Rubis-subs-bind domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rubisco LSMT substrate-binding, putative

Species:

Leishmania major

UniProt:

Q4Q7U0_LEIMA

TriTrypDb:

LmjF.30.0170 , LMJLV39_300006700 , LMJSD75_300006700

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7U0

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	11
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018026	peptidyl-lysine monomethylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	11
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.642
CLV_C14_Caspase3-7	469	473	PF00656	0.725
CLV_C14_Caspase3-7	87	91	PF00656	0.483
CLV_MEL_PAP_1	608	614	PF00089	0.362
CLV_NRD_NRD_1	272	274	PF00675	0.515
CLV_NRD_NRD_1	34	36	PF00675	0.519
CLV_NRD_NRD_1	398	400	PF00675	0.449
CLV_NRD_NRD_1	493	495	PF00675	0.410
CLV_NRD_NRD_1	541	543	PF00675	0.381
CLV_PCSK_KEX2_1	272	274	PF00082	0.515
CLV_PCSK_KEX2_1	309	311	PF00082	0.456
CLV_PCSK_KEX2_1	33	35	PF00082	0.400
CLV_PCSK_KEX2_1	493	495	PF00082	0.412
CLV_PCSK_KEX2_1	541	543	PF00082	0.381
CLV_PCSK_KEX2_1	615	617	PF00082	0.305
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.456
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.400
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.319
CLV_PCSK_PC7_1	268	274	PF00082	0.463
CLV_PCSK_PC7_1	611	617	PF00082	0.301
CLV_PCSK_SKI1_1	162	166	PF00082	0.673
CLV_PCSK_SKI1_1	172	176	PF00082	0.670
CLV_PCSK_SKI1_1	183	187	PF00082	0.532
CLV_PCSK_SKI1_1	243	247	PF00082	0.572
CLV_PCSK_SKI1_1	272	276	PF00082	0.441
CLV_PCSK_SKI1_1	493	497	PF00082	0.447
CLV_PCSK_SKI1_1	500	504	PF00082	0.392
DEG_APCC_DBOX_1	208	216	PF00400	0.466
DEG_APCC_DBOX_1	610	618	PF00400	0.501
DEG_APCC_DBOX_1	73	81	PF00400	0.463
DEG_Nend_UBRbox_3	1	3	PF02207	0.428
DOC_CYCLIN_RxL_1	268	276	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	454	460	PF00134	0.485
DOC_MAPK_MEF2A_6	602	610	PF00069	0.523
DOC_MAPK_RevD_3	295	310	PF00069	0.443
DOC_PP1_RVXF_1	110	116	PF00149	0.519
DOC_PP1_RVXF_1	181	187	PF00149	0.509
DOC_PP1_RVXF_1	33	40	PF00149	0.455
DOC_PP1_RVXF_1	618	625	PF00149	0.380
DOC_PP2B_LxvP_1	213	216	PF13499	0.428
DOC_PP2B_LxvP_1	458	461	PF13499	0.595
DOC_PP2B_LxvP_1	503	506	PF13499	0.520
DOC_USP7_MATH_1	127	131	PF00917	0.574
DOC_USP7_MATH_1	160	164	PF00917	0.672
DOC_USP7_MATH_1	205	209	PF00917	0.499
DOC_USP7_MATH_1	238	242	PF00917	0.554
DOC_USP7_MATH_1	308	312	PF00917	0.563
DOC_USP7_MATH_1	341	345	PF00917	0.572
DOC_USP7_MATH_1	346	350	PF00917	0.462
DOC_USP7_MATH_1	461	465	PF00917	0.651
DOC_USP7_MATH_1	556	560	PF00917	0.537
