF01048	0.708
MOD_GlcNHglycan	435	439	PF01048	0.731
MOD_GlcNHglycan	76	79	PF01048	0.788
MOD_GlcNHglycan	93	96	PF01048	0.601
MOD_GSK3_1	137	144	PF00069	0.682
MOD_GSK3_1	223	230	PF00069	0.756
MOD_GSK3_1	314	321	PF00069	0.710
MOD_GSK3_1	344	351	PF00069	0.707
MOD_GSK3_1	382	389	PF00069	0.674
MOD_GSK3_1	391	398	PF00069	0.608
MOD_GSK3_1	450	457	PF00069	0.669
MOD_GSK3_1	459	466	PF00069	0.621
MOD_GSK3_1	86	93	PF00069	0.643
MOD_LATS_1	304	310	PF00433	0.554
MOD_NEK2_1	209	214	PF00069	0.740
MOD_NEK2_1	257	262	PF00069	0.513
MOD_NEK2_2	320	325	PF00069	0.712
MOD_PIKK_1	108	114	PF00454	0.558
MOD_PIKK_1	257	263	PF00454	0.557
MOD_PIKK_1	27	33	PF00454	0.671
MOD_PIKK_1	467	473	PF00454	0.752
MOD_PKA_1	176	182	PF00069	0.553
MOD_PKA_1	306	312	PF00069	0.573
MOD_PKA_2	11	17	PF00069	0.595
MOD_PKA_2	121	127	PF00069	0.693
MOD_PKA_2	176	182	PF00069	0.494
MOD_PKA_2	272	278	PF00069	0.593
MOD_PKA_2	306	312	PF00069	0.636
MOD_PKA_2	313	319	PF00069	0.693
MOD_PKA_2	74	80	PF00069	0.684
MOD_PKA_2	90	96	PF00069	0.646
MOD_Plk_1	130	136	PF00069	0.725
MOD_Plk_1	398	404	PF00069	0.700
MOD_Plk_1	434	440	PF00069	0.761
MOD_Plk_2-3	429	435	PF00069	0.688
MOD_Plk_4	398	404	PF00069	0.812
MOD_ProDKin_1	135	141	PF00069	0.727
MOD_ProDKin_1	232	238	PF00069	0.736
MOD_ProDKin_1	251	257	PF00069	0.559
MOD_ProDKin_1	3	9	PF00069	0.700
MOD_ProDKin_1	314	320	PF00069	0.719
MOD_ProDKin_1	374	380	PF00069	0.705
MOD_ProDKin_1	393	399	PF00069	0.720
MOD_ProDKin_1	463	469	PF00069	0.598
TRG_DiLeu_BaEn_1	440	445	PF01217	0.703
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.683
TRG_ENDOCYTIC_2	154	157	PF00928	0.547
TRG_ENDOCYTIC_2	285	288	PF00928	0.533
TRG_ER_diArg_1	154	156	PF00400	0.576
TRG_ER_diArg_1	175	177	PF00400	0.569
TRG_ER_diArg_1	291	294	PF00400	0.464
TRG_ER_diArg_1	324	326	PF00400	0.755
TRG_ER_diArg_1	478	480	PF00400	0.593
TRG_ER_diArg_1	51	54	PF00400	0.560
TRG_NLS_MonoExtC_3	360	365	PF00514	0.747
TRG_NLS_MonoExtN_4	359	366	PF00514	0.749
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYA9	Leptomonas seymouri	49%	100%
A0A1X0NQL1	Trypanosomatidae	28%	100%
A0A3Q8IE22	Leishmania donovani	91%	100%
A0A3R7JYS6	Trypanosoma rangeli	27%	100%
A4HGY7	Leishmania braziliensis	72%	100%
A4I419	Leishmania infantum	91%	100%
E9B0A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%