TBC1 domain family member 23

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q7S6_LEIMA

TriTrypDb:

LmjF.30.0330 , LMJLV39_330034200 , LMJSD75_300008500

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005802	trans-Golgi network	4	3
GO:0005829	cytosol	2	18
GO:0031984	organelle subcompartment	2	3
GO:0098791	Golgi apparatus subcompartment	3	3
GO:0110165	cellular anatomical entity	1	18
GO:0005794	Golgi apparatus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11

Expansion

Sequence features

Q4Q7S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7S6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	18
GO:0009987	cellular process	1	18
GO:0016043	cellular component organization	3	3
GO:0016192	vesicle-mediated transport	4	18
GO:0016197	endosomal transport	4	18
GO:0016482	cytosolic transport	4	18
GO:0042147	retrograde transport, endosome to Golgi	5	18
GO:0046907	intracellular transport	3	18
GO:0051179	localization	1	18
GO:0051234	establishment of localization	2	18
GO:0051641	cellular localization	2	18
GO:0051649	establishment of localization in cell	3	18
GO:0071840	cellular component organization or biogenesis	2	3
GO:0099022	vesicle tethering	4	3
GO:0099041	vesicle tethering to Golgi	5	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.478
CLV_C14_Caspase3-7	277	281	PF00656	0.617
CLV_NRD_NRD_1	11	13	PF00675	0.673
CLV_NRD_NRD_1	203	205	PF00675	0.328
CLV_NRD_NRD_1	243	245	PF00675	0.420
CLV_NRD_NRD_1	410	412	PF00675	0.531
CLV_NRD_NRD_1	689	691	PF00675	0.669
CLV_PCSK_KEX2_1	11	13	PF00082	0.673
CLV_PCSK_KEX2_1	203	205	PF00082	0.328
CLV_PCSK_KEX2_1	243	245	PF00082	0.420
CLV_PCSK_KEX2_1	355	357	PF00082	0.622
CLV_PCSK_KEX2_1	410	412	PF00082	0.534
CLV_PCSK_KEX2_1	489	491	PF00082	0.552
CLV_PCSK_KEX2_1	554	556	PF00082	0.631
CLV_PCSK_KEX2_1	689	691	PF00082	0.671
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.622
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.552
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.650
CLV_PCSK_SKI1_1	137	141	PF00082	0.449
CLV_PCSK_SKI1_1	173	177	PF00082	0.328
CLV_PCSK_SKI1_1	203	207	PF00082	0.291
CLV_PCSK_SKI1_1	252	256	PF00082	0.517
CLV_PCSK_SKI1_1	293	297	PF00082	0.450
CLV_PCSK_SKI1_1	446	450	PF00082	0.456
CLV_PCSK_SKI1_1	690	694	PF00082	0.619
CLV_PCSK_SKI1_1	71	75	PF00082	0.627
DEG_APCC_DBOX_1	242	250	PF00400	0.394
DEG_APCC_DBOX_1	38	46	PF00400	0.481
DEG_SCF_FBW7_1	305	310	PF00400	0.478
DEG_SPOP_SBC_1	166	170	PF00917	0.477
DEG_SPOP_SBC_1	713	717	PF00917	0.754
DOC_CDC14_PxL_1	336	344	PF14671	0.267
DOC_CYCLIN_RxL_1	241	251	PF00134	0.380
