LeishMANIAdb
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AB hydrolase-1 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AB hydrolase-1 domain-containing protein
Gene product:
Alpha/beta hydrolase family, putative
Species:
Leishmania major
UniProt:
Q4Q7V8_LEIMA
TriTrypDb:
LmjF.30.0010 , LMJLV39_300005100 , LMJSD75_300005100 *
Length:
425

Annotations

LeishMANIAdb annotations

Posesses a conserved AB hydrolase domain. Due to the distribution of hydrophilic / hydrophobic amino acids, it likely only has a perimembrane helix, not a full TM one.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 26
NetGPI no yes: 0, no: 26
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

Q4Q7V8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7V8

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 4
GO:0008152 metabolic process 1 4
GO:0009987 cellular process 1 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044255 cellular lipid metabolic process 3 4
GO:0071704 organic substance metabolic process 2 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016298 lipase activity 4 4
GO:0016787 hydrolase activity 2 6
GO:0016788 hydrolase activity, acting on ester bonds 3 4
GO:0034338 short-chain carboxylesterase activity 5 4
GO:0047372 acylglycerol lipase activity 5 4
GO:0052689 carboxylic ester hydrolase activity 4 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 251 255 PF00656 0.354
CLV_C14_Caspase3-7 370 374 PF00656 0.151
CLV_NRD_NRD_1 281 283 PF00675 0.469
CLV_NRD_NRD_1 98 100 PF00675 0.494
CLV_PCSK_FUR_1 96 100 PF00082 0.393
CLV_PCSK_KEX2_1 281 283 PF00082 0.480
CLV_PCSK_KEX2_1 98 100 PF00082 0.494
CLV_PCSK_SKI1_1 126 130 PF00082 0.513
CLV_PCSK_SKI1_1 189 193 PF00082 0.416
CLV_PCSK_SKI1_1 282 286 PF00082 0.488
CLV_PCSK_SKI1_1 298 302 PF00082 0.445
CLV_PCSK_SKI1_1 321 325 PF00082 0.475
CLV_PCSK_SKI1_1 66 70 PF00082 0.499
DEG_SCF_FBW7_1 169 176 PF00400 0.277
DOC_CDC14_PxL_1 132 140 PF14671 0.281
DOC_CDC14_PxL_1 15 23 PF14671 0.426
DOC_CDC14_PxL_1 287 295 PF14671 0.314
DOC_CDC14_PxL_1 322 330 PF14671 0.336
DOC_CKS1_1 174 179 PF01111 0.299
DOC_CKS1_1 330 335 PF01111 0.309
DOC_MAPK_DCC_7 205 215 PF00069 0.344
DOC_MAPK_gen_1 126 135 PF00069 0.318
DOC_MAPK_gen_1 23 31 PF00069 0.539
DOC_MAPK_MEF2A_6 126 135 PF00069 0.318
DOC_MAPK_MEF2A_6 23 31 PF00069 0.544
DOC_MAPK_MEF2A_6 321 330 PF00069 0.336
DOC_MAPK_MEF2A_6 377 386 PF00069 0.270
DOC_PP1_RVXF_1 21 27 PF00149 0.502
DOC_PP2B_LxvP_1 133 136 PF13499 0.253
DOC_PP2B_LxvP_1 385 388 PF13499 0.258
DOC_PP2B_PxIxI_1 210 216 PF00149 0.354
DOC_PP4_FxxP_1 330 333 PF00568 0.272
DOC_PP4_FxxP_1 349 352 PF00568 0.336
DOC_USP7_MATH_1 300 304 PF00917 0.308
DOC_USP7_MATH_1 97 101 PF00917 0.344
DOC_USP7_UBL2_3 66 70 PF12436 0.227
DOC_WW_Pin1_4 169 174 PF00397 0.249
DOC_WW_Pin1_4 245 250 PF00397 0.261
DOC_WW_Pin1_4 291 296 PF00397 0.240
DOC_WW_Pin1_4 329 334 PF00397 0.291
DOC_WW_Pin1_4 338 343 PF00397 0.291
DOC_WW_Pin1_4 419 424 PF00397 0.255
LIG_14-3-3_CanoR_1 321 326 PF00244 0.329
LIG_Actin_WH2_2 28 44 PF00022 0.260
