Putative sodium/sulphate symporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Low-affinity phosphate transporter PHO91

Species:

Leishmania major

UniProt:

Q4Q7W9_LEIMA

TriTrypDb:

LmjF.28.2930 , LMJLV39_280037800 , LMJSD75_280037400

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000331	contractile vacuole	6	2
GO:0005773	vacuole	5	2
GO:0005777	peroxisome	6	2
GO:0016020	membrane	2	10
GO:0020015	glycosome	7	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q7W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7W9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006797	polyphosphate metabolic process	4	2
GO:0006810	transport	3	5
GO:0006811	monoatomic ion transport	4	2
GO:0006817	phosphate ion transport	7	2
GO:0006820	monoatomic anion transport	5	2
GO:0006873	intracellular monoatomic ion homeostasis	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	5
GO:0015698	inorganic anion transport	6	2
GO:0019725	cellular homeostasis	2	2
GO:0030002	intracellular monoatomic anion homeostasis	5	2
GO:0030643	intracellular phosphate ion homeostasis	7	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0042592	homeostatic process	3	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0048878	chemical homeostasis	4	2
GO:0050801	monoatomic ion homeostasis	5	2
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055062	phosphate ion homeostasis	8	2
GO:0055081	monoatomic anion homeostasis	6	2
GO:0055082	intracellular chemical homeostasis	3	2
GO:0055085	transmembrane transport	2	5
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0072502	obsolete cellular trivalent inorganic anion homeostasis	6	2
GO:0072506	obsolete trivalent inorganic anion homeostasis	7	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:0098771	inorganic ion homeostasis	6	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0005315	inorganic phosphate transmembrane transporter activity	4	2
GO:0015291	secondary active transmembrane transporter activity	4	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0022804	active transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.764
CLV_C14_Caspase3-7	604	608	PF00656	0.371
CLV_NRD_NRD_1	187	189	PF00675	0.353
CLV_NRD_NRD_1	198	200	PF00675	0.417
CLV_NRD_NRD_1	236	238	PF00675	0.351
CLV_NRD_NRD_1	87	89	PF00675	0.480
CLV_NRD_NRD_1	92	94	PF00675	0.490
CLV_PCSK_KEX2_1	142	144	PF00082	0.470
CLV_PCSK_KEX2_1	198	200	PF00082	0.433
CLV_PCSK_KEX2_1	23	25	PF00082	0.287
CLV_PCSK_KEX2_1	273	275	PF00082	0.348
CLV_PCSK_KEX2_1	327	329	PF00082	0.287
CLV_PCSK_KEX2_1	5	7	PF00082	0.287
CLV_PCSK_KEX2_1	92	94	PF00082	0.501
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.470
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.287
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.348
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.287
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.287
CLV_PCSK_PC7_1	88	94	PF00082	0.496