DOC_CYCLIN_yClb5_NLxxxL_5	430	439	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.437
DOC_MAPK_gen_1	243	249	PF00069	0.436
DOC_MAPK_gen_1	653	661	PF00069	0.509
DOC_MAPK_MEF2A_6	446	454	PF00069	0.481
DOC_MAPK_RevD_3	229	244	PF00069	0.315
DOC_PP1_RVXF_1	215	222	PF00149	0.437
DOC_PP1_RVXF_1	310	317	PF00149	0.444
DOC_PP2B_LxvP_1	692	695	PF13499	0.666
DOC_PP4_FxxP_1	178	181	PF00568	0.437
DOC_PP4_FxxP_1	264	267	PF00568	0.370
DOC_USP7_MATH_1	158	162	PF00917	0.389
DOC_USP7_MATH_1	167	171	PF00917	0.375
DOC_USP7_MATH_1	366	370	PF00917	0.619
DOC_USP7_MATH_1	544	548	PF00917	0.586
DOC_USP7_MATH_1	570	574	PF00917	0.646
DOC_USP7_MATH_1	602	606	PF00917	0.797
DOC_USP7_MATH_1	676	680	PF00917	0.681
DOC_USP7_MATH_1	682	686	PF00917	0.619
DOC_USP7_MATH_1	704	708	PF00917	0.761
DOC_USP7_MATH_1	714	718	PF00917	0.809
DOC_USP7_MATH_1	754	758	PF00917	0.655
DOC_USP7_UBL2_3	503	507	PF12436	0.443
DOC_WW_Pin1_4	284	289	PF00397	0.599
DOC_WW_Pin1_4	303	308	PF00397	0.356
DOC_WW_Pin1_4	473	478	PF00397	0.517
DOC_WW_Pin1_4	660	665	PF00397	0.628
DOC_WW_Pin1_4	695	700	PF00397	0.737
DOC_WW_Pin1_4	709	714	PF00397	0.629
DOC_WW_Pin1_4	749	754	PF00397	0.617
LIG_14-3-3_CanoR_1	12	18	PF00244	0.468
LIG_14-3-3_CanoR_1	133	141	PF00244	0.387
LIG_14-3-3_CanoR_1	243	247	PF00244	0.447
LIG_14-3-3_CanoR_1	282	286	PF00244	0.452
LIG_14-3-3_CanoR_1	490	497	PF00244	0.618
LIG_14-3-3_CanoR_1	689	695	PF00244	0.616
LIG_14-3-3_CanoR_1	727	732	PF00244	0.663
LIG_Actin_WH2_2	640	658	PF00022	0.573
LIG_BIR_II_1	1	5	PF00653	0.389
LIG_BIR_III_2	365	369	PF00653	0.510
LIG_Clathr_ClatBox_1	45	49	PF01394	0.453
LIG_deltaCOP1_diTrp_1	220	223	PF00928	0.440
LIG_EH1_1	468	476	PF00400	0.376
LIG_FHA_1	124	130	PF00498	0.426
LIG_FHA_1	166	172	PF00498	0.356
LIG_FHA_1	254	260	PF00498	0.364
LIG_FHA_1	460	466	PF00498	0.451
LIG_FHA_1	583	589	PF00498	0.768
LIG_FHA_1	656	662	PF00498	0.586
LIG_FHA_1	89	95	PF00498	0.439
LIG_FHA_2	183	189	PF00498	0.437
LIG_FHA_2	326	332	PF00498	0.498
LIG_FHA_2	93	99	PF00498	0.503
LIG_LIR_Apic_2	111	116	PF02991	0.429
LIG_LIR_Gen_1	220	229	PF02991	0.309
LIG_LIR_Gen_1	382	392	PF02991	0.429
LIG_LIR_Gen_1	739	749	PF02991	0.515
LIG_LIR_Nem_3	143	148	PF02991	0.363
LIG_LIR_Nem_3	220	224	PF02991	0.334
LIG_LIR_Nem_3	382	388	PF02991	0.426
LIG_LIR_Nem_3	64	69	PF02991	0.504
LIG_LIR_Nem_3	739	745	PF02991	0.517
LIG_NRBOX	41	47	PF00104	0.536
LIG_PCNA_PIPBox_1	191	200	PF02747	0.437
LIG_PCNA_yPIPBox_3	133	145	PF02747	0.375
LIG_PCNA_yPIPBox_3	191	204	PF02747	0.437
LIG_Pex14_2	742	746	PF04695	0.507
LIG_PTAP_UEV_1	671	676	PF05743	0.526
LIG_SH2_CRK	145	149	PF00017	0.421
LIG_SH2_CRK	385	389	PF00017	0.417
LIG_SH2_CRK	43	47	PF00017	0.362
