Conserved oligomeric Golgi complex subunit 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligomeric golgi complex component 8, putative

Species:

Leishmania major

UniProt:

Q4Q7X2_LEIMA

TriTrypDb:

LmjF.28.2900 , LMJLV39_280037500 , LMJSD75_280037100

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	4
GO:0016020	membrane	2	12
GO:0017119	Golgi transport complex	3	12
GO:0031090	organelle membrane	3	4
GO:0032991	protein-containing complex	1	12
GO:0098588	bounding membrane of organelle	4	4
GO:0099023	vesicle tethering complex	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q7X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7X2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006891	intra-Golgi vesicle-mediated transport	6	2
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	2
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.243
CLV_NRD_NRD_1	382	384	PF00675	0.313
CLV_PCSK_KEX2_1	170	172	PF00082	0.243
CLV_PCSK_SKI1_1	180	184	PF00082	0.280
CLV_PCSK_SKI1_1	192	196	PF00082	0.337
CLV_PCSK_SKI1_1	210	214	PF00082	0.187
CLV_PCSK_SKI1_1	239	243	PF00082	0.264
CLV_PCSK_SKI1_1	384	388	PF00082	0.501
CLV_PCSK_SKI1_1	424	428	PF00082	0.385
CLV_PCSK_SKI1_1	48	52	PF00082	0.347
DEG_SCF_FBW7_1	508	514	PF00400	0.517
DEG_SPOP_SBC_1	526	530	PF00917	0.725
DOC_CDC14_PxL_1	410	418	PF14671	0.428
DOC_CKS1_1	508	513	PF01111	0.514
DOC_CYCLIN_RxL_1	187	199	PF00134	0.413
DOC_CYCLIN_RxL_1	381	391	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	437	443	PF00134	0.415
DOC_PP2B_LxvP_1	506	509	PF13499	0.583
DOC_PP4_FxxP_1	390	393	PF00568	0.259
DOC_USP7_MATH_1	198	202	PF00917	0.259
DOC_USP7_MATH_1	284	288	PF00917	0.441
DOC_USP7_MATH_1	35	39	PF00917	0.258
DOC_USP7_MATH_1	484	488	PF00917	0.612
DOC_USP7_MATH_1	500	504	PF00917	0.691
DOC_USP7_MATH_1	519	523	PF00917	0.642
DOC_USP7_MATH_1	527	531	PF00917	0.650
DOC_USP7_MATH_1	67	71	PF00917	0.400
DOC_USP7_MATH_1	81	85	PF00917	0.257
DOC_WW_Pin1_4	172	177	PF00397	0.389
DOC_WW_Pin1_4	354	359	PF00397	0.384
DOC_WW_Pin1_4	507	512	PF00397	0.551
DOC_WW_Pin1_4	91	96	PF00397	0.308
LIG_14-3-3_CanoR_1	103	107	PF00244	0.413
LIG_14-3-3_CanoR_1	239	248	PF00244	0.404
LIG_14-3-3_CanoR_1	281	290	PF00244	0.400
LIG_14-3-3_CanoR_1	315	325	PF00244	0.402
LIG_14-3-3_CanoR_1	331	335	PF00244	0.372
LIG_14-3-3_CanoR_1	337	343	PF00244	0.505
LIG_APCC_ABBAyCdc20_2	103	109	PF00400	0.243
LIG_Clathr_ClatBox_1	111	115	PF01394	0.243
LIG_Clathr_ClatBox_1	473	477	PF01394	0.465
LIG_EH1_1	443	451	PF00400	0.450
