Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7X3_LEIMA

TriTrypDb:

LmjF.28.2890 , LMJLV39_280037400 , LMJSD75_280037000

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7X3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.482
CLV_NRD_NRD_1	228	230	PF00675	0.639
CLV_NRD_NRD_1	273	275	PF00675	0.538
CLV_NRD_NRD_1	98	100	PF00675	0.618
CLV_PCSK_FUR_1	55	59	PF00082	0.717
CLV_PCSK_KEX2_1	115	117	PF00082	0.406
CLV_PCSK_KEX2_1	125	127	PF00082	0.577
CLV_PCSK_KEX2_1	180	182	PF00082	0.482
CLV_PCSK_KEX2_1	228	230	PF00082	0.639
CLV_PCSK_KEX2_1	273	275	PF00082	0.538
CLV_PCSK_KEX2_1	57	59	PF00082	0.711
CLV_PCSK_KEX2_1	98	100	PF00082	0.671
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.590
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.696
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.711
CLV_PCSK_SKI1_1	208	212	PF00082	0.601
CLV_PCSK_SKI1_1	273	277	PF00082	0.533
DEG_APCC_DBOX_1	207	215	PF00400	0.627
DEG_APCC_DBOX_1	273	281	PF00400	0.557
DEG_APCC_DBOX_1	57	65	PF00400	0.654
DEG_SCF_FBW7_1	362	369	PF00400	0.578
DOC_USP7_MATH_1	179	183	PF00917	0.655
DOC_USP7_MATH_1	344	348	PF00917	0.634
DOC_USP7_MATH_1	351	355	PF00917	0.614
DOC_USP7_MATH_1	366	370	PF00917	0.567
DOC_WW_Pin1_4	362	367	PF00397	0.804
DOC_WW_Pin1_4	9	14	PF00397	0.642
LIG_14-3-3_CanoR_1	180	184	PF00244	0.642
LIG_14-3-3_CanoR_1	189	193	PF00244	0.469
LIG_14-3-3_CanoR_1	299	305	PF00244	0.586
LIG_14-3-3_CanoR_1	51	59	PF00244	0.644
LIG_14-3-3_CanoR_1	66	72	PF00244	0.589
LIG_Actin_WH2_2	102	120	PF00022	0.621
LIG_Actin_WH2_2	214	230	PF00022	0.562
LIG_APCC_ABBA_1	214	219	PF00400	0.565
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_BIR_III_2	219	223	PF00653	0.560
LIG_BIR_III_4	357	361	PF00653	0.677
LIG_BRCT_BRCA1_1	1	5	PF00533	0.525
LIG_BRCT_BRCA1_1	317	321	PF00533	0.502
LIG_Clathr_ClatBox_1	146	150	PF01394	0.510
LIG_Clathr_ClatBox_1	172	176	PF01394	0.567
LIG_deltaCOP1_diTrp_1	200	210	PF00928	0.632
LIG_FHA_1	167	173	PF00498	0.570
LIG_FHA_1	295	301	PF00498	0.488
LIG_FHA_1	51	57	PF00498	0.638
LIG_FHA_1	77	83	PF00498	0.605
LIG_FHA_2	262	268	PF00498	0.547
LIG_FHA_2	301	307	PF00498	0.618
LIG_LIR_Gen_1	142	151	PF02991	0.577
LIG_LIR_Gen_1	2	13	PF02991	0.523
LIG_LIR_Gen_1	233	242	PF02991	0.448
LIG_LIR_Gen_1	322	328	PF02991	0.568
LIG_LIR_Gen_1	69	78	PF02991	0.571
LIG_LIR_Nem_3	142	146	PF02991	0.552
LIG_LIR_Nem_3	153	157	PF02991	0.429
LIG_LIR_Nem_3	2	8	PF02991	0.647
LIG_LIR_Nem_3	233	237	PF02991	0.436
LIG_LIR_Nem_3	269	275	PF02991	0.495
LIG_LIR_Nem_3	287	293	PF02991	0.483
LIG_LIR_Nem_3	303	307	PF02991	0.577
LIG_LIR_Nem_3	318	324	PF02991	0.421
LIG_LIR_Nem_3	69	75	PF02991	0.566
LIG_RPA_C_Fungi	46	58	PF08784	0.705
LIG_SH2_CRK	162	166	PF00017	0.482
LIG_SH2_CRK	293	297	PF00017	0.553
LIG_SH2_NCK_1	187	191	PF00017	0.562
LIG_SH2_NCK_1	293	297	PF00017	0.642
LIG_SH2_STAP1	143	147	PF00017	0.603
LIG_SH2_STAP1	317	321	PF00017	0.521
