Putative U5 snRNP-specific 40 kDa protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U5 snRNP-specific 40 kDa protein, putative

Species:

Leishmania major

UniProt:

Q4Q7W6_LEIMA

TriTrypDb:

LmjF.28.2960 , LMJLV39_280038200 , LMJSD75_280037800

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	2
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q7W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7W6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0030627	pre-mRNA 5'-splice site binding	6	2
GO:0036002	pre-mRNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.397
CLV_C14_Caspase3-7	67	71	PF00656	0.427
CLV_NRD_NRD_1	45	47	PF00675	0.442
CLV_NRD_NRD_1	85	87	PF00675	0.449
CLV_PCSK_FUR_1	85	89	PF00082	0.440
CLV_PCSK_KEX2_1	269	271	PF00082	0.539
CLV_PCSK_KEX2_1	45	47	PF00082	0.442
CLV_PCSK_KEX2_1	84	86	PF00082	0.454
CLV_PCSK_KEX2_1	87	89	PF00082	0.426
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.539
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.432
CLV_PCSK_PC7_1	41	47	PF00082	0.408
CLV_PCSK_PC7_1	81	87	PF00082	0.457
CLV_PCSK_SKI1_1	109	113	PF00082	0.417
CLV_PCSK_SKI1_1	14	18	PF00082	0.414
CLV_PCSK_SKI1_1	336	340	PF00082	0.516
CLV_PCSK_SKI1_1	373	377	PF00082	0.390
DEG_APCC_DBOX_1	108	116	PF00400	0.415
DEG_APCC_DBOX_1	19	27	PF00400	0.416
DEG_Nend_UBRbox_4	1	3	PF02207	0.412
DEG_SPOP_SBC_1	130	134	PF00917	0.537
DOC_ANK_TNKS_1	67	74	PF00023	0.410
DOC_CDC14_PxL_1	30	38	PF14671	0.392
DOC_CYCLIN_RxL_1	103	117	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.416
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.410
DOC_MAPK_DCC_7	103	113	PF00069	0.398
DOC_MAPK_DCC_7	9	17	PF00069	0.412
DOC_MAPK_gen_1	269	280	PF00069	0.438
DOC_MAPK_gen_1	45	51	PF00069	0.416
DOC_MAPK_MEF2A_6	273	282	PF00069	0.331
DOC_MAPK_MEF2A_6	417	426	PF00069	0.436
DOC_MAPK_MEF2A_6	9	17	PF00069	0.412
DOC_PP1_RVXF_1	107	114	PF00149	0.398
DOC_PP1_RVXF_1	12	18	PF00149	0.411
DOC_PP2B_LxvP_1	105	108	PF13499	0.397
DOC_PP2B_LxvP_1	31	34	PF13499	0.391
DOC_PP2B_LxvP_1	4	7	PF13499	0.407
DOC_USP7_MATH_1	283	287	PF00917	0.359
DOC_USP7_UBL2_3	269	273	PF12436	0.473
LIG_14-3-3_CanoR_1	103	108	PF00244	0.415
LIG_14-3-3_CanoR_1	20	24	PF00244	0.416
LIG_14-3-3_CanoR_1	336	341	PF00244	0.488
LIG_14-3-3_CanoR_1	46	52	PF00244	0.444
LIG_14-3-3_CanoR_1	58	65	PF00244	0.420
LIG_14-3-3_CanoR_1	75	79	PF00244	0.486
LIG_Actin_WH2_2	214	230	PF00022	0.501
LIG_BIR_III_4	70	74	PF00653	0.427
LIG_BRCT_BRCA1_1	253	257	PF00533	0.432
LIG_BRCT_BRCA1_1	26	30	PF00533	0.414
LIG_CSL_BTD_1	380	383	PF09270	0.500
LIG_FHA_1	100	106	PF00498	0.396
LIG_FHA_1	164	170	PF00498	0.423
LIG_FHA_1	203	209	PF00498	0.500
LIG_FHA_1	324	330	PF00498	0.417
LIG_FHA_1	343	349	PF00498	0.239
LIG_FHA_1	408	414	PF00498	0.387
LIG_FHA_2	215	221	PF00498	0.474
LIG_FHA_2	248	254	PF00498	0.379
LIG_LIR_Gen_1	27	38	PF02991	0.422
LIG_LIR_Gen_1	289	299	PF02991	0.449
LIG_LIR_Gen_1	351	362	PF02991	0.351
LIG_LIR_Nem_3	141	147	PF02991	0.417
LIG_LIR_Nem_3	27	33	PF02991	0.424
LIG_LIR_Nem_3	289	295	PF02991	0.462
