Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7W4_LEIMA

TriTrypDb:

LmjF.28.2980 , LMJLV39_280038800 , LMJSD75_280038300

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

Q4Q7W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7W4

PDB structure(s): 7ane_ay

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	118	120	PF00082	0.361
CLV_PCSK_KEX2_1	26	28	PF00082	0.470
CLV_PCSK_KEX2_1	34	36	PF00082	0.434
CLV_PCSK_KEX2_1	75	77	PF00082	0.331
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.361
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.487
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.418
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.341
CLV_PCSK_SKI1_1	115	119	PF00082	0.364
CLV_PCSK_SKI1_1	12	16	PF00082	0.600

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J6	Leptomonas seymouri	90%	100%
A0A0S4IVN4	Bodo saltans	66%	84%
A0A1X0NQT8	Trypanosomatidae	76%	100%
A0A3Q8IDF2	Leishmania donovani	99%	100%
A0A3R7KDM2	Trypanosoma rangeli	75%	100%
A4HH01	Leishmania braziliensis	95%	100%
A4I433	Leishmania infantum	99%	100%
D0A8X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9B0C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BDQ9	Trypanosoma cruzi	75%	78%

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