Putative KU80 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KU80 protein, putative

Species:

Leishmania major

UniProt:

Q4Q7S5_LEIMA

TriTrypDb:

LmjF.30.0340 , LMJLV39_300008800 , LMJSD75_300008600

Length:

798

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0043564	Ku70:Ku80 complex	3	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0005694	chromosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q7S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7S5

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006302	double-strand break repair	6	12
GO:0006303	double-strand break repair via nonhomologous end joining	7	12
GO:0006310	DNA recombination	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0006996	organelle organization	4	12
GO:0008152	metabolic process	1	12
GO:0009314	response to radiation	3	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	12
GO:0010165	response to X-ray	5	2
GO:0010212	response to ionizing radiation	4	2
GO:0010332	response to gamma radiation	5	2
GO:0016043	cellular component organization	3	12
GO:0032200	telomere organization	6	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051276	chromosome organization	5	12
GO:0051716	cellular response to stimulus	2	12
GO:0071214	cellular response to abiotic stimulus	3	2
GO:0071478	cellular response to radiation	4	2
GO:0071479	cellular response to ionizing radiation	5	2
GO:0071480	cellular response to gamma radiation	6	2
GO:0071481	cellular response to X-ray	6	2
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0104004	cellular response to environmental stimulus	3	2
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042162	telomeric DNA binding	6	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043565	sequence-specific DNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.561
CLV_C14_Caspase3-7	277	281	PF00656	0.527
CLV_C14_Caspase3-7	452	456	PF00656	0.531
CLV_C14_Caspase3-7	549	553	PF00656	0.630
CLV_C14_Caspase3-7	623	627	PF00656	0.681
CLV_C14_Caspase3-7	687	691	PF00656	0.470
CLV_C14_Caspase3-7	743	747	PF00656	0.564
CLV_NRD_NRD_1	201	203	PF00675	0.565
CLV_NRD_NRD_1	239	241	PF00675	0.447
CLV_NRD_NRD_1	275	277	PF00675	0.359
CLV_NRD_NRD_1	383	385	PF00675	0.305
CLV_NRD_NRD_1	562	564	PF00675	0.539
CLV_NRD_NRD_1	693	695	PF00675	0.361
CLV_NRD_NRD_1	743	745	PF00675	0.361
CLV_PCSK_FUR_1	237	241	PF00082	0.489
CLV_PCSK_KEX2_1	239	241	PF00082	0.443
CLV_PCSK_KEX2_1	275	277	PF00082	0.317
CLV_PCSK_SKI1_1	248	252	PF00082	0.393
CLV_PCSK_SKI1_1	257	261	PF00082	0.271
CLV_PCSK_SKI1_1	29	33	PF00082	0.302
CLV_PCSK_SKI1_1	358	362	PF00082	0.317
CLV_PCSK_SKI1_1	385	389	PF00082	0.317
CLV_PCSK_SKI1_1	535	539	PF00082	0.534
CLV_PCSK_SKI1_1	54	58	PF00082	0.361
CLV_PCSK_SKI1_1	770	774	PF00082	0.303
CLV_Separin_Metazoa	682	686	PF03568	0.572
DEG_APCC_DBOX_1	481	489	PF00400	0.485
DEG_COP1_1	188	196	PF00400	0.457
DEG_ODPH_VHL_1	83	95	PF01847	0.505
DOC_CDC14_PxL_1	434	442	PF14671	0.505
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.540
DOC_MAPK_DCC_7	416	425	PF00069	0.561
DOC_MAPK_gen_1	130	138	PF00069	0.494
DOC_MAPK_gen_1	147	155	PF00069	0.536
DOC_MAPK_gen_1	239	249	PF00069	0.513
DOC_MAPK_gen_1	332	342	PF00069	0.497
DOC_MAPK_gen_1	384	391	PF00069	0.505
DOC_MAPK_gen_1	482	490	PF00069	0.495
DOC_MAPK_gen_1	775	784	PF00069	0.583
DOC_MAPK_MEF2A_6	161	168	PF00069	0.381
DOC_MAPK_MEF2A_6	240	249	PF00069	0.431
DOC_MAPK_MEF2A_6	3	12	PF00069	0.418
DOC_MAPK_MEF2A_6	384	391	PF00069	0.522
DOC_MAPK_MEF2A_6	433	442	PF00069	0.533
DOC_MAPK_MEF2A_6	775	784	PF00069	0.661
DOC_PIKK_1	446	453	PF02985	0.614
DOC_PP1_RVXF_1	132	139	PF00149	0.572
DOC_PP1_RVXF_1	428	435	PF00149	0.542
DOC_PP2B_LxvP_1	176	179	PF13499	0.550
DOC_PP2B_LxvP_1	217	220	PF13499	0.491
DOC_PP4_FxxP_1	736	739	PF00568	0.561
DOC_USP7_MATH_1	125	129	PF00917	0.527
DOC_USP7_MATH_1	179	183	PF00917	0.676
DOC_USP7_MATH_1	229	233	PF00917	0.454
DOC_USP7_MATH_1	379	383	PF00917	0.518
DOC_USP7_MATH_1	397	401	PF00917	0.438
DOC_USP7_MATH_1	409	413	PF00917	0.501
DOC_USP7_MATH_1	522	526	PF00917	0.561
DOC_USP7_MATH_1	533	537	PF00917	0.450
DOC_USP7_MATH_1	590	594	PF00917	0.662
DOC_USP7_MATH_1	645	649	PF00917	0.491
DOC_USP7_MATH_1	651	655	PF00917	0.482
DOC_USP7_MATH_1	77	81	PF00917	0.380
DOC_USP7_UBL2_3	494	498	PF12436	0.734
DOC_WW_Pin1_4	222	227	PF00397	0.510
DOC_WW_Pin1_4	498	503	PF00397	0.628
DOC_WW_Pin1_4	572	577	PF00397	0.660
DOC_WW_Pin1_4	582	587	PF00397	0.702
LIG_14-3-3_CanoR_1	126	132	PF00244	0.539
LIG_14-3-3_CanoR_1	257	265	PF00244	0.552
LIG_14-3-3_CanoR_1	275	284	PF00244	0.499
LIG_14-3-3_CanoR_1	29	37	PF00244	0.485
LIG_14-3-3_CanoR_1	390	399	PF00244	0.542
LIG_14-3-3_CanoR_1	433	440	PF00244	0.543
LIG_14-3-3_CanoR_1	482	490	PF00244	0.504
LIG_14-3-3_CanoR_1	514	521	PF00244	0.530
LIG_Actin_WH2_2	672	687	PF00022	0.472
LIG_BIR_II_1	1	5	PF00653	0.427
LIG_BIR_III_2	396	400	PF00653	0.504
LIG_BRCT_BRCA1_1	516	520	PF00533	0.499
LIG_Clathr_ClatBox_1	720	724	PF01394	0.505
LIG_CSL_BTD_1	736	739	PF09270	0.478
LIG_DLG_GKlike_1	270	278	PF00625	0.505
LIG_eIF4E_1	715	721	PF01652	0.517
LIG_FHA_1	188	194	PF00498	0.683
LIG_FHA_1	355	361	PF00498	0.542
LIG_FHA_1	573	579	PF00498	0.685
LIG_FHA_2	264	270	PF00498	0.502
LIG_FHA_2	498	504	PF00498	0.672
LIG_FHA_2	514	520	PF00498	0.611
LIG_FHA_2	621	627	PF00498	0.772
LIG_FHA_2	645	651	PF00498	0.519
LIG_FHA_2	707	713	PF00498	0.478
LIG_FHA_2	752	758	PF00498	0.481
LIG_FHA_2	785	791	PF00498	0.624
LIG_GBD_Chelix_1	6	14	PF00786	0.395
LIG_LIR_Apic_2	733	739	PF02991	0.561
LIG_LIR_Gen_1	108	118	PF02991	0.505
LIG_LIR_Gen_1	172	180	PF02991	0.564
LIG_LIR_Gen_1	195	204	PF02991	0.552
LIG_LIR_Gen_1	287	296	PF02991	0.505
LIG_LIR_Gen_1	349	359	PF02991	0.505
LIG_LIR_Gen_1	525	533	PF02991	0.553
LIG_LIR_Gen_1	654	663	PF02991	0.516
LIG_LIR_Gen_1	678	688	PF02991	0.546
LIG_LIR_Nem_3	108	113	PF02991	0.505
LIG_LIR_Nem_3	172	176	PF02991	0.501
LIG_LIR_Nem_3	195	200	PF02991	0.524
LIG_LIR_Nem_3	287	293	PF02991	0.467
LIG_LIR_Nem_3	310	316	PF02991	0.422
LIG_LIR_Nem_3	435	440	PF02991	0.466
LIG_LIR_Nem_3	468	473	PF02991	0.480
LIG_LIR_Nem_3	525	531	PF02991	0.546
LIG_LIR_Nem_3	654	658	PF02991	0.516
LIG_LIR_Nem_3	678	684	PF02991	0.456
LIG_LIR_Nem_3	735	740	PF02991	0.541
LIG_LYPXL_yS_3	437	440	PF13949	0.561
LIG_MYND_1	507	511	PF01753	0.620
LIG_NBox_RRM_1	112	122	PF00076	0.542
LIG_PCNA_yPIPBox_3	471	484	PF02747	0.460
LIG_SH2_CRK	478	482	PF00017	0.406
LIG_SH2_GRB2like	715	718	PF00017	0.482
LIG_SH2_NCK_1	528	532	PF00017	0.559
LIG_SH2_NCK_1	66	70	PF00017	0.478
LIG_SH2_PTP2	290	293	PF00017	0.561
LIG_SH2_SRC	37	40	PF00017	0.539
LIG_SH2_SRC	569	572	PF00017	0.610
LIG_SH2_STAP1	547	551	PF00017	0.598
LIG_SH2_STAP1	58	62	PF00017	0.563
LIG_SH2_STAT5	137	140	PF00017	0.470
LIG_SH2_STAT5	290	293	PF00017	0.518
LIG_SH2_STAT5	351	354	PF00017	0.464
LIG_SH2_STAT5	740	743	PF00017	0.561
LIG_SH3_3	328	334	PF00018	0.569
LIG_SH3_3	416	422	PF00018	0.538
LIG_SH3_3	460	466	PF00018	0.464
LIG_SH3_3	656	662	PF00018	0.561
LIG_SH3_4	566	573	PF00018	0.619
LIG_Sin3_3	373	380	PF02671	0.561
LIG_SUMO_SIM_anti_2	150	157	PF11976	0.580
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.316
LIG_SUMO_SIM_anti_2	232	237	PF11976	0.419
LIG_SUMO_SIM_anti_2	40	47	PF11976	0.517
LIG_SUMO_SIM_par_1	150	157	PF11976	0.481
LIG_SUMO_SIM_par_1	5	11	PF11976	0.379
LIG_TRAF2_1	266	269	PF00917	0.481
LIG_TRAF2_1	304	307	PF00917	0.561
LIG_TRAF2_1	444	447	PF00917	0.484
LIG_TRAF2_1	754	757	PF00917	0.557
LIG_TYR_ITIM	288	293	PF00017	0.533
LIG_WRC_WIRS_1	652	657	PF05994	0.481
MOD_CK1_1	540	546	PF00069	0.519
MOD_CK1_1	618	624	PF00069	0.713
MOD_CK1_1	629	635	PF00069	0.620
MOD_CK2_1	102	108	PF00069	0.505
MOD_CK2_1	179	185	PF00069	0.636
MOD_CK2_1	222	228	PF00069	0.486
MOD_CK2_1	263	269	PF00069	0.510
MOD_CK2_1	317	323	PF00069	0.525
MOD_CK2_1	440	446	PF00069	0.495
MOD_CK2_1	497	503	PF00069	0.655
MOD_CK2_1	751	757	PF00069	0.481
MOD_Cter_Amidation	561	564	PF01082	0.497
MOD_GlcNHglycan	194	197	PF01048	0.618
MOD_GlcNHglycan	411	414	PF01048	0.357
MOD_GlcNHglycan	442	445	PF01048	0.305
MOD_GlcNHglycan	485	488	PF01048	0.503
MOD_GlcNHglycan	490	493	PF01048	0.525
MOD_GlcNHglycan	531	534	PF01048	0.499
MOD_GlcNHglycan	535	538	PF01048	0.538
MOD_GlcNHglycan	54	57	PF01048	0.322
MOD_GlcNHglycan	555	558	PF01048	0.651
MOD_GlcNHglycan	615	620	PF01048	0.703
MOD_GlcNHglycan	638	641	PF01048	0.670
MOD_GlcNHglycan	759	762	PF01048	0.253
MOD_GSK3_1	188	195	PF00069	0.686
MOD_GSK3_1	218	225	PF00069	0.444
MOD_GSK3_1	257	264	PF00069	0.481
MOD_GSK3_1	270	277	PF00069	0.452
MOD_GSK3_1	37	44	PF00069	0.464
MOD_GSK3_1	405	412	PF00069	0.536
MOD_GSK3_1	455	462	PF00069	0.479
MOD_GSK3_1	494	501	PF00069	0.633
MOD_GSK3_1	509	516	PF00069	0.528
MOD_GSK3_1	529	536	PF00069	0.469
MOD_GSK3_1	618	625	PF00069	0.745
MOD_GSK3_1	636	643	PF00069	0.667
MOD_GSK3_1	98	105	PF00069	0.505
MOD_N-GLC_1	186	191	PF02516	0.675
