FoP_duplication domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7U6_LEIMA

TriTrypDb:

LmjF.30.0090 , LMJSD75_300005900

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7U6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.401
CLV_NRD_NRD_1	118	120	PF00675	0.614
CLV_NRD_NRD_1	123	125	PF00675	0.551
CLV_NRD_NRD_1	128	130	PF00675	0.455
CLV_NRD_NRD_1	134	136	PF00675	0.515
CLV_NRD_NRD_1	151	153	PF00675	0.513
CLV_NRD_NRD_1	158	160	PF00675	0.550
CLV_NRD_NRD_1	170	172	PF00675	0.530
CLV_NRD_NRD_1	20	22	PF00675	0.668
CLV_NRD_NRD_1	32	34	PF00675	0.556
CLV_NRD_NRD_1	43	45	PF00675	0.499
CLV_NRD_NRD_1	50	52	PF00675	0.658
CLV_NRD_NRD_1	69	71	PF00675	0.816
CLV_NRD_NRD_1	81	83	PF00675	0.567
CLV_NRD_NRD_1	9	11	PF00675	0.671
CLV_NRD_NRD_1	90	92	PF00675	0.610
CLV_NRD_NRD_1	98	100	PF00675	0.458
CLV_PCSK_FUR_1	116	120	PF00082	0.735
CLV_PCSK_FUR_1	17	21	PF00082	0.660
CLV_PCSK_FUR_1	29	33	PF00082	0.534
CLV_PCSK_FUR_1	79	83	PF00082	0.702
CLV_PCSK_FUR_1	96	100	PF00082	0.528
CLV_PCSK_KEX2_1	108	110	PF00082	0.401
CLV_PCSK_KEX2_1	118	120	PF00082	0.614
CLV_PCSK_KEX2_1	123	125	PF00082	0.551
CLV_PCSK_KEX2_1	128	130	PF00082	0.455
CLV_PCSK_KEX2_1	134	136	PF00082	0.515
CLV_PCSK_KEX2_1	150	152	PF00082	0.529
CLV_PCSK_KEX2_1	158	160	PF00082	0.597
CLV_PCSK_KEX2_1	169	171	PF00082	0.519
CLV_PCSK_KEX2_1	19	21	PF00082	0.666
CLV_PCSK_KEX2_1	31	33	PF00082	0.546
CLV_PCSK_KEX2_1	43	45	PF00082	0.482
CLV_PCSK_KEX2_1	50	52	PF00082	0.658
CLV_PCSK_KEX2_1	69	71	PF00082	0.816
CLV_PCSK_KEX2_1	8	10	PF00082	0.636
CLV_PCSK_KEX2_1	81	83	PF00082	0.567
CLV_PCSK_KEX2_1	90	92	PF00082	0.610
CLV_PCSK_KEX2_1	98	100	PF00082	0.458
CLV_PCSK_PC7_1	119	125	PF00082	0.712
CLV_PCSK_PC7_1	147	153	PF00082	0.668
CLV_PCSK_PC7_1	86	92	PF00082	0.676
CLV_PCSK_PC7_1	94	100	PF00082	0.564
CLV_PCSK_SKI1_1	86	90	PF00082	0.751
DEG_APCC_DBOX_1	7	15	PF00400	0.663
DOC_ANK_TNKS_1	151	158	PF00023	0.650
DOC_USP7_MATH_1	199	203	PF00917	0.678
DOC_USP7_MATH_1	206	210	PF00917	0.659
LIG_14-3-3_CanoR_1	44	54	PF00244	0.750
LIG_14-3-3_CanoR_1	81	89	PF00244	0.677
LIG_FHA_2	213	219	PF00498	0.736
LIG_FHA_2	50	56	PF00498	0.744
LIG_Integrin_RGD_1	119	121	PF01839	0.708
LIG_LIR_Apic_2	36	42	PF02991	0.770
LIG_LIR_Nem_3	110	115	PF02991	0.571
LIG_LIR_Nem_3	95	100	PF02991	0.675
LIG_RPA_C_Fungi	147	159	PF08784	0.658
LIG_SH2_CRK	39	43	PF00017	0.774
LIG_SH2_STAT5	45	48	PF00017	0.598
LIG_TRAF2_1	215	218	PF00917	0.733
MOD_CK2_1	212	218	PF00069	0.748
MOD_CK2_1	49	55	PF00069	0.742
MOD_Cter_Amidation	116	119	PF01082	0.658
MOD_Cter_Amidation	121	124	PF01082	0.693
MOD_Cter_Amidation	126	129	PF01082	0.623
MOD_Cter_Amidation	156	159	PF01082	0.664
MOD_Cter_Amidation	167	170	PF01082	0.625
MOD_GlcNHglycan	173	176	PF01048	0.705
MOD_GlcNHglycan	22	25	PF01048	0.670
MOD_GlcNHglycan	36	42	PF01048	0.440
MOD_GSK3_1	45	52	PF00069	0.746
MOD_NEK2_1	140	145	PF00069	0.684
MOD_PIKK_1	59	65	PF00454	0.672
MOD_PKA_1	20	26	PF00069	0.669
MOD_PKA_1	81	87	PF00069	0.754
MOD_PKA_2	140	146	PF00069	0.775
MOD_PKA_2	163	169	PF00069	0.622
MOD_PKA_2	20	26	PF00069	0.669
MOD_PKA_2	49	55	PF00069	0.664
MOD_PKA_2	81	87	PF00069	0.754
MOD_PKB_1	169	177	PF00069	0.762
MOD_PKB_1	79	87	PF00069	0.680
TRG_ER_diArg_1	115	118	PF00400	0.724
TRG_ER_diArg_1	123	125	PF00400	0.654
TRG_ER_diArg_1	128	130	PF00400	0.559
TRG_ER_diArg_1	134	137	PF00400	0.477
TRG_ER_diArg_1	138	141	PF00400	0.573
TRG_ER_diArg_1	150	152	PF00400	0.529
TRG_ER_diArg_1	158	161	PF00400	0.445
TRG_ER_diArg_1	169	171	PF00400	0.560
TRG_ER_diArg_1	17	20	PF00400	0.660
TRG_ER_diArg_1	31	33	PF00400	0.513
TRG_ER_diArg_1	42	44	PF00400	0.485
TRG_ER_diArg_1	50	53	PF00400	0.737
TRG_ER_diArg_1	68	70	PF00400	0.813
TRG_ER_diArg_1	78	81	PF00400	0.607
TRG_ER_diArg_1	8	10	PF00400	0.678
TRG_ER_diArg_1	89	91	PF00400	0.590
TRG_ER_diArg_1	97	99	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2W4	Leishmania donovani	96%	100%
A4HHV4	Leishmania braziliensis	65%	100%
A4I504	Leishmania infantum	93%	100%
E9B0D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%