Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania major

UniProt:

Q4Q7S4_LEIMA

TriTrypDb:

LmjF.30.0350 , LMJLV39_300008900 , LMJSD75_300008700

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	11
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q7S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7S4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0008574	plus-end-directed microtubule motor activity	3	2
GO:0015631	tubulin binding	4	11
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.282
CLV_C14_Caspase3-7	560	564	PF00656	0.714
CLV_NRD_NRD_1	207	209	PF00675	0.271
CLV_NRD_NRD_1	464	466	PF00675	0.418
CLV_NRD_NRD_1	49	51	PF00675	0.286
CLV_NRD_NRD_1	493	495	PF00675	0.566
CLV_NRD_NRD_1	592	594	PF00675	0.623
CLV_NRD_NRD_1	603	605	PF00675	0.603
CLV_PCSK_KEX2_1	360	362	PF00082	0.376
CLV_PCSK_KEX2_1	493	495	PF00082	0.501
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.376
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.477
CLV_PCSK_SKI1_1	106	110	PF00082	0.298
CLV_PCSK_SKI1_1	190	194	PF00082	0.377
CLV_PCSK_SKI1_1	256	260	PF00082	0.365
CLV_PCSK_SKI1_1	286	290	PF00082	0.406
CLV_PCSK_SKI1_1	293	297	PF00082	0.422
CLV_PCSK_SKI1_1	484	488	PF00082	0.507
CLV_PCSK_SKI1_1	594	598	PF00082	0.441
DEG_APCC_DBOX_1	255	263	PF00400	0.365
DEG_APCC_DBOX_1	481	489	PF00400	0.419
DOC_CYCLIN_RxL_1	283	290	PF00134	0.386
DOC_MAPK_gen_1	233	242	PF00069	0.273
DOC_MAPK_gen_1	482	489	PF00069	0.425
DOC_MAPK_gen_1	572	581	PF00069	0.575
DOC_MAPK_MEF2A_6	162	169	PF00069	0.295
DOC_MAPK_MEF2A_6	233	242	PF00069	0.374
DOC_MAPK_MEF2A_6	482	489	PF00069	0.443
DOC_MAPK_MEF2A_6	575	583	PF00069	0.395
DOC_MAPK_NFAT4_5	482	490	PF00069	0.533
DOC_USP7_MATH_1	212	216	PF00917	0.367
DOC_USP7_MATH_1	49	53	PF00917	0.236
DOC_USP7_MATH_1	539	543	PF00917	0.453
DOC_USP7_UBL2_3	356	360	PF12436	0.378
DOC_USP7_UBL2_3	51	55	PF12436	0.300
DOC_USP7_UBL2_3	9	13	PF12436	0.499
DOC_WW_Pin1_4	330	335	PF00397	0.254
DOC_WW_Pin1_4	437	442	PF00397	0.577
DOC_WW_Pin1_4	545	550	PF00397	0.596
LIG_14-3-3_CanoR_1	131	140	PF00244	0.186
LIG_14-3-3_CanoR_1	286	292	PF00244	0.383
LIG_14-3-3_CanoR_1	3	12	PF00244	0.664
LIG_14-3-3_CanoR_1	400	408	PF00244	0.554
LIG_14-3-3_CanoR_1	68	77	PF00244	0.282
LIG_Actin_WH2_2	422	437	PF00022	0.582
LIG_Actin_WH2_2	460	478	PF00022	0.486
LIG_APCC_ABBA_1	147	152	PF00400	0.254
LIG_BIR_II_1	1	5	PF00653	0.654
LIG_BIR_III_4	160	164	PF00653	0.186
LIG_FHA_1	105	111	PF00498	0.273
LIG_FHA_1	153	159	PF00498	0.267
LIG_FHA_1	226	232	PF00498	0.333
LIG_FHA_1	248	254	PF00498	0.385
LIG_FHA_1	311	317	PF00498	0.254
LIG_FHA_1	324	330	PF00498	0.254
LIG_FHA_1	52	58	PF00498	0.267
