Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endosomal integral membrane protein, putative

Species:

Leishmania major

UniProt:

Q4Q7S3_LEIMA

TriTrypDb:

LmjF.30.0360 , LMJLV39_300009000 , LMJSD75_300008800

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 4
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q7S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7S3

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0033036	macromolecule localization	2	2
GO:0051179	localization	1	2
GO:0051641	cellular localization	2	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0072657	protein localization to membrane	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.293
CLV_NRD_NRD_1	144	146	PF00675	0.464
CLV_NRD_NRD_1	287	289	PF00675	0.231
CLV_NRD_NRD_1	386	388	PF00675	0.315
CLV_NRD_NRD_1	71	73	PF00675	0.426
CLV_PCSK_KEX2_1	116	118	PF00082	0.480
CLV_PCSK_KEX2_1	144	146	PF00082	0.466
CLV_PCSK_KEX2_1	287	289	PF00082	0.248
CLV_PCSK_KEX2_1	385	387	PF00082	0.315
CLV_PCSK_KEX2_1	71	73	PF00082	0.479
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.480
CLV_PCSK_SKI1_1	116	120	PF00082	0.534
CLV_PCSK_SKI1_1	197	201	PF00082	0.383
CLV_PCSK_SKI1_1	355	359	PF00082	0.429
CLV_PCSK_SKI1_1	39	43	PF00082	0.592
CLV_PCSK_SKI1_1	476	480	PF00082	0.315
CLV_PCSK_SKI1_1	548	552	PF00082	0.224
CLV_PCSK_SKI1_1	575	579	PF00082	0.524
CLV_PCSK_SKI1_1	91	95	PF00082	0.483
CLV_PCSK_SKI1_1	97	101	PF00082	0.469
DEG_APCC_DBOX_1	354	362	PF00400	0.315
DEG_MDM2_SWIB_1	500	507	PF02201	0.256
DEG_SCF_FBW7_1	237	244	PF00400	0.267
DEG_SPOP_SBC_1	178	182	PF00917	0.181
DEG_SPOP_SBC_1	236	240	PF00917	0.233
DOC_CDC14_PxL_1	128	136	PF14671	0.267
DOC_CYCLIN_yCln2_LP_2	455	461	PF00134	0.448
DOC_MAPK_FxFP_2	16	19	PF00069	0.293
DOC_MAPK_gen_1	121	128	PF00069	0.238
DOC_MAPK_gen_1	316	326	PF00069	0.438
DOC_MAPK_gen_1	385	394	PF00069	0.424
DOC_MAPK_MEF2A_6	319	328	PF00069	0.456
DOC_MAPK_MEF2A_6	575	584	PF00069	0.362
DOC_PP1_RVXF_1	186	193	PF00149	0.224
DOC_PP2B_LxvP_1	134	137	PF13499	0.233
DOC_PP2B_LxvP_1	455	458	PF13499	0.364
DOC_PP4_FxxP_1	16	19	PF00568	0.377
DOC_PP4_FxxP_1	315	318	PF00568	0.413
DOC_USP7_MATH_1	178	182	PF00917	0.236
DOC_USP7_MATH_1	351	355	PF00917	0.164
DOC_USP7_MATH_1	424	428	PF00917	0.259
DOC_USP7_MATH_1	527	531	PF00917	0.465
DOC_WW_Pin1_4	237	242	PF00397	0.289
LIG_14-3-3_CanoR_1	105	114	PF00244	0.219
LIG_14-3-3_CanoR_1	157	166	PF00244	0.340
LIG_14-3-3_CanoR_1	228	234	PF00244	0.313
