Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7T5_LEIMA

TriTrypDb:

LmjF.30.0240 , LMJLV39_300007700 , LMJSD75_300007600

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7T5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016539	intein-mediated protein splicing	7	1
GO:0019538	protein metabolic process	3	1
GO:0030908	protein splicing	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.527
CLV_NRD_NRD_1	171	173	PF00675	0.383
CLV_NRD_NRD_1	191	193	PF00675	0.355
CLV_NRD_NRD_1	209	211	PF00675	0.360
CLV_NRD_NRD_1	265	267	PF00675	0.327
CLV_NRD_NRD_1	330	332	PF00675	0.507
CLV_NRD_NRD_1	373	375	PF00675	0.497
CLV_NRD_NRD_1	556	558	PF00675	0.493
CLV_NRD_NRD_1	579	581	PF00675	0.485
CLV_NRD_NRD_1	86	88	PF00675	0.447
CLV_PCSK_FUR_1	371	375	PF00082	0.457
CLV_PCSK_KEX2_1	171	173	PF00082	0.516
CLV_PCSK_KEX2_1	191	193	PF00082	0.414
CLV_PCSK_KEX2_1	209	211	PF00082	0.341
CLV_PCSK_KEX2_1	247	249	PF00082	0.393
CLV_PCSK_KEX2_1	267	269	PF00082	0.405
CLV_PCSK_KEX2_1	330	332	PF00082	0.452
CLV_PCSK_KEX2_1	362	364	PF00082	0.482
CLV_PCSK_KEX2_1	373	375	PF00082	0.502
CLV_PCSK_KEX2_1	556	558	PF00082	0.467
CLV_PCSK_KEX2_1	578	580	PF00082	0.491
CLV_PCSK_KEX2_1	94	96	PF00082	0.529
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.516
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.393
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.405
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.482
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.529
CLV_PCSK_PC7_1	326	332	PF00082	0.508
CLV_PCSK_SKI1_1	134	138	PF00082	0.649
CLV_PCSK_SKI1_1	164	168	PF00082	0.359
CLV_PCSK_SKI1_1	226	230	PF00082	0.323
CLV_PCSK_SKI1_1	248	252	PF00082	0.372
CLV_PCSK_SKI1_1	271	275	PF00082	0.327
CLV_PCSK_SKI1_1	335	339	PF00082	0.432
CLV_PCSK_SKI1_1	363	367	PF00082	0.447
CLV_PCSK_SKI1_1	452	456	PF00082	0.433
CLV_PCSK_SKI1_1	531	535	PF00082	0.533
CLV_PCSK_SKI1_1	54	58	PF00082	0.542
DEG_APCC_DBOX_1	265	273	PF00400	0.271
DEG_SCF_FBW7_1	198	205	PF00400	0.473
DEG_SPOP_SBC_1	538	542	PF00917	0.484
DOC_CDC14_PxL_1	230	238	PF14671	0.505
DOC_CDC14_PxL_1	545	553	PF14671	0.511
DOC_CKS1_1	136	141	PF01111	0.503
DOC_CKS1_1	199	204	PF01111	0.484
DOC_CYCLIN_RxL_1	330	341	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.510
DOC_MAPK_gen_1	191	198	PF00069	0.371
DOC_MAPK_gen_1	266	276	PF00069	0.371
DOC_MAPK_gen_1	330	340	PF00069	0.422
DOC_MAPK_gen_1	362	370	PF00069	0.615
DOC_MAPK_gen_1	556	567	PF00069	0.568
DOC_MAPK_MEF2A_6	267	276	PF00069	0.322
DOC_MAPK_MEF2A_6	305	312	PF00069	0.483
DOC_MAPK_MEF2A_6	560	569	PF00069	0.532
DOC_MAPK_RevD_3	565	580	PF00069	0.488
DOC_PP2B_LxvP_1	304	307	PF13499	0.509
DOC_PP2B_LxvP_1	495	498	PF13499	0.465
DOC_PP2B_LxvP_1	518	521	PF13499	0.620
DOC_PP4_FxxP_1	181	184	PF00568	0.338
DOC_PP4_FxxP_1	19	22	PF00568	0.553
DOC_USP7_MATH_1	519	523	PF00917	0.567
DOC_USP7_MATH_1	529	533	PF00917	0.652
DOC_USP7_MATH_1	538	542	PF00917	0.640
DOC_USP7_UBL2_3	31	35	PF12436	0.560