LIG_LIR_Nem_3	351	357	PF02991	0.360
LIG_LYPXL_S_1	4	8	PF13949	0.410
LIG_Pex14_1	95	99	PF04695	0.398
LIG_SH2_GRB2like	144	147	PF00017	0.430
LIG_SH2_STAT5	263	266	PF00017	0.445
LIG_SH2_STAT5	432	435	PF00017	0.473
LIG_SH2_STAT5	78	81	PF00017	0.465
LIG_SH2_STAT5	96	99	PF00017	0.383
LIG_SH3_3	12	18	PF00018	0.397
LIG_SH3_3	385	391	PF00018	0.457
LIG_SH3_3	4	10	PF00018	0.410
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.416
LIG_SUMO_SIM_par_1	22	27	PF11976	0.416
LIG_SUMO_SIM_par_1	396	401	PF11976	0.439
LIG_TRFH_1	30	34	PF08558	0.411
LIG_WRPW_2	8	11	PF00400	0.415
LIG_WW_3	11	15	PF00397	0.411
MOD_CK1_1	114	120	PF00069	0.393
MOD_CK1_1	134	140	PF00069	0.564
MOD_CK1_1	202	208	PF00069	0.440
MOD_CK1_1	286	292	PF00069	0.418
MOD_GlcNHglycan	133	136	PF01048	0.499
MOD_GlcNHglycan	201	204	PF01048	0.527
MOD_GlcNHglycan	285	288	PF01048	0.471
MOD_GlcNHglycan	321	324	PF01048	0.541
MOD_GlcNHglycan	342	345	PF01048	0.533
MOD_GlcNHglycan	391	394	PF01048	0.477
MOD_GlcNHglycan	400	403	PF01048	0.493
MOD_GlcNHglycan	419	422	PF01048	0.375
MOD_GlcNHglycan	435	438	PF01048	0.251
MOD_GSK3_1	111	118	PF00069	0.618
MOD_GSK3_1	126	133	PF00069	0.470
MOD_GSK3_1	247	254	PF00069	0.434
MOD_GSK3_1	282	289	PF00069	0.357
MOD_GSK3_1	305	312	PF00069	0.412
MOD_GSK3_1	319	326	PF00069	0.464
MOD_GSK3_1	336	343	PF00069	0.269
MOD_GSK3_1	47	54	PF00069	0.437
MOD_GSK3_1	99	106	PF00069	0.414
MOD_N-GLC_1	422	427	PF02516	0.436
MOD_NEK2_1	111	116	PF00069	0.595
MOD_NEK2_1	121	126	PF00069	0.546
MOD_NEK2_1	128	133	PF00069	0.429
MOD_NEK2_1	24	29	PF00069	0.426
MOD_NEK2_1	342	347	PF00069	0.402
MOD_NEK2_1	422	427	PF00069	0.436
MOD_NEK2_1	47	52	PF00069	0.426
MOD_NEK2_1	64	69	PF00069	0.421
MOD_OFUCOSY	21	28	PF10250	0.397
MOD_PIKK_1	121	127	PF00454	0.382
MOD_PIKK_1	348	354	PF00454	0.467
MOD_PIKK_1	57	63	PF00454	0.410
MOD_PKA_2	19	25	PF00069	0.416
MOD_PKA_2	251	257	PF00069	0.444
MOD_PKA_2	57	63	PF00069	0.426
MOD_PKA_2	74	80	PF00069	0.480
MOD_PKB_1	226	234	PF00069	0.480
MOD_Plk_1	422	428	PF00069	0.480
MOD_Plk_4	116	122	PF00069	0.500
MOD_Plk_4	19	25	PF00069	0.416
MOD_Plk_4	214	220	PF00069	0.415
MOD_Plk_4	251	257	PF00069	0.421
MOD_Plk_4	26	32	PF00069	0.401
MOD_Plk_4	324	330	PF00069	0.352
MOD_Plk_4	74	80	PF00069	0.460
TRG_DiLeu_BaEn_1	372	377	PF01217	0.535
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.398
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.410
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.410
TRG_ENDOCYTIC_2	144	147	PF00928	0.430
TRG_ENDOCYTIC_2	5	8	PF00928	0.410
TRG_ENDOCYTIC_2	96	99	PF00928	0.398
TRG_ER_diArg_1	44	46	PF00400	0.438
TRG_ER_diArg_1	84	86	PF00400	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J8	Leptomonas seymouri	63%	100%
A0A1X0NQJ3	Trypanosomatidae	34%	100%
A0A3S7X1X9	Leishmania donovani	90%	100%
A0A422NG23	Trypanosoma rangeli	37%	100%
A4HGZ9	Leishmania braziliensis	87%	100%
A4I431	Leishmania infantum	93%	100%
E9B0B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O94620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%