C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7W7_LEIMA

TriTrypDb:

LmjF.28.2950 , LMJLV39_280038100 , LMJSD75_280037700

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7W7

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.467
CLV_C14_Caspase3-7	293	297	PF00656	0.468
CLV_NRD_NRD_1	12	14	PF00675	0.586
CLV_NRD_NRD_1	227	229	PF00675	0.471
CLV_NRD_NRD_1	59	61	PF00675	0.556
CLV_PCSK_FUR_1	9	13	PF00082	0.714
CLV_PCSK_KEX2_1	11	13	PF00082	0.622
CLV_PCSK_KEX2_1	227	229	PF00082	0.471
CLV_PCSK_KEX2_1	43	45	PF00082	0.464
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.464

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY30	Leptomonas seymouri	29%	81%
A0A0N1I3L5	Leptomonas seymouri	68%	100%
A0A1X0NQH6	Trypanosomatidae	40%	100%
A0A3S5IR49	Trypanosoma rangeli	42%	100%
A0A3S7X224	Leishmania donovani	95%	100%
A4HGZ8	Leishmania braziliensis	84%	100%
A4I430	Leishmania infantum	95%	100%
E9AV45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	68%
E9B0B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q57Y77	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	30%	73%

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