Glucosamine 6-phosphate N-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glucosamine 6-phosphate N-acetyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q7W1_LEIMA

TriTrypDb:

LmjF.28.3005 , LMJLV39_280039100 , LMJSD75_280038600

Length:

148

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0005783	endoplasmic reticulum	5	2
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	2
GO:0005794	Golgi apparatus	5	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7W1

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	11
GO:0006044	N-acetylglucosamine metabolic process	6	2
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	11
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009225	nucleotide-sugar metabolic process	4	11
GO:0009226	nucleotide-sugar biosynthetic process	5	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046349	amino sugar biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901071	glucosamine-containing compound metabolic process	5	2
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004343	glucosamine 6-phosphate N-acetyltransferase activity	7	11
GO:0005488	binding	1	2
GO:0008080	N-acetyltransferase activity	6	11
GO:0016407	acetyltransferase activity	5	11
GO:0016410	N-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0030246	carbohydrate binding	2	2
GO:0036094	small molecule binding	2	2
GO:0048029	monosaccharide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.410
CLV_NRD_NRD_1	42	44	PF00675	0.426
CLV_PCSK_KEX2_1	42	44	PF00082	0.425
CLV_PCSK_SKI1_1	116	120	PF00082	0.297
CLV_PCSK_SKI1_1	42	46	PF00082	0.608
CLV_PCSK_SKI1_1	99	103	PF00082	0.433
DEG_APCC_DBOX_1	41	49	PF00400	0.539
DEG_APCC_DBOX_1	98	106	PF00400	0.342
DEG_SPOP_SBC_1	53	57	PF00917	0.340
DOC_ANK_TNKS_1	92	99	PF00023	0.410
DOC_CDC14_PxL_1	25	33	PF14671	0.404
DOC_CYCLIN_RxL_1	93	104	PF00134	0.410
DOC_USP7_MATH_1	109	113	PF00917	0.342
DOC_USP7_MATH_1	53	57	PF00917	0.342
LIG_14-3-3_CanoR_1	110	118	PF00244	0.298
LIG_14-3-3_CanoR_1	51	61	PF00244	0.298
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_FHA_1	10	16	PF00498	0.377
LIG_FHA_1	56	62	PF00498	0.284
LIG_FHA_2	86	92	PF00498	0.342
LIG_LIR_Nem_3	112	118	PF02991	0.384
LIG_SH2_CRK	115	119	PF00017	0.277
LIG_SH2_NCK_1	129	133	PF00017	0.391
LIG_SH3_3	84	90	PF00018	0.247
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.379
LIG_SUMO_SIM_par_1	17	23	PF11976	0.465
LIG_TRAF2_1	32	35	PF00917	0.460
MOD_CK1_1	23	29	PF00069	0.435
MOD_CK1_1	55	61	PF00069	0.298
MOD_CK2_1	101	107	PF00069	0.211
MOD_CK2_1	29	35	PF00069	0.496
MOD_GlcNHglycan	26	29	PF01048	0.407
MOD_GSK3_1	20	27	PF00069	0.458
MOD_N-GLC_1	119	124	PF02516	0.298
MOD_NEK2_1	1	6	PF00069	0.554
MOD_NEK2_1	101	106	PF00069	0.313
MOD_NEK2_1	141	146	PF00069	0.386
MOD_PIKK_1	29	35	PF00454	0.455
MOD_PIKK_1	55	61	PF00454	0.342
MOD_PKA_2	109	115	PF00069	0.298
MOD_PKA_2	141	147	PF00069	0.350
MOD_Plk_4	1	7	PF00069	0.573
MOD_Plk_4	101	107	PF00069	0.211
MOD_Plk_4	141	147	PF00069	0.350
MOD_Plk_4	63	69	PF00069	0.292
MOD_SUMO_rev_2	66	74	PF00179	0.296
TRG_DiLeu_BaEn_1	17	22	PF01217	0.399
TRG_DiLeu_BaEn_4	34	40	PF01217	0.389
TRG_ENDOCYTIC_2	115	118	PF00928	0.303
TRG_ER_diArg_1	42	44	PF00400	0.462
TRG_ER_diArg_1	48	51	PF00400	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6H6	Leptomonas seymouri	69%	100%
A0A0S4IVM5	Bodo saltans	35%	98%
A0A1X0NQZ8	Trypanosomatidae	50%	100%
A0A3Q8IE29	Leishmania donovani	94%	100%
A0A3R7MEM9	Trypanosoma rangeli	42%	100%
A4HH04	Leishmania braziliensis	84%	100%
A4I436	Leishmania infantum	95%	100%
C7IZ16	Oryza sativa subsp. japonica	40%	89%
D0A8X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B0C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O93806	Candida albicans	31%	99%
P43577	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	93%
Q17427	Caenorhabditis elegans	35%	90%
Q1XDU5	Neopyropia yezoensis	29%	85%
Q54WR8	Dictyostelium discoideum	32%	94%
Q5RAL9	Pongo abelii	33%	80%
Q5U9F2	Oryza sativa subsp. japonica	39%	90%
Q5UPZ9	Acanthamoeba polyphaga mimivirus	32%	100%
Q96EK6	Homo sapiens	33%	80%
Q9JK38	Mus musculus	33%	80%
Q9LFU9	Arabidopsis thaliana	31%	99%
Q9VAI0	Drosophila melanogaster	28%	68%
V5BI73	Trypanosoma cruzi	45%	100%