DOC_WW_Pin1_4	547	552	PF00397	0.576
LIG_14-3-3_CanoR_1	172	177	PF00244	0.684
LIG_14-3-3_CanoR_1	272	282	PF00244	0.505
LIG_14-3-3_CanoR_1	493	498	PF00244	0.386
LIG_14-3-3_CanoR_1	63	69	PF00244	0.553
LIG_14-3-3_CterR_2	627	629	PF00244	0.500
LIG_Actin_WH2_2	601	617	PF00022	0.545
LIG_AP2alpha_2	103	105	PF02296	0.457
LIG_BRCT_BRCA1_1	217	221	PF00533	0.436
LIG_BRCT_BRCA1_1	348	352	PF00533	0.466
LIG_BRCT_BRCA1_1	365	369	PF00533	0.233
LIG_Clathr_ClatBox_1	77	81	PF01394	0.463
LIG_deltaCOP1_diTrp_1	178	186	PF00928	0.485
LIG_FHA_1	12	18	PF00498	0.606
LIG_FHA_1	142	148	PF00498	0.439
LIG_FHA_1	221	227	PF00498	0.450
LIG_FHA_1	392	398	PF00498	0.514
LIG_FHA_1	407	413	PF00498	0.510
LIG_FHA_2	173	179	PF00498	0.648
LIG_FHA_2	285	291	PF00498	0.481
LIG_FHA_2	415	421	PF00498	0.448
LIG_FHA_2	573	579	PF00498	0.515
LIG_FHA_2	580	586	PF00498	0.488
LIG_FHA_2	65	71	PF00498	0.542
LIG_FHA_2	82	88	PF00498	0.481
LIG_LIR_Gen_1	52	61	PF02991	0.451
LIG_LIR_Gen_1	533	543	PF02991	0.492
LIG_LIR_Gen_1	64	72	PF02991	0.306
LIG_LIR_Gen_1	84	94	PF02991	0.411
LIG_LIR_Nem_3	269	274	PF02991	0.399
LIG_LIR_Nem_3	280	285	PF02991	0.400
LIG_LIR_Nem_3	424	429	PF02991	0.376
LIG_LIR_Nem_3	52	58	PF02991	0.439
LIG_LIR_Nem_3	540	546	PF02991	0.446
LIG_LIR_Nem_3	64	69	PF02991	0.320
LIG_LIR_Nem_3	84	89	PF02991	0.400
LIG_LYPXL_yS_3	282	285	PF13949	0.388
LIG_NRBOX	241	247	PF00104	0.453
LIG_NRBOX	520	526	PF00104	0.517
LIG_SH2_CRK	229	233	PF00017	0.460
LIG_SH2_CRK	429	433	PF00017	0.368
LIG_SH2_CRK	441	445	PF00017	0.378
LIG_SH2_NCK_1	142	146	PF00017	0.544
LIG_SH2_STAP1	259	263	PF00017	0.389
LIG_SH2_STAP1	501	505	PF00017	0.429
LIG_SH2_STAT5	229	232	PF00017	0.432
LIG_SH2_STAT5	36	39	PF00017	0.421
LIG_SH3_1	542	548	PF00018	0.581
LIG_SH3_3	182	188	PF00018	0.435
LIG_SH3_3	280	286	PF00018	0.389
LIG_SH3_3	542	548	PF00018	0.581
LIG_SH3_3	98	104	PF00018	0.481
LIG_SUMO_SIM_anti_2	323	328	PF11976	0.286
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.281
LIG_SUMO_SIM_par_1	76	81	PF11976	0.447
LIG_TRAF2_1	247	250	PF00917	0.509
LIG_TRFH_1	443	447	PF08558	0.545
LIG_TYR_ITIM	227	232	PF00017	0.447
MOD_CK1_1	130	136	PF00069	0.532
MOD_CK1_1	158	164	PF00069	0.684
MOD_CK1_1	196	202	PF00069	0.526
MOD_CK1_1	208	214	PF00069	0.501
MOD_CK1_1	471	477	PF00069	0.791
MOD_CK1_1	550	556	PF00069	0.494
MOD_CK1_1	571	577	PF00069	0.559
MOD_CK2_1	151	157	PF00069	0.693
MOD_CK2_1	284	290	PF00069	0.536
MOD_CK2_1	572	578	PF00069	0.518
MOD_CK2_1	579	585	PF00069	0.491
MOD_CK2_1	64	70	PF00069	0.514
MOD_CK2_1	81	87	PF00069	0.297
MOD_GlcNHglycan	132	135	PF01048	0.501
