Putative Zn finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein 1, putative

Species:

Leishmania major

UniProt:

Q4Q7T3_LEIMA

TriTrypDb:

LmjF.30.0260 , LMJLV39_300007900 , LMJSD75_300007800

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7T3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.456
CLV_C14_Caspase3-7	184	188	PF00656	0.502
CLV_C14_Caspase3-7	323	327	PF00656	0.637
CLV_C14_Caspase3-7	600	604	PF00656	0.706
CLV_C14_Caspase3-7	63	67	PF00656	0.433
CLV_C14_Caspase3-7	78	82	PF00656	0.484
CLV_NRD_NRD_1	219	221	PF00675	0.552
CLV_NRD_NRD_1	264	266	PF00675	0.583
CLV_NRD_NRD_1	362	364	PF00675	0.594
CLV_NRD_NRD_1	620	622	PF00675	0.586
CLV_NRD_NRD_1	625	627	PF00675	0.591
CLV_PCSK_KEX2_1	219	221	PF00082	0.553
CLV_PCSK_KEX2_1	264	266	PF00082	0.742
CLV_PCSK_KEX2_1	511	513	PF00082	0.442
CLV_PCSK_KEX2_1	625	627	PF00082	0.592
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.442
CLV_PCSK_PC7_1	621	627	PF00082	0.606
CLV_PCSK_SKI1_1	103	107	PF00082	0.473
CLV_PCSK_SKI1_1	130	134	PF00082	0.409
CLV_PCSK_SKI1_1	251	255	PF00082	0.565
CLV_PCSK_SKI1_1	364	368	PF00082	0.479
CLV_PCSK_SKI1_1	46	50	PF00082	0.455
CLV_PCSK_SKI1_1	549	553	PF00082	0.419
CLV_PCSK_SKI1_1	621	625	PF00082	0.633
DEG_APCC_DBOX_1	102	110	PF00400	0.491
DEG_SCF_FBW7_1	92	98	PF00400	0.468
DEG_SPOP_SBC_1	598	602	PF00917	0.605
DOC_ANK_TNKS_1	330	337	PF00023	0.591
DOC_CDC14_PxL_1	514	522	PF14671	0.419
DOC_CKS1_1	576	581	PF01111	0.606
DOC_CKS1_1	92	97	PF01111	0.558
DOC_CYCLIN_RxL_1	523	535	PF00134	0.500
DOC_CYCLIN_yClb5_NLxxxL_5	302	311	PF00134	0.478
DOC_MAPK_MEF2A_6	139	146	PF00069	0.574
DOC_MAPK_RevD_3	612	627	PF00069	0.648
DOC_PP1_RVXF_1	121	128	PF00149	0.451
DOC_PP1_RVXF_1	141	147	PF00149	0.360
DOC_PP4_FxxP_1	379	382	PF00568	0.437
DOC_PP4_FxxP_1	403	406	PF00568	0.497
DOC_PP4_FxxP_1	576	579	PF00568	0.605
DOC_USP7_MATH_1	107	111	PF00917	0.519
DOC_USP7_MATH_1	121	125	PF00917	0.386
DOC_USP7_MATH_1	126	130	PF00917	0.270
DOC_USP7_MATH_1	178	182	PF00917	0.777
DOC_USP7_MATH_1	203	207	PF00917	0.536
DOC_USP7_MATH_1	268	272	PF00917	0.573
DOC_USP7_MATH_1	322	326	PF00917	0.678
DOC_USP7_MATH_1	338	342	PF00917	0.620
DOC_USP7_MATH_1	346	350	PF00917	0.507
DOC_USP7_MATH_1	449	453	PF00917	0.684
DOC_USP7_MATH_1	458	462	PF00917	0.731
DOC_USP7_MATH_1	485	489	PF00917	0.446
DOC_USP7_MATH_1	572	576	PF00917	0.579
DOC_USP7_MATH_1	598	602	PF00917	0.661
DOC_USP7_MATH_1	604	608	PF00917	0.665
DOC_USP7_MATH_1	79	83	PF00917	0.754
DOC_USP7_UBL2_3	139	143	PF12436	0.494
DOC_WW_Pin1_4	168	173	PF00397	0.802
DOC_WW_Pin1_4	344	349	PF00397	0.741
DOC_WW_Pin1_4	575	580	PF00397	0.594
DOC_WW_Pin1_4	607	612	PF00397	0.637
DOC_WW_Pin1_4	91	96	PF00397	0.761
LIG_14-3-3_CanoR_1	299	308	PF00244	0.539
