Putative phosphatase 2C

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatase 2C, putative

Species:

Leishmania major

UniProt:

Q4Q7S1_LEIMA

TriTrypDb:

LmjF.30.0380 , LMJLV39_300009200 , LMJSD75_300009000

Length:

384

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 1
Pissara et al.	no	yes: 7

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

Q4Q7S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7S1

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0035970	peptidyl-threonine dephosphorylation	6	3
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0004721	phosphoprotein phosphatase activity	3	27
GO:0004722	protein serine/threonine phosphatase activity	4	27
GO:0016787	hydrolase activity	2	27
GO:0016788	hydrolase activity, acting on ester bonds	3	27
GO:0016791	phosphatase activity	5	27
GO:0017018	myosin phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	27
GO:0140096	catalytic activity, acting on a protein	2	27
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.394
CLV_PCSK_SKI1_1	117	121	PF00082	0.372
CLV_PCSK_SKI1_1	138	142	PF00082	0.259
CLV_PCSK_SKI1_1	343	347	PF00082	0.427
CLV_PCSK_SKI1_1	371	375	PF00082	0.466
CLV_PCSK_SKI1_1	7	11	PF00082	0.302
DOC_MAPK_DCC_7	196	205	PF00069	0.422
DOC_MAPK_gen_1	116	123	PF00069	0.266
DOC_MAPK_gen_1	190	200	PF00069	0.394
DOC_MAPK_MEF2A_6	116	123	PF00069	0.297
DOC_MAPK_MEF2A_6	196	205	PF00069	0.422
DOC_PP1_RVXF_1	136	142	PF00149	0.270
DOC_PP2B_LxvP_1	3	6	PF13499	0.498
DOC_USP7_MATH_1	17	21	PF00917	0.392
DOC_USP7_MATH_1	201	205	PF00917	0.402
DOC_USP7_MATH_1	25	29	PF00917	0.315
DOC_USP7_MATH_1	62	66	PF00917	0.395
LIG_14-3-3_CanoR_1	16	22	PF00244	0.355
LIG_14-3-3_CanoR_1	33	37	PF00244	0.271
LIG_BRCT_BRCA1_1	175	179	PF00533	0.250
LIG_deltaCOP1_diTrp_1	355	361	PF00928	0.358
LIG_FHA_1	109	115	PF00498	0.270
LIG_FHA_1	118	124	PF00498	0.253
LIG_FHA_1	152	158	PF00498	0.372
LIG_FHA_1	284	290	PF00498	0.514
LIG_FHA_2	100	106	PF00498	0.158
LIG_FHA_2	342	348	PF00498	0.421
LIG_LIR_Gen_1	109	119	PF02991	0.277
LIG_LIR_Gen_1	212	221	PF02991	0.331
LIG_LIR_Gen_1	322	330	PF02991	0.338
LIG_LIR_Gen_1	355	366	PF02991	0.405
LIG_LIR_LC3C_4	267	271	PF02991	0.236
LIG_LIR_Nem_3	109	115	PF02991	0.287
LIG_LIR_Nem_3	212	216	PF02991	0.327
LIG_LIR_Nem_3	322	327	PF02991	0.330
LIG_LIR_Nem_3	355	361	PF02991	0.358
LIG_LIR_Nem_3	49	55	PF02991	0.387
LIG_Pex14_2	222	226	PF04695	0.250
LIG_REV1ctd_RIR_1	358	364	PF16727	0.427
LIG_SH2_CRK	324	328	PF00017	0.316
LIG_SH2_SRC	149	152	PF00017	0.191
LIG_SH2_STAP1	305	309	PF00017	0.352
LIG_SH2_STAT3	192	195	PF00017	0.306
LIG_SH2_STAT5	149	152	PF00017	0.219
LIG_SH2_STAT5	52	55	PF00017	0.322
LIG_SH2_STAT5	67	70	PF00017	0.294
LIG_SH3_3	145	151	PF00018	0.348
LIG_SH3_3	286	292	PF00018	0.349
LIG_SUMO_SIM_anti_2	202	207	PF11976	0.341
