Glutamate dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutamate dehydrogenase, putative

Species:

Leishmania major

UniProt:

Q4Q7X1_LEIMA

TriTrypDb:

LmjF.28.2910 , LMJLV39_280037600 , LMJSD75_280037200

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7X1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	9
GO:0006520	amino acid metabolic process	3	9
GO:0006536	glutamate metabolic process	6	2
GO:0006537	glutamate biosynthetic process	7	2
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0008652	amino acid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009064	glutamine family amino acid metabolic process	5	2
GO:0009084	glutamine family amino acid biosynthetic process	6	2
GO:0009987	cellular process	1	9
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	9
GO:0043436	oxoacid metabolic process	4	9
GO:0043648	dicarboxylic acid metabolic process	6	2
GO:0043650	dicarboxylic acid biosynthetic process	6	2
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	9
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1901607	alpha-amino acid biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	9
GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	5	2
GO:0004354	glutamate dehydrogenase (NADP+) activity	6	2
GO:0005488	binding	1	8
GO:0016491	oxidoreductase activity	2	9
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	3	9
GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	4	9
GO:0036094	small molecule binding	2	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.547
CLV_C14_Caspase3-7	333	337	PF00656	0.643
CLV_C14_Caspase3-7	401	405	PF00656	0.643
CLV_C14_Caspase3-7	429	433	PF00656	0.588
CLV_PCSK_KEX2_1	313	315	PF00082	0.374
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.403
CLV_PCSK_SKI1_1	17	21	PF00082	0.513
CLV_PCSK_SKI1_1	238	242	PF00082	0.340
CLV_PCSK_SKI1_1	262	266	PF00082	0.377
CLV_PCSK_SKI1_1	283	287	PF00082	0.405
CLV_PCSK_SKI1_1	338	342	PF00082	0.277
CLV_PCSK_SKI1_1	76	80	PF00082	0.430
CLV_Separin_Metazoa	147	151	PF03568	0.571
DOC_CYCLIN_RxL_1	109	119	PF00134	0.547
DOC_CYCLIN_RxL_1	199	209	PF00134	0.527
DOC_MAPK_gen_1	281	290	PF00069	0.568
DOC_MAPK_MEF2A_6	101	110	PF00069	0.547
DOC_PP1_RVXF_1	110	117	PF00149	0.547
DOC_PP1_RVXF_1	200	207	PF00149	0.458
DOC_PP1_RVXF_1	393	399	PF00149	0.547
DOC_PP1_RVXF_1	62	69	PF00149	0.547
DOC_PP1_RVXF_1	84	90	PF00149	0.547
DOC_PP1_SILK_1	108	113	PF00149	0.547
DOC_PP2B_LxvP_1	370	373	PF13499	0.559
DOC_PP4_FxxP_1	68	71	PF00568	0.605
DOC_USP7_MATH_1	266	270	PF00917	0.605
LIG_14-3-3_CanoR_1	150	156	PF00244	0.643
LIG_Actin_WH2_2	177	194	PF00022	0.643
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_EH1_1	221	229	PF00400	0.507
LIG_eIF4E_1	50	56	PF01652	0.512
LIG_FHA_1	237	243	PF00498	0.564
LIG_FHA_1	28	34	PF00498	0.601
LIG_FHA_1	340	346	PF00498	0.597
LIG_FHA_2	263	269	PF00498	0.605
LIG_FHA_2	295	301	PF00498	0.547
LIG_FHA_2	326	332	PF00498	0.547