LIG_SH2_GRB2like	113	116	PF00017	0.461
LIG_SH2_NCK_1	164	168	PF00017	0.477
LIG_SH2_NCK_1	336	340	PF00017	0.292
LIG_SH2_SRC	164	167	PF00017	0.484
LIG_SH2_SRC	372	375	PF00017	0.488
LIG_SH2_STAP1	212	216	PF00017	0.437
LIG_SH2_STAP1	69	73	PF00017	0.557
LIG_SH2_STAT3	179	182	PF00017	0.371
LIG_SH2_STAT3	518	521	PF00017	0.625
LIG_SH2_STAT3	69	72	PF00017	0.348
LIG_SH2_STAT5	113	116	PF00017	0.480
LIG_SH2_STAT5	127	130	PF00017	0.334
LIG_SH2_STAT5	197	200	PF00017	0.388
LIG_SH2_STAT5	233	236	PF00017	0.356
LIG_SH2_STAT5	238	241	PF00017	0.347
LIG_SH2_STAT5	372	375	PF00017	0.347
LIG_SH2_STAT5	43	46	PF00017	0.399
LIG_SH2_STAT5	442	445	PF00017	0.402
LIG_SH2_STAT5	518	521	PF00017	0.625
LIG_SH2_STAT5	69	72	PF00017	0.499
LIG_SH3_2	651	656	PF14604	0.580
LIG_SH3_3	337	343	PF00018	0.520
LIG_SH3_3	51	57	PF00018	0.504
LIG_SH3_3	648	654	PF00018	0.612
LIG_SH3_3	669	675	PF00018	0.698
LIG_SH3_3	707	713	PF00018	0.660
LIG_SUMO_SIM_anti_2	245	251	PF11976	0.533
LIG_SUMO_SIM_anti_2	641	649	PF11976	0.592
LIG_SUMO_SIM_par_1	204	211	PF11976	0.351
LIG_SUMO_SIM_par_1	44	50	PF11976	0.534
LIG_SUMO_SIM_par_1	657	663	PF11976	0.544
LIG_SxIP_EBH_1	456	467	PF03271	0.462
LIG_TRAF2_1	61	64	PF00917	0.666
LIG_UBA3_1	147	153	PF00899	0.410
LIG_UBA3_1	246	252	PF00899	0.456
MOD_CK1_1	132	138	PF00069	0.454
MOD_CK1_1	16	22	PF00069	0.552
MOD_CK1_1	379	385	PF00069	0.466
MOD_CK1_1	561	567	PF00069	0.597
MOD_CK1_1	572	578	PF00069	0.640
MOD_CK1_1	591	597	PF00069	0.761
MOD_CK1_1	600	606	PF00069	0.682
MOD_CK1_1	712	718	PF00069	0.799
MOD_CK2_1	325	331	PF00069	0.502
MOD_CK2_1	556	562	PF00069	0.736
MOD_CK2_1	631	637	PF00069	0.717
MOD_CK2_1	682	688	PF00069	0.807
MOD_CK2_1	760	766	PF00069	0.688
MOD_CK2_1	92	98	PF00069	0.436
MOD_Cter_Amidation	487	490	PF01082	0.457
MOD_GlcNHglycan	350	353	PF01048	0.557
MOD_GlcNHglycan	508	511	PF01048	0.707
MOD_GlcNHglycan	514	518	PF01048	0.669
MOD_GlcNHglycan	574	577	PF01048	0.686
MOD_GlcNHglycan	588	591	PF01048	0.626
MOD_GlcNHglycan	594	597	PF01048	0.604
MOD_GlcNHglycan	599	602	PF01048	0.662
MOD_GlcNHglycan	672	675	PF01048	0.689
MOD_GlcNHglycan	679	682	PF01048	0.617
MOD_GlcNHglycan	684	687	PF01048	0.529
MOD_GlcNHglycan	716	719	PF01048	0.826
MOD_GlcNHglycan	729	732	PF01048	0.633
MOD_GlcNHglycan	762	765	PF01048	0.718
MOD_GSK3_1	12	19	PF00069	0.518
MOD_GSK3_1	207	214	PF00069	0.394
MOD_GSK3_1	238	245	PF00069	0.470
MOD_GSK3_1	28	35	PF00069	0.332
MOD_GSK3_1	303	310	PF00069	0.350
MOD_GSK3_1	344	351	PF00069	0.476
MOD_GSK3_1	556	563	PF00069	0.612
MOD_GSK3_1	566	573	PF00069	0.585
MOD_GSK3_1	582	589	PF00069	0.558
MOD_GSK3_1	600	607	PF00069	0.760