LIG_FHA_1	532	538	PF00498	0.464
LIG_FHA_2	134	140	PF00498	0.322
LIG_FHA_2	242	248	PF00498	0.265
LIG_FHA_2	269	275	PF00498	0.273
LIG_FHA_2	383	389	PF00498	0.513
LIG_FHA_2	70	76	PF00498	0.340
LIG_Integrin_RGD_1	174	176	PF01839	0.251
LIG_LIR_Gen_1	127	137	PF02991	0.310
LIG_LIR_Gen_1	143	154	PF02991	0.177
LIG_LIR_Gen_1	32	38	PF02991	0.405
LIG_LIR_Gen_1	454	464	PF02991	0.439
LIG_LIR_Gen_1	60	71	PF02991	0.212
LIG_LIR_Gen_1	75	85	PF02991	0.308
LIG_LIR_Nem_3	127	132	PF02991	0.254
LIG_LIR_Nem_3	143	149	PF02991	0.254
LIG_LIR_Nem_3	32	36	PF02991	0.405
LIG_LIR_Nem_3	366	370	PF02991	0.414
LIG_LIR_Nem_3	454	460	PF02991	0.499
LIG_LIR_Nem_3	60	66	PF02991	0.212
LIG_LIR_Nem_3	75	80	PF02991	0.308
LIG_NRBOX	153	159	PF00104	0.254
LIG_PCNA_yPIPBox_3	151	164	PF02747	0.254
LIG_PCNA_yPIPBox_3	419	429	PF02747	0.542
LIG_PCNA_yPIPBox_3	459	468	PF02747	0.500
LIG_Pex14_2	63	67	PF04695	0.254
LIG_PTB_Apo_2	32	39	PF02174	0.310
LIG_PTB_Apo_2	61	68	PF02174	0.298
LIG_PTB_Phospho_1	32	38	PF10480	0.310
LIG_SH2_CRK	18	22	PF00017	0.367
LIG_SH2_CRK	367	371	PF00017	0.429
LIG_SH2_PTP2	146	149	PF00017	0.254
LIG_SH2_SRC	38	41	PF00017	0.210
LIG_SH2_SRC	428	431	PF00017	0.476
LIG_SH2_STAP1	140	144	PF00017	0.273
LIG_SH2_STAP1	397	401	PF00017	0.469
LIG_SH2_STAP1	77	81	PF00017	0.298
LIG_SH2_STAT5	146	149	PF00017	0.260
LIG_SH2_STAT5	18	21	PF00017	0.377
LIG_SH2_STAT5	428	431	PF00017	0.476
LIG_SH2_STAT5	536	539	PF00017	0.500
LIG_SH2_STAT5	61	64	PF00017	0.367
LIG_SH3_1	20	26	PF00018	0.298
LIG_SH3_3	18	24	PF00018	0.271
LIG_SH3_3	546	552	PF00018	0.744
LIG_SH3_3	63	69	PF00018	0.298
LIG_SUMO_SIM_par_1	176	184	PF11976	0.254
LIG_SUMO_SIM_par_1	236	241	PF11976	0.227
LIG_SUMO_SIM_par_1	249	254	PF11976	0.320
LIG_TRAF2_1	385	388	PF00917	0.625
LIG_TRAF2_1	389	392	PF00917	0.581
LIG_TYR_ITIM	144	149	PF00017	0.254
LIG_TYR_ITIM	365	370	PF00017	0.413
LIG_UBA3_1	153	162	PF00899	0.273
LIG_UBA3_1	226	233	PF00899	0.282
LIG_UBA3_1	288	293	PF00899	0.254
LIG_UBA3_1	374	381	PF00899	0.459
LIG_WRC_WIRS_1	503	508	PF05994	0.476
LIG_WRC_WIRS_1	540	545	PF05994	0.645
LIG_WRC_WIRS_1	77	82	PF05994	0.305
MOD_CK1_1	104	110	PF00069	0.254
MOD_CK1_1	181	187	PF00069	0.340
MOD_CK1_1	215	221	PF00069	0.262
MOD_CK1_1	287	293	PF00069	0.406
MOD_CK1_1	310	316	PF00069	0.261
MOD_CK1_1	443	449	PF00069	0.585
MOD_CK1_1	548	554	PF00069	0.653
MOD_CK1_1	7	13	PF00069	0.627
MOD_CK2_1	108	114	PF00069	0.403
MOD_CK2_1	241	247	PF00069	0.355
MOD_CK2_1	268	274	PF00069	0.292
MOD_CK2_1	382	388	PF00069	0.585
MOD_GlcNHglycan	103	106	PF01048	0.254
MOD_GlcNHglycan	343	346	PF01048	0.287
MOD_GlcNHglycan	401	404	PF01048	0.506
MOD_GlcNHglycan	442	445	PF01048	0.680