LIG_FHA_2	354	360	PF00498	0.532
LIG_LIR_Gen_1	277	287	PF02991	0.560
LIG_LIR_Nem_3	158	163	PF02991	0.573
LIG_LIR_Nem_3	216	221	PF02991	0.530
LIG_LIR_Nem_3	277	282	PF02991	0.560
LIG_LIR_Nem_3	38	44	PF02991	0.450
LIG_PCNA_PIPBox_1	153	162	PF02747	0.605
LIG_PCNA_yPIPBox_3	101	114	PF02747	0.547
LIG_PCNA_yPIPBox_3	150	160	PF02747	0.614
LIG_Pex14_2	116	120	PF04695	0.547
LIG_Pex14_2	68	72	PF04695	0.547
LIG_Pex14_2	85	89	PF04695	0.547
LIG_PTB_Apo_2	182	189	PF02174	0.605
LIG_PTB_Apo_2	44	51	PF02174	0.564
LIG_PTB_Phospho_1	182	188	PF10480	0.605
LIG_PTB_Phospho_1	44	50	PF10480	0.565
LIG_SH2_CRK	218	222	PF00017	0.547
LIG_SH2_GRB2like	183	186	PF00017	0.605
LIG_SH2_NCK_1	8	12	PF00017	0.496
LIG_SH2_SRC	309	312	PF00017	0.623
LIG_SH2_SRC	430	433	PF00017	0.547
LIG_SH2_STAT3	222	225	PF00017	0.605
LIG_SH2_STAT5	222	225	PF00017	0.534
LIG_SH2_STAT5	272	275	PF00017	0.605
LIG_SH2_STAT5	309	312	PF00017	0.591
LIG_SH2_STAT5	430	433	PF00017	0.547
LIG_SH2_STAT5	50	53	PF00017	0.486
LIG_SH3_3	21	27	PF00018	0.520
LIG_SUMO_SIM_par_1	238	243	PF11976	0.548
LIG_TRAF2_1	297	300	PF00917	0.571
LIG_TRAF2_1	356	359	PF00917	0.605
LIG_TYR_ITIM	6	11	PF00017	0.503
LIG_TYR_ITSM	214	221	PF00017	0.547
LIG_UBA3_1	287	291	PF00899	0.519
MOD_CK1_1	123	129	PF00069	0.599
MOD_CK1_1	226	232	PF00069	0.463
MOD_CK1_1	409	415	PF00069	0.584
MOD_CK2_1	141	147	PF00069	0.536
MOD_CK2_1	294	300	PF00069	0.547
MOD_CK2_1	325	331	PF00069	0.547
MOD_CK2_1	353	359	PF00069	0.532
MOD_CK2_1	382	388	PF00069	0.529
MOD_Cter_Amidation	311	314	PF01082	0.371
MOD_GlcNHglycan	2	5	PF01048	0.598
MOD_GlcNHglycan	208	211	PF01048	0.417
MOD_GlcNHglycan	242	245	PF01048	0.347
MOD_GlcNHglycan	275	279	PF01048	0.374
MOD_GlcNHglycan	384	387	PF01048	0.335
MOD_GlcNHglycan	90	93	PF01048	0.405
MOD_GSK3_1	102	109	PF00069	0.532
MOD_GSK3_1	116	123	PF00069	0.519
MOD_GSK3_1	191	198	PF00069	0.523
MOD_GSK3_1	236	243	PF00069	0.543
MOD_GSK3_1	262	269	PF00069	0.547
MOD_GSK3_1	354	361	PF00069	0.532
MOD_GSK3_1	402	409	PF00069	0.615
MOD_GSK3_1	410	417	PF00069	0.566
MOD_N-GLC_1	106	111	PF02516	0.367
MOD_N-GLC_1	231	236	PF02516	0.416
MOD_N-GLC_2	195	197	PF02516	0.555
MOD_N-GLC_2	292	294	PF02516	0.396
MOD_NEK2_1	116	121	PF00069	0.547
MOD_NEK2_1	151	156	PF00069	0.585
MOD_NEK2_1	206	211	PF00069	0.414
MOD_NEK2_1	223	228	PF00069	0.555
MOD_NEK2_1	387	392	PF00069	0.571
MOD_PIKK_1	27	33	PF00454	0.605
MOD_PIKK_1	325	331	PF00454	0.546
MOD_PIKK_1	387	393	PF00454	0.547
MOD_PIKK_1	48	54	PF00454	0.511
MOD_PK_1	406	412	PF00069	0.588
MOD_PK_1	7	13	PF00069	0.477
MOD_PKA_2	191	197	PF00069	0.619
MOD_PKA_2	294	300	PF00069	0.571
MOD_PKA_2	302	308	PF00069	0.571
MOD_Plk_1	106	112	PF00069	0.567
MOD_Plk_1	116	122	PF00069	0.547
MOD_Plk_1	195	201	PF00069	0.531
MOD_Plk_1	231	237	PF00069	0.616
MOD_Plk_4	106	112	PF00069	0.529
MOD_Plk_4	151	157	PF00069	0.605
MOD_Plk_4	223	229	PF00069	0.623
MOD_Plk_4	236	242	PF00069	0.529
MOD_Plk_4	305	311	PF00069	0.643
MOD_Plk_4	336	342	PF00069	0.643