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.300
LIG_SUMO_SIM_par_1	196	202	PF11976	0.257
LIG_TYR_ITIM	50	55	PF00017	0.394
MOD_CK1_1	163	169	PF00069	0.394
MOD_CK2_1	341	347	PF00069	0.424
MOD_CK2_1	57	63	PF00069	0.456
MOD_CK2_1	99	105	PF00069	0.408
MOD_GlcNHglycan	63	67	PF01048	0.335
MOD_GSK3_1	101	108	PF00069	0.427
MOD_GSK3_1	377	384	PF00069	0.583
MOD_N-GLC_1	224	229	PF02516	0.306
MOD_N-GLC_1	264	269	PF02516	0.300
MOD_NEK2_1	119	124	PF00069	0.394
MOD_NEK2_1	173	178	PF00069	0.283
MOD_NEK2_1	283	288	PF00069	0.557
MOD_NEK2_1	311	316	PF00069	0.438
MOD_NEK2_1	377	382	PF00069	0.469
MOD_NEK2_2	180	185	PF00069	0.263
MOD_PIKK_1	25	31	PF00454	0.384
MOD_PIKK_1	334	340	PF00454	0.317
MOD_PKA_2	32	38	PF00069	0.283
MOD_Plk_1	117	123	PF00069	0.235
MOD_Plk_1	180	186	PF00069	0.275
MOD_Plk_1	201	207	PF00069	0.309
MOD_Plk_1	264	270	PF00069	0.300
MOD_Plk_1	356	362	PF00069	0.514
MOD_Plk_1	62	68	PF00069	0.375
MOD_Plk_4	160	166	PF00069	0.394
MOD_Plk_4	17	23	PF00069	0.369
MOD_Plk_4	201	207	PF00069	0.413
MOD_Plk_4	284	290	PF00069	0.403
MOD_SUMO_rev_2	144	148	PF00179	0.289
TRG_DiLeu_BaEn_2	208	214	PF01217	0.203
TRG_ENDOCYTIC_2	305	308	PF00928	0.329
TRG_ENDOCYTIC_2	324	327	PF00928	0.303
TRG_ENDOCYTIC_2	52	55	PF00928	0.394
TRG_NES_CRM1_1	81	97	PF08389	0.409
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C7	Leptomonas seymouri	31%	97%
A0A0N1I8W9	Leptomonas seymouri	29%	88%
A0A0N1IHU6	Leptomonas seymouri	44%	94%
A0A0N1PAL8	Leptomonas seymouri	86%	100%
A0A0N1PEL9	Leptomonas seymouri	30%	100%
A0A0S4IY95	Bodo saltans	32%	100%
A0A0S4J0A6	Bodo saltans	41%	94%
A0A0S4J8Y7	Bodo saltans	34%	74%
A0A0S4JHB4	Bodo saltans	54%	100%
A0A0S4JPC3	Bodo saltans	34%	100%
A0A0S4JPM8	Bodo saltans	33%	100%
A0A1X0NRG3	Trypanosomatidae	31%	100%
A0A1X0NUB7	Trypanosomatidae	32%	80%
A0A1X0NVC4	Trypanosomatidae	33%	93%
A0A1X0P2A0	Trypanosomatidae	56%	100%
A0A1X0P568	Trypanosomatidae	40%	94%
A0A1X0P991	Trypanosomatidae	33%	100%
A0A1X0PAN4	Trypanosomatidae	31%	100%
A0A3Q8IEK6	Leishmania donovani	33%	100%
A0A3Q8IFG7	Leishmania donovani	98%	100%
A0A3Q8IGS1	Leishmania donovani	31%	68%
A0A3Q8IK65	Leishmania donovani	38%	100%
A0A3Q8IL63	Leishmania donovani	30%	98%
A0A3S7WTA2	Leishmania donovani	31%	95%
A0A3S7WZ14	Leishmania donovani	45%	95%
A0A3S7X808	Leishmania donovani	28%	85%
A0A422N8D7	Trypanosoma rangeli	28%	100%
A0A422NAJ1	Trypanosoma rangeli	30%	100%
A0A422NBV9	Trypanosoma rangeli	41%	94%
A0A422NL94	Trypanosoma rangeli	31%	88%
A0A422NML6	Trypanosoma rangeli	56%	100%
A0A422NS77	Trypanosoma rangeli	35%	93%
A0A422P293	Trypanosoma rangeli	33%	100%
A0CUB5	Paramecium tetraurelia	30%	100%
A0DSB3	Paramecium tetraurelia	30%	100%
A0DTY1	Paramecium tetraurelia	30%	100%
A3A8W2	Oryza sativa subsp. japonica	29%	100%
A3A8W6	Oryza sativa subsp. japonica	25%	66%
