SUN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sad1 / UNC-like C-terminal, putative

Species:

Leishmania major

UniProt:

Q4Q7S7_LEIMA

TriTrypDb:

LmjF.30.0320 , LMJLV39_300008500 , LMJSD75_300008400

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q7S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7S7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.545
CLV_NRD_NRD_1	101	103	PF00675	0.546
CLV_NRD_NRD_1	157	159	PF00675	0.626
CLV_PCSK_KEX2_1	157	159	PF00082	0.619
CLV_PCSK_KEX2_1	48	50	PF00082	0.765
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.765
CLV_PCSK_SKI1_1	131	135	PF00082	0.529
CLV_PCSK_SKI1_1	172	176	PF00082	0.594
CLV_PCSK_SKI1_1	405	409	PF00082	0.718
CLV_PCSK_SKI1_1	454	458	PF00082	0.651
CLV_PCSK_SKI1_1	491	495	PF00082	0.603
DEG_APCC_DBOX_1	474	482	PF00400	0.439
DOC_CKS1_1	241	246	PF01111	0.555
DOC_CKS1_1	399	404	PF01111	0.532
DOC_CYCLIN_RxL_1	451	459	PF00134	0.489
DOC_CYCLIN_RxL_1	488	498	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.619
DOC_MAPK_gen_1	102	109	PF00069	0.346
DOC_MAPK_gen_1	168	176	PF00069	0.351
DOC_MAPK_MEF2A_6	268	277	PF00069	0.497
DOC_PP1_RVXF_1	168	174	PF00149	0.351
DOC_PP1_RVXF_1	452	458	PF00149	0.322
DOC_PP2B_LxvP_1	304	307	PF13499	0.617
DOC_PP4_FxxP_1	20	23	PF00568	0.676
DOC_USP7_MATH_1	220	224	PF00917	0.543
DOC_USP7_MATH_1	253	257	PF00917	0.560
DOC_USP7_MATH_1	267	271	PF00917	0.530
DOC_USP7_MATH_1	273	277	PF00917	0.460
DOC_USP7_MATH_1	326	330	PF00917	0.589
DOC_USP7_MATH_1	331	335	PF00917	0.622
DOC_USP7_MATH_1	343	347	PF00917	0.454
DOC_USP7_MATH_1	409	413	PF00917	0.524
DOC_USP7_MATH_1	417	421	PF00917	0.419
DOC_USP7_MATH_1	507	511	PF00917	0.576
DOC_USP7_MATH_1	522	526	PF00917	0.389
DOC_USP7_MATH_1	70	74	PF00917	0.399
DOC_WW_Pin1_4	226	231	PF00397	0.635
DOC_WW_Pin1_4	240	245	PF00397	0.513
DOC_WW_Pin1_4	269	274	PF00397	0.506
DOC_WW_Pin1_4	327	332	PF00397	0.600
DOC_WW_Pin1_4	398	403	PF00397	0.524
DOC_WW_Pin1_4	40	45	PF00397	0.581
LIG_14-3-3_CanoR_1	131	136	PF00244	0.419
LIG_14-3-3_CanoR_1	427	436	PF00244	0.510
LIG_14-3-3_CanoR_1	49	56	PF00244	0.474
LIG_14-3-3_CanoR_1	509	515	PF00244	0.507
LIG_deltaCOP1_diTrp_1	185	193	PF00928	0.376
LIG_EVH1_1	240	244	PF00568	0.540
LIG_FHA_1	10	16	PF00498	0.515
LIG_FHA_1	143	149	PF00498	0.419
LIG_FHA_1	227	233	PF00498	0.577
LIG_FHA_1	270	276	PF00498	0.617
LIG_FHA_1	314	320	PF00498	0.594
LIG_FHA_1	330	336	PF00498	0.481
LIG_FHA_1	384	390	PF00498	0.438
LIG_FHA_1	421	427	PF00498	0.510
LIG_FHA_1	451	457	PF00498	0.473
LIG_FHA_1	50	56	PF00498	0.409
LIG_FHA_1	530	536	PF00498	0.317
LIG_FHA_1	90	96	PF00498	0.339
LIG_FHA_2	203	209	PF00498	0.454
LIG_FHA_2	241	247	PF00498	0.604