MOD_Plk_4	36	42	PF00069	0.459
MOD_Plk_4	426	432	PF00069	0.588
MOD_SUMO_for_1	290	293	PF00179	0.616
MOD_SUMO_rev_2	233	240	PF00179	0.588
MOD_SUMO_rev_2	331	340	PF00179	0.571
MOD_SUMO_rev_2	423	429	PF00179	0.560
TRG_ENDOCYTIC_2	160	163	PF00928	0.571
TRG_ENDOCYTIC_2	188	191	PF00928	0.554
TRG_ENDOCYTIC_2	218	221	PF00928	0.538
TRG_ENDOCYTIC_2	8	11	PF00928	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD76	Leptomonas seymouri	77%	100%
A0A1X0NL49	Trypanosomatidae	76%	100%
A0A3S7X1Z4	Leishmania donovani	95%	100%
A0A422MUR9	Trypanosoma rangeli	72%	100%
A2XMV1	Oryza sativa subsp. indica	32%	100%
A2XW22	Oryza sativa subsp. indica	33%	100%
A3MUY9	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	33%	100%
A3MWK6	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	33%	100%
A4HGZ4	Leishmania braziliensis	88%	100%
A4I426	Leishmania infantum	95%	100%
B2RKJ1	Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)	57%	100%
E9B0B3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
F2Z610	Halobacterium salinarum	32%	100%
O04937	Nicotiana plumbaginifolia	33%	100%
O59650	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	35%	100%
O69056	Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858)	24%	100%
O74024	Thermococcus profundus	33%	100%
O93934	Botryotinia fuckeliana	53%	100%
P00366	Bos taurus	28%	81%
P00367	Homo sapiens	28%	81%
P00368	Gallus gallus	27%	90%
P00369	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	55%	100%
P00370	Escherichia coli (strain K12)	69%	100%
P07262	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	100%
P0A392	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	25%	100%
P0A393	Bacillus cereus	25%	100%
P0C934	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	57%	100%
P0CL72	Pyrococcus horikoshii	35%	100%
P0CL73	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	35%	100%
P0DMG3	Halobacterium salinarum	31%	100%
P0DMG4	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	31%	100%
P10860	Rattus norvegicus	28%	81%
P13154	Geobacillus stearothermophilus	27%	100%
P14657	Unknown prokaryotic organism	66%	100%
P15111	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	69%	100%
P18819	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	52%	98%
P23307	Lysinibacillus sphaericus	22%	100%
P24295	Clostridium symbiosum	56%	100%
P26443	Mus musculus	28%	81%
P27346	Clostridioides difficile	33%	100%
P28724	Giardia intestinalis	60%	100%
P28997	Peptoniphilus asaccharolyticus	33%	100%
P28998	Chlorella sorokiniana	56%	86%
P29051	Halobacterium salinarum	30%	100%
P29507	Schwanniomyces occidentalis	49%	98%
P31026	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	59%	100%
P39475	Saccharolobus shibatae	30%	100%
P39633	Bacillus subtilis (strain 168)	32%	100%
P39708	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	99%
P42174	Sus scrofa	28%	81%
P43793	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	69%	100%
