Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7V1_LEIMA

TriTrypDb:

LmjF.30.0200 , LMJLV39_300007100 , LMJSD75_300007000

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7V1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.468
CLV_C14_Caspase3-7	305	309	PF00656	0.560
CLV_C14_Caspase3-7	34	38	PF00656	0.423
CLV_C14_Caspase3-7	401	405	PF00656	0.739
CLV_NRD_NRD_1	188	190	PF00675	0.653
CLV_NRD_NRD_1	276	278	PF00675	0.623
CLV_NRD_NRD_1	319	321	PF00675	0.517
CLV_NRD_NRD_1	443	445	PF00675	0.582
CLV_NRD_NRD_1	493	495	PF00675	0.532
CLV_PCSK_KEX2_1	187	189	PF00082	0.587
CLV_PCSK_KEX2_1	276	278	PF00082	0.623
CLV_PCSK_KEX2_1	319	321	PF00082	0.515
CLV_PCSK_KEX2_1	338	340	PF00082	0.513
CLV_PCSK_KEX2_1	484	486	PF00082	0.543
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.513
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.543
CLV_PCSK_SKI1_1	121	125	PF00082	0.564
CLV_PCSK_SKI1_1	236	240	PF00082	0.580
CLV_PCSK_SKI1_1	319	323	PF00082	0.497
CLV_PCSK_SKI1_1	473	477	PF00082	0.464
CLV_PCSK_SKI1_1	485	489	PF00082	0.432
CLV_PCSK_SKI1_1	89	93	PF00082	0.460
CLV_Separin_Metazoa	133	137	PF03568	0.571
DEG_APCC_DBOX_1	443	451	PF00400	0.589
DEG_Kelch_Keap1_1	389	394	PF01344	0.649
DEG_SCF_FBW7_2	275	282	PF00400	0.620
DOC_CDC14_PxL_1	221	229	PF14671	0.550
DOC_CYCLIN_RxL_1	481	492	PF00134	0.507
DOC_CYCLIN_RxL_1	86	93	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.559
DOC_MAPK_MEF2A_6	456	465	PF00069	0.422
DOC_PP2B_LxvP_1	238	241	PF13499	0.458
DOC_PP4_MxPP_1	242	245	PF00568	0.616
DOC_USP7_MATH_1	163	167	PF00917	0.682
DOC_USP7_MATH_1	178	182	PF00917	0.610
DOC_USP7_MATH_1	353	357	PF00917	0.583
DOC_USP7_MATH_1	39	43	PF00917	0.574
DOC_USP7_MATH_1	398	402	PF00917	0.697
DOC_USP7_MATH_1	408	412	PF00917	0.663
DOC_USP7_MATH_1	420	424	PF00917	0.703
DOC_USP7_MATH_1	82	86	PF00917	0.565
DOC_USP7_UBL2_3	473	477	PF12436	0.507
DOC_WW_Pin1_4	253	258	PF00397	0.638
DOC_WW_Pin1_4	275	280	PF00397	0.627
DOC_WW_Pin1_4	78	83	PF00397	0.556
DOC_WW_Pin1_4	9	14	PF00397	0.676
LIG_14-3-3_CanoR_1	144	149	PF00244	0.350
LIG_14-3-3_CanoR_1	319	329	PF00244	0.550
LIG_14-3-3_CanoR_1	331	340	PF00244	0.368
LIG_Actin_WH2_2	458	475	PF00022	0.511
LIG_BIR_III_2	129	133	PF00653	0.400
LIG_CSL_BTD_1	225	228	PF09270	0.542
LIG_EH1_1	432	440	PF00400	0.585
LIG_EVH1_1	240	244	PF00568	0.561
LIG_FHA_1	151	157	PF00498	0.651
LIG_FHA_1	17	23	PF00498	0.569
LIG_FHA_1	259	265	PF00498	0.575
LIG_FHA_1	276	282	PF00498	0.399
LIG_FHA_1	332	338	PF00498	0.479
LIG_FHA_1	430	436	PF00498	0.475
LIG_FHA_1	456	462	PF00498	0.498
LIG_FHA_1	477	483	PF00498	0.470
LIG_FHA_2	1	7	PF00498	0.564
LIG_FHA_2	112	118	PF00498	0.588
LIG_FHA_2	323	329	PF00498	0.512
LIG_FHA_2	352	358	PF00498	0.502
LIG_FHA_2	366	372	PF00498	0.528
LIG_LIR_Gen_1	209	217	PF02991	0.495
LIG_LIR_Nem_3	209	215	PF02991	0.496
LIG_LIR_Nem_3	260	265	PF02991	0.583
LIG_LIR_Nem_3	288	292	PF02991	0.456
LIG_LIR_Nem_3	369	375	PF02991	0.524
LIG_Pex14_2	212	216	PF04695	0.559
LIG_Pex14_2	476	480	PF04695	0.467
LIG_PTB_Apo_2	109	116	PF02174	0.531
LIG_PTB_Apo_2	210	217	PF02174	0.517