CLV_PCSK_SKI1_1	142	146	PF00082	0.406
CLV_PCSK_SKI1_1	163	167	PF00082	0.439
CLV_PCSK_SKI1_1	189	193	PF00082	0.359
CLV_PCSK_SKI1_1	216	220	PF00082	0.402
CLV_PCSK_SKI1_1	225	229	PF00082	0.407
CLV_PCSK_SKI1_1	23	27	PF00082	0.287
CLV_PCSK_SKI1_1	237	241	PF00082	0.381
CLV_PCSK_SKI1_1	260	264	PF00082	0.352
CLV_PCSK_SKI1_1	701	705	PF00082	0.270
CLV_PCSK_SKI1_1	71	75	PF00082	0.477
DEG_APCC_DBOX_1	133	141	PF00400	0.642
DEG_APCC_DBOX_1	142	150	PF00400	0.511
DEG_APCC_DBOX_1	213	221	PF00400	0.574
DEG_APCC_DBOX_1	224	232	PF00400	0.571
DEG_APCC_DBOX_1	381	389	PF00400	0.287
DEG_Nend_UBRbox_1	1	4	PF02207	0.487
DOC_CYCLIN_RxL_1	160	171	PF00134	0.642
DOC_CYCLIN_RxL_1	222	232	PF00134	0.634
DOC_MAPK_DCC_7	494	504	PF00069	0.515
DOC_MAPK_gen_1	142	149	PF00069	0.616
DOC_MAPK_gen_1	223	231	PF00069	0.585
DOC_MAPK_gen_1	237	243	PF00069	0.576
DOC_MAPK_gen_1	5	13	PF00069	0.571
DOC_MAPK_gen_1	71	81	PF00069	0.648
DOC_MAPK_HePTP_8	340	352	PF00069	0.470
DOC_MAPK_MEF2A_6	223	231	PF00069	0.563
DOC_MAPK_MEF2A_6	343	352	PF00069	0.470
DOC_MAPK_MEF2A_6	74	81	PF00069	0.658
DOC_PP1_RVXF_1	462	468	PF00149	0.332
DOC_PP1_RVXF_1	641	647	PF00149	0.348
DOC_PP4_FxxP_1	239	242	PF00568	0.630
DOC_PP4_FxxP_1	315	318	PF00568	0.417
DOC_PP4_FxxP_1	646	649	PF00568	0.287
DOC_USP7_MATH_1	114	118	PF00917	0.756
DOC_USP7_MATH_1	399	403	PF00917	0.324
DOC_USP7_MATH_1	588	592	PF00917	0.270
DOC_USP7_MATH_1	677	681	PF00917	0.324
DOC_USP7_MATH_1	689	693	PF00917	0.470
DOC_USP7_UBL2_3	189	193	PF12436	0.559
DOC_WW_Pin1_4	158	163	PF00397	0.617
DOC_WW_Pin1_4	443	448	PF00397	0.324
DOC_WW_Pin1_4	605	610	PF00397	0.311
DOC_WW_Pin1_4	655	660	PF00397	0.267
LIG_14-3-3_CanoR_1	188	194	PF00244	0.583
LIG_14-3-3_CanoR_1	216	221	PF00244	0.555
LIG_14-3-3_CanoR_1	377	385	PF00244	0.270
LIG_Actin_WH2_2	22	37	PF00022	0.532
LIG_APCC_ABBA_1	73	78	PF00400	0.537
LIG_BRCT_BRCA1_1	231	235	PF00533	0.625
LIG_deltaCOP1_diTrp_1	254	259	PF00928	0.606
LIG_EH1_1	629	637	PF00400	0.324
LIG_FHA_1	106	112	PF00498	0.765
LIG_FHA_1	113	119	PF00498	0.748
LIG_FHA_1	203	209	PF00498	0.572
LIG_FHA_1	294	300	PF00498	0.332
LIG_FHA_1	306	312	PF00498	0.282
LIG_FHA_1	330	336	PF00498	0.483
LIG_FHA_1	46	52	PF00498	0.630
LIG_FHA_1	517	523	PF00498	0.490
LIG_FHA_1	528	534	PF00498	0.284
LIG_FHA_1	543	549	PF00498	0.348
LIG_FHA_1	611	617	PF00498	0.312
LIG_FHA_1	623	629	PF00498	0.352
LIG_FHA_1	713	719	PF00498	0.338
LIG_FHA_1	724	730	PF00498	0.310
LIG_FHA_2	324	330	PF00498	0.515
LIG_FHA_2	363	369	PF00498	0.324
LIG_FHA_2	415	421	PF00498	0.470
LIG_FHA_2	507	513	PF00498	0.520
LIG_FHA_2	602	608	PF00498	0.371
LIG_GBD_Chelix_1	525	533	PF00786	0.388
LIG_LIR_Apic_2	236	242	PF02991	0.627
LIG_LIR_Apic_2	417	422	PF02991	0.470
LIG_LIR_Apic_2	532	537	PF02991	0.465
LIG_LIR_Apic_2	720	724	PF02991	0.325
LIG_LIR_Apic_2	726	731	PF02991	0.317
LIG_LIR_Gen_1	244	251	PF02991	0.671
LIG_LIR_Gen_1	55	65	PF02991	0.570
LIG_LIR_Gen_1	565	575	PF02991	0.470
LIG_LIR_Gen_1	608	619	PF02991	0.382