LIG_14-3-3_CanoR_1	359	367	PF00244	0.623
LIG_14-3-3_CanoR_1	368	377	PF00244	0.456
LIG_14-3-3_CanoR_1	474	480	PF00244	0.298
LIG_BIR_II_1	1	5	PF00653	0.476
LIG_BIR_III_4	424	428	PF00653	0.461
LIG_BIR_III_4	603	607	PF00653	0.641
LIG_BRCT_BRCA1_1	123	127	PF00533	0.478
LIG_BRCT_BRCA1_1	370	374	PF00533	0.399
LIG_BRCT_BRCA1_1	399	403	PF00533	0.637
LIG_FHA_1	13	19	PF00498	0.543
LIG_FHA_1	228	234	PF00498	0.664
LIG_FHA_1	607	613	PF00498	0.597
LIG_FHA_1	71	77	PF00498	0.650
LIG_FHA_2	106	112	PF00498	0.599
LIG_FHA_2	182	188	PF00498	0.534
LIG_FHA_2	224	230	PF00498	0.620
LIG_FHA_2	28	34	PF00498	0.482
LIG_FHA_2	414	420	PF00498	0.402
LIG_FHA_2	582	588	PF00498	0.715
LIG_FHA_2	598	604	PF00498	0.546
LIG_FHA_2	61	67	PF00498	0.408
LIG_LIR_Apic_2	400	406	PF02991	0.561
LIG_LIR_Apic_2	503	508	PF02991	0.547
LIG_LIR_Apic_2	575	579	PF02991	0.694
LIG_LIR_Gen_1	116	127	PF02991	0.433
LIG_LIR_Gen_1	145	154	PF02991	0.588
LIG_LIR_Gen_1	371	382	PF02991	0.385
LIG_LIR_Gen_1	461	471	PF02991	0.581
LIG_LIR_Gen_1	473	484	PF02991	0.287
LIG_LIR_Nem_3	116	122	PF02991	0.610
LIG_LIR_Nem_3	145	149	PF02991	0.591
LIG_LIR_Nem_3	295	301	PF02991	0.498
LIG_LIR_Nem_3	371	377	PF02991	0.368
LIG_LIR_Nem_3	461	466	PF02991	0.608
LIG_LIR_Nem_3	473	479	PF02991	0.298
LIG_LIR_Nem_3	513	517	PF02991	0.557
LIG_MAD2	441	449	PF02301	0.497
LIG_MYND_3	517	521	PF01753	0.416
LIG_SH2_NCK_1	50	54	PF00017	0.441
LIG_SH2_STAP1	115	119	PF00017	0.522
LIG_SH2_STAT5	115	118	PF00017	0.392
LIG_SH3_2	617	622	PF14604	0.610
LIG_SH3_3	101	107	PF00018	0.697
LIG_SH3_3	150	156	PF00018	0.471
LIG_SH3_3	171	177	PF00018	0.725
LIG_SH3_3	211	217	PF00018	0.604
LIG_SH3_3	539	545	PF00018	0.486
LIG_SH3_3	592	598	PF00018	0.732
LIG_SH3_3	611	617	PF00018	0.566
LIG_SUMO_SIM_par_1	155	161	PF11976	0.475
LIG_SUMO_SIM_par_1	467	473	PF11976	0.456
LIG_TYR_ITIM	552	557	PF00017	0.484
LIG_UBA3_1	23	32	PF00899	0.528
LIG_UBA3_1	307	314	PF00899	0.535
LIG_WRC_WIRS_1	573	578	PF05994	0.683
MOD_CDK_SPxxK_3	168	175	PF00069	0.618
MOD_CK1_1	181	187	PF00069	0.509
MOD_CK1_1	271	277	PF00069	0.677
MOD_CK1_1	313	319	PF00069	0.692
MOD_CK1_1	325	331	PF00069	0.584
MOD_CK1_1	339	345	PF00069	0.683
MOD_CK1_1	347	353	PF00069	0.660
MOD_CK1_1	461	467	PF00069	0.573
MOD_CK1_1	496	502	PF00069	0.667
MOD_CK1_1	519	525	PF00069	0.501
MOD_CK1_1	575	581	PF00069	0.623
MOD_CK1_1	605	611	PF00069	0.638
MOD_CK1_1	91	97	PF00069	0.676
MOD_CK2_1	105	111	PF00069	0.520
MOD_CK2_1	27	33	PF00069	0.471
MOD_CK2_1	346	352	PF00069	0.683
MOD_CK2_1	475	481	PF00069	0.399
MOD_CK2_1	537	543	PF00069	0.554
MOD_CK2_1	581	587	PF00069	0.514
MOD_Cter_Amidation	262	265	PF01082	0.589
MOD_GlcNHglycan	270	273	PF01048	0.617
MOD_GlcNHglycan	276	279	PF01048	0.620
MOD_GlcNHglycan	3	6	PF01048	0.461
MOD_GlcNHglycan	338	341	PF01048	0.624
MOD_GlcNHglycan	370	373	PF01048	0.396
MOD_GlcNHglycan	443	446	PF01048	0.725
MOD_GlcNHglycan	451	454	PF01048	0.761
MOD_GlcNHglycan	463	466	PF01048	0.467
MOD_GlcNHglycan	487	490	PF01048	0.280
MOD_GlcNHglycan	567	570	PF01048	0.624
MOD_GlcNHglycan	580	583	PF01048	0.544
MOD_GlcNHglycan	603	607	PF01048	0.772
MOD_GSK3_1	105	112	PF00069	0.423
MOD_GSK3_1	121	128	PF00069	0.463
MOD_GSK3_1	181	188	PF00069	0.594
MOD_GSK3_1	223	230	PF00069	0.675
MOD_GSK3_1	268	275	PF00069	0.662
MOD_GSK3_1	313	320	PF00069	0.657
MOD_GSK3_1	334	341	PF00069	0.665
MOD_GSK3_1	368	375	PF00069	0.435
MOD_GSK3_1	413	420	PF00069	0.511
MOD_GSK3_1	454	461	PF00069	0.732
MOD_GSK3_1	493	500	PF00069	0.589
MOD_GSK3_1	598	605	PF00069	0.680
MOD_GSK3_1	628	635	PF00069	0.678
MOD_GSK3_1	90	97	PF00069	0.668
MOD_N-GLC_1	485	490	PF02516	0.278
MOD_N-GLC_1	529	534	PF02516	0.482
MOD_N-GLC_2	118	120	PF02516	0.395
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	157	162	PF00069	0.665
MOD_NEK2_1	242	247	PF00069	0.626
MOD_NEK2_1	367	372	PF00069	0.543
MOD_NEK2_1	475	480	PF00069	0.399
MOD_NEK2_1	90	95	PF00069	0.616
MOD_NEK2_2	433	438	PF00069	0.494
MOD_NEK2_2	60	65	PF00069	0.469
MOD_PKA_1	621	627	PF00069	0.606
MOD_PKA_2	263	269	PF00069	0.708
MOD_PKA_2	358	364	PF00069	0.632
MOD_PKA_2	367	373	PF00069	0.462
MOD_PKA_2	397	403	PF00069	0.528
MOD_PKA_2	51	57	PF00069	0.488
MOD_Plk_1	181	187	PF00069	0.508
MOD_Plk_1	325	331	PF00069	0.624
MOD_Plk_1	413	419	PF00069	0.659
MOD_Plk_1	433	439	PF00069	0.518
MOD_Plk_1	485	491	PF00069	0.478
MOD_Plk_1	529	535	PF00069	0.679
MOD_Plk_2-3	516	522	PF00069	0.399
MOD_Plk_4	148	154	PF00069	0.577
MOD_Plk_4	458	464	PF00069	0.688
MOD_Plk_4	500	506	PF00069	0.654
MOD_ProDKin_1	168	174	PF00069	0.801
MOD_ProDKin_1	344	350	PF00069	0.736
MOD_ProDKin_1	575	581	PF00069	0.596
MOD_ProDKin_1	607	613	PF00069	0.637
MOD_ProDKin_1	91	97	PF00069	0.755
MOD_SUMO_for_1	235	238	PF00179	0.624
MOD_SUMO_rev_2	358	366	PF00179	0.482
MOD_SUMO_rev_2	452	458	PF00179	0.573
TRG_ENDOCYTIC_2	50	53	PF00928	0.412
TRG_ENDOCYTIC_2	554	557	PF00928	0.477
TRG_ER_diArg_1	218	220	PF00400	0.553
TRG_ER_diArg_1	264	267	PF00400	0.565
TRG_ER_diArg_1	471	474	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W2	Leptomonas seymouri	37%	87%
A0A0S4JVS9	Bodo saltans	29%	94%
A0A1X0P2C9	Trypanosomatidae	34%	100%
A0A3Q8IEK7	Leishmania donovani	90%	99%
A0A3R7MIW1	Trypanosoma rangeli	33%	100%
A4HHX0	Leishmania braziliensis	71%	99%
A4I520	Leishmania infantum	90%	99%
C9ZQH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B0F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q585P3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	34%	100%
V5DD36	Trypanosoma cruzi	33%	100%