MOD_GSK3_1	690	697	PF00069	0.724
MOD_GSK3_1	709	716	PF00069	0.684
MOD_GSK3_1	88	95	PF00069	0.453
MOD_N-GLC_1	325	330	PF02516	0.523
MOD_N-GLC_1	484	489	PF02516	0.468
MOD_NEK2_1	123	128	PF00069	0.456
MOD_NEK2_1	140	145	PF00069	0.402
MOD_NEK2_1	199	204	PF00069	0.403
MOD_NEK2_1	247	252	PF00069	0.536
MOD_NEK2_1	262	267	PF00069	0.413
MOD_NEK2_1	325	330	PF00069	0.525
MOD_NEK2_1	422	427	PF00069	0.480
MOD_NEK2_1	459	464	PF00069	0.491
MOD_NEK2_1	583	588	PF00069	0.694
MOD_NEK2_1	646	651	PF00069	0.532
MOD_NEK2_1	655	660	PF00069	0.589
MOD_NEK2_2	108	113	PF00069	0.389
MOD_NEK2_2	13	18	PF00069	0.544
MOD_PIKK_1	253	259	PF00454	0.437
MOD_PIKK_1	307	313	PF00454	0.402
MOD_PKA_2	132	138	PF00069	0.515
MOD_PKA_2	242	248	PF00069	0.387
MOD_PKA_2	281	287	PF00069	0.551
MOD_PKA_2	379	385	PF00069	0.394
MOD_PKA_2	556	562	PF00069	0.586
MOD_PKA_2	623	629	PF00069	0.668
MOD_PKA_2	655	661	PF00069	0.684
MOD_Plk_1	108	114	PF00069	0.532
MOD_Plk_1	64	70	PF00069	0.492
MOD_Plk_1	747	753	PF00069	0.753
MOD_Plk_4	108	114	PF00069	0.554
MOD_Plk_4	123	129	PF00069	0.295
MOD_Plk_4	167	173	PF00069	0.360
MOD_Plk_4	193	199	PF00069	0.429
MOD_Plk_4	291	297	PF00069	0.464
MOD_Plk_4	655	661	PF00069	0.666
MOD_ProDKin_1	284	290	PF00069	0.585
MOD_ProDKin_1	303	309	PF00069	0.354
MOD_ProDKin_1	473	479	PF00069	0.512
MOD_ProDKin_1	660	666	PF00069	0.629
MOD_ProDKin_1	695	701	PF00069	0.737
MOD_ProDKin_1	709	715	PF00069	0.652
MOD_ProDKin_1	749	755	PF00069	0.619
TRG_DiLeu_BaEn_1	431	436	PF01217	0.386
TRG_DiLeu_BaEn_1	642	647	PF01217	0.637
TRG_DiLeu_BaEn_4	431	437	PF01217	0.386
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.437
TRG_DiLeu_BaLyEn_6	461	466	PF01217	0.394
TRG_ENDOCYTIC_2	145	148	PF00928	0.358
TRG_ENDOCYTIC_2	385	388	PF00928	0.428
TRG_ENDOCYTIC_2	43	46	PF00928	0.348
TRG_ER_diArg_1	203	205	PF00400	0.331
TRG_ER_diArg_1	409	411	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	204	209	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P357	Leptomonas seymouri	58%	90%
A0A0S4JBQ9	Bodo saltans	27%	83%
A0A1X0P274	Trypanosomatidae	30%	100%
A0A3Q8IGR4	Leishmania donovani	92%	90%
A0A3R7MQU5	Trypanosoma rangeli	35%	100%
A0A3S7X2Z8	Leishmania donovani	92%	88%
A4HHX7	Leishmania braziliensis	74%	100%
A4HHY0	Leishmania braziliensis	76%	90%
A4HLU8	Leishmania braziliensis	76%	90%
A4I560	Leishmania infantum	92%	70%
C9ZQI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AHQ3	Leishmania infantum	92%	90%
E9B0F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	90%
E9B474	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	90%
Q4Q3V2	Leishmania major	100%	100%
V5DD41	Trypanosoma cruzi	38%	100%