LIG_LIR_LC3C_4	613	617	PF02991	0.366
LIG_LIR_Nem_3	14	18	PF02991	0.489
LIG_LIR_Nem_3	21	25	PF02991	0.490
LIG_LIR_Nem_3	244	249	PF02991	0.622
LIG_LIR_Nem_3	461	465	PF02991	0.295
LIG_LIR_Nem_3	498	504	PF02991	0.516
LIG_LIR_Nem_3	55	61	PF02991	0.557
LIG_LIR_Nem_3	565	570	PF02991	0.470
LIG_LIR_Nem_3	608	614	PF02991	0.382
LIG_LIR_Nem_3	679	684	PF02991	0.324
LIG_NRBOX	136	142	PF00104	0.677
LIG_NRBOX	143	149	PF00104	0.658
LIG_NRBOX	223	229	PF00104	0.633
LIG_NRBOX	573	579	PF00104	0.324
LIG_PCNA_PIPBox_1	338	347	PF02747	0.523
LIG_Pex14_1	15	19	PF04695	0.487
LIG_Pex14_1	259	263	PF04695	0.466
LIG_Pex14_1	572	576	PF04695	0.324
LIG_Pex14_2	235	239	PF04695	0.610
LIG_SH2_CRK	22	26	PF00017	0.487
LIG_SH2_CRK	246	250	PF00017	0.628
LIG_SH2_GRB2like	246	249	PF00017	0.680
LIG_SH2_NCK_1	246	250	PF00017	0.682
LIG_SH2_PTP2	261	264	PF00017	0.380
LIG_SH2_PTP2	501	504	PF00017	0.541
LIG_SH2_PTP2	728	731	PF00017	0.398
LIG_SH2_SRC	246	249	PF00017	0.680
LIG_SH2_STAP1	246	250	PF00017	0.642
LIG_SH2_STAP1	370	374	PF00017	0.310
LIG_SH2_STAT5	19	22	PF00017	0.487
LIG_SH2_STAT5	261	264	PF00017	0.380
LIG_SH2_STAT5	386	389	PF00017	0.324
LIG_SH2_STAT5	501	504	PF00017	0.541
LIG_SH2_STAT5	611	614	PF00017	0.324
LIG_SH2_STAT5	697	700	PF00017	0.470
LIG_SH2_STAT5	728	731	PF00017	0.368
LIG_SH3_1	74	80	PF00018	0.715
LIG_SH3_3	115	121	PF00018	0.785
LIG_SH3_3	319	325	PF00018	0.500
LIG_SH3_3	401	407	PF00018	0.334
LIG_SH3_3	470	476	PF00018	0.347
LIG_SH3_3	489	495	PF00018	0.194
LIG_SH3_3	497	503	PF00018	0.470
LIG_SH3_3	74	80	PF00018	0.632
LIG_SH3_3	81	87	PF00018	0.667
LIG_SUMO_SIM_anti_2	519	525	PF11976	0.444
LIG_SUMO_SIM_anti_2	613	619	PF11976	0.325
LIG_SUMO_SIM_anti_2	708	715	PF11976	0.380
LIG_SUMO_SIM_par_1	145	152	PF11976	0.717
LIG_SUMO_SIM_par_1	227	232	PF11976	0.592
LIG_SUMO_SIM_par_1	291	296	PF11976	0.409
LIG_SUMO_SIM_par_1	475	481	PF11976	0.380
LIG_SUMO_SIM_par_1	521	527	PF11976	0.328
LIG_SUMO_SIM_par_1	661	666	PF11976	0.300
LIG_TRAF2_1	104	107	PF00917	0.763
LIG_TRAF2_1	510	513	PF00917	0.571
LIG_TYR_ITIM	20	25	PF00017	0.487
LIG_TYR_ITIM	499	504	PF00017	0.541
LIG_UBA3_1	593	602	PF00899	0.341
LIG_UBA3_1	635	643	PF00899	0.326
LIG_WRC_WIRS_1	624	629	PF05994	0.470
LIG_WRPW_2	493	496	PF00400	0.453
MOD_CDK_SPK_2	158	163	PF00069	0.617
MOD_CK1_1	112	118	PF00069	0.769
MOD_CK1_1	37	43	PF00069	0.597
MOD_CK1_1	458	464	PF00069	0.295
MOD_CK1_1	516	522	PF00069	0.501
MOD_CK1_1	527	533	PF00069	0.268
MOD_CK1_1	600	606	PF00069	0.371
MOD_CK2_1	323	329	PF00069	0.515
MOD_CK2_1	362	368	PF00069	0.324
MOD_CK2_1	414	420	PF00069	0.470
MOD_CK2_1	506	512	PF00069	0.541
MOD_Cter_Amidation	3	6	PF01082	0.287
MOD_GlcNHglycan	189	192	PF01048	0.405
MOD_GlcNHglycan	329	332	PF01048	0.320
MOD_GlcNHglycan	457	460	PF01048	0.541
MOD_GlcNHglycan	516	519	PF01048	0.341
MOD_GlcNHglycan	526	529	PF01048	0.423
MOD_GlcNHglycan	665	668	PF01048	0.306
MOD_GlcNHglycan	670	673	PF01048	0.319
MOD_GlcNHglycan	97	100	PF01048	0.576