LIG_FHA_2	362	368	PF00498	0.511
LIG_FHA_2	430	436	PF00498	0.500
LIG_LIR_Gen_1	143	154	PF02991	0.419
LIG_LIR_Gen_1	185	195	PF02991	0.362
LIG_LIR_Gen_1	217	226	PF02991	0.448
LIG_LIR_Gen_1	525	534	PF02991	0.414
LIG_LIR_Gen_1	59	70	PF02991	0.407
LIG_LIR_Nem_3	143	149	PF02991	0.338
LIG_LIR_Nem_3	185	190	PF02991	0.362
LIG_LIR_Nem_3	191	196	PF02991	0.393
LIG_LIR_Nem_3	217	221	PF02991	0.444
LIG_LIR_Nem_3	525	529	PF02991	0.414
LIG_LIR_Nem_3	552	557	PF02991	0.778
LIG_LIR_Nem_3	59	65	PF02991	0.400
LIG_MYND_1	238	242	PF01753	0.593
LIG_MYND_1	575	579	PF01753	0.817
LIG_NRBOX	421	427	PF00104	0.510
LIG_NRBOX	9	15	PF00104	0.539
LIG_NRP_CendR_1	585	587	PF00754	0.575
LIG_Pex14_1	178	182	PF04695	0.419
LIG_Pex14_1	554	558	PF04695	0.813
LIG_SH2_CRK	218	222	PF00017	0.444
LIG_SH2_CRK	62	66	PF00017	0.399
LIG_SH2_GRB2like	557	560	PF00017	0.760
LIG_SH2_NCK_1	218	222	PF00017	0.444
LIG_SH2_STAP1	218	222	PF00017	0.444
LIG_SH2_STAP1	62	66	PF00017	0.357
LIG_SH2_STAT5	162	165	PF00017	0.404
LIG_SH2_STAT5	66	69	PF00017	0.401
LIG_SH2_STAT5	93	96	PF00017	0.419
LIG_SH3_3	235	241	PF00018	0.591
LIG_SH3_3	385	391	PF00018	0.550
LIG_SH3_3	396	402	PF00018	0.538
LIG_SH3_3	544	550	PF00018	0.763
LIG_SH3_3	573	579	PF00018	0.744
LIG_SH3_3	91	97	PF00018	0.340
LIG_SUMO_SIM_anti_2	435	440	PF11976	0.508
LIG_SUMO_SIM_anti_2	5	12	PF11976	0.583
LIG_SUMO_SIM_anti_2	532	537	PF11976	0.353
LIG_SUMO_SIM_par_1	21	28	PF11976	0.601
LIG_SUMO_SIM_par_1	527	532	PF11976	0.338
LIG_TRFH_1	93	97	PF08558	0.419
LIG_WRC_WIRS_1	190	195	PF05994	0.419
LIG_WRC_WIRS_1	523	528	PF05994	0.436
MOD_CDC14_SPxK_1	45	48	PF00782	0.607
MOD_CDK_SPxK_1	42	48	PF00069	0.605
MOD_CDK_SPxxK_3	398	405	PF00069	0.531
MOD_CDK_SPxxK_3	42	49	PF00069	0.550
MOD_CK1_1	313	319	PF00069	0.543
MOD_CK1_1	329	335	PF00069	0.503
MOD_CK1_1	383	389	PF00069	0.542
MOD_CK1_1	398	404	PF00069	0.592
MOD_CK1_1	42	48	PF00069	0.590
MOD_CK1_1	420	426	PF00069	0.481
MOD_CK1_1	51	57	PF00069	0.474
MOD_CK1_1	510	516	PF00069	0.539
MOD_CK1_1	540	546	PF00069	0.697
MOD_CK1_1	89	95	PF00069	0.224
MOD_CK2_1	240	246	PF00069	0.585
MOD_CK2_1	273	279	PF00069	0.547
MOD_CK2_1	429	435	PF00069	0.499
MOD_GlcNHglycan	127	130	PF01048	0.520
MOD_GlcNHglycan	20	23	PF01048	0.680
MOD_GlcNHglycan	222	225	PF01048	0.744
MOD_GlcNHglycan	255	258	PF01048	0.787
MOD_GlcNHglycan	265	268	PF01048	0.714
MOD_GlcNHglycan	312	315	PF01048	0.777
MOD_GlcNHglycan	349	352	PF01048	0.753
MOD_GlcNHglycan	392	395	PF01048	0.703
MOD_GlcNHglycan	415	418	PF01048	0.635
MOD_GlcNHglycan	508	512	PF01048	0.757
MOD_GlcNHglycan	551	554	PF01048	0.547
MOD_GlcNHglycan	563	566	PF01048	0.467
MOD_GSK3_1	131	138	PF00069	0.419
MOD_GSK3_1	248	255	PF00069	0.585
