C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7W7_LEIMA

TriTrypDb:

LmjF.28.2950 , LMJLV39_280038100 , LMJSD75_280037700

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7W7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.467
CLV_C14_Caspase3-7	293	297	PF00656	0.468
CLV_NRD_NRD_1	12	14	PF00675	0.586
CLV_NRD_NRD_1	227	229	PF00675	0.471
CLV_NRD_NRD_1	59	61	PF00675	0.556
CLV_PCSK_FUR_1	9	13	PF00082	0.714
CLV_PCSK_KEX2_1	11	13	PF00082	0.622
CLV_PCSK_KEX2_1	227	229	PF00082	0.471
CLV_PCSK_KEX2_1	43	45	PF00082	0.464
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.464
CLV_PCSK_PC7_1	7	13	PF00082	0.707
CLV_PCSK_SKI1_1	216	220	PF00082	0.491
CLV_PCSK_SKI1_1	43	47	PF00082	0.383
CLV_PCSK_SKI1_1	68	72	PF00082	0.502
DEG_Nend_UBRbox_1	1	4	PF02207	0.588
DOC_ANK_TNKS_1	12	19	PF00023	0.681
DOC_CYCLIN_RxL_1	40	50	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.561
DOC_MAPK_gen_1	43	49	PF00069	0.539
DOC_MAPK_MEF2A_6	216	225	PF00069	0.638
DOC_PP2B_LxvP_1	218	221	PF13499	0.688
DOC_PP2B_LxvP_1	45	48	PF13499	0.390
DOC_USP7_MATH_1	153	157	PF00917	0.609
DOC_USP7_MATH_1	259	263	PF00917	0.630
DOC_USP7_MATH_1	306	310	PF00917	0.686
DOC_USP7_MATH_1	325	329	PF00917	0.646
DOC_USP7_MATH_1	48	52	PF00917	0.421
DOC_USP7_MATH_2	15	21	PF00917	0.619
DOC_WW_Pin1_4	180	185	PF00397	0.546
DOC_WW_Pin1_4	248	253	PF00397	0.726
DOC_WW_Pin1_4	273	278	PF00397	0.581
DOC_WW_Pin1_4	302	307	PF00397	0.593
DOC_WW_Pin1_4	312	317	PF00397	0.628
LIG_14-3-3_CanoR_1	310	316	PF00244	0.563
LIG_BRCT_BRCA1_1	308	312	PF00533	0.720
LIG_EVH1_2	277	281	PF00568	0.659
LIG_EVH1_2	31	35	PF00568	0.526
LIG_FHA_1	112	118	PF00498	0.516
LIG_FHA_1	142	148	PF00498	0.450
LIG_FHA_1	168	174	PF00498	0.418
LIG_FHA_1	217	223	PF00498	0.605
LIG_FHA_1	25	31	PF00498	0.566
LIG_FHA_1	274	280	PF00498	0.611
LIG_FHA_2	230	236	PF00498	0.571
LIG_FHA_2	237	243	PF00498	0.564
LIG_IBAR_NPY_1	324	326	PF08397	0.529
LIG_LIR_Gen_1	191	202	PF02991	0.334
LIG_LIR_Nem_3	191	197	PF02991	0.325
LIG_SH3_3	163	169	PF00018	0.378
LIG_SH3_3	260	266	PF00018	0.743
LIG_SH3_3	272	278	PF00018	0.728
LIG_SH3_3	34	40	PF00018	0.417
LIG_SUMO_SIM_anti_2	235	242	PF11976	0.592
LIG_SUMO_SIM_par_1	235	242	PF11976	0.659
LIG_UBA3_1	34	43	PF00899	0.355
MOD_CDK_SPxxK_3	180	187	PF00069	0.531
MOD_CDK_SPxxK_3	273	280	PF00069	0.679
MOD_CK1_1	112	118	PF00069	0.500
MOD_CK1_1	248	254	PF00069	0.574
MOD_CK1_1	261	267	PF00069	0.453
MOD_CK1_1	311	317	PF00069	0.557
MOD_CK1_1	329	335	PF00069	0.591
MOD_CK2_1	229	235	PF00069	0.484
MOD_CK2_1	330	336	PF00069	0.590
MOD_Cter_Amidation	225	228	PF01082	0.473
MOD_GlcNHglycan	113	117	PF01048	0.451
MOD_GlcNHglycan	155	158	PF01048	0.572
MOD_GlcNHglycan	170	173	PF01048	0.355
MOD_GlcNHglycan	177	180	PF01048	0.437
MOD_GlcNHglycan	247	250	PF01048	0.771
MOD_GlcNHglycan	269	272	PF01048	0.693
MOD_GlcNHglycan	316	319	PF01048	0.671
MOD_GSK3_1	254	261	PF00069	0.667
MOD_GSK3_1	286	293	PF00069	0.583
MOD_GSK3_1	302	309	PF00069	0.601
MOD_GSK3_1	310	317	PF00069	0.566
MOD_GSK3_1	325	332	PF00069	0.604
MOD_GSK3_1	48	55	PF00069	0.458
MOD_N-GLC_1	326	331	PF02516	0.663
MOD_NEK2_1	245	250	PF00069	0.629
MOD_NEK2_1	267	272	PF00069	0.650
MOD_NEK2_1	286	291	PF00069	0.662
MOD_NEK2_1	308	313	PF00069	0.564
MOD_NEK2_1	52	57	PF00069	0.380
MOD_PIKK_1	254	260	PF00454	0.596
MOD_PKB_1	74	82	PF00069	0.487
MOD_Plk_2-3	236	242	PF00069	0.608
MOD_Plk_4	138	144	PF00069	0.540
MOD_Plk_4	236	242	PF00069	0.564
MOD_Plk_4	330	336	PF00069	0.589
MOD_Plk_4	48	54	PF00069	0.501
MOD_ProDKin_1	180	186	PF00069	0.534
MOD_ProDKin_1	248	254	PF00069	0.727
MOD_ProDKin_1	273	279	PF00069	0.581
MOD_ProDKin_1	302	308	PF00069	0.593
MOD_ProDKin_1	312	318	PF00069	0.629
MOD_SUMO_for_1	212	215	PF00179	0.572
TRG_ER_diArg_1	227	229	PF00400	0.718
TRG_ER_diArg_1	9	12	PF00400	0.624
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY30	Leptomonas seymouri	29%	81%
A0A0N1I3L5	Leptomonas seymouri	68%	100%
A0A1X0NQH6	Trypanosomatidae	40%	100%
A0A3S5IR49	Trypanosoma rangeli	42%	100%
A0A3S7X224	Leishmania donovani	95%	100%
A4HGZ8	Leishmania braziliensis	84%	100%
A4I430	Leishmania infantum	95%	100%
E9AV45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	68%
E9B0B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q57Y77	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	30%	73%
V5BI47	Trypanosoma cruzi	44%	100%