DOC_USP7_UBL2_3	362	366	PF12436	0.618
DOC_WW_Pin1_4	135	140	PF00397	0.595
DOC_WW_Pin1_4	18	23	PF00397	0.485
DOC_WW_Pin1_4	198	203	PF00397	0.337
DOC_WW_Pin1_4	379	384	PF00397	0.416
LIG_14-3-3_CanoR_1	215	223	PF00244	0.431
LIG_14-3-3_CanoR_1	226	231	PF00244	0.273
LIG_14-3-3_CanoR_1	248	257	PF00244	0.447
LIG_14-3-3_CanoR_1	26	34	PF00244	0.512
LIG_14-3-3_CanoR_1	87	96	PF00244	0.400
LIG_BRCT_BRCA1_1	584	588	PF00533	0.406
LIG_Clathr_ClatBox_1	337	341	PF01394	0.451
LIG_CSL_BTD_1	199	202	PF09270	0.347
LIG_DLG_GKlike_1	95	103	PF00625	0.524
LIG_FHA_1	199	205	PF00498	0.479
LIG_FHA_1	312	318	PF00498	0.448
LIG_FHA_1	412	418	PF00498	0.645
LIG_FHA_2	151	157	PF00498	0.359
LIG_FHA_2	502	508	PF00498	0.440
LIG_HCF-1_HBM_1	259	262	PF13415	0.340
LIG_Integrin_RGD_1	580	582	PF01839	0.417
LIG_LIR_Apic_2	16	22	PF02991	0.632
LIG_LIR_Gen_1	104	113	PF02991	0.376
LIG_LIR_Gen_1	153	162	PF02991	0.358
LIG_LIR_Gen_1	403	409	PF02991	0.558
LIG_LIR_Gen_1	476	485	PF02991	0.469
LIG_LIR_Gen_1	590	596	PF02991	0.594
LIG_LIR_Nem_3	104	109	PF02991	0.348
LIG_LIR_Nem_3	130	136	PF02991	0.577
LIG_LIR_Nem_3	153	157	PF02991	0.307
LIG_LIR_Nem_3	403	407	PF02991	0.546
LIG_LIR_Nem_3	471	477	PF02991	0.371
LIG_LIR_Nem_3	590	595	PF02991	0.486
LIG_MYND_1	3	7	PF01753	0.555
LIG_Pex14_1	473	477	PF04695	0.365
LIG_Pex14_2	588	592	PF04695	0.387
LIG_Pex14_2	74	78	PF04695	0.393
LIG_PTB_Apo_2	395	402	PF02174	0.412
LIG_PTB_Phospho_1	395	401	PF10480	0.411
LIG_SH2_CRK	477	481	PF00017	0.418
LIG_SH2_CRK	49	53	PF00017	0.461
LIG_SH2_GRB2like	147	150	PF00017	0.456
LIG_SH2_SRC	433	436	PF00017	0.532
LIG_SH2_STAP1	401	405	PF00017	0.369
LIG_SH2_STAP1	477	481	PF00017	0.419
LIG_SH2_STAT3	147	150	PF00017	0.549
LIG_SH2_STAT5	154	157	PF00017	0.326
LIG_SH2_STAT5	203	206	PF00017	0.429
LIG_SH2_STAT5	235	238	PF00017	0.506
LIG_SH2_STAT5	275	278	PF00017	0.362
LIG_SH2_STAT5	51	54	PF00017	0.412
LIG_SH2_STAT5	545	548	PF00017	0.483
LIG_SH2_STAT5	550	553	PF00017	0.569
LIG_SH2_STAT5	572	575	PF00017	0.419
LIG_SH3_3	133	139	PF00018	0.625
LIG_SH3_3	4	10	PF00018	0.685
LIG_SH3_3	451	457	PF00018	0.608
LIG_SH3_3	518	524	PF00018	0.501
LIG_SH3_3	543	549	PF00018	0.566
LIG_SH3_3	63	69	PF00018	0.389
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.503
LIG_SUMO_SIM_par_1	336	341	PF11976	0.532
LIG_TRAF2_1	128	131	PF00917	0.472
LIG_TRAF2_1	504	507	PF00917	0.487
LIG_WRC_WIRS_1	401	406	PF05994	0.436
MOD_CDC14_SPxK_1	382	385	PF00782	0.535
MOD_CDK_SPxK_1	379	385	PF00069	0.416
MOD_CK1_1	107	113	PF00069	0.307
MOD_CK1_1	214	220	PF00069	0.398
MOD_CK1_1	237	243	PF00069	0.388
MOD_CK1_1	311	317	PF00069	0.550
MOD_CK1_1	322	328	PF00069	0.516
MOD_CK1_1	411	417	PF00069	0.634
MOD_CK1_1	436	442	PF00069	0.629
MOD_CK2_1	150	156	PF00069	0.356
MOD_CK2_1	434	440	PF00069	0.653
MOD_CK2_1	501	507	PF00069	0.505
MOD_CK2_1	568	574	PF00069	0.384
MOD_CK2_1	584	590	PF00069	0.444
MOD_CMANNOS	285	288	PF00535	0.316
MOD_Cter_Amidation	371	374	PF01082	0.452
