DUF2231 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0220), putative

Species:

Leishmania major

UniProt:

Q4Q7V5_LEIMA

TriTrypDb:

LmjF.30.0040 , LMJLV39_300005400 , LMJSD75_300005400

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q7V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7V5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007034	vacuolar transport	4	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0032509	endosome transport via multivesicular body sorting pathway	5	2
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	2
GO:0045324	late endosome to vacuole transport	5	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0071985	multivesicular body sorting pathway	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.561
CLV_PCSK_KEX2_1	133	135	PF00082	0.561
CLV_PCSK_SKI1_1	75	79	PF00082	0.487
DOC_CYCLIN_RxL_1	72	81	PF00134	0.361
DOC_MAPK_gen_1	106	115	PF00069	0.508
DOC_MAPK_MEF2A_6	106	115	PF00069	0.487
DOC_MAPK_MEF2A_6	73	80	PF00069	0.361
DOC_PP1_RVXF_1	73	80	PF00149	0.297
DOC_USP7_MATH_1	111	115	PF00917	0.436
DOC_WW_Pin1_4	60	65	PF00397	0.392
LIG_14-3-3_CanoR_1	40	44	PF00244	0.551
LIG_BIR_II_1	1	5	PF00653	0.474
LIG_CaM_NSCaTE_8	82	89	PF13499	0.252
LIG_FHA_1	119	125	PF00498	0.408
LIG_FHA_1	51	57	PF00498	0.390
LIG_GBD_Chelix_1	11	19	PF00786	0.291
LIG_LIR_Gen_1	81	90	PF02991	0.423
LIG_MYND_1	6	10	PF01753	0.475
LIG_SH2_STAP1	118	122	PF00017	0.444
LIG_SH2_STAT3	100	103	PF00017	0.510
LIG_SH2_STAT5	100	103	PF00017	0.527
LIG_SH2_STAT5	118	121	PF00017	0.264
LIG_SH3_3	3	9	PF00018	0.460
LIG_TRAF2_1	31	34	PF00917	0.551
MOD_CK2_1	60	66	PF00069	0.369
MOD_Cter_Amidation	131	134	PF01082	0.429
MOD_GSK3_1	98	105	PF00069	0.373
MOD_NEK2_1	78	83	PF00069	0.351
MOD_NEK2_1	85	90	PF00069	0.320
MOD_NEK2_1	98	103	PF00069	0.155
MOD_PKA_2	39	45	PF00069	0.551
MOD_Plk_4	111	117	PF00069	0.354
MOD_Plk_4	124	130	PF00069	0.361
MOD_Plk_4	17	23	PF00069	0.410
MOD_Plk_4	78	84	PF00069	0.416
MOD_ProDKin_1	60	66	PF00069	0.392
TRG_ER_diArg_1	133	135	PF00400	0.361
TRG_ER_diArg_1	73	76	PF00400	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM91	Leptomonas seymouri	70%	98%
A0A0S4IVS2	Bodo saltans	27%	91%
A0A1X0P3F9	Trypanosomatidae	45%	100%
A0A3Q8IDZ8	Leishmania donovani	94%	100%
A0A422N652	Trypanosoma rangeli	45%	100%
A4HHU9	Leishmania braziliensis	78%	100%
A4I4Z9	Leishmania infantum	94%	100%
E9B0C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%