LIG_EH1_1	466	474	PF00400	0.389
LIG_eIF4E_1	163	169	PF01652	0.420
LIG_eIF4E_1	467	473	PF01652	0.319
LIG_FHA_1	145	151	PF00498	0.341
LIG_FHA_1	240	246	PF00498	0.308
LIG_FHA_1	290	296	PF00498	0.298
LIG_FHA_1	355	361	PF00498	0.494
LIG_FHA_1	460	466	PF00498	0.442
LIG_FHA_1	49	55	PF00498	0.360
LIG_FHA_1	508	514	PF00498	0.603
LIG_FHA_2	351	357	PF00498	0.576
LIG_FHA_2	40	46	PF00498	0.343
LIG_GBD_Chelix_1	368	376	PF00786	0.316
LIG_LIR_Gen_1	21	31	PF02991	0.389
LIG_LIR_Gen_1	377	387	PF02991	0.317
LIG_LIR_Gen_1	59	67	PF02991	0.308
LIG_LIR_LC3C_4	272	277	PF02991	0.308
LIG_LIR_Nem_3	160	166	PF02991	0.340
LIG_LIR_Nem_3	21	26	PF02991	0.305
LIG_LIR_Nem_3	377	382	PF02991	0.298
LIG_LIR_Nem_3	59	63	PF02991	0.308
LIG_LYPXL_yS_3	439	442	PF13949	0.331
LIG_MAD2	87	95	PF02301	0.308
LIG_Pex14_2	430	434	PF04695	0.287
LIG_SH2_CRK	163	167	PF00017	0.389
LIG_SH2_CRK	205	209	PF00017	0.243
LIG_SH2_CRK	23	27	PF00017	0.206
LIG_SH2_PTP2	211	214	PF00017	0.389
LIG_SH2_STAP1	205	209	PF00017	0.259
LIG_SH2_STAT3	128	131	PF00017	0.371
LIG_SH2_STAT3	66	69	PF00017	0.264
LIG_SH2_STAT5	128	131	PF00017	0.371
LIG_SH2_STAT5	190	193	PF00017	0.282
LIG_SH2_STAT5	211	214	PF00017	0.259
LIG_SH2_STAT5	335	338	PF00017	0.525
LIG_SH2_STAT5	441	444	PF00017	0.400
LIG_SH3_3	494	500	PF00018	0.692
LIG_SH3_3	505	511	PF00018	0.621
LIG_SH3_3	515	521	PF00018	0.709
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.371
LIG_SUMO_SIM_par_1	87	94	PF11976	0.389
LIG_TRAF2_1	241	244	PF00917	0.399
LIG_TRAF2_1	5	8	PF00917	0.530
LIG_TYR_ITIM	203	208	PF00017	0.303
LIG_TYR_ITIM	209	214	PF00017	0.303
LIG_TYR_ITIM	437	442	PF00017	0.415
LIG_TYR_ITSM	159	166	PF00017	0.389
LIG_UBA3_1	208	216	PF00899	0.371
LIG_UBA3_1	297	305	PF00899	0.286
LIG_WRC_WIRS_1	376	381	PF05994	0.449
MOD_CK1_1	175	181	PF00069	0.452
MOD_CK1_1	282	288	PF00069	0.344
MOD_CK1_1	38	44	PF00069	0.331
MOD_CK1_1	487	493	PF00069	0.600
MOD_CK1_1	53	59	PF00069	0.203
MOD_CK2_1	1	7	PF00069	0.561
MOD_CK2_1	229	235	PF00069	0.260
MOD_CK2_1	38	44	PF00069	0.342
MOD_GlcNHglycan	153	156	PF01048	0.287
MOD_GlcNHglycan	284	287	PF01048	0.278
MOD_GlcNHglycan	4	7	PF01048	0.521
MOD_GlcNHglycan	420	423	PF01048	0.521
MOD_GlcNHglycan	486	489	PF01048	0.633
MOD_GlcNHglycan	529	532	PF01048	0.742
MOD_GlcNHglycan	79	82	PF01048	0.317
MOD_GSK3_1	151	158	PF00069	0.389
MOD_GSK3_1	239	246	PF00069	0.308
MOD_GSK3_1	316	323	PF00069	0.421
MOD_GSK3_1	326	333	PF00069	0.435
MOD_GSK3_1	337	344	PF00069	0.660
MOD_GSK3_1	35	42	PF00069	0.374
MOD_GSK3_1	350	357	PF00069	0.415