LIG_EVH1_1 79 83 PF00568 0.215
LIG_FHA_1 142 148 PF00498 0.274
LIG_FHA_1 174 180 PF00498 0.264
LIG_FHA_1 183 189 PF00498 0.220
LIG_FHA_1 42 48 PF00498 0.302
LIG_FHA_2 170 176 PF00498 0.313
LIG_FHA_2 313 319 PF00498 0.254
LIG_FHA_2 406 412 PF00498 0.359
LIG_GBD_Chelix_1 35 43 PF00786 0.383
LIG_IRF3_LxIS_1 351 357 PF10401 0.198
LIG_LIR_Apic_2 327 333 PF02991 0.288
LIG_LIR_Gen_1 100 111 PF02991 0.254
LIG_LIR_Gen_1 318 326 PF02991 0.290
LIG_LIR_Gen_1 334 343 PF02991 0.171
LIG_LIR_Nem_3 100 106 PF02991 0.390
LIG_LIR_Nem_3 318 322 PF02991 0.289
LIG_LIR_Nem_3 334 340 PF02991 0.175
LIG_LIR_Nem_3 67 71 PF02991 0.247
LIG_MYND_1 291 295 PF01753 0.336
LIG_NRP_CendR_1 424 425 PF00754 0.647
LIG_Pex14_1 345 349 PF04695 0.336
LIG_Pex14_2 155 159 PF04695 0.198
LIG_REV1ctd_RIR_1 66 74 PF16727 0.231
LIG_SH2_CRK 103 107 PF00017 0.345
LIG_SH2_NCK_1 415 419 PF00017 0.261
LIG_SH2_SRC 146 149 PF00017 0.336
LIG_SH2_SRC 268 271 PF00017 0.327
LIG_SH2_STAP1 415 419 PF00017 0.400
LIG_SH2_STAT5 146 149 PF00017 0.250
LIG_SH2_STAT5 227 230 PF00017 0.276
LIG_SH2_STAT5 395 398 PF00017 0.289
LIG_SH3_3 103 109 PF00018 0.354
LIG_SH3_3 243 249 PF00018 0.297
LIG_SH3_3 74 80 PF00018 0.354
LIG_SUMO_SIM_anti_2 241 248 PF11976 0.198
LIG_TRAF2_1 201 204 PF00917 0.151
LIG_TYR_ITIM 101 106 PF00017 0.388
MOD_CDK_SPK_2 173 178 PF00069 0.290
MOD_CDK_SPK_2 419 424 PF00069 0.253
MOD_CDK_SPxK_1 419 425 PF00069 0.256
MOD_CDK_SPxxK_3 291 298 PF00069 0.228
MOD_CK1_1 153 159 PF00069 0.238
MOD_CK2_1 169 175 PF00069 0.318
MOD_CK2_1 405 411 PF00069 0.337
MOD_GlcNHglycan 141 144 PF01048 0.468
MOD_GlcNHglycan 152 155 PF01048 0.392
MOD_GlcNHglycan 180 183 PF01048 0.469
MOD_GlcNHglycan 302 305 PF01048 0.500
MOD_GlcNHglycan 356 359 PF01048 0.501
MOD_GlcNHglycan 4 8 PF01048 0.501
MOD_GlcNHglycan 84 87 PF01048 0.511
MOD_GSK3_1 137 144 PF00069 0.216
MOD_GSK3_1 169 176 PF00069 0.258
MOD_GSK3_1 178 185 PF00069 0.249
MOD_GSK3_1 257 264 PF00069 0.256
MOD_GSK3_1 268 275 PF00069 0.292
MOD_GSK3_1 368 375 PF00069 0.363
MOD_GSK3_1 41 48 PF00069 0.566
MOD_GSK3_1 82 89 PF00069 0.301
MOD_NEK2_1 122 127 PF00069 0.372
MOD_NEK2_1 150 155 PF00069 0.298
MOD_NEK2_1 272 277 PF00069 0.316
MOD_NEK2_1 354 359 PF00069 0.293
MOD_NEK2_1 372 377 PF00069 0.150
MOD_NEK2_1 41 46 PF00069 0.513
MOD_NEK2_1 5 10 PF00069 0.687
MOD_NEK2_2 395 400 PF00069 0.332
MOD_PKA_2 405 411 PF00069 0.271
MOD_PKA_2 41 47 PF00069 0.607
MOD_PKA_2 97 103 PF00069 0.312
MOD_Plk_1 372 378 PF00069 0.345
MOD_Plk_4 405 411 PF00069 0.276
MOD_Plk_4 64 70 PF00069 0.336
MOD_Plk_4 87 93 PF00069 0.277
MOD_ProDKin_1 169 175 PF00069 0.249
MOD_ProDKin_1 245 251 PF00069 0.261
MOD_ProDKin_1 291 297 PF00069 0.240
MOD_ProDKin_1 329 335 PF00069 0.291
MOD_ProDKin_1 338 344 PF00069 0.291
MOD_ProDKin_1 419 425 PF00069 0.270
TRG_DiLeu_BaEn_1 175 180 PF01217 0.336
TRG_DiLeu_BaLyEn_6 10 15 PF01217 0.511
TRG_DiLeu_BaLyEn_6 318 323 PF01217 0.327
TRG_ENDOCYTIC_2 103 106 PF00928 0.346
TRG_ENDOCYTIC_2 337 340 PF00928 0.247
TRG_ER_diArg_1 423 425 PF00400 0.305
TRG_ER_diArg_1 95 98 PF00400 0.281
TRG_Pf-PMV_PEXEL_1 236 241 PF00026 0.487

