Putative mitotic cyclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitotic cyclin, putative

Species:

Leishmania major

UniProt:

Q4Q7U8_LEIMA

TriTrypDb:

LmjF.30.0080 , LMJLV39_300005800 , LMJSD75_300005800

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	7	2
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2
GO:1902554	serine/threonine protein kinase complex	6	2
GO:1902911	protein kinase complex	5	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4Q7U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7U8

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	2
GO:0001932	regulation of protein phosphorylation	7	2
GO:0009987	cellular process	1	2
GO:0019220	regulation of phosphate metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0022402	cell cycle process	2	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031399	regulation of protein modification process	6	2
GO:0042325	regulation of phosphorylation	7	2
GO:0043549	regulation of kinase activity	5	2
GO:0044770	cell cycle phase transition	3	2
GO:0044772	mitotic cell cycle phase transition	4	2
GO:0045859	regulation of protein kinase activity	6	2
GO:0050789	regulation of biological process	2	2
GO:0050790	regulation of catalytic activity	3	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051174	regulation of phosphorus metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051338	regulation of transferase activity	4	2
GO:0051726	regulation of cell cycle	4	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0071900	regulation of protein serine/threonine kinase activity	7	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903047	mitotic cell cycle process	3	2
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	2

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	2
GO:0019207	kinase regulator activity	3	2
GO:0019887	protein kinase regulator activity	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0098772	molecular function regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.298
CLV_NRD_NRD_1	283	285	PF00675	0.605
CLV_NRD_NRD_1	417	419	PF00675	0.405
CLV_NRD_NRD_1	72	74	PF00675	0.483
CLV_PCSK_KEX2_1	283	285	PF00082	0.590
CLV_PCSK_KEX2_1	359	361	PF00082	0.388
CLV_PCSK_KEX2_1	417	419	PF00082	0.405
CLV_PCSK_KEX2_1	72	74	PF00082	0.558
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.326
CLV_PCSK_SKI1_1	283	287	PF00082	0.549
CLV_PCSK_SKI1_1	359	363	PF00082	0.379
CLV_PCSK_SKI1_1	388	392	PF00082	0.412
CLV_PCSK_SKI1_1	42	46	PF00082	0.517
CLV_PCSK_SKI1_1	51	55	PF00082	0.462
CLV_PCSK_SKI1_1	73	77	PF00082	0.522
DEG_APCC_DBOX_1	264	272	PF00400	0.386
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.490
DOC_MAPK_MEF2A_6	218	225	PF00069	0.381
DOC_MAPK_MEF2A_6	89	97	PF00069	0.288
DOC_USP7_MATH_1	203	207	PF00917	0.412
DOC_USP7_UBL2_3	355	359	PF12436	0.561
DOC_USP7_UBL2_3	47	51	PF12436	0.347
DOC_WW_Pin1_4	349	354	PF00397	0.457
LIG_14-3-3_CanoR_1	218	224	PF00244	0.437
LIG_14-3-3_CanoR_1	265	275	PF00244	0.416
LIG_14-3-3_CanoR_1	333	338	PF00244	0.434
LIG_14-3-3_CanoR_1	89	94	PF00244	0.356
LIG_14-3-3_CterR_2	417	420	PF00244	0.586
LIG_Actin_WH2_2	126	143	PF00022	0.281
LIG_Actin_WH2_2	75	91	PF00022	0.281
LIG_BIR_II_1	1	5	PF00653	0.453
LIG_BRCT_BRCA1_1	16	20	PF00533	0.489
LIG_eIF4E_1	181	187	PF01652	0.391
LIG_EVH1_1	400	404	PF00568	0.583
LIG_EVH1_2	403	407	PF00568	0.581
LIG_FHA_1	172	178	PF00498	0.306
LIG_FHA_1	267	273	PF00498	0.387
LIG_FHA_1	320	326	PF00498	0.385
LIG_FHA_1	372	378	PF00498	0.585
LIG_FHA_1	74	80	PF00498	0.281
LIG_FHA_1	90	96	PF00498	0.281
LIG_FHA_2	295	301	PF00498	0.435
LIG_FHA_2	325	331	PF00498	0.321
LIG_FHA_2	391	397	PF00498	0.643
LIG_IRF3_LxIS_1	365	372	PF10401	0.573
