Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania major

UniProt:

Q4Q7T6_LEIMA

TriTrypDb:

LmjF.30.0230 , LMJLV39_300007600 , LMJSD75_300007500

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q7T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7T6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.561
CLV_NRD_NRD_1	278	280	PF00675	0.414
CLV_NRD_NRD_1	351	353	PF00675	0.548
CLV_PCSK_KEX2_1	135	137	PF00082	0.639
CLV_PCSK_KEX2_1	277	279	PF00082	0.405
CLV_PCSK_KEX2_1	83	85	PF00082	0.388
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.388
CLV_PCSK_SKI1_1	195	199	PF00082	0.429
CLV_PCSK_SKI1_1	270	274	PF00082	0.467
CLV_PCSK_SKI1_1	293	297	PF00082	0.342
CLV_PCSK_SKI1_1	89	93	PF00082	0.366
DEG_APCC_DBOX_1	251	259	PF00400	0.669
DOC_MAPK_gen_1	184	193	PF00069	0.531
DOC_MAPK_MEF2A_6	184	193	PF00069	0.533
DOC_MAPK_MEF2A_6	225	232	PF00069	0.356
DOC_MAPK_NFAT4_5	225	233	PF00069	0.391
DOC_PP1_RVXF_1	202	209	PF00149	0.391
DOC_PP1_RVXF_1	87	93	PF00149	0.639
DOC_USP7_MATH_1	247	251	PF00917	0.600
DOC_USP7_MATH_1	72	76	PF00917	0.630
DOC_WW_Pin1_4	16	21	PF00397	0.707
LIG_14-3-3_CanoR_1	195	200	PF00244	0.364
LIG_14-3-3_CanoR_1	225	229	PF00244	0.431
LIG_14-3-3_CanoR_1	28	38	PF00244	0.615
LIG_14-3-3_CanoR_1	313	321	PF00244	0.576
LIG_14-3-3_CanoR_1	7	15	PF00244	0.762
LIG_14-3-3_CanoR_1	77	87	PF00244	0.616
LIG_Actin_WH2_2	145	162	PF00022	0.419
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_BRCT_BRCA1_1	204	208	PF00533	0.485
LIG_EVH1_2	346	350	PF00568	0.750
LIG_FHA_1	113	119	PF00498	0.435
LIG_FHA_1	123	129	PF00498	0.349
LIG_FHA_1	143	149	PF00498	0.436
LIG_FHA_1	160	166	PF00498	0.450
LIG_FHA_1	196	202	PF00498	0.408
LIG_FHA_1	314	320	PF00498	0.579
LIG_FHA_1	328	334	PF00498	0.596
LIG_FHA_1	54	60	PF00498	0.547
LIG_FHA_2	304	310	PF00498	0.533
LIG_LIR_Apic_2	18	24	PF02991	0.700
LIG_LIR_Apic_2	316	321	PF02991	0.607
LIG_LIR_Gen_1	101	109	PF02991	0.513
LIG_LIR_Gen_1	114	123	PF02991	0.333
LIG_LIR_Nem_3	101	105	PF02991	0.528
LIG_LIR_Nem_3	114	119	PF02991	0.236
LIG_LIR_Nem_3	271	276	PF02991	0.572
LIG_LIR_Nem_3	283	289	PF02991	0.545
LIG_LIR_Nem_3	312	318	PF02991	0.590
LIG_LIR_Nem_3	63	68	PF02991	0.632
LIG_PCNA_yPIPBox_3	204	218	PF02747	0.438
LIG_Pex14_2	208	212	PF04695	0.358
LIG_Pex14_2	88	92	PF04695	0.554
LIG_Rb_pABgroove_1	280	288	PF01858	0.651
LIG_REV1ctd_RIR_1	287	293	PF16727	0.543
LIG_REV1ctd_RIR_1	85	93	PF16727	0.589
LIG_SH2_CRK	109	113	PF00017	0.485
LIG_SH2_CRK	149	153	PF00017	0.324