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5L7 Leptomonas seymouri 31% 93%
A0A0N1HZ60 Leptomonas seymouri 33% 92%
A0A0N1I523 Leptomonas seymouri 31% 96%
A0A0N1I5Q2 Leptomonas seymouri 31% 84%
A0A0N1I7U8 Leptomonas seymouri 65% 100%
A0A0S4JMS7 Bodo saltans 37% 98%
A0A0S4JTS9 Bodo saltans 36% 99%
A0A1X0NEW5 Trypanosomatidae 43% 100%
A0A1X0NSK7 Trypanosomatidae 43% 100%
A0A1X0NUZ6 Trypanosomatidae 27% 100%
A0A3S5H6J1 Leishmania donovani 30% 90%
A0A3S7X2V6 Leishmania donovani 91% 100%
A0A422NB49 Trypanosoma rangeli 43% 100%
A0A422NQC5 Trypanosoma rangeli 36% 97%
A4H6L0 Leishmania braziliensis 33% 87%
A4HHU6 Leishmania braziliensis 78% 100%
A4HUZ4 Leishmania infantum 30% 90%
A4I4Z6 Leishmania infantum 91% 100%
C9ZPB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9ANM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9ANM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 90%
E9B0C6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
P45524 Escherichia coli (strain K12) 29% 100%
P73879 Synechocystis sp. (strain PCC 6803 / Kazusa) 25% 100%
Q05AK6 Danio rerio 25% 100%
Q0VC00 Bos taurus 23% 100%
Q18610 Caenorhabditis elegans 25% 100%
Q24093 Drosophila melanogaster 24% 100%
Q3T0A0 Bos taurus 25% 100%
Q40863 Picea glauca 30% 93%
Q4QGZ4 Leishmania major 30% 88%
Q4QGZ5 Leishmania major 30% 100%
Q54H38 Dictyostelium discoideum 27% 100%
Q5F2F2 Mus musculus 25% 93%
Q5RK23 Rattus norvegicus 26% 100%
Q6UXT9 Homo sapiens 24% 91%
Q802V6 Danio rerio 25% 98%
Q8WU67 Homo sapiens 24% 100%
Q91ZH7 Mus musculus 25% 100%
Q96SE0 Homo sapiens 24% 100%
Q9QZC8 Mus musculus 26% 100%
V5AZF4 Trypanosoma cruzi 41% 100%
V5BBC2 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS