Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7X7_LEIMA

TriTrypDb:

LmjF.28.2850 , LMJLV39_280037000 , LMJSD75_280036600

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

Q4Q7X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7X7

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.518
CLV_C14_Caspase3-7	326	330	PF00656	0.650
CLV_NRD_NRD_1	123	125	PF00675	0.566
CLV_NRD_NRD_1	16	18	PF00675	0.585
CLV_NRD_NRD_1	233	235	PF00675	0.397
CLV_NRD_NRD_1	43	45	PF00675	0.515
CLV_NRD_NRD_1	435	437	PF00675	0.645
CLV_NRD_NRD_1	93	95	PF00675	0.416
CLV_PCSK_KEX2_1	123	125	PF00082	0.450
CLV_PCSK_KEX2_1	16	18	PF00082	0.582
CLV_PCSK_KEX2_1	233	235	PF00082	0.397
CLV_PCSK_KEX2_1	297	299	PF00082	0.478
CLV_PCSK_KEX2_1	434	436	PF00082	0.614
CLV_PCSK_KEX2_1	93	95	PF00082	0.397
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.488
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.636
CLV_PCSK_PC7_1	119	125	PF00082	0.424
CLV_PCSK_SKI1_1	123	127	PF00082	0.406
CLV_PCSK_SKI1_1	297	301	PF00082	0.397
CLV_PCSK_SKI1_1	93	97	PF00082	0.550
CLV_Separin_Metazoa	222	226	PF03568	0.395
DEG_APCC_DBOX_1	92	100	PF00400	0.416
DOC_ANK_TNKS_1	224	231	PF00023	0.385
DOC_CDC14_PxL_1	174	182	PF14671	0.385
DOC_CDC14_PxL_1	408	416	PF14671	0.447
DOC_CKS1_1	106	111	PF01111	0.490
DOC_CYCLIN_RxL_1	133	145	PF00134	0.499
DOC_CYCLIN_RxL_1	90	101	PF00134	0.548
DOC_CYCLIN_yClb5_NLxxxL_5	284	291	PF00134	0.244
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	287	293	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	338	344	PF00134	0.577
DOC_MAPK_gen_1	123	129	PF00069	0.404
DOC_MAPK_gen_1	281	291	PF00069	0.438
DOC_MAPK_MEF2A_6	281	289	PF00069	0.477
DOC_PP1_RVXF_1	184	191	PF00149	0.328
DOC_PP2B_LxvP_1	163	166	PF13499	0.482
DOC_PP2B_LxvP_1	266	269	PF13499	0.391
DOC_PP2B_LxvP_1	287	290	PF13499	0.421
DOC_PP2B_LxvP_1	336	339	PF13499	0.477
DOC_PP4_FxxP_1	74	77	PF00568	0.518
DOC_USP7_MATH_1	131	135	PF00917	0.516
DOC_USP7_MATH_1	193	197	PF00917	0.453
DOC_USP7_MATH_1	344	348	PF00917	0.754
DOC_USP7_MATH_2	249	255	PF00917	0.430
DOC_USP7_UBL2_3	434	438	PF12436	0.602
DOC_WW_Pin1_4	1	6	PF00397	0.673
DOC_WW_Pin1_4	105	110	PF00397	0.351
DOC_WW_Pin1_4	155	160	PF00397	0.563
DOC_WW_Pin1_4	259	264	PF00397	0.642
DOC_WW_Pin1_4	337	342	PF00397	0.634
DOC_WW_Pin1_4	351	356	PF00397	0.665
DOC_WW_Pin1_4	52	57	PF00397	0.565