LIG_SH2_CRK	156	160	PF00017	0.507
LIG_SH2_CRK	21	25	PF00017	0.749
LIG_SH2_CRK	220	224	PF00017	0.384
LIG_SH2_CRK	269	273	PF00017	0.635
LIG_SH2_SRC	318	321	PF00017	0.641
LIG_SH2_STAP1	149	153	PF00017	0.393
LIG_SH2_STAP1	315	319	PF00017	0.570
LIG_SH2_STAT3	246	249	PF00017	0.590
LIG_SH2_STAT5	233	236	PF00017	0.328
LIG_SH2_STAT5	31	34	PF00017	0.604
LIG_SH2_STAT5	315	318	PF00017	0.579
LIG_SH2_STAT5	341	344	PF00017	0.762
LIG_SH2_STAT5	66	69	PF00017	0.616
LIG_SH3_3	125	131	PF00018	0.317
LIG_SH3_3	149	155	PF00018	0.348
LIG_SH3_3	333	339	PF00018	0.677
LIG_SH3_3	52	58	PF00018	0.577
LIG_SUMO_SIM_anti_2	198	203	PF11976	0.439
LIG_TYR_ITIM	147	152	PF00017	0.293
LIG_TYR_ITIM	218	223	PF00017	0.395
LIG_WRC_WIRS_1	113	118	PF05994	0.485
LIG_WRC_WIRS_1	236	241	PF05994	0.444
LIG_WW_1	345	348	PF00397	0.739
MOD_CK1_1	2	8	PF00069	0.672
MOD_CK1_1	332	338	PF00069	0.707
MOD_GlcNHglycan	172	175	PF01048	0.343
MOD_GlcNHglycan	296	299	PF01048	0.409
MOD_GSK3_1	122	129	PF00069	0.448
MOD_GSK3_1	159	166	PF00069	0.457
MOD_GSK3_1	309	316	PF00069	0.541
MOD_GSK3_1	321	328	PF00069	0.636
MOD_N-GLC_1	258	263	PF02516	0.446
MOD_NEK2_1	111	116	PF00069	0.384
MOD_NEK2_1	148	153	PF00069	0.485
MOD_NEK2_1	202	207	PF00069	0.457
MOD_NEK2_1	3	8	PF00069	0.698
MOD_NEK2_1	303	308	PF00069	0.562
MOD_NEK2_2	247	252	PF00069	0.544
MOD_PIKK_1	31	37	PF00454	0.700
MOD_PIKK_1	327	333	PF00454	0.743
MOD_PKA_2	159	165	PF00069	0.508
MOD_PKA_2	224	230	PF00069	0.404
MOD_PKA_2	9	15	PF00069	0.766
MOD_Plk_1	73	79	PF00069	0.657
MOD_Plk_4	148	154	PF00069	0.471
MOD_Plk_4	224	230	PF00069	0.414
MOD_Plk_4	235	241	PF00069	0.389
MOD_ProDKin_1	16	22	PF00069	0.708
TRG_ENDOCYTIC_2	109	112	PF00928	0.384
TRG_ENDOCYTIC_2	149	152	PF00928	0.333
TRG_ENDOCYTIC_2	156	159	PF00928	0.501
TRG_ENDOCYTIC_2	194	197	PF00928	0.344
TRG_ENDOCYTIC_2	215	218	PF00928	0.299
TRG_ENDOCYTIC_2	220	223	PF00928	0.375
TRG_ENDOCYTIC_2	233	236	PF00928	0.275
TRG_ENDOCYTIC_2	269	272	PF00928	0.636
TRG_ENDOCYTIC_2	286	289	PF00928	0.545
TRG_ER_diArg_1	135	137	PF00400	0.384
TRG_ER_diArg_1	263	266	PF00400	0.641
TRG_ER_diArg_1	276	279	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD65	Leptomonas seymouri	67%	100%
A0A1X0P2B3	Trypanosomatidae	55%	99%
A0A3S7X2Y8	Leishmania donovani	93%	100%
A4HHW7	Leishmania braziliensis	84%	100%
A4I517	Leishmania infantum	93%	100%
C9ZQH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B0E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DD32	Trypanosoma cruzi	54%	100%