LIG_14-3-3_CanoR_1	385	390	PF00244	0.480
LIG_14-3-3_CanoR_1	51	56	PF00244	0.375
LIG_14-3-3_CanoR_1	510	515	PF00244	0.267
LIG_BRCT_BRCA1_1	225	229	PF00533	0.335
LIG_BRCT_BRCA1_1	52	56	PF00533	0.279
LIG_BRCT_BRCA1_1	605	609	PF00533	0.311
LIG_deltaCOP1_diTrp_1	234	242	PF00928	0.266
LIG_eIF4E_1	167	173	PF01652	0.216
LIG_eIF4E_1	293	299	PF01652	0.515
LIG_eIF4E_1	407	413	PF01652	0.362
LIG_eIF4E_1	535	541	PF01652	0.515
LIG_FHA_1	159	165	PF00498	0.259
LIG_FHA_1	184	190	PF00498	0.227
LIG_FHA_1	200	206	PF00498	0.257
LIG_FHA_1	31	37	PF00498	0.391
LIG_FHA_1	375	381	PF00498	0.283
LIG_FHA_1	407	413	PF00498	0.285
LIG_FHA_1	424	430	PF00498	0.178
LIG_FHA_1	591	597	PF00498	0.262
LIG_FHA_2	178	184	PF00498	0.233
LIG_FHA_2	220	226	PF00498	0.315
LIG_FHA_2	242	248	PF00498	0.216
LIG_FHA_2	80	86	PF00498	0.241
LIG_LIR_Apic_2	13	19	PF02991	0.481
LIG_LIR_Apic_2	313	318	PF02991	0.413
LIG_LIR_Gen_1	160	170	PF02991	0.301
LIG_LIR_Gen_1	388	397	PF02991	0.534
LIG_LIR_Gen_1	422	433	PF02991	0.262
LIG_LIR_Gen_1	480	489	PF02991	0.311
LIG_LIR_Gen_1	492	500	PF02991	0.301
LIG_LIR_Gen_1	533	543	PF02991	0.285
LIG_LIR_Gen_1	606	617	PF02991	0.343
LIG_LIR_Nem_3	140	146	PF02991	0.164
LIG_LIR_Nem_3	160	166	PF02991	0.275
LIG_LIR_Nem_3	175	179	PF02991	0.197
LIG_LIR_Nem_3	244	249	PF02991	0.218
LIG_LIR_Nem_3	304	310	PF02991	0.444
LIG_LIR_Nem_3	388	392	PF02991	0.429
LIG_LIR_Nem_3	422	428	PF02991	0.262
LIG_LIR_Nem_3	480	484	PF02991	0.302
LIG_LIR_Nem_3	492	496	PF02991	0.244
LIG_LIR_Nem_3	498	503	PF02991	0.180
LIG_LIR_Nem_3	530	535	PF02991	0.271
LIG_LIR_Nem_3	606	612	PF02991	0.321
LIG_MAD2	188	196	PF02301	0.280
LIG_MYND_3	131	135	PF01753	0.315
LIG_NRBOX	357	363	PF00104	0.416
LIG_NRBOX	379	385	PF00104	0.546
LIG_NRBOX	427	433	PF00104	0.256
LIG_Pex14_1	389	393	PF04695	0.421
LIG_Pex14_1	52	56	PF04695	0.359
LIG_Pex14_1	546	550	PF04695	0.414
LIG_Pex14_1	559	563	PF04695	0.248
LIG_Pex14_2	500	504	PF04695	0.225
LIG_SH2_CRK	143	147	PF00017	0.183
LIG_SH2_CRK	262	266	PF00017	0.253
LIG_SH2_CRK	535	539	PF00017	0.433
LIG_SH2_CRK	563	567	PF00017	0.382
LIG_SH2_CRK	586	590	PF00017	0.427
LIG_SH2_NCK_1	262	266	PF00017	0.205
LIG_SH2_PTP2	280	283	PF00017	0.309
LIG_SH2_PTP2	481	484	PF00017	0.384
LIG_SH2_PTP2	493	496	PF00017	0.410
LIG_SH2_STAP1	114	118	PF00017	0.259
LIG_SH2_STAP1	231	235	PF00017	0.217
LIG_SH2_STAT5	249	252	PF00017	0.280
LIG_SH2_STAT5	280	283	PF00017	0.284
LIG_SH2_STAT5	407	410	PF00017	0.250
LIG_SH2_STAT5	430	433	PF00017	0.393