MOD_GlcNHglycan	453	456	PF01048	0.623
MOD_GlcNHglycan	51	54	PF01048	0.236
MOD_GlcNHglycan	537	540	PF01048	0.559
MOD_GlcNHglycan	565	568	PF01048	0.637
MOD_GSK3_1	1	8	PF00069	0.692
MOD_GSK3_1	104	111	PF00069	0.254
MOD_GSK3_1	138	145	PF00069	0.294
MOD_GSK3_1	211	218	PF00069	0.286
MOD_GSK3_1	262	269	PF00069	0.298
MOD_GSK3_1	332	339	PF00069	0.294
MOD_GSK3_1	34	41	PF00069	0.257
MOD_GSK3_1	439	446	PF00069	0.478
MOD_GSK3_1	523	530	PF00069	0.530
MOD_GSK3_1	531	538	PF00069	0.460
MOD_GSK3_1	539	546	PF00069	0.526
MOD_N-GLC_1	216	221	PF02516	0.254
MOD_N-GLC_1	284	289	PF02516	0.254
MOD_N-GLC_1	324	329	PF02516	0.260
MOD_N-GLC_1	330	335	PF02516	0.248
MOD_N-GLC_1	34	39	PF02516	0.294
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	121	126	PF00069	0.365
MOD_NEK2_1	211	216	PF00069	0.253
MOD_NEK2_1	307	312	PF00069	0.270
MOD_NEK2_1	316	321	PF00069	0.312
MOD_NEK2_1	543	548	PF00069	0.732
MOD_NEK2_1	57	62	PF00069	0.186
MOD_PIKK_1	1	7	PF00454	0.568
MOD_PIKK_1	350	356	PF00454	0.386
MOD_PIKK_1	515	521	PF00454	0.528
MOD_PIKK_1	69	75	PF00454	0.298
MOD_PKA_2	266	272	PF00069	0.254
MOD_PKA_2	307	313	PF00069	0.294
MOD_PKA_2	350	356	PF00069	0.395
MOD_PKA_2	399	405	PF00069	0.538
MOD_PKA_2	49	55	PF00069	0.279
MOD_PKA_2	67	73	PF00069	0.298
MOD_Plk_1	279	285	PF00069	0.273
MOD_Plk_1	324	330	PF00069	0.268
MOD_Plk_1	339	345	PF00069	0.219
MOD_Plk_1	34	40	PF00069	0.291
MOD_Plk_1	382	388	PF00069	0.554
MOD_Plk_1	57	63	PF00069	0.248
MOD_Plk_2-3	274	280	PF00069	0.273
MOD_Plk_2-3	336	342	PF00069	0.273
MOD_Plk_4	142	148	PF00069	0.254
MOD_Plk_4	222	228	PF00069	0.264
MOD_Plk_4	316	322	PF00069	0.299
MOD_Plk_4	324	330	PF00069	0.289
MOD_Plk_4	57	63	PF00069	0.231
MOD_ProDKin_1	330	336	PF00069	0.254
MOD_ProDKin_1	437	443	PF00069	0.580
MOD_ProDKin_1	545	551	PF00069	0.597
MOD_SUMO_rev_2	189	198	PF00179	0.387
MOD_SUMO_rev_2	269	278	PF00179	0.273
MOD_SUMO_rev_2	363	370	PF00179	0.405
MOD_SUMO_rev_2	402	411	PF00179	0.565
TRG_DiLeu_BaEn_1	406	411	PF01217	0.439
TRG_DiLeu_BaEn_1	577	582	PF01217	0.508
TRG_DiLeu_BaEn_4	406	412	PF01217	0.563
TRG_ENDOCYTIC_2	146	149	PF00928	0.254
TRG_ENDOCYTIC_2	150	153	PF00928	0.254
TRG_ENDOCYTIC_2	18	21	PF00928	0.377
TRG_ENDOCYTIC_2	318	321	PF00928	0.273
TRG_ENDOCYTIC_2	367	370	PF00928	0.425
TRG_ENDOCYTIC_2	371	374	PF00928	0.436
TRG_ENDOCYTIC_2	77	80	PF00928	0.254
TRG_ER_diArg_1	20	23	PF00400	0.258
TRG_ER_diArg_1	482	485	PF00400	0.528
TRG_NES_CRM1_1	399	414	PF08389	0.544
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.273
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	572	577	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	593	598	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	25%	69%