MOD_GSK3_1	263	270	PF00069	0.487
MOD_GSK3_1	288	295	PF00069	0.589
MOD_GSK3_1	313	320	PF00069	0.617
MOD_GSK3_1	327	334	PF00069	0.534
MOD_GSK3_1	343	350	PF00069	0.455
MOD_GSK3_1	357	364	PF00069	0.572
MOD_GSK3_1	376	383	PF00069	0.567
MOD_GSK3_1	401	408	PF00069	0.553
MOD_GSK3_1	409	416	PF00069	0.431
MOD_GSK3_1	510	517	PF00069	0.601
MOD_GSK3_1	537	544	PF00069	0.539
MOD_GSK3_1	57	64	PF00069	0.400
MOD_GSK3_1	70	77	PF00069	0.334
MOD_N-GLC_1	131	136	PF02516	0.619
MOD_N-GLC_1	347	352	PF02516	0.767
MOD_N-GLC_1	357	362	PF02516	0.695
MOD_N-GLC_1	450	455	PF02516	0.689
MOD_NEK2_1	135	140	PF00069	0.329
MOD_NEK2_1	18	23	PF00069	0.506
MOD_NEK2_1	252	257	PF00069	0.573
MOD_NEK2_1	337	342	PF00069	0.561
MOD_NEK2_1	347	352	PF00069	0.481
MOD_NEK2_1	361	366	PF00069	0.511
MOD_NEK2_1	407	412	PF00069	0.483
MOD_NEK2_1	450	455	PF00069	0.442
MOD_NEK2_1	529	534	PF00069	0.396
MOD_NEK2_1	537	542	PF00069	0.587
MOD_NEK2_2	357	362	PF00069	0.458
MOD_NEK2_2	395	400	PF00069	0.467
MOD_NEK2_2	409	414	PF00069	0.514
MOD_OFUCOSY	375	380	PF10250	0.628
MOD_PIKK_1	317	323	PF00454	0.644
MOD_PKA_1	48	54	PF00069	0.537
MOD_PKA_2	429	435	PF00069	0.480
MOD_PKA_2	48	54	PF00069	0.483
MOD_PKA_2	561	567	PF00069	0.780
MOD_Plk_1	131	137	PF00069	0.419
MOD_Plk_1	357	363	PF00069	0.553
MOD_Plk_1	383	389	PF00069	0.582
MOD_Plk_1	434	440	PF00069	0.412
MOD_Plk_1	450	456	PF00069	0.327
MOD_Plk_4	142	148	PF00069	0.404
MOD_Plk_4	25	31	PF00069	0.618
MOD_Plk_4	417	423	PF00069	0.466
MOD_Plk_4	434	440	PF00069	0.442
MOD_Plk_4	510	516	PF00069	0.606
MOD_Plk_4	522	528	PF00069	0.249
MOD_Plk_4	529	535	PF00069	0.310
MOD_Plk_4	61	67	PF00069	0.452
MOD_Plk_4	89	95	PF00069	0.272
MOD_Plk_4	9	15	PF00069	0.502
MOD_ProDKin_1	226	232	PF00069	0.636
MOD_ProDKin_1	240	246	PF00069	0.514
MOD_ProDKin_1	269	275	PF00069	0.506
MOD_ProDKin_1	327	333	PF00069	0.600
MOD_ProDKin_1	398	404	PF00069	0.522
MOD_ProDKin_1	40	46	PF00069	0.580
TRG_DiLeu_BaEn_1	435	440	PF01217	0.453
TRG_ENDOCYTIC_2	162	165	PF00928	0.419
TRG_ENDOCYTIC_2	17	20	PF00928	0.660
TRG_ENDOCYTIC_2	218	221	PF00928	0.446
TRG_ENDOCYTIC_2	557	560	PF00928	0.817
TRG_ENDOCYTIC_2	62	65	PF00928	0.392
TRG_ER_diArg_1	157	160	PF00400	0.389
TRG_ER_diArg_1	167	170	PF00400	0.311
TRG_ER_diArg_1	452	455	PF00400	0.420
TRG_NES_CRM1_1	476	490	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	444	448	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	491	496	PF00026	0.704

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X320	Leishmania donovani	90%	100%
A4HHX6	Leishmania braziliensis	66%	100%
A4I526	Leishmania infantum	90%	100%
E9B0F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5AWZ8	Trypanosoma cruzi	29%	100%