rRNA adenine N(6)-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal RNA adenine dimethylase family protein, putative

Species:

Leishmania major

UniProt:

Q4Q7U7_LEIMA

TriTrypDb:

LmjF.30.0210 , LMJLV39_300007300 , LMJSD75_300007200

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q7U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7U7

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0001510	RNA methylation	4	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0031167	rRNA methylation	5	2
GO:0032259	methylation	2	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity	6	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008173	RNA methyltransferase activity	4	12
GO:0008649	rRNA methyltransferase activity	5	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016433	rRNA (adenine) methyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140102	catalytic activity, acting on a rRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.626
CLV_NRD_NRD_1	272	274	PF00675	0.250
CLV_NRD_NRD_1	298	300	PF00675	0.541
CLV_NRD_NRD_1	43	45	PF00675	0.675
CLV_PCSK_KEX2_1	137	139	PF00082	0.270
CLV_PCSK_KEX2_1	43	45	PF00082	0.783
CLV_PCSK_KEX2_1	54	56	PF00082	0.533
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.270
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.645
CLV_PCSK_SKI1_1	181	185	PF00082	0.274
CLV_PCSK_SKI1_1	23	27	PF00082	0.582
CLV_PCSK_SKI1_1	268	272	PF00082	0.250
CLV_PCSK_SKI1_1	30	34	PF00082	0.608
CLV_PCSK_SKI1_1	315	319	PF00082	0.745
CLV_PCSK_SKI1_1	335	339	PF00082	0.297
DEG_APCC_DBOX_1	334	342	PF00400	0.436
DEG_SPOP_SBC_1	316	320	PF00917	0.673
DOC_CKS1_1	140	145	PF01111	0.474
DOC_CKS1_1	183	188	PF01111	0.555
DOC_CYCLIN_RxL_1	265	272	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.450
DOC_MAPK_DCC_7	252	260	PF00069	0.465
DOC_MAPK_gen_1	3	12	PF00069	0.589
DOC_MAPK_gen_1	350	359	PF00069	0.279
DOC_MAPK_MEF2A_6	252	260	PF00069	0.450
DOC_MAPK_MEF2A_6	96	104	PF00069	0.450
DOC_PP1_RVXF_1	119	126	PF00149	0.444
DOC_PP1_RVXF_1	21	28	PF00149	0.579
DOC_PP4_FxxP_1	236	239	PF00568	0.450
DOC_USP7_MATH_1	143	147	PF00917	0.490
DOC_USP7_MATH_1	173	177	PF00917	0.449
DOC_USP7_MATH_1	223	227	PF00917	0.461
DOC_USP7_MATH_1	316	320	PF00917	0.686
DOC_USP7_MATH_1	323	327	PF00917	0.654
DOC_USP7_UBL2_3	26	30	PF12436	0.626
DOC_USP7_UBL2_3	92	96	PF12436	0.450
DOC_WW_Pin1_4	139	144	PF00397	0.450
DOC_WW_Pin1_4	182	187	PF00397	0.554
DOC_WW_Pin1_4	35	40	PF00397	0.774
LIG_14-3-3_CanoR_1	214	218	PF00244	0.444
LIG_14-3-3_CanoR_1	224	231	PF00244	0.448
LIG_14-3-3_CanoR_1	55	59	PF00244	0.706
LIG_BRCT_BRCA1_1	278	282	PF00533	0.450
LIG_FHA_1	106	112	PF00498	0.450
LIG_FHA_1	27	33	PF00498	0.675
LIG_FHA_1	96	102	PF00498	0.450
LIG_LIR_Apic_2	235	239	PF02991	0.450
LIG_LIR_Apic_2	250	256	PF02991	0.450
LIG_LIR_Gen_1	209	217	PF02991	0.441
LIG_LIR_Nem_3	157	163	PF02991	0.450
LIG_LIR_Nem_3	209	215	PF02991	0.441
LIG_LIR_Nem_3	261	266	PF02991	0.450
LIG_LIR_Nem_3	293	298	PF02991	0.377
LIG_LIR_Nem_3	332	337	PF02991	0.410
LIG_Pex14_2	195	199	PF04695	0.450
LIG_Pex14_2	71	75	PF04695	0.461
LIG_PTB_Apo_2	166	173	PF02174	0.444
LIG_PTB_Apo_2	69	76	PF02174	0.318
LIG_PTB_Phospho_1	166	172	PF10480	0.450
LIG_SH2_CRK	212	216	PF00017	0.450
LIG_SH2_SRC	172	175	PF00017	0.450
LIG_SH2_STAP1	292	296	PF00017	0.451
LIG_SH2_STAT5	212	215	PF00017	0.446
LIG_SH2_STAT5	295	298	PF00017	0.397
LIG_SH3_1	248	254	PF00018	0.450
LIG_SH3_3	248	254	PF00018	0.450
LIG_SUMO_SIM_anti_2	355	361	PF11976	0.281
LIG_UBA3_1	228	233	PF00899	0.433
LIG_UBA3_1	359	368	PF00899	0.438
MOD_CDK_SPxxK_3	182	189	PF00069	0.555
MOD_CK1_1	216	222	PF00069	0.458
MOD_CK1_1	232	238	PF00069	0.418
MOD_CK1_1	327	333	PF00069	0.536
MOD_GlcNHglycan	13	16	PF01048	0.596
MOD_GlcNHglycan	175	178	PF01048	0.250
MOD_GlcNHglycan	311	314	PF01048	0.760