LIG_14-3-3_CanoR_1	124	130	PF00244	0.489
LIG_14-3-3_CanoR_1	16	24	PF00244	0.563
LIG_Actin_WH2_2	282	299	PF00022	0.388
LIG_APCC_ABBA_1	140	145	PF00400	0.377
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_BIR_III_4	329	333	PF00653	0.537
LIG_BRCT_BRCA1_1	269	273	PF00533	0.371
LIG_BRCT_BRCA1_1	81	85	PF00533	0.507
LIG_CSL_BTD_1	287	290	PF09270	0.374
LIG_CtBP_PxDLS_1	249	253	PF00389	0.422
LIG_DLG_GKlike_1	23	30	PF00625	0.472
LIG_FHA_1	137	143	PF00498	0.515
LIG_FHA_1	255	261	PF00498	0.687
LIG_FHA_1	333	339	PF00498	0.702
LIG_FHA_1	369	375	PF00498	0.575
LIG_FHA_1	37	43	PF00498	0.607
LIG_FHA_1	385	391	PF00498	0.468
LIG_FHA_1	420	426	PF00498	0.388
LIG_FHA_2	179	185	PF00498	0.366
LIG_FHA_2	347	353	PF00498	0.622
LIG_FHA_2	387	393	PF00498	0.426
LIG_FHA_2	425	431	PF00498	0.606
LIG_LIR_Apic_2	245	250	PF02991	0.589
LIG_LIR_Gen_1	22	30	PF02991	0.517
LIG_LIR_Gen_1	270	279	PF02991	0.342
LIG_LIR_Gen_1	402	412	PF02991	0.471
LIG_LIR_LC3C_4	239	243	PF02991	0.438
LIG_LIR_Nem_3	22	27	PF02991	0.487
LIG_LIR_Nem_3	270	275	PF02991	0.336
LIG_LIR_Nem_3	307	311	PF02991	0.467
LIG_LYPXL_S_1	381	385	PF13949	0.396
LIG_LYPXL_yS_3	382	385	PF13949	0.476
LIG_MLH1_MIPbox_1	269	273	PF16413	0.257
LIG_NRBOX	198	204	PF00104	0.387
LIG_SH2_CRK	308	312	PF00017	0.326
LIG_SH2_STAT5	179	182	PF00017	0.387
LIG_SH2_STAT5	201	204	PF00017	0.403
LIG_SH2_STAT5	247	250	PF00017	0.522
LIG_SH2_STAT5	272	275	PF00017	0.378
LIG_SH3_3	103	109	PF00018	0.413
LIG_SH3_3	257	263	PF00018	0.725
LIG_SH3_CIN85_PxpxPR_1	52	57	PF14604	0.521
LIG_SUMO_SIM_anti_2	101	106	PF11976	0.459
LIG_SUMO_SIM_par_1	103	108	PF11976	0.361
LIG_SUMO_SIM_par_1	138	145	PF11976	0.544
LIG_SUMO_SIM_par_1	389	395	PF11976	0.508
LIG_SUMO_SIM_par_1	4	10	PF11976	0.695
LIG_SUMO_SIM_par_1	421	427	PF11976	0.403
LIG_SUMO_SIM_par_1	59	65	PF11976	0.566
LIG_TYR_ITIM	306	311	PF00017	0.332
LIG_WRC_WIRS_1	126	131	PF05994	0.366
LIG_WRC_WIRS_1	24	29	PF05994	0.507
MOD_CDK_SPK_2	52	57	PF00069	0.521
MOD_CDK_SPxxK_3	351	358	PF00069	0.591
MOD_CK1_1	115	121	PF00069	0.435
MOD_CK1_1	19	25	PF00069	0.517
MOD_CK1_1	254	260	PF00069	0.698
MOD_CK1_1	262	268	PF00069	0.596
MOD_CK1_1	304	310	PF00069	0.490
MOD_CK1_1	351	357	PF00069	0.592
MOD_CK1_1	360	366	PF00069	0.565
MOD_CK1_1	424	430	PF00069	0.751
MOD_CK1_1	79	85	PF00069	0.385
MOD_CK2_1	261	267	PF00069	0.566
MOD_CK2_1	346	352	PF00069	0.694
MOD_CK2_1	424	430	PF00069	0.615
