LIM zinc-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7T1_LEIMA

TriTrypDb:

LmjF.30.0280 , LMJLV39_300008100 , LMJSD75_300008000

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7T1

PDB structure(s): 7aih_Ax , 7am2_Ax , 7ane_Ax

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.410
CLV_NRD_NRD_1	5	7	PF00675	0.572
CLV_NRD_NRD_1	61	63	PF00675	0.480
CLV_PCSK_KEX2_1	180	182	PF00082	0.410
CLV_PCSK_KEX2_1	5	7	PF00082	0.572
CLV_PCSK_KEX2_1	61	63	PF00082	0.466
CLV_PCSK_PC7_1	176	182	PF00082	0.410
CLV_PCSK_SKI1_1	141	145	PF00082	0.400
DEG_Nend_Nbox_1	1	3	PF02207	0.624
DOC_CDC14_PxL_1	4	12	PF14671	0.435
DOC_MAPK_gen_1	203	210	PF00069	0.432
DOC_PP2B_LxvP_1	38	41	PF13499	0.625
DOC_PP4_FxxP_1	20	23	PF00568	0.581
DOC_USP7_MATH_1	23	27	PF00917	0.674
DOC_WW_Pin1_4	210	215	PF00397	0.515
LIG_14-3-3_CanoR_1	129	138	PF00244	0.386
LIG_14-3-3_CanoR_1	18	23	PF00244	0.523
LIG_14-3-3_CanoR_1	181	187	PF00244	0.411
LIG_14-3-3_CanoR_1	24	31	PF00244	0.560
LIG_CSL_BTD_1	121	124	PF09270	0.349
LIG_FHA_1	182	188	PF00498	0.411
LIG_FHA_1	33	39	PF00498	0.658
LIG_FHA_1	88	94	PF00498	0.497
LIG_LIR_Gen_1	119	128	PF02991	0.382
LIG_LIR_Nem_3	119	123	PF02991	0.348
LIG_Pex14_1	146	150	PF04695	0.378
LIG_Pex14_1	182	186	PF04695	0.433
LIG_PTB_Apo_2	152	159	PF02174	0.398
LIG_PTB_Phospho_1	152	158	PF10480	0.400
LIG_REV1ctd_RIR_1	135	145	PF16727	0.397
LIG_SH2_CRK	150	154	PF00017	0.494
LIG_SH2_CRK	4	8	PF00017	0.507
LIG_SH2_GRB2like	186	189	PF00017	0.405
LIG_SH2_PTP2	120	123	PF00017	0.361
LIG_SH2_STAP1	89	93	PF00017	0.547
LIG_SH2_STAT5	120	123	PF00017	0.398
LIG_SH2_STAT5	136	139	PF00017	0.307
LIG_SH2_STAT5	186	189	PF00017	0.434
LIG_SH2_STAT5	2	5	PF00017	0.439
LIG_SH2_STAT5	89	92	PF00017	0.488
LIG_SH3_1	81	87	PF00018	0.487
LIG_SH3_3	118	124	PF00018	0.398
LIG_SH3_3	81	87	PF00018	0.497
LIG_SH3_3	90	96	PF00018	0.404
LIG_TRAF2_1	76	79	PF00917	0.608
MOD_CDK_SPK_2	210	215	PF00069	0.449
MOD_CK1_1	159	165	PF00069	0.274
MOD_CK1_1	194	200	PF00069	0.432
MOD_CK1_1	9	15	PF00069	0.489
MOD_CK2_1	210	216	PF00069	0.460
MOD_GlcNHglycan	124	127	PF01048	0.498
MOD_GlcNHglycan	25	28	PF01048	0.637
MOD_GlcNHglycan	50	53	PF01048	0.666
MOD_GSK3_1	18	25	PF00069	0.713
MOD_GSK3_1	182	189	PF00069	0.417
MOD_LATS_1	16	22	PF00433	0.469
MOD_LATS_1	46	52	PF00433	0.606
MOD_NEK2_1	31	36	PF00069	0.559
MOD_PIKK_1	130	136	PF00454	0.396
MOD_PIKK_1	54	60	PF00454	0.498
MOD_PKA_2	194	200	PF00069	0.411
MOD_PKA_2	23	29	PF00069	0.683
MOD_Plk_4	116	122	PF00069	0.386
MOD_Plk_4	182	188	PF00069	0.451
MOD_ProDKin_1	210	216	PF00069	0.526
TRG_ENDOCYTIC_2	120	123	PF00928	0.361
TRG_ENDOCYTIC_2	150	153	PF00928	0.396
TRG_ENDOCYTIC_2	4	7	PF00928	0.510
TRG_ER_diArg_1	180	182	PF00400	0.410
TRG_ER_diArg_1	202	205	PF00400	0.532
TRG_ER_diArg_1	4	6	PF00400	0.574
TRG_ER_diArg_1	61	63	PF00400	0.480
TRG_ER_diArg_1	81	84	PF00400	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF24	Leptomonas seymouri	81%	100%
A0A0S4JZ50	Bodo saltans	62%	98%
A0A1X0P3Q2	Trypanosomatidae	75%	100%
A0A3R7L3B1	Trypanosoma rangeli	72%	100%
A0A3S7X2Y9	Leishmania donovani	95%	100%
A4HHX2	Leishmania braziliensis	93%	100%
A4I522	Leishmania infantum	95%	100%
C9ZQI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9B0F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%