MOD_GSK3_1	507	514	PF00069	0.570
MOD_GSK3_1	526	533	PF00069	0.637
MOD_GSK3_1	73	80	PF00069	0.302
MOD_N-GLC_1	268	273	PF02516	0.259
MOD_N-GLC_1	337	342	PF02516	0.592
MOD_NEK2_1	1	6	PF00069	0.613
MOD_NEK2_1	183	188	PF00069	0.389
MOD_NEK2_1	297	302	PF00069	0.317
MOD_NEK2_1	325	330	PF00069	0.402
MOD_NEK2_1	342	347	PF00069	0.580
MOD_NEK2_1	375	380	PF00069	0.338
MOD_NEK2_1	415	420	PF00069	0.520
MOD_NEK2_1	50	55	PF00069	0.248
MOD_NEK2_2	330	335	PF00069	0.483
MOD_PIKK_1	459	465	PF00454	0.572
MOD_PIKK_1	58	64	PF00454	0.277
MOD_PIKK_1	73	79	PF00454	0.277
MOD_PKA_2	102	108	PF00069	0.429
MOD_PKA_2	11	17	PF00069	0.355
MOD_PKA_2	317	323	PF00069	0.446
MOD_PKA_2	330	336	PF00069	0.445
MOD_Plk_1	198	204	PF00069	0.341
MOD_Plk_1	220	226	PF00069	0.397
MOD_Plk_1	243	249	PF00069	0.389
MOD_Plk_1	337	343	PF00069	0.624
MOD_Plk_1	511	517	PF00069	0.461
MOD_Plk_1	73	79	PF00069	0.177
MOD_Plk_4	102	108	PF00069	0.402
MOD_Plk_4	11	17	PF00069	0.337
MOD_Plk_4	198	204	PF00069	0.406
MOD_Plk_4	243	249	PF00069	0.414
MOD_Plk_4	297	303	PF00069	0.327
MOD_Plk_4	330	336	PF00069	0.465
MOD_Plk_4	343	349	PF00069	0.520
MOD_Plk_4	415	421	PF00069	0.498
MOD_ProDKin_1	172	178	PF00069	0.389
MOD_ProDKin_1	354	360	PF00069	0.387
MOD_ProDKin_1	507	513	PF00069	0.553
MOD_ProDKin_1	91	97	PF00069	0.308
TRG_DiLeu_BaEn_1	397	402	PF01217	0.441
TRG_DiLeu_BaEn_1	93	98	PF01217	0.389
TRG_DiLeu_BaEn_2	422	428	PF01217	0.378
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.501
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.382
TRG_ENDOCYTIC_2	163	166	PF00928	0.389
TRG_ENDOCYTIC_2	205	208	PF00928	0.243
TRG_ENDOCYTIC_2	211	214	PF00928	0.243
TRG_ENDOCYTIC_2	23	26	PF00928	0.259
TRG_ENDOCYTIC_2	439	442	PF00928	0.366
TRG_ER_diArg_1	169	171	PF00400	0.243
TRG_ER_diArg_1	184	187	PF00400	0.243
TRG_NES_CRM1_1	109	122	PF08389	0.389
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.264
TRG_Pf-PMV_PEXEL_1	399	404	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS6	Leptomonas seymouri	67%	89%
A0A0S4IRC0	Bodo saltans	34%	100%
A0A1X0NS75	Trypanosomatidae	38%	100%
A0A3R7LW05	Trypanosoma rangeli	39%	100%
A0A3S7X1Y9	Leishmania donovani	93%	100%
A4HGZ3	Leishmania braziliensis	84%	100%
A4I425	Leishmania infantum	93%	100%
D0A8Y2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B0B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q2TBH9	Bos taurus	23%	85%
Q84K25	Arabidopsis thaliana	23%	94%
Q96MW5	Homo sapiens	24%	87%
Q9JJA2	Mus musculus	23%	83%
V5BI51	Trypanosoma cruzi	38%	100%