RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7T7_LEIMA

TriTrypDb:

LmjF.30.0220 , LMJLV39_300007500 , LMJSD75_300007400

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7T7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0005515	protein binding	2	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0035091	phosphatidylinositol binding	4	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.616
CLV_C14_Caspase3-7	42	46	PF00656	0.553
CLV_NRD_NRD_1	163	165	PF00675	0.587
CLV_NRD_NRD_1	265	267	PF00675	0.667
CLV_PCSK_KEX2_1	105	107	PF00082	0.575
CLV_PCSK_KEX2_1	163	165	PF00082	0.593
CLV_PCSK_KEX2_1	265	267	PF00082	0.667
CLV_PCSK_KEX2_1	27	29	PF00082	0.513
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.561
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.357
CLV_PCSK_SKI1_1	134	138	PF00082	0.437
CLV_PCSK_SKI1_1	193	197	PF00082	0.732
DEG_Nend_UBRbox_3	1	3	PF02207	0.539
DEG_SCF_FBW7_1	241	248	PF00400	0.703
DEG_SPOP_SBC_1	250	254	PF00917	0.669
DOC_CYCLIN_RxL_1	193	202	PF00134	0.733
DOC_MAPK_DCC_7	265	275	PF00069	0.693
DOC_MAPK_gen_1	114	123	PF00069	0.499
DOC_MAPK_MEF2A_6	266	275	PF00069	0.693
DOC_PP1_RVXF_1	161	168	PF00149	0.580
DOC_PP2B_LxvP_1	215	218	PF13499	0.571
DOC_USP7_MATH_1	141	145	PF00917	0.486
DOC_USP7_MATH_1	288	292	PF00917	0.591
DOC_WW_Pin1_4	176	181	PF00397	0.543
DOC_WW_Pin1_4	237	242	PF00397	0.692
DOC_WW_Pin1_4	245	250	PF00397	0.707
DOC_WW_Pin1_4	264	269	PF00397	0.644
DOC_WW_Pin1_4	298	303	PF00397	0.777
DOC_WW_Pin1_4	349	354	PF00397	0.770
LIG_14-3-3_CanoR_1	120	124	PF00244	0.424
LIG_14-3-3_CanoR_1	138	146	PF00244	0.304
LIG_14-3-3_CanoR_1	149	155	PF00244	0.510
LIG_APCC_ABBA_1	55	60	PF00400	0.534
LIG_BRCT_BRCA1_1	126	130	PF00533	0.420
LIG_Clathr_ClatBox_1	274	278	PF01394	0.542
LIG_Clathr_ClatBox_1	71	75	PF01394	0.524
LIG_FHA_1	52	58	PF00498	0.358
LIG_FHA_2	120	126	PF00498	0.427
LIG_FHA_2	40	46	PF00498	0.548
LIG_LIR_Apic_2	60	64	PF02991	0.482
LIG_LIR_Gen_1	125	131	PF02991	0.479
LIG_LIR_Nem_3	125	129	PF02991	0.474
LIG_LIR_Nem_3	32	36	PF02991	0.519
LIG_MYND_2	271	275	PF01753	0.541
LIG_Pex14_1	306	310	PF04695	0.543
LIG_PTB_Apo_2	79	86	PF02174	0.549
LIG_SH2_CRK	126	130	PF00017	0.545
LIG_SH2_GRB2like	214	217	PF00017	0.504
LIG_SH2_NCK_1	61	65	PF00017	0.564
LIG_SH2_SRC	214	217	PF00017	0.576
LIG_SH2_STAP1	126	130	PF00017	0.474
LIG_SH2_STAP1	251	255	PF00017	0.552
LIG_SH2_STAP1	83	87	PF00017	0.539
LIG_SH2_STAT5	214	217	PF00017	0.504
LIG_SH2_STAT5	3	6	PF00017	0.569
LIG_SH2_STAT5	58	61	PF00017	0.485
LIG_SH3_1	265	271	PF00018	0.651
LIG_SH3_1	28	34	PF00018	0.548
LIG_SH3_3	174	180	PF00018	0.543