LIG_SH2_NCK_1	208	212	PF00017	0.535
LIG_SH2_SRC	208	211	PF00017	0.502
LIG_SH2_STAP1	208	212	PF00017	0.529
LIG_SH2_STAP1	64	68	PF00017	0.558
LIG_SH2_STAT5	23	26	PF00017	0.444
LIG_SH3_3	10	16	PF00018	0.677
LIG_SH3_3	125	131	PF00018	0.610
LIG_SH3_3	222	228	PF00018	0.490
LIG_SH3_3	238	244	PF00018	0.453
LIG_SH3_3	382	388	PF00018	0.509
LIG_SH3_3	43	49	PF00018	0.450
LIG_SUMO_SIM_par_1	152	157	PF11976	0.632
LIG_SUMO_SIM_par_1	175	181	PF11976	0.658
LIG_SUMO_SIM_par_1	2	8	PF11976	0.521
MOD_CK1_1	253	259	PF00069	0.541
MOD_CK1_1	351	357	PF00069	0.591
MOD_CK1_1	389	395	PF00069	0.693
MOD_CK2_1	158	164	PF00069	0.703
MOD_CK2_1	28	34	PF00069	0.601
MOD_CK2_1	285	291	PF00069	0.512
MOD_CK2_1	351	357	PF00069	0.524
MOD_CK2_1	365	371	PF00069	0.575
MOD_GlcNHglycan	164	168	PF01048	0.557
MOD_GlcNHglycan	37	40	PF01048	0.497
MOD_GlcNHglycan	400	403	PF01048	0.733
MOD_GlcNHglycan	422	425	PF01048	0.719
MOD_GSK3_1	158	165	PF00069	0.567
MOD_GSK3_1	24	31	PF00069	0.379
MOD_GSK3_1	319	326	PF00069	0.582
MOD_GSK3_1	344	351	PF00069	0.498
MOD_GSK3_1	35	42	PF00069	0.549
MOD_GSK3_1	398	405	PF00069	0.680
MOD_GSK3_1	476	483	PF00069	0.543
MOD_GSK3_1	5	12	PF00069	0.597
MOD_GSK3_1	60	67	PF00069	0.532
MOD_GSK3_1	78	85	PF00069	0.522
MOD_N-GLC_1	111	116	PF02516	0.569
MOD_NEK2_1	24	29	PF00069	0.521
MOD_NEK2_1	258	263	PF00069	0.539
MOD_NEK2_1	285	290	PF00069	0.506
MOD_NEK2_1	35	40	PF00069	0.554
MOD_NEK2_1	429	434	PF00069	0.549
MOD_NEK2_1	450	455	PF00069	0.535
MOD_NEK2_1	476	481	PF00069	0.466
MOD_NEK2_1	60	65	PF00069	0.412
MOD_NEK2_1	83	88	PF00069	0.508
MOD_PIKK_1	16	22	PF00454	0.613
MOD_PIKK_1	189	195	PF00454	0.686
MOD_PIKK_1	245	251	PF00454	0.427
MOD_PIKK_1	344	350	PF00454	0.597
MOD_PIKK_1	39	45	PF00454	0.558
MOD_PKA_1	319	325	PF00069	0.586
MOD_PKA_2	143	149	PF00069	0.589
MOD_PKA_2	319	325	PF00069	0.565
MOD_PKA_2	330	336	PF00069	0.437
MOD_PKA_2	373	379	PF00069	0.459
MOD_PKA_2	455	461	PF00069	0.550
MOD_PKB_1	187	195	PF00069	0.656
MOD_Plk_1	111	117	PF00069	0.522
MOD_Plk_4	18	24	PF00069	0.581
MOD_Plk_4	226	232	PF00069	0.517
MOD_Plk_4	83	89	PF00069	0.459
MOD_ProDKin_1	253	259	PF00069	0.627
MOD_ProDKin_1	275	281	PF00069	0.622
MOD_ProDKin_1	78	84	PF00069	0.555
MOD_ProDKin_1	9	15	PF00069	0.672
MOD_SUMO_for_1	159	162	PF00179	0.601
MOD_SUMO_rev_2	29	38	PF00179	0.629
MOD_SUMO_rev_2	468	475	PF00179	0.456
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.617
TRG_ENDOCYTIC_2	208	211	PF00928	0.521
TRG_ENDOCYTIC_2	289	292	PF00928	0.455
TRG_ER_diArg_1	187	189	PF00400	0.625
TRG_ER_diArg_1	275	277	PF00400	0.605
TRG_ER_diArg_1	313	316	PF00400	0.408
TRG_ER_diArg_1	319	321	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH5	Leptomonas seymouri	66%	84%
A0A0S4JF66	Bodo saltans	27%	98%
A0A1X0P302	Trypanosomatidae	34%	96%
A0A3R7LKS4	Trypanosoma rangeli	35%	97%
A0A3S5H7M2	Leishmania donovani	95%	100%
A4HHW3	Leishmania braziliensis	82%	100%
A4I513	Leishmania infantum	95%	100%
C9ZQG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
E9B0E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BLF7	Trypanosoma cruzi	35%	89%