P49448	Homo sapiens	28%	81%
P50735	Bacillus subtilis (strain 168)	31%	100%
P52596	Vitis vinifera	32%	100%
P54385	Drosophila melanogaster	30%	80%
P54386	Synechocystis sp. (strain PCC 6803 / Kazusa)	31%	100%
P54387	Agaricus bisporus	54%	99%
P54388	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	55%	100%
P55990	Helicobacter pylori (strain ATCC 700392 / 26695)	56%	100%
P78804	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	100%
P80053	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	32%	100%
P80319	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	33%	100%
P82264	Chaenocephalus aceratus	28%	90%
P93541	Solanum lycopersicum	30%	100%
P94316	Bacteroides fragilis (strain YCH46)	58%	100%
P94598	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	62%	100%
P95544	Prevotella ruminicola	64%	100%
P96110	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	35%	100%
P97014	Sporosarcina ureae	21%	100%
Q33E23	Oryza sativa subsp. japonica	33%	100%
Q38946	Arabidopsis thaliana	32%	100%
Q43260	Zea mays	32%	100%
Q43314	Arabidopsis thaliana	31%	100%
Q47950	Pyrococcus abyssi (strain GE5 / Orsay)	34%	100%
Q47951	Pyrococcus endeavori	34%	100%
Q53199	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	28%	100%
Q53560	Bacillus licheniformis	27%	100%
Q54KB7	Dictyostelium discoideum	28%	90%
Q56304	Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)	33%	100%
Q59224	Bacillus badius	24%	100%
Q5HHC7	Staphylococcus aureus (strain COL)	33%	100%
Q5MBG2	Halobacterium salinarum	32%	100%
Q60030	Thermoactinomyces intermedius	27%	100%
Q64HZ8	Pan troglodytes	29%	81%
Q64HZ9	Hylobates lar	28%	81%
Q64I00	Pongo pygmaeus	28%	81%
Q64I01	Gorilla gorilla gorilla	29%	81%
Q6GAW8	Staphylococcus aureus (strain MSSA476)	33%	100%
Q6GID0	Staphylococcus aureus (strain MRSA252)	33%	100%
Q6H3Y7	Oryza sativa subsp. japonica	31%	100%
Q7A1B9	Staphylococcus aureus (strain MW2)	33%	100%
Q7A6H8	Staphylococcus aureus (strain N315)	33%	100%
Q852M0	Oryza sativa subsp. japonica	32%	100%
Q8RQP4	Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)	59%	100%
Q8TFF6	Saccharomyces uvarum (strain ATCC 76518 / CBS 7001 / CLIB 283 / NBRC 10550 / MCYC 623 / NCYC 2669 / NRRL Y-11845)	52%	100%
Q8Z6F6	Salmonella typhi	69%	100%
Q96UJ9	Hebeloma cylindrosporum	55%	100%
Q96VJ7	Gibberella fujikuroi	53%	100%
Q99VD0	Staphylococcus aureus (strain Mu50 / ATCC 700699)	33%	100%
Q9HFR6	Tuber borchii	53%	99%
Q9HGU3	Neurospora sitophila	55%	100%
Q9HGU4	Neurospora intermedia	54%	100%
Q9HQE1	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	32%	100%
Q9HRM7	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	32%	100%
Q9LEC8	Nicotiana plumbaginifolia	32%	100%
Q9S1F9	Psychrobacter sp. (strain TAD1)	53%	100%
Q9S7A0	Arabidopsis thaliana	31%	100%
Q9URS1	Penicillium chrysogenum	52%	98%
Q9YC65	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	33%	100%
Q9ZKD8	Helicobacter pylori (strain J99 / ATCC 700824)	56%	100%