A0A0N1HY56	Leptomonas seymouri	28%	88%
A0A0N1I0Y5	Leptomonas seymouri	72%	99%
A0A0N1I2F8	Leptomonas seymouri	26%	72%
A0A0S4IP49	Bodo saltans	27%	75%
A0A0S4IR67	Bodo saltans	27%	78%
A0A0S4JEF6	Bodo saltans	51%	90%
A0A0S4JUR0	Bodo saltans	30%	69%
A0A0S4JXY6	Bodo saltans	24%	71%
A0A1X0NNQ8	Trypanosomatidae	25%	94%
A0A1X0NQ03	Trypanosomatidae	24%	73%
A0A1X0NY69	Trypanosomatidae	30%	80%
A0A1X0P2B6	Trypanosomatidae	58%	99%
A0A1X0P9E3	Trypanosomatidae	29%	100%
A0A1X0P9T0	Trypanosomatidae	31%	100%
A0A3Q8IBS7	Leishmania donovani	92%	100%
A0A3Q8IG88	Leishmania donovani	26%	87%
A0A3R7KSK0	Trypanosoma rangeli	29%	82%
A0A3R7MDH9	Trypanosoma rangeli	27%	85%
A0A3R7R330	Trypanosoma rangeli	29%	100%
A0A3S5IRH3	Trypanosoma rangeli	56%	100%
A0A422N2N4	Trypanosoma rangeli	29%	70%
A2ZRG4	Oryza sativa subsp. japonica	33%	73%
A4H4I4	Leishmania braziliensis	26%	92%
A4HAQ7	Leishmania braziliensis	26%	100%
A4HHN7	Leishmania braziliensis	32%	100%
A4HHN8	Leishmania braziliensis	31%	100%
A4HHY2	Leishmania braziliensis	74%	100%
A4HSA6	Leishmania infantum	35%	100%
A4I562	Leishmania infantum	91%	100%
A4IBA7	Leishmania infantum	27%	87%
B9G2X9	Oryza sativa subsp. japonica	31%	100%
C9ZK93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	81%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	97%
C9ZTM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	95%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	81%
C9ZZN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	89%
E9AEA0	Leishmania major	30%	100%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	68%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
F4I1T9	Arabidopsis thaliana	30%	71%
O59751	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	77%
P46870	Chlamydomonas reinhardtii	30%	78%
Q1MTQ1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	97%
Q2NL05	Bos taurus	27%	92%
Q2R2P7	Oryza sativa subsp. japonica	33%	95%
Q4QEL8	Leishmania major	27%	75%
Q4QJ61	Leishmania major	27%	90%
Q4R918	Macaca fascicularis	27%	100%
Q75HV1	Oryza sativa subsp. japonica	31%	72%
Q86ZC1	Botryotinia fuckeliana	35%	69%
Q8NI77	Homo sapiens	30%	68%
Q8W0Y9	Arabidopsis thaliana	30%	97%
Q91WD7	Mus musculus	31%	69%
Q965T6	Caenorhabditis elegans	36%	94%
Q96FN5	Homo sapiens	31%	94%
Q9D2Z8	Mus musculus	32%	95%
Q9FZ06	Arabidopsis thaliana	34%	66%
Q9SCJ4	Arabidopsis thaliana	29%	75%
Q9UTL2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
V5BHY4	Trypanosoma cruzi	30%	81%
V5BK25	Trypanosoma cruzi	28%	84%
V5BNJ8	Trypanosoma cruzi	27%	100%
V5DFA7	Trypanosoma cruzi	28%	100%
V5DTU1	Trypanosoma cruzi	32%	100%