A3CCP9	Oryza sativa subsp. japonica	26%	77%
A4H7Y6	Leishmania braziliensis	32%	95%
A4HAW5	Leishmania braziliensis	32%	97%
A4HAW6	Leishmania braziliensis	29%	85%
A4HE10	Leishmania braziliensis	44%	95%
A4HG10	Leishmania braziliensis	32%	100%
A4HHY5	Leishmania braziliensis	92%	100%
A4HKF6	Leishmania braziliensis	31%	68%
A4HNR1	Leishmania braziliensis	36%	100%
A4HWB4	Leishmania infantum	31%	95%
A4I1B7	Leishmania infantum	45%	95%
A4I329	Leishmania infantum	33%	100%
A4I565	Leishmania infantum	98%	100%
A4I7Y4	Leishmania infantum	31%	68%
A4IA25	Leishmania infantum	30%	98%
A4IA26	Leishmania infantum	28%	85%
A4ICT4	Leishmania infantum	37%	100%
A5PJZ2	Bos taurus	32%	100%
C9ZJK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZMJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZNW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	90%
C9ZQJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
D0A2L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A5L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
D0AA51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	90%
E9ACV0	Leishmania major	31%	100%
E9AQ14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	95%
E9ASH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AXF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	95%
E9AZD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B0G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B2U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	68%
E9B540	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	98%
E9B541	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O04719	Arabidopsis thaliana	30%	91%
O62829	Bos taurus	34%	100%
O62830	Bos taurus	33%	79%
O75688	Homo sapiens	32%	80%
O80492	Arabidopsis thaliana	28%	90%
O80871	Arabidopsis thaliana	27%	97%
P20650	Rattus norvegicus	34%	100%
P34221	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	82%
P35182	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P35813	Homo sapiens	34%	100%
P35814	Oryctolagus cuniculus	34%	100%
P35815	Rattus norvegicus	33%	98%
P36982	Leishmania chagasi	45%	95%
P36993	Mus musculus	32%	98%
P38089	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	98%
P40371	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
P49443	Mus musculus	34%	100%
P49593	Homo sapiens	29%	85%
P49596	Caenorhabditis elegans	34%	100%
P49597	Arabidopsis thaliana	29%	88%
P49599	Arabidopsis thaliana	28%	99%
P93006	Arabidopsis thaliana	27%	100%
Q0DBU3	Oryza sativa subsp. japonica	31%	100%
Q0IIF0	Bos taurus	32%	100%
Q0J2L7	Oryza sativa subsp. japonica	33%	100%
Q0J2R1	Oryza sativa subsp. japonica	34%	100%
Q0JL75	Oryza sativa subsp. japonica	32%	100%
Q0JLP9	Oryza sativa subsp. japonica	29%	82%
Q10MN6	Oryza sativa subsp. japonica	27%	89%
Q10MX1	Oryza sativa subsp. japonica	30%	98%
