Protein YIPF

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein YIPF

Gene product:

Yip1 domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q7U1_LEIMA

TriTrypDb:

LmjF.30.0140 , LMJLV39_300006500 , LMJSD75_300006500

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	12
GO:0016020	membrane	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q7U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7U1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0019899	enzyme binding	3	12
GO:0031267	small GTPase binding	5	12
GO:0051020	GTPase binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.301
CLV_PCSK_SKI1_1	127	131	PF00082	0.315
DEG_APCC_DBOX_1	126	134	PF00400	0.533
DEG_MDM2_SWIB_1	293	300	PF02201	0.304
DEG_SPOP_SBC_1	36	40	PF00917	0.609
DOC_CYCLIN_yClb5_NLxxxL_5	249	258	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.462
DOC_MAPK_MEF2A_6	316	324	PF00069	0.556
DOC_USP7_MATH_1	101	105	PF00917	0.725
DOC_USP7_MATH_1	107	111	PF00917	0.605
DOC_USP7_MATH_1	18	22	PF00917	0.769
DOC_USP7_MATH_1	199	203	PF00917	0.381
DOC_USP7_MATH_1	28	32	PF00917	0.710
DOC_USP7_MATH_1	36	40	PF00917	0.618
DOC_USP7_MATH_1	4	8	PF00917	0.658
DOC_WW_Pin1_4	76	81	PF00397	0.702
LIG_14-3-3_CanoR_1	132	138	PF00244	0.547
LIG_Actin_WH2_2	117	134	PF00022	0.521
LIG_AP2alpha_2	12	14	PF02296	0.627
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BIR_III_1	1	5	PF00653	0.648
LIG_BIR_III_3	1	5	PF00653	0.648
LIG_BRCT_BRCA1_1	335	339	PF00533	0.337
LIG_deltaCOP1_diTrp_1	315	325	PF00928	0.499
LIG_FHA_1	124	130	PF00498	0.513
LIG_FHA_1	195	201	PF00498	0.348
LIG_FHA_1	257	263	PF00498	0.477
LIG_FHA_1	297	303	PF00498	0.319
LIG_FHA_1	77	83	PF00498	0.767
LIG_FHA_2	167	173	PF00498	0.621
LIG_FHA_2	255	261	PF00498	0.492
LIG_FHA_2	310	316	PF00498	0.537
LIG_FHA_2	49	55	PF00498	0.716
LIG_IBAR_NPY_1	3	5	PF08397	0.636
LIG_LIR_Apic_2	110	116	PF02991	0.642
LIG_LIR_Gen_1	192	201	PF02991	0.303
LIG_LIR_Gen_1	228	239	PF02991	0.424
LIG_LIR_Gen_1	285	296	PF02991	0.409
LIG_LIR_Gen_1	298	309	PF02991	0.212
LIG_LIR_Gen_1	49	59	PF02991	0.725
LIG_LIR_Nem_3	109	115	PF02991	0.560
LIG_LIR_Nem_3	183	188	PF02991	0.451
LIG_LIR_Nem_3	192	198	PF02991	0.303
LIG_LIR_Nem_3	228	234	PF02991	0.424
LIG_LIR_Nem_3	285	291	PF02991	0.409
LIG_LIR_Nem_3	298	304	PF02991	0.201
LIG_LIR_Nem_3	334	340	PF02991	0.331
LIG_LIR_Nem_3	49	55	PF02991	0.719
LIG_PALB2_WD40_1	314	322	PF16756	0.537
LIG_PDZ_Class_2	341	346	PF00595	0.320
LIG_Pex14_1	113	117	PF04695	0.524
LIG_Pex14_1	220	224	PF04695	0.248
LIG_Pex14_1	297	301	PF04695	0.319
LIG_Pex14_2	117	121	PF04695	0.509
LIG_Pex14_2	293	297	PF04695	0.376
LIG_Pex14_2	325	329	PF04695	0.406
LIG_Pex14_2	337	341	PF04695	0.303
LIG_REV1ctd_RIR_1	339	346	PF16727	0.394
LIG_SH2_CRK	231	235	PF00017	0.436
LIG_SH2_CRK	237	241	PF00017	0.393
LIG_SH2_NCK_1	231	235	PF00017	0.450
LIG_SH2_NCK_1	283	287	PF00017	0.285
LIG_SH2_NCK_1	47	51	PF00017	0.667
LIG_SH2_NCK_1	52	56	PF00017	0.684
LIG_SH2_STAP1	222	226	PF00017	0.262