LIG_LIR_Apic_2	36	41	PF02991	0.518
LIG_LIR_Gen_1	219	225	PF02991	0.402
LIG_LIR_Gen_1	250	261	PF02991	0.315
LIG_LIR_Gen_1	303	310	PF02991	0.363
LIG_LIR_Gen_1	312	321	PF02991	0.351
LIG_LIR_Gen_1	330	338	PF02991	0.232
LIG_LIR_Gen_1	43	53	PF02991	0.300
LIG_LIR_Nem_3	219	223	PF02991	0.404
LIG_LIR_Nem_3	250	256	PF02991	0.311
LIG_LIR_Nem_3	303	307	PF02991	0.380
LIG_LIR_Nem_3	312	317	PF02991	0.394
LIG_LIR_Nem_3	330	334	PF02991	0.282
LIG_LIR_Nem_3	339	344	PF02991	0.354
LIG_PCNA_PIPBox_1	232	241	PF02747	0.389
LIG_Pex14_2	256	260	PF04695	0.400
LIG_PTB_Apo_2	175	182	PF02174	0.303
LIG_PTB_Phospho_1	175	181	PF10480	0.302
LIG_SH2_CRK	335	339	PF00017	0.434
LIG_SH2_PTP2	304	307	PF00017	0.393
LIG_SH2_SRC	170	173	PF00017	0.402
LIG_SH2_SRC	38	41	PF00017	0.458
LIG_SH2_STAT5	103	106	PF00017	0.364
LIG_SH2_STAT5	170	173	PF00017	0.415
LIG_SH2_STAT5	181	184	PF00017	0.271
LIG_SH2_STAT5	304	307	PF00017	0.393
LIG_SH2_STAT5	337	340	PF00017	0.434
LIG_SH2_STAT5	413	416	PF00017	0.599
LIG_SH3_3	398	404	PF00018	0.623
LIG_SUMO_SIM_anti_2	2	10	PF11976	0.464
LIG_SUMO_SIM_anti_2	206	211	PF11976	0.374
LIG_SUMO_SIM_anti_2	219	227	PF11976	0.358
LIG_SUMO_SIM_par_1	142	148	PF11976	0.323
LIG_SUMO_SIM_par_1	203	208	PF11976	0.363
LIG_UBA3_1	44	51	PF00899	0.323
MOD_CDC14_SPxK_1	352	355	PF00782	0.594
MOD_CDK_SPxK_1	349	355	PF00069	0.460
MOD_CK1_1	12	18	PF00069	0.493
MOD_CK1_1	227	233	PF00069	0.414
MOD_CK1_1	247	253	PF00069	0.247
MOD_CK1_1	289	295	PF00069	0.418
MOD_CK1_1	309	315	PF00069	0.388
MOD_CK1_1	336	342	PF00069	0.342
MOD_CK1_1	57	63	PF00069	0.382
MOD_CK2_1	192	198	PF00069	0.398
MOD_CK2_1	294	300	PF00069	0.442
MOD_CK2_1	324	330	PF00069	0.322
MOD_CK2_1	390	396	PF00069	0.635
MOD_GlcNHglycan	239	242	PF01048	0.615
MOD_GlcNHglycan	311	314	PF01048	0.584
MOD_GlcNHglycan	370	374	PF01048	0.389
MOD_GSK3_1	244	251	PF00069	0.493
MOD_GSK3_1	288	295	PF00069	0.430
MOD_GSK3_1	6	13	PF00069	0.447
MOD_NEK2_1	192	197	PF00069	0.454
MOD_NEK2_1	224	229	PF00069	0.327
MOD_NEK2_1	239	244	PF00069	0.384
MOD_NEK2_1	245	250	PF00069	0.453
MOD_NEK2_1	255	260	PF00069	0.336
MOD_NEK2_1	286	291	PF00069	0.348
MOD_NEK2_1	369	374	PF00069	0.582
MOD_NEK2_1	382	387	PF00069	0.536
MOD_NEK2_1	407	412	PF00069	0.631
MOD_NEK2_1	62	67	PF00069	0.281
MOD_NEK2_1	88	93	PF00069	0.281
MOD_NEK2_1	99	104	PF00069	0.281
MOD_PIKK_1	192	198	PF00454	0.425
MOD_PIKK_1	289	295	PF00454	0.480
MOD_PIKK_1	319	325	PF00454	0.386
MOD_PIKK_1	371	377	PF00454	0.598
MOD_PKA_2	300	306	PF00069	0.393
MOD_PKA_2	407	413	PF00069	0.581
MOD_PKA_2	88	94	PF00069	0.364
MOD_Plk_1	57	63	PF00069	0.335
MOD_Plk_4	172	178	PF00069	0.315
MOD_Plk_4	219	225	PF00069	0.432
MOD_Plk_4	248	254	PF00069	0.428
MOD_Plk_4	300	306	PF00069	0.384
MOD_Plk_4	333	339	PF00069	0.434
MOD_Plk_4	40	46	PF00069	0.450
MOD_Plk_4	62	68	PF00069	0.266
MOD_Plk_4	99	105	PF00069	0.335
MOD_ProDKin_1	349	355	PF00069	0.460
MOD_SUMO_for_1	128	131	PF00179	0.281
MOD_SUMO_for_1	34	37	PF00179	0.547
MOD_SUMO_rev_2	352	361	PF00179	0.530
MOD_SUMO_rev_2	36	44	PF00179	0.459
TRG_ENDOCYTIC_2	181	184	PF00928	0.305
TRG_ENDOCYTIC_2	304	307	PF00928	0.393
TRG_ENDOCYTIC_2	335	338	PF00928	0.434
TRG_ER_diArg_1	283	285	PF00400	0.405
TRG_ER_diArg_1	417	419	PF00400	0.605
TRG_ER_diArg_1	72	74	PF00400	0.328
TRG_NES_CRM1_1	136	148	PF08389	0.299
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P2	Leptomonas seymouri	79%	100%
A0A0S4JZZ8	Bodo saltans	46%	99%
A0A1X0P2F8	Trypanosomatidae	44%	100%
A0A3Q8IHJ8	Leishmania donovani	96%	100%
A4HHV3	Leishmania braziliensis	90%	100%
A4I503	Leishmania infantum	96%	100%
C9ZQF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	93%
E9B0D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%