MOD_N-GLC_1	488	493	PF02516	0.595
MOD_N-GLC_2	133	135	PF02516	0.326
MOD_N-GLC_2	25	27	PF02516	0.299
MOD_NEK2_1	10	15	PF00069	0.427
MOD_NEK2_1	186	191	PF00069	0.734
MOD_NEK2_1	274	279	PF00069	0.481
MOD_NEK2_1	354	359	PF00069	0.542
MOD_NEK2_1	380	385	PF00069	0.525
MOD_NEK2_1	405	410	PF00069	0.554
MOD_NEK2_1	440	445	PF00069	0.515
MOD_NEK2_1	513	518	PF00069	0.493
MOD_NEK2_1	644	649	PF00069	0.575
MOD_NEK2_1	683	688	PF00069	0.487
MOD_NEK2_2	477	482	PF00069	0.440
MOD_PIKK_1	125	131	PF00454	0.533
MOD_PIKK_1	179	185	PF00454	0.713
MOD_PIKK_1	257	263	PF00454	0.512
MOD_PIKK_1	275	281	PF00454	0.564
MOD_PIKK_1	706	712	PF00454	0.478
MOD_PKA_1	275	281	PF00069	0.517
MOD_PKA_2	102	108	PF00069	0.505
MOD_PKA_2	125	131	PF00069	0.561
MOD_PKA_2	274	280	PF00069	0.499
MOD_PKA_2	317	323	PF00069	0.535
MOD_PKA_2	432	438	PF00069	0.533
MOD_PKA_2	513	519	PF00069	0.528
MOD_PKA_2	684	690	PF00069	0.464
MOD_Plk_1	10	16	PF00069	0.444
MOD_Plk_1	187	193	PF00069	0.647
MOD_Plk_1	41	47	PF00069	0.490
MOD_Plk_1	459	465	PF00069	0.472
MOD_Plk_1	58	64	PF00069	0.335
MOD_Plk_2-3	151	157	PF00069	0.457
MOD_Plk_2-3	455	461	PF00069	0.494
MOD_Plk_4	151	157	PF00069	0.391
MOD_Plk_4	188	194	PF00069	0.597
MOD_Plk_4	219	225	PF00069	0.454
MOD_Plk_4	231	237	PF00069	0.443
MOD_Plk_4	41	47	PF00069	0.458
MOD_Plk_4	459	465	PF00069	0.498
MOD_Plk_4	574	580	PF00069	0.695
MOD_ProDKin_1	222	228	PF00069	0.513
MOD_ProDKin_1	498	504	PF00069	0.615
MOD_ProDKin_1	572	578	PF00069	0.668
MOD_ProDKin_1	582	588	PF00069	0.705
MOD_SUMO_for_1	304	307	PF00179	0.561
MOD_SUMO_for_1	721	724	PF00179	0.530
MOD_SUMO_rev_2	195	204	PF00179	0.588
TRG_DiLeu_BaEn_1	349	354	PF01217	0.542
TRG_DiLeu_BaEn_1	550	555	PF01217	0.675
TRG_DiLeu_BaEn_2	107	113	PF01217	0.561
TRG_DiLeu_BaEn_2	337	343	PF01217	0.542
TRG_ENDOCYTIC_2	110	113	PF00928	0.542
TRG_ENDOCYTIC_2	290	293	PF00928	0.504
TRG_ENDOCYTIC_2	351	354	PF00928	0.464
TRG_ENDOCYTIC_2	437	440	PF00928	0.467
TRG_ENDOCYTIC_2	478	481	PF00928	0.405
TRG_ENDOCYTIC_2	528	531	PF00928	0.508
TRG_ENDOCYTIC_2	569	572	PF00928	0.663
TRG_ENDOCYTIC_2	66	69	PF00928	0.499
TRG_ENDOCYTIC_2	716	719	PF00928	0.561
TRG_ER_diArg_1	236	239	PF00400	0.417
TRG_ER_diArg_1	274	276	PF00400	0.561
TRG_NES_CRM1_1	111	124	PF08389	0.542
TRG_NES_CRM1_1	447	461	PF08389	0.580
TRG_NLS_MonoExtC_3	562	567	PF00514	0.484
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUA9	Leptomonas seymouri	57%	100%
A0A0S4JHV4	Bodo saltans	27%	97%
A0A1X0P2Y5	Trypanosomatidae	30%	95%
A0A3Q8IRQ2	Leishmania donovani	92%	100%
A0A422NMK3	Trypanosoma rangeli	35%	100%
A4HHY1	Leishmania braziliensis	77%	100%
A4I561	Leishmania infantum	92%	100%
C9ZQI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B0F8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q54LY5	Dictyostelium discoideum	20%	100%
Q75IP6	Oryza sativa subsp. japonica	22%	100%
Q7RX73	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	20%	100%
V5BGZ6	Trypanosoma cruzi	34%	100%