LIG_SH3_3	191	197	PF00018	0.530
LIG_SH3_3	265	271	PF00018	0.693
LIG_SH3_3	28	34	PF00018	0.548
LIG_SUMO_SIM_par_1	273	278	PF11976	0.545
LIG_SUMO_SIM_par_1	70	75	PF11976	0.451
LIG_TYR_ITIM	124	129	PF00017	0.553
LIG_TYR_ITIM	366	371	PF00017	0.569
LIG_UBA3_1	175	181	PF00899	0.585
LIG_UBA3_1	99	105	PF00899	0.483
LIG_WRC_WIRS_1	143	148	PF05994	0.569
MOD_CDK_SPK_2	176	181	PF00069	0.591
MOD_CDK_SPK_2	241	246	PF00069	0.767
MOD_CK1_1	240	246	PF00069	0.709
MOD_CK1_1	254	260	PF00069	0.739
MOD_CK1_1	301	307	PF00069	0.736
MOD_CK1_1	341	347	PF00069	0.777
MOD_CK1_1	354	360	PF00069	0.542
MOD_CK2_1	119	125	PF00069	0.466
MOD_CK2_1	141	147	PF00069	0.559
MOD_CK2_1	176	182	PF00069	0.604
MOD_CK2_1	199	205	PF00069	0.702
MOD_Cter_Amidation	263	266	PF01082	0.672
MOD_GlcNHglycan	139	142	PF01048	0.522
MOD_GlcNHglycan	189	192	PF01048	0.739
MOD_GlcNHglycan	201	204	PF01048	0.674
MOD_GlcNHglycan	218	221	PF01048	0.311
MOD_GlcNHglycan	290	293	PF01048	0.724
MOD_GSK3_1	137	144	PF00069	0.509
MOD_GSK3_1	225	232	PF00069	0.618
MOD_GSK3_1	233	240	PF00069	0.677
MOD_GSK3_1	241	248	PF00069	0.600
MOD_GSK3_1	250	257	PF00069	0.714
MOD_GSK3_1	297	304	PF00069	0.742
MOD_GSK3_1	334	341	PF00069	0.772
MOD_GSK3_1	342	349	PF00069	0.654
MOD_GSK3_1	35	42	PF00069	0.566
MOD_N-GLC_1	258	263	PF02516	0.699
MOD_NEK2_1	124	129	PF00069	0.402
MOD_NEK2_1	137	142	PF00069	0.371
MOD_NEK2_1	186	191	PF00069	0.660
MOD_NEK2_1	198	203	PF00069	0.727
MOD_NEK2_1	286	291	PF00069	0.656
MOD_NEK2_1	348	353	PF00069	0.588
MOD_NEK2_1	50	55	PF00069	0.488
MOD_NEK2_2	225	230	PF00069	0.614
MOD_PKA_2	119	125	PF00069	0.466
MOD_PKA_2	137	143	PF00069	0.334
MOD_PKA_2	15	21	PF00069	0.464
MOD_PKA_2	229	235	PF00069	0.699
MOD_Plk_1	124	130	PF00069	0.439
MOD_Plk_1	306	312	PF00069	0.736
MOD_Plk_2-3	39	45	PF00069	0.473
MOD_Plk_4	119	125	PF00069	0.460
MOD_Plk_4	150	156	PF00069	0.438
MOD_ProDKin_1	176	182	PF00069	0.551
MOD_ProDKin_1	237	243	PF00069	0.693
MOD_ProDKin_1	245	251	PF00069	0.709
MOD_ProDKin_1	264	270	PF00069	0.641
MOD_ProDKin_1	298	304	PF00069	0.774
MOD_ProDKin_1	349	355	PF00069	0.769
MOD_SUMO_for_1	26	29	PF00179	0.359
TRG_DiLeu_BaEn_1	32	37	PF01217	0.433
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.536
TRG_ENDOCYTIC_2	126	129	PF00928	0.429
TRG_ENDOCYTIC_2	368	371	PF00928	0.686
TRG_ER_diArg_1	163	166	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JFL9	Bodo saltans	29%	92%
A0A3Q8IE12	Leishmania donovani	88%	100%
A0A3R7MAL9	Trypanosoma rangeli	36%	100%
A4HHW6	Leishmania braziliensis	70%	89%
A4I516	Leishmania infantum	88%	100%
E9B0E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%