F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7U4_LEIMA

TriTrypDb:

LmjF.30.0110 , LMJLV39_300006200 , LMJSD75_300006200

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Show entries

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

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Expansion

Sequence features

Q4Q7U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7U4

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.496
CLV_NRD_NRD_1	148	150	PF00675	0.606
CLV_NRD_NRD_1	186	188	PF00675	0.544
CLV_PCSK_KEX2_1	148	150	PF00082	0.489
CLV_PCSK_KEX2_1	186	188	PF00082	0.544
CLV_PCSK_SKI1_1	186	190	PF00082	0.492
CLV_PCSK_SKI1_1	264	268	PF00082	0.481
DEG_Nend_UBRbox_2	1	3	PF02207	0.630
DEG_SCF_FBW7_1	368	375	PF00400	0.465
DOC_CDC14_PxL_1	225	233	PF14671	0.485

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2N3	Leptomonas seymouri	48%	99%
A0A1X0P2E5	Trypanosomatidae	26%	100%
A0A3Q8IEP2	Leishmania donovani	93%	100%
A4HHV6	Leishmania braziliensis	79%	100%
A4I506	Leishmania infantum	93%	100%
C9ZQF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	98%
E9B0D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BLE7	Trypanosoma cruzi	26%	100%

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