MATH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MATH domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q7V4_LEIMA

TriTrypDb:

LmjF.30.0050 , LMJLV39_300005500 , LMJSD75_300005500

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7V4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.724
CLV_C14_Caspase3-7	126	130	PF00656	0.668
CLV_NRD_NRD_1	134	136	PF00675	0.545
CLV_NRD_NRD_1	141	143	PF00675	0.535
CLV_NRD_NRD_1	144	146	PF00675	0.539
CLV_NRD_NRD_1	154	156	PF00675	0.330
CLV_NRD_NRD_1	187	189	PF00675	0.626
CLV_NRD_NRD_1	40	42	PF00675	0.522
CLV_NRD_NRD_1	583	585	PF00675	0.529
CLV_NRD_NRD_1	601	603	PF00675	0.377
CLV_NRD_NRD_1	635	637	PF00675	0.515
CLV_PCSK_FUR_1	142	146	PF00082	0.562
CLV_PCSK_KEX2_1	136	138	PF00082	0.548
CLV_PCSK_KEX2_1	141	143	PF00082	0.532
CLV_PCSK_KEX2_1	144	146	PF00082	0.529
CLV_PCSK_KEX2_1	625	627	PF00082	0.548
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.548
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.532
CLV_PCSK_PC1ET2_1	625	627	PF00082	0.611
CLV_PCSK_PC7_1	137	143	PF00082	0.649
CLV_PCSK_PC7_1	621	627	PF00082	0.603
CLV_PCSK_SKI1_1	155	159	PF00082	0.624
CLV_PCSK_SKI1_1	188	192	PF00082	0.666
CLV_PCSK_SKI1_1	356	360	PF00082	0.390
CLV_PCSK_SKI1_1	402	406	PF00082	0.563
CLV_PCSK_SKI1_1	585	589	PF00082	0.510
CLV_PCSK_SKI1_1	603	607	PF00082	0.509
CLV_PCSK_SKI1_1	65	69	PF00082	0.425
CLV_PCSK_SKI1_1	685	689	PF00082	0.574
CLV_PCSK_SKI1_1	699	703	PF00082	0.497
CLV_PCSK_SKI1_1	92	96	PF00082	0.724
CLV_Separin_Metazoa	35	39	PF03568	0.524
CLV_Separin_Metazoa	43	47	PF03568	0.489
DEG_APCC_KENBOX_2	667	671	PF00400	0.558
DEG_SCF_FBW7_1	196	203	PF00400	0.773
DEG_SCF_FBW7_1	734	740	PF00400	0.726
DEG_SPOP_SBC_1	200	204	PF00917	0.660
DOC_CKS1_1	197	202	PF01111	0.771
DOC_CKS1_1	545	550	PF01111	0.648
DOC_CKS1_1	734	739	PF01111	0.724
DOC_CYCLIN_yClb5_NLxxxL_5	444	453	PF00134	0.436
DOC_MAPK_gen_1	359	367	PF00069	0.399
DOC_MAPK_gen_1	398	406	PF00069	0.492
DOC_MAPK_MEF2A_6	360	369	PF00069	0.407
DOC_MAPK_MEF2A_6	459	466	PF00069	0.335
DOC_MAPK_NFAT4_5	459	467	PF00069	0.335
DOC_MIT_MIM_1	658	668	PF04212	0.603
DOC_PP1_RVXF_1	400	407	PF00149	0.487
DOC_PP2B_LxvP_1	325	328	PF13499	0.584
DOC_PP4_FxxP_1	171	174	PF00568	0.630
DOC_PP4_FxxP_1	234	237	PF00568	0.429
DOC_PP4_FxxP_1	406	409	PF00568	0.450
DOC_USP7_MATH_1	486	490	PF00917	0.445
DOC_USP7_MATH_1	721	725	PF00917	0.648
DOC_USP7_MATH_1	737	741	PF00917	0.550
DOC_USP7_MATH_1	75	79	PF00917	0.638