MOD_Cter_Amidation	14	17	PF01082	0.523
MOD_GlcNHglycan	1	4	PF01048	0.575
MOD_GlcNHglycan	11	14	PF01048	0.478
MOD_GlcNHglycan	114	117	PF01048	0.540
MOD_GlcNHglycan	133	136	PF01048	0.249
MOD_GlcNHglycan	303	306	PF01048	0.566
MOD_GlcNHglycan	346	349	PF01048	0.752
MOD_GlcNHglycan	359	362	PF01048	0.641
MOD_GlcNHglycan	375	378	PF01048	0.489
MOD_GlcNHglycan	81	84	PF01048	0.510
MOD_GSK3_1	1	8	PF00069	0.589
MOD_GSK3_1	19	26	PF00069	0.499
MOD_GSK3_1	250	257	PF00069	0.670
MOD_GSK3_1	267	274	PF00069	0.426
MOD_GSK3_1	321	328	PF00069	0.532
MOD_GSK3_1	342	349	PF00069	0.619
MOD_N-GLC_1	236	241	PF02516	0.376
MOD_N-GLC_2	418	420	PF02516	0.512
MOD_NEK2_1	85	90	PF00069	0.449
MOD_NEK2_1	9	14	PF00069	0.556
MOD_OFUCOSY	320	325	PF10250	0.457
MOD_PIKK_1	172	178	PF00454	0.473
MOD_PIKK_1	193	199	PF00454	0.511
MOD_PKA_1	16	22	PF00069	0.601
MOD_PKA_2	118	124	PF00069	0.556
MOD_PKA_2	16	22	PF00069	0.601
MOD_PKA_2	357	363	PF00069	0.653
MOD_PKA_2	79	85	PF00069	0.564
MOD_Plk_1	236	242	PF00069	0.374
MOD_Plk_4	237	243	PF00069	0.517
MOD_Plk_4	256	262	PF00069	0.542
MOD_Plk_4	386	392	PF00069	0.426
MOD_ProDKin_1	1	7	PF00069	0.672
MOD_ProDKin_1	105	111	PF00069	0.349
MOD_ProDKin_1	155	161	PF00069	0.559
MOD_ProDKin_1	259	265	PF00069	0.626
MOD_ProDKin_1	337	343	PF00069	0.635
MOD_ProDKin_1	351	357	PF00069	0.664
MOD_ProDKin_1	52	58	PF00069	0.561
MOD_SUMO_for_1	150	153	PF00179	0.544
MOD_SUMO_rev_2	46	52	PF00179	0.455
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.319
TRG_ENDOCYTIC_2	272	275	PF00928	0.459
TRG_ENDOCYTIC_2	308	311	PF00928	0.323
TRG_ENDOCYTIC_2	382	385	PF00928	0.507
TRG_ENDOCYTIC_2	404	407	PF00928	0.438
TRG_ER_diArg_1	122	124	PF00400	0.544
TRG_ER_diArg_1	232	234	PF00400	0.476
TRG_ER_diArg_1	92	94	PF00400	0.409
TRG_NES_CRM1_1	409	421	PF08389	0.498
TRG_NLS_MonoCore_2	432	437	PF00514	0.576
TRG_NLS_MonoExtC_3	433	438	PF00514	0.578
TRG_NLS_MonoExtN_4	432	438	PF00514	0.734

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Z3	Leptomonas seymouri	45%	93%
A0A0S4IUX7	Bodo saltans	25%	98%
A0A1X0NQH2	Trypanosomatidae	28%	100%
A0A3S7X213	Leishmania donovani	94%	100%
A0A422N0P3	Trypanosoma rangeli	27%	99%
A4HGY8	Leishmania braziliensis	77%	100%
A4I420	Leishmania infantum	94%	100%
D0A8Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
E9B0A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	95%
V5ATM8	Trypanosoma cruzi	28%	100%