LIG_SH2_STAP1	34	38	PF00017	0.685
LIG_SH2_STAP1	78	82	PF00017	0.630
LIG_SH2_STAT3	317	320	PF00017	0.522
LIG_SH2_STAT3	34	37	PF00017	0.674
LIG_SH2_STAT5	290	293	PF00017	0.494
LIG_SH2_STAT5	34	37	PF00017	0.602
LIG_SH2_STAT5	38	41	PF00017	0.606
LIG_SH2_STAT5	67	70	PF00017	0.565
LIG_SH2_STAT5	78	81	PF00017	0.534
LIG_SH3_1	118	124	PF00018	0.668
LIG_SH3_2	121	126	PF14604	0.713
LIG_SH3_3	118	124	PF00018	0.653
LIG_SH3_3	369	375	PF00018	0.742
LIG_SH3_3	53	59	PF00018	0.521
LIG_SUMO_SIM_anti_2	129	136	PF11976	0.654
LIG_SUMO_SIM_par_1	145	150	PF11976	0.516
LIG_TYR_ITIM	291	296	PF00017	0.622
LIG_UBA3_1	146	152	PF00899	0.482
MOD_CK1_1	188	194	PF00069	0.513
MOD_CK1_1	22	28	PF00069	0.436
MOD_CK1_1	76	82	PF00069	0.616
MOD_CK1_1	9	15	PF00069	0.610
MOD_CK1_1	91	97	PF00069	0.538
MOD_CK2_1	18	24	PF00069	0.651
MOD_CK2_1	240	246	PF00069	0.705
MOD_CK2_1	261	267	PF00069	0.551
MOD_CK2_1	300	306	PF00069	0.615
MOD_CK2_1	59	65	PF00069	0.603
MOD_GlcNHglycan	21	24	PF01048	0.389
MOD_GlcNHglycan	353	356	PF01048	0.647
MOD_GlcNHglycan	79	82	PF01048	0.605
MOD_GlcNHglycan	8	11	PF01048	0.685
MOD_GlcNHglycan	90	93	PF01048	0.595
MOD_GSK3_1	18	25	PF00069	0.702
MOD_GSK3_1	240	247	PF00069	0.578
MOD_GSK3_1	32	39	PF00069	0.448
MOD_GSK3_1	361	368	PF00069	0.655
MOD_GSK3_1	73	80	PF00069	0.613
MOD_N-GLC_1	360	365	PF02516	0.693
MOD_NEK2_1	300	305	PF00069	0.486
MOD_NEK2_1	77	82	PF00069	0.603
MOD_NEK2_2	161	166	PF00069	0.518
MOD_NEK2_2	67	72	PF00069	0.424
MOD_PIKK_1	32	38	PF00454	0.563
MOD_PIKK_1	329	335	PF00454	0.555
MOD_PIKK_1	59	65	PF00454	0.564
MOD_PKA_2	179	185	PF00069	0.573
MOD_PKA_2	188	194	PF00069	0.555
MOD_PKA_2	300	306	PF00069	0.584
MOD_PKA_2	50	56	PF00069	0.606
MOD_Plk_1	315	321	PF00069	0.520
MOD_Plk_1	73	79	PF00069	0.619
MOD_Plk_2-3	263	269	PF00069	0.596
MOD_Plk_4	150	156	PF00069	0.506
MOD_Plk_4	161	167	PF00069	0.502
MOD_Plk_4	240	246	PF00069	0.643
MOD_Plk_4	67	73	PF00069	0.585
MOD_ProDKin_1	362	368	PF00069	0.807
MOD_ProDKin_1	9	15	PF00069	0.641
MOD_SUMO_rev_2	145	154	PF00179	0.520
TRG_DiLeu_BaEn_1	142	147	PF01217	0.525
TRG_DiLeu_BaEn_2	149	155	PF01217	0.602
TRG_DiLeu_BaEn_2	205	211	PF01217	0.422
TRG_DiLeu_BaEn_2	305	311	PF01217	0.631
TRG_ENDOCYTIC_2	143	146	PF00928	0.606
TRG_ENDOCYTIC_2	162	165	PF00928	0.322
TRG_ENDOCYTIC_2	293	296	PF00928	0.641
TRG_ENDOCYTIC_2	304	307	PF00928	0.557
TRG_ER_diArg_1	109	112	PF00400	0.431
TRG_ER_diArg_1	227	229	PF00400	0.644
TRG_ER_diArg_1	272	274	PF00400	0.559
TRG_ER_diArg_1	334	337	PF00400	0.600
TRG_ER_diArg_1	97	99	PF00400	0.691
TRG_NLS_Bipartite_1	98	119	PF00514	0.553
TRG_NLS_MonoExtN_4	112	119	PF00514	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J9	Leptomonas seymouri	48%	100%
A0A3S7X1Y7	Leishmania donovani	92%	100%
A4HGZ2	Leishmania braziliensis	72%	93%
A4I424	Leishmania infantum	91%	100%
E9B0B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5B930	Trypanosoma cruzi	24%	100%