Q19775	Caenorhabditis elegans	33%	82%
Q2PC20	Bos taurus	31%	100%
Q2QWE3	Oryza sativa subsp. japonica	28%	91%
Q2R637	Oryza sativa subsp. japonica	27%	89%
Q3EAF9	Arabidopsis thaliana	28%	100%
Q4PSE8	Arabidopsis thaliana	36%	86%
Q4Q225	Leishmania major	38%	100%
Q4Q2U5	Leishmania major	28%	85%
Q4Q2U6	Leishmania major	30%	100%
Q4Q5B1	Leishmania major	31%	68%
Q4QA19	Leishmania major	45%	100%
Q4QFG7	Leishmania major	31%	95%
Q53Q11	Oryza sativa subsp. japonica	31%	97%
Q5JKN1	Oryza sativa subsp. japonica	28%	99%
Q5N9N2	Oryza sativa subsp. japonica	31%	93%
Q5SGD2	Homo sapiens	34%	100%
Q5SMK6	Oryza sativa subsp. japonica	27%	100%
Q5Z6F5	Oryza sativa subsp. japonica	35%	100%
Q652Z7	Oryza sativa subsp. japonica	30%	100%
Q653S3	Oryza sativa subsp. japonica	28%	100%
Q65XK7	Oryza sativa subsp. japonica	27%	100%
Q67J17	Oryza sativa subsp. japonica	25%	91%
Q67UX7	Oryza sativa subsp. japonica	35%	100%
Q69QZ0	Oryza sativa subsp. japonica	28%	100%
Q69VD9	Oryza sativa subsp. japonica	28%	100%
Q6AUQ4	Oryza sativa subsp. japonica	27%	99%
Q6EN45	Oryza sativa subsp. japonica	33%	100%
Q6ING9	Xenopus laevis	30%	100%
Q6K1U4	Oryza sativa subsp. japonica	24%	74%
Q6K5I0	Oryza sativa subsp. japonica	24%	74%
Q6L4R7	Oryza sativa subsp. japonica	28%	86%
Q6L5C4	Oryza sativa subsp. japonica	33%	78%
Q6L5H6	Oryza sativa subsp. japonica	29%	99%
Q6YTI2	Oryza sativa subsp. japonica	24%	87%
Q6ZKL8	Oryza sativa subsp. japonica	28%	72%
Q7XJ53	Arabidopsis thaliana	25%	100%
Q7XR06	Oryza sativa subsp. japonica	33%	100%
Q7XU84	Oryza sativa subsp. japonica	30%	100%
Q8BGL1	Mus musculus	32%	95%
Q8BHN0	Mus musculus	34%	100%
Q8BXN7	Mus musculus	32%	100%
Q8CGA0	Mus musculus	29%	85%
Q8LAY8	Arabidopsis thaliana	37%	100%
Q8N3J5	Homo sapiens	32%	100%
Q8N819	Homo sapiens	33%	89%
Q8R0F6	Mus musculus	32%	98%
Q8RX37	Arabidopsis thaliana	27%	100%
Q8RXV3	Arabidopsis thaliana	34%	100%
Q8VZN9	Arabidopsis thaliana	34%	100%
Q93YS2	Arabidopsis thaliana	27%	73%
Q9FX08	Arabidopsis thaliana	25%	90%
Q9FYN7	Oryza sativa subsp. japonica	28%	100%
Q9H0C8	Homo sapiens	32%	98%
Q9LME4	Arabidopsis thaliana	31%	100%
Q9LMT1	Arabidopsis thaliana	30%	100%
Q9LNF4	Arabidopsis thaliana	28%	100%
Q9LNP9	Arabidopsis thaliana	27%	75%
Q9LR65	Arabidopsis thaliana	27%	83%
Q9LUU7	Arabidopsis thaliana	29%	91%
Q9M9C6	Arabidopsis thaliana	30%	88%
Q9M9W9	Arabidopsis thaliana	31%	100%
Q9S9Z7	Arabidopsis thaliana	32%	100%
Q9SD02	Arabidopsis thaliana	28%	100%
Q9SLA1	Arabidopsis thaliana	28%	98%
Q9WVR7	Rattus norvegicus	29%	85%
Q9XEE8	Arabidopsis thaliana	28%	98%
Q9Z1Z6	Rattus norvegicus	32%	98%
V5AZJ4	Trypanosoma cruzi	30%	97%
V5BA03	Trypanosoma cruzi	33%	100%
V5BCX6	Trypanosoma cruzi	32%	100%
V5BH00	Trypanosoma cruzi	57%	100%
V5BSS7	Trypanosoma cruzi	41%	94%
V5DCR6	Trypanosoma cruzi	34%	93%