MOD_GlcNHglycan	66	69	PF01048	0.498
MOD_GSK3_1	105	112	PF00069	0.455
MOD_GSK3_1	139	146	PF00069	0.465
MOD_GSK3_1	26	33	PF00069	0.601
MOD_GSK3_1	277	284	PF00069	0.450
MOD_GSK3_1	323	330	PF00069	0.601
MOD_N-GLC_1	109	114	PF02516	0.249
MOD_NEK2_1	115	120	PF00069	0.462
MOD_NEK2_1	229	234	PF00069	0.450
MOD_NEK2_1	269	274	PF00069	0.499
MOD_NEK2_1	317	322	PF00069	0.725
MOD_NEK2_1	34	39	PF00069	0.643
MOD_PIKK_1	216	222	PF00454	0.461
MOD_PIKK_1	62	68	PF00454	0.570
MOD_PK_1	277	283	PF00069	0.450
MOD_PKA_1	276	282	PF00069	0.450
MOD_PKA_1	43	49	PF00069	0.686
MOD_PKA_1	54	60	PF00069	0.709
MOD_PKA_2	213	219	PF00069	0.450
MOD_PKA_2	223	229	PF00069	0.450
MOD_PKA_2	43	49	PF00069	0.734
MOD_PKA_2	54	60	PF00069	0.660
MOD_Plk_1	242	248	PF00069	0.450
MOD_Plk_4	242	248	PF00069	0.450
MOD_Plk_4	277	283	PF00069	0.450
MOD_Plk_4	358	364	PF00069	0.410
MOD_ProDKin_1	139	145	PF00069	0.450
MOD_ProDKin_1	182	188	PF00069	0.554
MOD_ProDKin_1	35	41	PF00069	0.774
MOD_SUMO_for_1	240	243	PF00179	0.450
MOD_SUMO_rev_2	244	254	PF00179	0.450
TRG_DiLeu_BaEn_1	262	267	PF01217	0.450
TRG_ENDOCYTIC_2	212	215	PF00928	0.448
TRG_ENDOCYTIC_2	298	301	PF00928	0.422
TRG_ER_diArg_1	350	353	PF00400	0.379
TRG_NLS_MonoExtC_3	272	277	PF00514	0.450
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB33	Leptomonas seymouri	86%	100%
A0A0S4JJ91	Bodo saltans	67%	100%
A0A1X0P2H9	Trypanosomatidae	72%	100%
A0A3S7X2X5	Leishmania donovani	95%	100%
A0A422N140	Trypanosoma rangeli	71%	100%
A3CQN5	Streptococcus sanguinis (strain SK36)	33%	100%
A4HHW5	Leishmania braziliensis	89%	100%
A4I515	Leishmania infantum	96%	100%
A4YT90	Bradyrhizobium sp. (strain ORS 278)	32%	100%
A5EIA8	Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)	34%	100%
B1AJP2	Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)	32%	100%
B3EIC2	Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)	26%	100%
B5ZCB6	Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)	31%	100%
B7VIE2	Vibrio atlanticus (strain LGP32)	31%	100%
C0QFJ2	Desulforapulum autotrophicum (strain ATCC 43914 / DSM 3382 / VKM B-1955 / HRM2)	32%	100%
C1AXY5	Rhodococcus opacus (strain B4)	28%	100%
C9ZQH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	98%
E9B0E5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
G0SEH7	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	44%	97%
O22268	Arabidopsis thaliana	46%	100%
P41819	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P78697	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	47%	100%
Q09522	Caenorhabditis elegans	46%	100%
Q0KEA7	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	31%	100%
Q1J8J4	Streptococcus pyogenes serotype M4 (strain MGAS10750)	30%	100%
Q2KHT8	Bos taurus	56%	100%
Q31RH6	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	33%	100%
Q38V22	Latilactobacillus sakei subsp. sakei (strain 23K)	29%	100%
Q54QK7	Dictyostelium discoideum	52%	100%
Q5N2S8	Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)	33%	100%
Q6BSY5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	47%	100%
Q6C7H6	Yarrowia lipolytica (strain CLIB 122 / E 150)	43%	100%
Q6FKY3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	44%	100%
Q74C12	Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)	30%	100%
Q75C90	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	45%	100%
Q7VM33	Haemophilus ducreyi (strain 35000HP / ATCC 700724)	32%	100%
Q95KJ0	Macaca fascicularis	55%	100%
Q9CLL5	Pasteurella multocida (strain Pm70)	27%	100%
Q9D0D4	Mus musculus	55%	100%
Q9FK02	Arabidopsis thaliana	40%	98%
Q9PPN8	Ureaplasma parvum serovar 3 (strain ATCC 700970)	32%	100%
Q9UNQ2	Homo sapiens	55%	100%
Q9USU2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
Q9VAQ5	Drosophila melanogaster	50%	100%
V5BCC0	Trypanosoma cruzi	71%	100%