LIG_SH2_STAT5	481	484	PF00017	0.268
LIG_SH2_STAT5	493	496	PF00017	0.330
LIG_SH2_STAT5	563	566	PF00017	0.283
LIG_SH3_1	466	472	PF00018	0.424
LIG_SH3_3	311	317	PF00018	0.486
LIG_SH3_3	394	400	PF00018	0.240
LIG_SH3_3	435	441	PF00018	0.265
LIG_SH3_3	466	472	PF00018	0.421
LIG_Sin3_3	340	347	PF02671	0.181
LIG_SUMO_SIM_anti_2	269	275	PF11976	0.292
LIG_SUMO_SIM_anti_2	360	365	PF11976	0.278
LIG_SUMO_SIM_anti_2	593	598	PF11976	0.326
LIG_SUMO_SIM_par_1	269	275	PF11976	0.413
LIG_TYR_ITIM	174	179	PF00017	0.256
LIG_TYR_ITIM	278	283	PF00017	0.284
LIG_TYR_ITIM	479	484	PF00017	0.299
LIG_TYR_ITIM	565	570	PF00017	0.319
LIG_Vh1_VBS_1	597	615	PF01044	0.181
LIG_WRC_WIRS_1	511	516	PF05994	0.342
LIG_WW_3	316	320	PF00397	0.515
MOD_CDK_SPxK_1	237	243	PF00069	0.267
MOD_CK1_1	10	16	PF00069	0.557
MOD_CK1_1	156	162	PF00069	0.214
MOD_CK1_1	181	187	PF00069	0.323
MOD_CK1_1	254	260	PF00069	0.309
MOD_CK1_1	40	46	PF00069	0.267
MOD_CK1_1	453	459	PF00069	0.500
MOD_CK1_1	498	504	PF00069	0.302
MOD_CK1_1	530	536	PF00069	0.353
MOD_CK1_1	63	69	PF00069	0.300
MOD_CK1_1	70	76	PF00069	0.303
MOD_CK2_1	104	110	PF00069	0.269
MOD_CK2_1	219	225	PF00069	0.322
MOD_CK2_1	26	32	PF00069	0.370
MOD_CK2_1	289	295	PF00069	0.515
MOD_CK2_1	489	495	PF00069	0.309
MOD_GlcNHglycan	102	105	PF01048	0.495
MOD_GlcNHglycan	303	307	PF01048	0.291
MOD_GlcNHglycan	552	555	PF01048	0.252
MOD_GlcNHglycan	84	88	PF01048	0.467
MOD_GSK3_1	10	17	PF00069	0.504
MOD_GSK3_1	100	107	PF00069	0.248
MOD_GSK3_1	153	160	PF00069	0.269
MOD_GSK3_1	177	184	PF00069	0.262
MOD_GSK3_1	195	202	PF00069	0.306
MOD_GSK3_1	219	226	PF00069	0.257
MOD_GSK3_1	237	244	PF00069	0.298
MOD_GSK3_1	26	33	PF00069	0.318
MOD_GSK3_1	414	421	PF00069	0.255
MOD_GSK3_1	449	456	PF00069	0.299
MOD_GSK3_1	495	502	PF00069	0.396
MOD_GSK3_1	527	534	PF00069	0.309
MOD_GSK3_1	546	553	PF00069	0.341
MOD_GSK3_1	58	65	PF00069	0.281
MOD_GSK3_1	79	86	PF00069	0.361
MOD_N-GLC_1	153	158	PF02516	0.467
MOD_N-GLC_1	453	458	PF02516	0.303
MOD_NEK2_1	100	105	PF00069	0.256
MOD_NEK2_1	172	177	PF00069	0.230
MOD_NEK2_1	26	31	PF00069	0.397
MOD_NEK2_1	272	277	PF00069	0.267
MOD_NEK2_1	282	287	PF00069	0.253
MOD_NEK2_1	357	362	PF00069	0.367
MOD_NEK2_1	368	373	PF00069	0.249
MOD_NEK2_1	37	42	PF00069	0.285
MOD_NEK2_1	393	398	PF00069	0.286
MOD_NEK2_1	436	441	PF00069	0.307
MOD_NEK2_1	489	494	PF00069	0.289
MOD_NEK2_1	50	55	PF00069	0.315
MOD_NEK2_1	550	555	PF00069	0.262
MOD_NEK2_1	603	608	PF00069	0.274
MOD_NEK2_1	613	618	PF00069	0.509