DOC_USP7_UBL2_3	124	128	PF12436	0.602
DOC_USP7_UBL2_3	356	360	PF12436	0.449
DOC_USP7_UBL2_3	625	629	PF12436	0.614
DOC_USP7_UBL2_3	685	689	PF12436	0.489
DOC_WW_Pin1_4	196	201	PF00397	0.678
DOC_WW_Pin1_4	438	443	PF00397	0.335
DOC_WW_Pin1_4	517	522	PF00397	0.368
DOC_WW_Pin1_4	544	549	PF00397	0.628
DOC_WW_Pin1_4	733	738	PF00397	0.727
LIG_14-3-3_CanoR_1	175	179	PF00244	0.655
LIG_14-3-3_CanoR_1	220	228	PF00244	0.666
LIG_14-3-3_CanoR_1	255	264	PF00244	0.579
LIG_14-3-3_CanoR_1	662	667	PF00244	0.600
LIG_14-3-3_CanoR_1	86	94	PF00244	0.748
LIG_Actin_WH2_2	228	246	PF00022	0.480
LIG_Actin_WH2_2	303	320	PF00022	0.489
LIG_Actin_WH2_2	343	361	PF00022	0.392
LIG_BRCT_BRCA1_1	305	309	PF00533	0.478
LIG_BRCT_BRCA1_1	440	444	PF00533	0.335
LIG_deltaCOP1_diTrp_1	504	509	PF00928	0.335
LIG_FHA_1	230	236	PF00498	0.550
LIG_FHA_1	291	297	PF00498	0.578
LIG_FHA_1	421	427	PF00498	0.406
LIG_FHA_1	467	473	PF00498	0.335
LIG_FHA_1	532	538	PF00498	0.335
LIG_FHA_1	66	72	PF00498	0.455
LIG_FHA_1	750	756	PF00498	0.670
LIG_FHA_2	124	130	PF00498	0.685
LIG_FHA_2	193	199	PF00498	0.765
LIG_FHA_2	257	263	PF00498	0.602
LIG_FHA_2	310	316	PF00498	0.566
LIG_FHA_2	455	461	PF00498	0.447
LIG_FHA_2	525	531	PF00498	0.447
LIG_FHA_2	547	553	PF00498	0.753
LIG_FHA_2	592	598	PF00498	0.559
LIG_FHA_2	599	605	PF00498	0.562
LIG_FHA_2	625	631	PF00498	0.614
LIG_FHA_2	64	70	PF00498	0.533
LIG_FHA_2	85	91	PF00498	0.639
LIG_FHA_2	93	99	PF00498	0.610
LIG_GBD_Chelix_1	361	369	PF00786	0.491
LIG_GBD_Chelix_1	694	702	PF00786	0.623
LIG_LIR_Apic_2	232	237	PF02991	0.440
LIG_LIR_Gen_1	17	28	PF02991	0.535
LIG_LIR_Gen_1	335	346	PF02991	0.395
LIG_LIR_Gen_1	375	386	PF02991	0.454
LIG_LIR_Gen_1	418	429	PF02991	0.429
LIG_LIR_Gen_1	443	454	PF02991	0.428
LIG_LIR_Gen_1	495	504	PF02991	0.384
LIG_LIR_Gen_1	506	516	PF02991	0.277
LIG_LIR_Gen_1	610	620	PF02991	0.549
LIG_LIR_Gen_1	724	734	PF02991	0.732
LIG_LIR_Gen_1	752	762	PF02991	0.709
LIG_LIR_Nem_3	17	23	PF02991	0.481
LIG_LIR_Nem_3	375	381	PF02991	0.444
LIG_LIR_Nem_3	418	424	PF02991	0.426
LIG_LIR_Nem_3	443	449	PF02991	0.355
LIG_LIR_Nem_3	506	512	PF02991	0.335
LIG_LIR_Nem_3	610	616	PF02991	0.552
LIG_LIR_Nem_3	62	67	PF02991	0.448
LIG_LIR_Nem_3	724	729	PF02991	0.697
LIG_LIR_Nem_3	752	757	PF02991	0.684
LIG_SH2_CRK	165	169	PF00017	0.536
LIG_SH2_CRK	20	24	PF00017	0.509
LIG_SH2_CRK	64	68	PF00017	0.477
LIG_SH2_STAP1	726	730	PF00017	0.697
LIG_SH2_STAT3	465	468	PF00017	0.335
LIG_SH2_STAT5	465	468	PF00017	0.319