LIG_SH2_STAP1	231	235	PF00017	0.297
LIG_SH2_STAP1	267	271	PF00017	0.303
LIG_SH2_STAP1	5	9	PF00017	0.580
LIG_SH2_STAT5	210	213	PF00017	0.337
LIG_SH2_STAT5	235	238	PF00017	0.308
LIG_SH2_STAT5	301	304	PF00017	0.338
LIG_SH2_STAT5	340	343	PF00017	0.290
LIG_SH2_STAT5	52	55	PF00017	0.693
LIG_SH3_3	136	142	PF00018	0.557
LIG_SH3_3	84	90	PF00018	0.695
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.388
LIG_SUMO_SIM_anti_2	273	279	PF11976	0.424
LIG_SUMO_SIM_par_1	196	202	PF11976	0.388
LIG_TRAF2_1	170	173	PF00917	0.655
LIG_TYR_ITIM	229	234	PF00017	0.424
LIG_TYR_ITSM	297	304	PF00017	0.388
LIG_UBA3_1	204	212	PF00899	0.432
LIG_UBA3_1	302	311	PF00899	0.450
MOD_CK1_1	225	231	PF00069	0.257
MOD_CK1_1	31	37	PF00069	0.729
MOD_CK1_1	48	54	PF00069	0.754
MOD_CK1_1	7	13	PF00069	0.698
MOD_CK2_1	166	172	PF00069	0.645
MOD_CK2_1	309	315	PF00069	0.537
MOD_CK2_1	48	54	PF00069	0.715
MOD_CMANNOS	307	310	PF00535	0.262
MOD_GlcNHglycan	30	33	PF01048	0.534
MOD_GlcNHglycan	48	51	PF01048	0.517
MOD_GlcNHglycan	76	79	PF01048	0.470
MOD_GlcNHglycan	8	12	PF01048	0.472
MOD_GSK3_1	103	110	PF00069	0.652
MOD_GSK3_1	190	197	PF00069	0.317
MOD_GSK3_1	199	206	PF00069	0.282
MOD_GSK3_1	254	261	PF00069	0.467
MOD_GSK3_1	31	38	PF00069	0.724
MOD_GSK3_1	46	53	PF00069	0.729
MOD_GSK3_1	76	83	PF00069	0.672
MOD_N-GLC_1	213	218	PF02516	0.525
MOD_N-GLC_1	74	79	PF02516	0.513
MOD_N-GLC_2	154	156	PF02516	0.352
MOD_NEK2_1	131	136	PF00069	0.490
MOD_NEK2_1	194	199	PF00069	0.334
MOD_NEK2_1	258	263	PF00069	0.506
MOD_NEK2_1	309	314	PF00069	0.497
MOD_NEK2_1	331	336	PF00069	0.338
MOD_NEK2_2	265	270	PF00069	0.303
MOD_NEK2_2	296	301	PF00069	0.351
MOD_PIKK_1	101	107	PF00454	0.713
MOD_PKA_2	131	137	PF00069	0.513
MOD_Plk_1	166	172	PF00069	0.672
MOD_Plk_1	222	228	PF00069	0.244
MOD_Plk_2-3	167	173	PF00069	0.658
MOD_Plk_4	133	139	PF00069	0.521
MOD_Plk_4	190	196	PF00069	0.303
MOD_Plk_4	265	271	PF00069	0.342
MOD_Plk_4	296	302	PF00069	0.353
MOD_ProDKin_1	76	82	PF00069	0.706
TRG_DiLeu_BaEn_2	314	320	PF01217	0.537
TRG_ENDOCYTIC_2	118	121	PF00928	0.511
TRG_ENDOCYTIC_2	185	188	PF00928	0.451
TRG_ENDOCYTIC_2	231	234	PF00928	0.424
TRG_ENDOCYTIC_2	237	240	PF00928	0.380
TRG_ENDOCYTIC_2	267	270	PF00928	0.342
TRG_ENDOCYTIC_2	301	304	PF00928	0.360
TRG_ENDOCYTIC_2	52	55	PF00928	0.773

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG17	Leptomonas seymouri	61%	95%
A0A0S4JRK9	Bodo saltans	61%	100%
A0A1X0P3E9	Trypanosomatidae	49%	95%
A0A3Q8IBR6	Leishmania donovani	96%	100%
A0A422N136	Trypanosoma rangeli	46%	99%
A4HHV9	Leishmania braziliensis	88%	100%
A4I509	Leishmania infantum	96%	100%
C9ZQG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
E9B0D9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q54TS4	Dictyostelium discoideum	30%	100%
Q5RBL0	Pongo abelii	28%	100%
Q6P6G5	Rattus norvegicus	26%	100%
Q91VU1	Mus musculus	27%	100%
Q9UTD3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9Y548	Homo sapiens	28%	100%
V5BLF2	Trypanosoma cruzi	53%	100%