MOD_Cter_Amidation	554	557	PF01082	0.489
MOD_GlcNHglycan	22	25	PF01048	0.510
MOD_GlcNHglycan	410	413	PF01048	0.544
MOD_GlcNHglycan	426	429	PF01048	0.594
MOD_GlcNHglycan	531	534	PF01048	0.671
MOD_GlcNHglycan	553	556	PF01048	0.540
MOD_GlcNHglycan	561	564	PF01048	0.488
MOD_GlcNHglycan	63	66	PF01048	0.457
MOD_GSK3_1	198	205	PF00069	0.358
MOD_GSK3_1	275	282	PF00069	0.353
MOD_GSK3_1	322	329	PF00069	0.527
MOD_GSK3_1	353	360	PF00069	0.546
MOD_GSK3_1	411	418	PF00069	0.552
MOD_GSK3_1	527	534	PF00069	0.632
MOD_N-GLC_1	211	216	PF02516	0.479
MOD_N-GLC_1	357	362	PF02516	0.414
MOD_NEK2_1	109	114	PF00069	0.393
MOD_NEK2_1	122	127	PF00069	0.446
MOD_NEK2_1	253	258	PF00069	0.461
MOD_NEK2_1	287	292	PF00069	0.335
MOD_NEK2_1	353	358	PF00069	0.566
MOD_NEK2_1	400	405	PF00069	0.476
MOD_NEK2_1	499	504	PF00069	0.445
MOD_NEK2_1	551	556	PF00069	0.554
MOD_NEK2_2	203	208	PF00069	0.420
MOD_PIKK_1	248	254	PF00454	0.360
MOD_PIKK_1	501	507	PF00454	0.545
MOD_PKA_1	267	273	PF00069	0.396
MOD_PKA_1	87	93	PF00069	0.407
MOD_PKA_2	208	214	PF00069	0.424
MOD_PKA_2	25	31	PF00069	0.620
MOD_PKA_2	267	273	PF00069	0.396
MOD_PKA_2	424	430	PF00069	0.605
MOD_PKA_2	559	565	PF00069	0.570
MOD_Plk_1	211	217	PF00069	0.481
MOD_Plk_1	237	243	PF00069	0.424
MOD_Plk_1	279	285	PF00069	0.390
MOD_Plk_1	59	65	PF00069	0.573
MOD_Plk_2-3	568	574	PF00069	0.430
MOD_Plk_4	150	156	PF00069	0.384
MOD_Plk_4	203	209	PF00069	0.377
MOD_Plk_4	237	243	PF00069	0.385
MOD_Plk_4	299	305	PF00069	0.540
MOD_Plk_4	400	406	PF00069	0.536
MOD_Plk_4	476	482	PF00069	0.459
MOD_Plk_4	568	574	PF00069	0.478
MOD_Plk_4	68	74	PF00069	0.306
MOD_Plk_4	95	101	PF00069	0.447
MOD_ProDKin_1	135	141	PF00069	0.588
MOD_ProDKin_1	18	24	PF00069	0.484
MOD_ProDKin_1	198	204	PF00069	0.343
MOD_ProDKin_1	379	385	PF00069	0.409
MOD_SUMO_for_1	1	4	PF00179	0.593
MOD_SUMO_for_1	184	187	PF00179	0.400
MOD_SUMO_rev_2	259	269	PF00179	0.342
MOD_SUMO_rev_2	444	454	PF00179	0.706
TRG_DiLeu_BaEn_1	513	518	PF01217	0.375
TRG_DiLeu_BaEn_4	463	469	PF01217	0.393
TRG_DiLeu_BaEn_4	506	512	PF01217	0.278
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.464
TRG_ENDOCYTIC_2	106	109	PF00928	0.347
TRG_ENDOCYTIC_2	154	157	PF00928	0.351
TRG_ENDOCYTIC_2	401	404	PF00928	0.502
TRG_ENDOCYTIC_2	477	480	PF00928	0.532
TRG_ENDOCYTIC_2	49	52	PF00928	0.324
TRG_ER_diArg_1	208	210	PF00400	0.476
TRG_ER_diArg_1	266	269	PF00400	0.285
TRG_ER_diArg_1	330	333	PF00400	0.565
TRG_ER_diArg_1	370	373	PF00400	0.491
TRG_ER_diArg_1	556	558	PF00400	0.478
TRG_ER_diArg_1	577	580	PF00400	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C2	Leptomonas seymouri	67%	100%
A0A1X0P2D9	Trypanosomatidae	41%	100%
A0A3S5IRH4	Trypanosoma rangeli	40%	100%
A0A3S7X2Z0	Leishmania donovani	93%	100%
A4HHW8	Leishmania braziliensis	80%	100%
A4I518	Leishmania infantum	93%	100%
C9ZQH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B0E8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BLG2	Trypanosoma cruzi	43%	100%