LIG_SH2_STAT5	56	59	PF00017	0.569
LIG_SH3_2	170	175	PF14604	0.705
LIG_SH3_3	167	173	PF00018	0.619
LIG_SH3_3	175	181	PF00018	0.700
LIG_SH3_3	731	737	PF00018	0.688
LIG_SH3_4	356	363	PF00018	0.444
LIG_SH3_CIN85_PxpxPR_1	170	175	PF14604	0.593
LIG_SUMO_SIM_anti_2	364	369	PF11976	0.575
LIG_SUMO_SIM_par_1	236	242	PF11976	0.547
LIG_SUMO_SIM_par_1	538	543	PF11976	0.401
LIG_TYR_ITSM	16	23	PF00017	0.491
LIG_UBA3_1	36	42	PF00899	0.550
LIG_UBA3_1	453	459	PF00899	0.335
LIG_UBA3_1	571	579	PF00899	0.630
LIG_WRC_WIRS_1	421	426	PF05994	0.384
LIG_WW_3	172	176	PF00397	0.736
MOD_CDK_SPxxK_3	544	551	PF00069	0.707
MOD_CK1_1	201	207	PF00069	0.742
MOD_CK1_1	218	224	PF00069	0.622
MOD_CK1_1	239	245	PF00069	0.454
MOD_CK1_1	320	326	PF00069	0.612
MOD_CK1_1	348	354	PF00069	0.510
MOD_CK1_1	430	436	PF00069	0.447
MOD_CK1_1	499	505	PF00069	0.340
MOD_CK1_1	5	11	PF00069	0.553
MOD_CK2_1	192	198	PF00069	0.680
MOD_CK2_1	256	262	PF00069	0.519
MOD_CK2_1	454	460	PF00069	0.447
MOD_CK2_1	546	552	PF00069	0.740
MOD_CK2_1	591	597	PF00069	0.599
MOD_CK2_1	624	630	PF00069	0.610
MOD_CK2_1	721	727	PF00069	0.644
MOD_CK2_1	737	743	PF00069	0.594
MOD_GlcNHglycan	248	251	PF01048	0.472
MOD_GlcNHglycan	498	501	PF01048	0.411
MOD_GlcNHglycan	72	75	PF01048	0.499
MOD_GlcNHglycan	77	80	PF01048	0.589
MOD_GSK3_1	10	17	PF00069	0.548
MOD_GSK3_1	118	125	PF00069	0.670
MOD_GSK3_1	192	199	PF00069	0.732
MOD_GSK3_1	200	207	PF00069	0.674
MOD_GSK3_1	215	222	PF00069	0.476
MOD_GSK3_1	291	298	PF00069	0.684
MOD_GSK3_1	454	461	PF00069	0.447
MOD_GSK3_1	492	499	PF00069	0.337
MOD_GSK3_1	603	610	PF00069	0.573
MOD_GSK3_1	63	70	PF00069	0.529
MOD_GSK3_1	658	665	PF00069	0.581
MOD_GSK3_1	721	728	PF00069	0.630
MOD_GSK3_1	733	740	PF00069	0.620
MOD_GSK3_1	745	752	PF00069	0.605
MOD_N-GLC_1	372	377	PF02516	0.446
MOD_N-GLC_1	427	432	PF02516	0.335
MOD_N-GLC_1	84	89	PF02516	0.722
MOD_NEK2_1	14	19	PF00069	0.508
MOD_NEK2_1	216	221	PF00069	0.710
MOD_NEK2_1	309	314	PF00069	0.450
MOD_NEK2_1	317	322	PF00069	0.427
MOD_NEK2_1	36	41	PF00069	0.517
MOD_NEK2_1	449	454	PF00069	0.335
MOD_NEK2_1	466	471	PF00069	0.335
MOD_NEK2_1	476	481	PF00069	0.319
MOD_NEK2_1	63	68	PF00069	0.515
MOD_NEK2_2	10	15	PF00069	0.491
MOD_NEK2_2	174	179	PF00069	0.651
MOD_NEK2_2	420	425	PF00069	0.497
MOD_PIKK_1	262	268	PF00454	0.441
MOD_PIKK_1	492	498	PF00454	0.335
MOD_PIKK_1	499	505	PF00454	0.335
MOD_PIKK_1	5	11	PF00454	0.553
MOD_PIKK_1	603	609	PF00454	0.596
MOD_PIKK_1	624	630	PF00454	0.610
