Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7W3_LEIMA

TriTrypDb:

LmjF.28.2990 , LMJLV39_280038900 , LMJSD75_280038400

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7W3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.565
CLV_NRD_NRD_1	165	167	PF00675	0.615
CLV_NRD_NRD_1	17	19	PF00675	0.679
CLV_NRD_NRD_1	213	215	PF00675	0.476
CLV_PCSK_KEX2_1	165	167	PF00082	0.647
CLV_PCSK_KEX2_1	17	19	PF00082	0.647
CLV_PCSK_SKI1_1	105	109	PF00082	0.559
CLV_PCSK_SKI1_1	194	198	PF00082	0.789
CLV_Separin_Metazoa	229	233	PF03568	0.591
DEG_APCC_DBOX_1	213	221	PF00400	0.496
DEG_APCC_DBOX_1	66	74	PF00400	0.672
DOC_ANK_TNKS_1	52	59	PF00023	0.657
DOC_USP7_MATH_1	222	226	PF00917	0.592
DOC_USP7_UBL2_3	135	139	PF12436	0.528
DOC_USP7_UBL2_3	148	152	PF12436	0.556
DOC_WW_Pin1_4	187	192	PF00397	0.730
DOC_WW_Pin1_4	196	201	PF00397	0.627
DOC_WW_Pin1_4	72	77	PF00397	0.593
LIG_14-3-3_CterR_2	232	235	PF00244	0.665
LIG_FHA_1	119	125	PF00498	0.600
LIG_FHA_1	23	29	PF00498	0.765
LIG_FHA_1	52	58	PF00498	0.606
LIG_FHA_2	109	115	PF00498	0.543
LIG_FHA_2	39	45	PF00498	0.713
LIG_LIR_Gen_1	91	100	PF02991	0.585
LIG_LIR_Nem_3	130	136	PF02991	0.501
LIG_LIR_Nem_3	91	97	PF02991	0.581
LIG_NRBOX	226	232	PF00104	0.665
LIG_SH2_STAT5	161	164	PF00017	0.604
LIG_SH2_STAT5	64	67	PF00017	0.746
LIG_SH3_2	100	105	PF14604	0.584
LIG_SH3_3	185	191	PF00018	0.739
LIG_SH3_3	97	103	PF00018	0.588
LIG_SUMO_SIM_par_1	182	187	PF11976	0.798
LIG_TRAF2_1	111	114	PF00917	0.585
LIG_TRAF2_1	115	118	PF00917	0.552
LIG_TRAF2_1	209	212	PF00917	0.695
LIG_TRAF2_1	41	44	PF00917	0.708
LIG_TRAF2_2	200	205	PF00917	0.743
MOD_CDK_SPxxK_3	187	194	PF00069	0.733
MOD_CK1_1	206	212	PF00069	0.663
MOD_CK2_1	108	114	PF00069	0.551
MOD_CK2_1	206	212	PF00069	0.721
MOD_CK2_1	222	228	PF00069	0.593
MOD_CK2_1	38	44	PF00069	0.712
MOD_CK2_1	68	74	PF00069	0.647
MOD_GlcNHglycan	12	15	PF01048	0.704
MOD_GlcNHglycan	20	23	PF01048	0.670
MOD_GlcNHglycan	208	211	PF01048	0.567
MOD_GlcNHglycan	34	37	PF01048	0.492
MOD_GSK3_1	18	25	PF00069	0.662
MOD_GSK3_1	30	37	PF00069	0.523
MOD_GSK3_1	68	75	PF00069	0.621
MOD_N-GLC_1	222	227	PF02516	0.593
MOD_NEK2_1	204	209	PF00069	0.584
MOD_NEK2_1	38	43	PF00069	0.584
MOD_PIKK_1	174	180	PF00454	0.565
MOD_PKA_2	5	11	PF00069	0.764
MOD_Plk_1	174	180	PF00069	0.526
MOD_Plk_1	204	210	PF00069	0.751
MOD_Plk_1	222	228	PF00069	0.617
MOD_Plk_1	68	74	PF00069	0.614
MOD_Plk_2-3	44	50	PF00069	0.560
MOD_Plk_4	24	30	PF00069	0.552
MOD_Plk_4	34	40	PF00069	0.621
MOD_Plk_4	5	11	PF00069	0.733
MOD_ProDKin_1	187	193	PF00069	0.731
MOD_ProDKin_1	196	202	PF00069	0.626
MOD_ProDKin_1	72	78	PF00069	0.585
MOD_SUMO_rev_2	83	90	PF00179	0.603
TRG_ER_diArg_1	17	19	PF00400	0.679
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYA2	Leptomonas seymouri	59%	95%
A0A3S7X226	Leishmania donovani	89%	100%
A4HH02	Leishmania braziliensis	76%	100%
A4I434	Leishmania infantum	90%	100%
E9B0C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%