MOD_NEK2_1	62	67	PF00069	0.236
MOD_NEK2_1	83	88	PF00069	0.243
MOD_NEK2_2	527	532	PF00069	0.386
MOD_NEK2_2	546	551	PF00069	0.551
MOD_PIKK_1	26	32	PF00454	0.326
MOD_PIKK_1	60	66	PF00454	0.327
MOD_PK_1	51	57	PF00069	0.285
MOD_PKA_1	385	391	PF00069	0.515
MOD_PKA_2	104	110	PF00069	0.178
MOD_PKA_2	156	162	PF00069	0.310
MOD_PKA_2	227	233	PF00069	0.334
MOD_PKA_2	254	260	PF00069	0.254
MOD_PKA_2	385	391	PF00069	0.515
MOD_PKA_2	50	56	PF00069	0.410
MOD_PKA_2	70	76	PF00069	0.121
MOD_Plk_1	288	294	PF00069	0.426
MOD_Plk_1	453	459	PF00069	0.479
MOD_Plk_2-3	135	141	PF00069	0.254
MOD_Plk_2-3	289	295	PF00069	0.515
MOD_Plk_4	172	178	PF00069	0.320
MOD_Plk_4	260	266	PF00069	0.247
MOD_Plk_4	272	278	PF00069	0.212
MOD_Plk_4	322	328	PF00069	0.476
MOD_Plk_4	338	344	PF00069	0.217
MOD_Plk_4	357	363	PF00069	0.142
MOD_Plk_4	424	430	PF00069	0.235
MOD_Plk_4	477	483	PF00069	0.287
MOD_Plk_4	489	495	PF00069	0.271
MOD_Plk_4	499	505	PF00069	0.186
MOD_Plk_4	51	57	PF00069	0.285
MOD_Plk_4	527	533	PF00069	0.280
MOD_Plk_4	536	542	PF00069	0.434
MOD_Plk_4	603	609	PF00069	0.317
MOD_ProDKin_1	237	243	PF00069	0.289
MOD_SUMO_rev_2	251	259	PF00179	0.305
TRG_ENDOCYTIC_2	143	146	PF00928	0.295
TRG_ENDOCYTIC_2	167	170	PF00928	0.280
TRG_ENDOCYTIC_2	176	179	PF00928	0.219
TRG_ENDOCYTIC_2	262	265	PF00928	0.421
TRG_ENDOCYTIC_2	280	283	PF00928	0.215
TRG_ENDOCYTIC_2	407	410	PF00928	0.250
TRG_ENDOCYTIC_2	481	484	PF00928	0.389
TRG_ENDOCYTIC_2	493	496	PF00928	0.310
TRG_ENDOCYTIC_2	509	512	PF00928	0.151
TRG_ENDOCYTIC_2	535	538	PF00928	0.422
TRG_ENDOCYTIC_2	563	566	PF00928	0.254
TRG_ENDOCYTIC_2	567	570	PF00928	0.245
TRG_ENDOCYTIC_2	586	589	PF00928	0.159
TRG_ER_diArg_1	143	145	PF00400	0.297
TRG_ER_diArg_1	286	288	PF00400	0.448
TRG_ER_diArg_1	384	387	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	29%	93%
A0A0N1I2B1	Leptomonas seymouri	57%	98%
A0A0N1I6Y7	Leptomonas seymouri	28%	100%
A0A0N1IME8	Leptomonas seymouri	21%	100%
A0A0S4IV41	Bodo saltans	33%	97%
A0A0S4J9X2	Bodo saltans	30%	96%
A0A0S4JBB1	Bodo saltans	38%	97%
A0A0S4JCH7	Bodo saltans	30%	90%
A0A0S4JEU5	Bodo saltans	30%	97%
A0A0S4JIF4	Bodo saltans	36%	97%
A0A0S4JWZ9	Bodo saltans	28%	100%
A0A0S4JZ31	Bodo saltans	30%	100%
A0A1X0NJN3	Trypanosomatidae	24%	100%
A0A1X0NK64	Trypanosomatidae	33%	99%
A0A1X0NLM6	Trypanosomatidae	24%	100%
A0A1X0NZX5	Trypanosomatidae	31%	96%
A0A1X0P2G3	Trypanosomatidae	46%	98%
A0A1X0P6M4	Trypanosomatidae	32%	81%
A0A1X0PA12	Trypanosomatidae	32%	98%
A0A3Q8IBT4	Leishmania donovani	26%	100%