MOD_GlcNHglycan	157	161	PF01048	0.676
MOD_GlcNHglycan	162	165	PF01048	0.656
MOD_GlcNHglycan	28	31	PF01048	0.364
MOD_GlcNHglycan	3	6	PF01048	0.649
MOD_GlcNHglycan	338	341	PF01048	0.559
MOD_GlcNHglycan	347	351	PF01048	0.528
MOD_GlcNHglycan	476	479	PF01048	0.725
MOD_GlcNHglycan	7	10	PF01048	0.732
MOD_GSK3_1	1	8	PF00069	0.580
MOD_GSK3_1	151	158	PF00069	0.679
MOD_GSK3_1	359	366	PF00069	0.462
MOD_GSK3_1	474	481	PF00069	0.721
MOD_GSK3_1	556	563	PF00069	0.507
MOD_GSK3_1	568	575	PF00069	0.482
MOD_LATS_1	170	176	PF00433	0.633
MOD_N-GLC_1	151	156	PF02516	0.664
MOD_N-GLC_1	24	29	PF02516	0.541
MOD_N-GLC_1	391	396	PF02516	0.398
MOD_NEK2_1	1	6	PF00069	0.575
MOD_NEK2_1	128	133	PF00069	0.610
MOD_NEK2_1	222	227	PF00069	0.371
MOD_NEK2_1	320	325	PF00069	0.487
MOD_NEK2_1	425	430	PF00069	0.383
MOD_NEK2_1	7	12	PF00069	0.716
MOD_NEK2_2	143	148	PF00069	0.500
MOD_PIKK_1	308	314	PF00454	0.495
MOD_PKA_1	493	499	PF00069	0.389
MOD_PKA_2	208	214	PF00069	0.479
MOD_PKA_2	493	499	PF00069	0.389
MOD_Plk_1	151	157	PF00069	0.629
MOD_Plk_1	266	272	PF00069	0.479
MOD_Plk_1	486	492	PF00069	0.566
MOD_Plk_1	579	585	PF00069	0.554
MOD_Plk_2-3	466	472	PF00069	0.550
MOD_Plk_2-3	579	585	PF00069	0.547
MOD_Plk_2-3	81	87	PF00069	0.483
MOD_Plk_4	208	214	PF00069	0.469
MOD_Plk_4	222	228	PF00069	0.329
MOD_Plk_4	320	326	PF00069	0.431
MOD_Plk_4	493	499	PF00069	0.379
MOD_Plk_4	556	562	PF00069	0.563
MOD_ProDKin_1	547	553	PF00069	0.576
TRG_DiLeu_BaEn_1	249	254	PF01217	0.418
TRG_DiLeu_BaEn_2	50	56	PF01217	0.532
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.509
TRG_ENDOCYTIC_2	229	232	PF00928	0.432
TRG_ENDOCYTIC_2	259	262	PF00928	0.456
TRG_ENDOCYTIC_2	282	285	PF00928	0.388
TRG_ENDOCYTIC_2	429	432	PF00928	0.371
TRG_ENDOCYTIC_2	441	444	PF00928	0.374
TRG_ENDOCYTIC_2	543	546	PF00928	0.553
TRG_ER_diArg_1	271	273	PF00400	0.509
TRG_ER_diArg_1	34	36	PF00400	0.457
TRG_ER_diArg_1	493	495	PF00400	0.497
TRG_ER_diArg_1	541	543	PF00400	0.525
TRG_ER_diArg_1	73	76	PF00400	0.442
TRG_ER_diArg_1	96	99	PF00400	0.511
TRG_NES_CRM1_1	293	305	PF08389	0.428
TRG_NES_CRM1_1	87	100	PF08389	0.278
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8B9	Leptomonas seymouri	60%	100%
A0A0S4JJX6	Bodo saltans	34%	91%
A0A1X0P2C3	Trypanosomatidae	42%	100%
A0A3Q8IFL1	Leishmania donovani	93%	100%
A0A422N122	Trypanosoma rangeli	44%	100%
A4HHW1	Leishmania braziliensis	79%	100%
A4I511	Leishmania infantum	93%	100%
C9ZQG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B0E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5AWY0	Trypanosoma cruzi	44%	100%