MOD_PIKK_1	678	684	PF00454	0.534
MOD_PIKK_1	711	717	PF00454	0.612
MOD_PK_1	725	731	PF00069	0.684
MOD_PKA_1	155	161	PF00069	0.639
MOD_PKA_1	688	694	PF00069	0.535
MOD_PKA_2	174	180	PF00069	0.670
MOD_PKA_2	219	225	PF00069	0.714
MOD_PKA_2	254	260	PF00069	0.594
MOD_PKA_2	607	613	PF00069	0.559
MOD_PKA_2	85	91	PF00069	0.728
MOD_PKB_1	135	143	PF00069	0.651
MOD_PKB_1	619	627	PF00069	0.603
MOD_Plk_1	10	16	PF00069	0.373
MOD_Plk_1	363	369	PF00069	0.545
MOD_Plk_1	427	433	PF00069	0.335
MOD_Plk_1	486	492	PF00069	0.335
MOD_Plk_1	529	535	PF00069	0.408
MOD_Plk_1	749	755	PF00069	0.678
MOD_Plk_2-3	531	537	PF00069	0.335
MOD_Plk_2-3	745	751	PF00069	0.712
MOD_Plk_4	10	16	PF00069	0.489
MOD_Plk_4	320	326	PF00069	0.601
MOD_Plk_4	345	351	PF00069	0.488
MOD_Plk_4	363	369	PF00069	0.388
MOD_Plk_4	67	73	PF00069	0.463
MOD_Plk_4	725	731	PF00069	0.684
MOD_ProDKin_1	196	202	PF00069	0.679
MOD_ProDKin_1	438	444	PF00069	0.335
MOD_ProDKin_1	517	523	PF00069	0.368
MOD_ProDKin_1	544	550	PF00069	0.637
MOD_ProDKin_1	733	739	PF00069	0.725
MOD_SUMO_for_1	587	590	PF00179	0.537
MOD_SUMO_for_1	666	669	PF00179	0.501
MOD_SUMO_rev_2	116	126	PF00179	0.732
MOD_SUMO_rev_2	148	158	PF00179	0.585
MOD_SUMO_rev_2	25	32	PF00179	0.647
MOD_SUMO_rev_2	323	333	PF00179	0.626
MOD_SUMO_rev_2	592	601	PF00179	0.607
MOD_SUMO_rev_2	618	627	PF00179	0.600
MOD_SUMO_rev_2	654	661	PF00179	0.565
MOD_SUMO_rev_2	691	701	PF00179	0.534
TRG_DiLeu_BaEn_1	147	152	PF01217	0.536
TRG_ENDOCYTIC_2	165	168	PF00928	0.593
TRG_ENDOCYTIC_2	20	23	PF00928	0.474
TRG_ENDOCYTIC_2	613	616	PF00928	0.551
TRG_ENDOCYTIC_2	64	67	PF00928	0.477
TRG_ENDOCYTIC_2	726	729	PF00928	0.707
TRG_ER_diArg_1	142	145	PF00400	0.620
TRG_NES_CRM1_1	315	330	PF08389	0.462
TRG_NES_CRM1_1	531	543	PF08389	0.378
TRG_NLS_MonoCore_2	140	145	PF00514	0.613
TRG_NLS_MonoExtC_3	140	145	PF00514	0.613
TRG_NLS_MonoExtC_3	583	588	PF00514	0.491
TRG_NLS_MonoExtN_4	400	406	PF00514	0.500
TRG_NLS_MonoExtN_4	584	589	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.778
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG40	Leptomonas seymouri	88%	100%
A0A1X0P2N7	Trypanosomatidae	60%	100%
A0A3Q8IJ33	Leishmania donovani	99%	100%
A0A3R7ME83	Trypanosoma rangeli	56%	98%
A4HHV0	Leishmania braziliensis	94%	100%
A4I500	Leishmania infantum	99%	100%
C9ZQE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9B0D0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
V5BLE1	Trypanosoma cruzi	57%	99%