A0A3Q8IFM1	Leishmania donovani	92%	97%
A0A3Q8IHT3	Leishmania donovani	29%	97%
A0A3R7MBZ3	Trypanosoma rangeli	32%	99%
A0A3S7X2L7	Leishmania donovani	29%	91%
A0A422NED2	Trypanosoma rangeli	30%	96%
A0A422NMS9	Trypanosoma rangeli	46%	95%
A0A422P482	Trypanosoma rangeli	25%	100%
A4H7C1	Leishmania braziliensis	23%	100%
A4HB85	Leishmania braziliensis	29%	99%
A4HHH4	Leishmania braziliensis	29%	91%
A4HHY3	Leishmania braziliensis	77%	97%
A4HVR6	Leishmania infantum	26%	100%
A4I4M3	Leishmania infantum	29%	91%
A4I563	Leishmania infantum	93%	97%
A4IAD3	Leishmania infantum	29%	97%
A4IFE9	Bos taurus	30%	100%
A5D7E2	Bos taurus	33%	97%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	85%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	99%
D0A6H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AE21	Leishmania major	30%	100%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	91%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	94%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	97%
F4HW17	Arabidopsis thaliana	27%	100%
F4JRE0	Arabidopsis thaliana	30%	95%
F4KIB2	Arabidopsis thaliana	32%	96%
O15321	Homo sapiens	30%	100%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	93%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	88%
P58021	Mus musculus	31%	94%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	92%
Q4KLL4	Rattus norvegicus	32%	96%
Q4Q2H8	Leishmania major	27%	97%
Q4QG16	Leishmania major	25%	100%
Q54ZW0	Dictyostelium discoideum	27%	100%
Q55FP0	Dictyostelium discoideum	29%	97%
Q5R8F1	Pongo abelii	31%	100%
Q5R8Y6	Pongo abelii	31%	94%
Q5RDY2	Pongo abelii	33%	97%
Q66HF2	Rattus norvegicus	29%	100%
Q66HG5	Rattus norvegicus	31%	94%
Q7YTA6	Dictyostelium discoideum	26%	95%
Q8BH24	Mus musculus	32%	96%
Q8RWW1	Arabidopsis thaliana	33%	97%
Q92544	Homo sapiens	33%	97%
Q940G0	Arabidopsis thaliana	29%	100%
Q940S0	Arabidopsis thaliana	28%	100%
Q99805	Homo sapiens	31%	94%
Q9C5N2	Arabidopsis thaliana	33%	96%
Q9C720	Arabidopsis thaliana	31%	97%
Q9DBU0	Mus musculus	30%	100%
Q9ET30	Mus musculus	30%	100%
Q9FHT4	Arabidopsis thaliana	28%	100%
Q9FYQ8	Arabidopsis thaliana	31%	94%
Q9HD45	Homo sapiens	30%	100%
Q9LIC2	Arabidopsis thaliana	31%	97%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	99%
Q9ZPS7	Arabidopsis thaliana	28%	100%
V5BCD5	Trypanosoma cruzi	45%	98%
V5BHS7	Trypanosoma cruzi	32%	100%
V5D9U0	Trypanosoma cruzi	30%	96%
V5DII3	Trypanosoma cruzi	23%	100%