MOD_GSK3_1	105	112	PF00069	0.735
MOD_GSK3_1	212	219	PF00069	0.576
MOD_GSK3_1	293	300	PF00069	0.324
MOD_GSK3_1	323	330	PF00069	0.482
MOD_GSK3_1	443	450	PF00069	0.324
MOD_GSK3_1	597	604	PF00069	0.301
MOD_GSK3_1	622	629	PF00069	0.351
MOD_GSK3_1	708	715	PF00069	0.409
MOD_NEK2_1	110	115	PF00069	0.776
MOD_NEK2_1	212	217	PF00069	0.605
MOD_NEK2_1	293	298	PF00069	0.338
MOD_NEK2_1	305	310	PF00069	0.296
MOD_NEK2_1	362	367	PF00069	0.348
MOD_NEK2_1	391	396	PF00069	0.342
MOD_NEK2_1	524	529	PF00069	0.409
MOD_NEK2_1	542	547	PF00069	0.181
MOD_NEK2_1	601	606	PF00069	0.270
MOD_NEK2_1	668	673	PF00069	0.324
MOD_NEK2_1	705	710	PF00069	0.300
MOD_NEK2_1	712	717	PF00069	0.300
MOD_PIKK_1	149	155	PF00454	0.675
MOD_PIKK_1	249	255	PF00454	0.674
MOD_PIKK_1	334	340	PF00454	0.536
MOD_PKA_1	327	333	PF00069	0.487
MOD_PKA_1	94	100	PF00069	0.744
MOD_PKA_2	187	193	PF00069	0.580
MOD_PKA_2	327	333	PF00069	0.487
MOD_PKA_2	34	40	PF00069	0.628
MOD_PKA_2	376	382	PF00069	0.270
MOD_PKA_2	588	594	PF00069	0.271
MOD_PKB_1	214	222	PF00069	0.572
MOD_Plk_1	229	235	PF00069	0.619
MOD_Plk_4	119	125	PF00069	0.712
MOD_Plk_4	216	222	PF00069	0.570
MOD_Plk_4	370	376	PF00069	0.344
MOD_Plk_4	381	387	PF00069	0.251
MOD_Plk_4	458	464	PF00069	0.281
MOD_Plk_4	610	616	PF00069	0.346
MOD_Plk_4	623	629	PF00069	0.324
MOD_Plk_4	658	664	PF00069	0.287
MOD_Plk_4	683	689	PF00069	0.470
MOD_Plk_4	705	711	PF00069	0.311
MOD_Plk_4	717	723	PF00069	0.349
MOD_ProDKin_1	158	164	PF00069	0.613
MOD_ProDKin_1	443	449	PF00069	0.324
MOD_ProDKin_1	605	611	PF00069	0.311
MOD_ProDKin_1	655	661	PF00069	0.267
MOD_SUMO_for_1	52	55	PF00179	0.632
MOD_SUMO_rev_2	230	239	PF00179	0.557
TRG_DiLeu_BaEn_1	68	73	PF01217	0.641
TRG_DiLeu_BaEn_2	105	111	PF01217	0.713
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.324
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.343
TRG_ENDOCYTIC_2	197	200	PF00928	0.619
TRG_ENDOCYTIC_2	22	25	PF00928	0.487
TRG_ENDOCYTIC_2	246	249	PF00928	0.626
TRG_ENDOCYTIC_2	261	264	PF00928	0.348
TRG_ENDOCYTIC_2	501	504	PF00928	0.541
TRG_ENDOCYTIC_2	611	614	PF00928	0.324
TRG_ER_diArg_1	197	199	PF00400	0.614
TRG_ER_diArg_1	214	217	PF00400	0.499
TRG_ER_diArg_1	222	225	PF00400	0.540
TRG_NES_CRM1_1	175	185	PF08389	0.601
TRG_NLS_Bipartite_1	5	27	PF00514	0.510
TRG_NLS_MonoExtC_3	191	196	PF00514	0.576
TRG_NLS_MonoExtN_4	189	196	PF00514	0.568
TRG_NLS_MonoExtN_4	92	97	PF00514	0.758
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWP2	Leptomonas seymouri	81%	99%
A0A1X0NQK1	Trypanosomatidae	65%	100%
A0A3Q8IB88	Leishmania donovani	98%	100%
A0A422NG32	Trypanosoma rangeli	71%	100%
A4HGZ6	Leishmania braziliensis	91%	100%
A4I428	Leishmania infantum	98%	100%
D0A8X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9B0B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P27514	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	82%
Q21339	Caenorhabditis elegans	26%	100%
Q93655	Caenorhabditis elegans	20%	100%
Q9ES88	Mus musculus	22%	100%